Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Epidemiological evidence from the last fifty years has demonstrated that nutrition plays a decisive role in human health. Eating properly is not only necessary to meet energy demands. It also actively contributes, through both preventive actions and therapeutic effects, to improving human wellness. Nutrition owes its functional role in human health to the biological activity of specific, small dietary molecules. Plants are the most important source of bioactive molecules, and dietary phytochemicals are mainly responsible for the documented protective effects of diets which are rich in plant foods. Dietary phytochemicals have attracted increasing interest in human nutrition research over the past few years due to their ability to exert several biological effects that are potentially useful for human health, In this Special Issue, the biological activity of dietary phytochemicals, either purified or in extracts from plant foods, and their potential effects on human health are addressed and investigated.

resveratrol --- bioactivities --- anticancer --- anti-obesity --- antidiabetes --- molecular mechanisms --- durum wheat bread --- Portulaca oleracea L. --- essential fatty acids --- omega-6/omega-3 ratio --- antioxidants --- Bangladesh --- vegetables --- polyphenols --- amylase --- glucosidase --- renin --- angiotensin-converting enzyme --- lipase --- mass spectrometry --- yeast --- antioxidant --- cytotoxicity --- bioavailability --- viability --- Punica granatum --- hydrolysable tannins --- flavonoids --- Ultra High Performance Liquid Chromatography-Orbitrap-Mass Spectrometry --- tempura --- deep-fried product --- barley --- buckwheat --- Job’s tears --- antioxidant capacity --- oil deterioration --- polyphenol --- oxidative stress --- necroptosis --- plant extract --- secondary metabolite --- γH2AX --- copper --- African food spices --- GC-MS (gas chromatography mass spectrometry) --- antimicrobial --- antibiofilm --- violacein inhibition --- swarming inhibition --- swimming inhibition --- anticholinesterase --- antiurease --- antityrosinase --- sensory analysis --- mineral content --- proanthocyanidins --- carotenoids --- antioxidant activity --- FRAP --- DPPH --- ABTS --- CAA --- n/a --- Job's tears

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Nature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, natural products feature pharmacologically active pharmacophores which are pharmaceutically validated starting points for the development of new lead compounds. Over half of all approved (from 1981 to 2014) small-molecule drugs derived from NPs, including unaltered NPs, NPs synthetic derivatives and synthetic natural mimics, originated from a NPs pharmacophore or template. According to the FDA, NPs and their derivatives represent over one-third of all FDA-approved new drugs, in particular for anticancer/antibiotic lead compounds, which are remarkably enriched with NPs.

