Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

An explosion of new techniques with vastly improved visualization and sensitivity is leading a veritable revolution in modern neuroanatomy. Basic questions related to cell types, input localization, and connectivity are being re-visited and tackled with significantly more accurate and higher resolution experimental approaches. A major goal of this e-Book is thus to highlight in one place the impressive range of available techniques, even as these are fast becoming routine. This is not meant as a technical review, however, but rather will project the technical explosion as indicative of a field now in a vibrant state of renewal. Thus, contributions will be mainly research articles using the newer techniques. A second goal is to showcase what has become the conspicuous interdisciplinary reach of the field: neuroanatomical standards and the close association of structure-function and underlying circuitry mechanisms are increasingly relevant to investigations in development, physiology, and disease. Another feature of this Research Topic is that it includes a breadth of cross-species contributions from investigators working with rodent, nonhuman primate, and human brains. This is important since most of our current knowledge of brain structure has been obtained from experimental animals. However, recent technical advances, coupled with researcher willingness to use the human tissue available, will undoubtedly lead to major advances in the near future regarding human brain mapping and connectomes. Thus, of particular interest will be the methods that can help to define general wiring principles in the brain, both structural and functional. Overall, the state of the field is: exciting.

Human neuroanatomy --- light-sheet imaging --- two-photon tomography --- FIB/SEM --- fMOST --- synaptic weights --- text-mining --- Polarized light microscopy --- viral vectors --- Human neuroanatomy --- light-sheet imaging --- two-photon tomography --- FIB/SEM --- fMOST --- synaptic weights --- text-mining --- Polarized light microscopy --- viral vectors

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

An explosion of new techniques with vastly improved visualization and sensitivity is leading a veritable revolution in modern neuroanatomy. Basic questions related to cell types, input localization, and connectivity are being re-visited and tackled with significantly more accurate and higher resolution experimental approaches. A major goal of this e-Book is thus to highlight in one place the impressive range of available techniques, even as these are fast becoming routine. This is not meant as a technical review, however, but rather will project the technical explosion as indicative of a field now in a vibrant state of renewal. Thus, contributions will be mainly research articles using the newer techniques. A second goal is to showcase what has become the conspicuous interdisciplinary reach of the field: neuroanatomical standards and the close association of structure-function and underlying circuitry mechanisms are increasingly relevant to investigations in development, physiology, and disease. Another feature of this Research Topic is that it includes a breadth of cross-species contributions from investigators working with rodent, nonhuman primate, and human brains. This is important since most of our current knowledge of brain structure has been obtained from experimental animals. However, recent technical advances, coupled with researcher willingness to use the human tissue available, will undoubtedly lead to major advances in the near future regarding human brain mapping and connectomes. Thus, of particular interest will be the methods that can help to define general wiring principles in the brain, both structural and functional. Overall, the state of the field is: exciting.

Human neuroanatomy --- light-sheet imaging --- two-photon tomography --- FIB/SEM --- fMOST --- synaptic weights --- text-mining --- Polarized light microscopy --- viral vectors

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This compilation of articles elaborates on plant virus diseases that are among the most recent epidemiological concerns. The chapters explore several paradigms in plant virus epidemiology, outbreaks, epidemics, and pandemics paralleling zoonotic viruses and that can be consequential to global food security. There is evidence that the local, regional, national, and global trade of agricultural products has aided the global dispersal of plant virus diseases. Expanding farmlands into pristine natural areas has created opportunities for viruses in native landscapes to invade crops, while the movement of food and food products disseminates viruses, creating epidemics or pandemics. Moreover, plant virus outbreaks not only directly impact food supply, but also incidentally affect human health.

Research & information: general --- sugar beet --- rhizomania --- RNAseq --- virus --- necrovirus --- helper virus --- Aphis gossypii --- Cucumis melo --- cucurbit viruses --- disease progress curve --- insect trapping --- logistic model --- Spearman correlation --- temporal dynamics --- Bunyavirale --- RNA virus --- emerging virus --- virus evolution --- plant virus --- cophylogeny --- hallmark genes --- common bean --- Phaseolus vulgaris --- cytorhabdovirus --- whitefly --- Bemisia tabaci --- vector --- virus transmission --- ToTV --- emerging disease --- prevalence --- whole-genome sequencing --- phylogeny --- tomato torrado virus --- sGFP --- plant pathology --- infectious clone --- plant-virus interaction --- pandemics --- epidemics --- global --- disease --- threat --- food insecurity --- crop losses --- crop failure --- indigenous viruses --- introduced crops --- new encounter --- spillover --- developing countries --- domestication centers --- sub-Saharan Africa --- Potyviruses --- whole genome sequencing --- epidemiology --- virus resistance --- virus host interactions --- plant viruses --- viral vectors --- plant diseases --- virus spread --- biopharming --- vaccines --- viruses --- Nicotiana benthamiana --- COVID-19 --- plant-based biologics production --- sugar beet --- rhizomania --- RNAseq --- virus --- necrovirus --- helper virus --- Aphis gossypii --- Cucumis melo --- cucurbit viruses --- disease progress curve --- insect trapping --- logistic model --- Spearman correlation --- temporal dynamics --- Bunyavirale --- RNA virus --- emerging virus --- virus evolution --- plant virus --- cophylogeny --- hallmark genes --- common bean --- Phaseolus vulgaris --- cytorhabdovirus --- whitefly --- Bemisia tabaci --- vector --- virus transmission --- ToTV --- emerging disease --- prevalence --- whole-genome sequencing --- phylogeny --- tomato torrado virus --- sGFP --- plant pathology --- infectious clone --- plant-virus interaction --- pandemics --- epidemics --- global --- disease --- threat --- food insecurity --- crop losses --- crop failure --- indigenous viruses --- introduced crops --- new encounter --- spillover --- developing countries --- domestication centers --- sub-Saharan Africa --- Potyviruses --- whole genome sequencing --- epidemiology --- virus resistance --- virus host interactions --- plant viruses --- viral vectors --- plant diseases --- virus spread --- biopharming --- vaccines --- viruses --- Nicotiana benthamiana --- COVID-19 --- plant-based biologics production

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book is a compilation of articles that brings together current knowledge from an international team of contributors who are dedicated investigators exploring novel strategies for the treatment of glioblastoma. These articles describe some of the latest concepts that will provide students, researchers and clinicians with an overview of the therapeutic approaches being developed in the field of neuro-oncology to combat this deadly disease.

glioblastoma --- glioma --- temozolomide --- radiotherapy --- immunotherapy --- novel therapy --- personalized treatment --- drug repurposing --- invasion --- invadopodia --- ion channels --- gene therapy --- viral vectors --- brain tumor --- nanomedicine --- cancer stem cell --- targeted therapy --- brain cancer --- cell cycle --- differentiation --- proliferation --- RAS --- SRGAP2 --- stem cell --- TP53 --- glioblastoma multiforme --- GBM --- nerve/glial antigen 2 --- NG2 --- CK2 --- CX-4945 --- migration --- CRISPR/Cas9 --- anticancer --- anti-angiogenesis --- thyrointegrin αvβ3 --- PEG --- triazole tetrac --- P-bi-TAT --- P-m-TAT --- tetrac --- one-carbon metabolism --- de novo purine synthesis --- metabolic reprogramming --- metabolic treatment --- vaccine --- immune checkpoint inhibitors --- chimeric antigen receptor (CAR) T cells --- glioblastoma (GB) --- prolyl-oligopeptidase (POP) --- vascular endothelial growth factor (VEGF) --- transforming growth factor-β (TGF-β) --- angiopoietin (Ang) --- endothelial nitric oxide synthase (eNOS) --- newly diagnosed glioblastoma --- recurrent glioblastoma --- new trial design --- drug-inducible gene expression --- Mardepodect --- Regorafenib --- drug targets --- tumor antigens --- renin–angiotensin system --- pluripotent stem cells --- organoids --- cancer stem cells --- cancer stem cell niche --- tumor microenvironment --- n/a --- renin-angiotensin system

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Lysosomal storage disorders are a heterogenoeus group of rare genetic conditions affecting worldwide population and often exhibiting severe clinical manifestations. During the last two decades, the joined collaboration between scientists and clinicians has allowed to offer valuable therapeutic options to affected patients. Therefore, the tight connection between basic science and clinical medicine represents the gold standard approach to these disorders. In this context, the present book collects a piece of current scientific advances in the knowledge of disease pathogenesis and in the development of novel diagnostic and therapeutic strategies for some of these diseases. Altogether, these articles define and recapitulate which essential steps are required during the clinical management of a rare inherited disorder and describe forthcoming advances and a breakthrough in the field of lysosomal diseases.

mucopolysaccharidosis IIIB --- quantitative proteomics --- NAGLU --- lysosomes --- Gaucher disease --- bone involvement --- enzyme replacement therapy --- substrate reduction therapy --- Osteoimmunology --- RANK/RANKL --- Osteopontin --- MIP-1β --- mucolipidosis II --- sortilin --- TGF-beta --- cathepsin D --- Fabry disease --- alpha-galactosidase A --- endocytosis --- lysosome --- IGF2R/M6P --- clathrin --- chloroquine --- lysosomal diseases --- precision medicine --- pharmacological chaperones --- gene therapy. --- Pompe disease --- lysosomal targeting --- autophagy --- gene therapy --- muscle --- satellite cells --- rhGAA --- glycogen --- lysosomal α-glucosidase --- GAA biomarker --- Gaucher Disease --- Wnt/β-catenin --- Dkk1 --- Wnt3a --- iPSC --- neuronopathy --- Krabbe disease --- Twitcher mouse --- psychosine --- visual system --- visual cortex --- astrogliosis --- mucopolysaccharidosis type I --- Hurler syndrome --- hematopoietic stem cell transplantations --- animal models --- experimental therapies --- axon guidance --- lysosomal storage disorders --- neuronal circuit --- α-galactosidase A --- A4GALT --- globotriaosylceramide (Gb3) --- globotriaosyl-sphingosine (lysoGb3) --- pharmacological chaperone therapy --- exosomes --- endocytic pathways --- neurodegenerative disease --- Parkinson disease --- lysosomal storage disorder --- viral vectors --- newborn screening --- variant interpretation --- second tier test --- tandem mass spectrometry --- lyso-Gb3 --- dried blood spot --- GLA gene --- globotriaosylsphingosine --- biomarkers