Research & information: general --- Chemistry --- Organic chemistry --- multi-component reaction --- fusidic acid --- TEMPO-conjugate --- electron paramagnetic resonance (EPR) spectroscopy --- caspase-3 --- incomptine A --- sesquiterpene lactone --- Decachaeta incompta --- cytotoxic activity --- iTRAQ --- apoptosis --- ROS production --- violacein --- hepatocellular carcinoma --- proliferation --- stemness --- natural products --- tumor microenvironment (TME) --- lung cancer --- phytochemicals --- botanical agents --- steroidal alkaloids --- solanidane alkaloids --- demissidine --- solanidine --- flavonoids --- coronavirus --- SARS-CoV-2 --- SARS-CoV --- MERS-CoV --- anticancer activity --- apoptosis resistance --- ophiobolin A --- polygodial --- Wittig reaction --- melanoma --- tumor heterogeneity --- pregnancy --- anti-tumor peptides --- in vitro model --- medicinal herbs --- cancer treatment --- cancer stem cells --- drug resistance --- metastasis --- RCE-4 --- PCD --- ATG 4B --- the Bcl-2-Beclin 1 complex --- Sparticola junci --- structure elucidation --- ECD-TDDFT --- COX inhibitory --- molecular docking --- antiproliferative --- cytotoxic --- Sepedonium ampullosporum --- peptaibols --- ampullosporin --- glutamic acid methyl ester --- solid-phase peptide synthesis --- antifungal --- anticancer --- target identification --- kaempferol --- docking --- DARTS --- Src --- breast cancer --- butein --- frondoside-A --- STAT3 --- angiogenesis --- invasion --- viability --- tumor growth --- marine fungi --- Cosmospora sp. --- soudanone --- Magnaporthe oryzae --- co-culture --- phytopathogen --- molecular networking --- metabolomics --- bispecific antibody --- Trypsiligase --- click chemistry --- biorthogonal chemistry --- antibody engineering --- multi-component reaction --- fusidic acid --- TEMPO-conjugate --- electron paramagnetic resonance (EPR) spectroscopy --- caspase-3 --- incomptine A --- sesquiterpene lactone --- Decachaeta incompta --- cytotoxic activity --- iTRAQ --- apoptosis --- ROS production --- violacein --- hepatocellular carcinoma --- proliferation --- stemness --- natural products --- tumor microenvironment (TME) --- lung cancer --- phytochemicals --- botanical agents --- steroidal alkaloids --- solanidane alkaloids --- demissidine --- solanidine --- flavonoids --- coronavirus --- SARS-CoV-2 --- SARS-CoV --- MERS-CoV --- anticancer activity --- apoptosis resistance --- ophiobolin A --- polygodial --- Wittig reaction --- melanoma --- tumor heterogeneity --- pregnancy --- anti-tumor peptides --- in vitro model --- medicinal herbs --- cancer treatment --- cancer stem cells --- drug resistance --- metastasis --- RCE-4 --- PCD --- ATG 4B --- the Bcl-2-Beclin 1 complex --- Sparticola junci --- structure elucidation --- ECD-TDDFT --- COX inhibitory --- molecular docking --- antiproliferative --- cytotoxic --- Sepedonium ampullosporum --- peptaibols --- ampullosporin --- glutamic acid methyl ester --- solid-phase peptide synthesis --- antifungal --- anticancer --- target identification --- kaempferol --- docking --- DARTS --- Src --- breast cancer --- butein --- frondoside-A --- STAT3 --- angiogenesis --- invasion --- viability --- tumor growth --- marine fungi --- Cosmospora sp. --- soudanone --- Magnaporthe oryzae --- co-culture --- phytopathogen --- molecular networking --- metabolomics --- bispecific antibody --- Trypsiligase --- click chemistry --- biorthogonal chemistry --- antibody engineering

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Nature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, natural products feature pharmacologically active pharmacophores which are pharmaceutically validated starting points for the development of new lead compounds. Over half of all approved (from 1981 to 2014) small-molecule drugs derived from NPs, including unaltered NPs, NPs synthetic derivatives and synthetic natural mimics, originated from a NPs pharmacophore or template. According to the FDA, NPs and their derivatives represent over one-third of all FDA-approved new drugs, in particular for anticancer/antibiotic lead compounds, which are remarkably enriched with NPs.

multi-component reaction --- fusidic acid --- TEMPO-conjugate --- electron paramagnetic resonance (EPR) spectroscopy --- caspase-3 --- incomptine A --- sesquiterpene lactone --- Decachaeta incompta --- cytotoxic activity --- iTRAQ --- apoptosis --- ROS production --- violacein --- hepatocellular carcinoma --- proliferation --- stemness --- natural products --- tumor microenvironment (TME) --- lung cancer --- phytochemicals --- botanical agents --- steroidal alkaloids --- solanidane alkaloids --- demissidine --- solanidine --- flavonoids --- coronavirus --- SARS-CoV-2 --- SARS-CoV --- MERS-CoV --- anticancer activity --- apoptosis resistance --- ophiobolin A --- polygodial --- Wittig reaction --- melanoma --- tumor heterogeneity --- pregnancy --- anti-tumor peptides --- in vitro model --- medicinal herbs --- cancer treatment --- cancer stem cells --- drug resistance --- metastasis --- RCE-4 --- PCD --- ATG 4B --- the Bcl-2–Beclin 1 complex --- Sparticola junci --- structure elucidation --- ECD-TDDFT --- COX inhibitory --- molecular docking --- antiproliferative --- cytotoxic --- Sepedonium ampullosporum --- peptaibols --- ampullosporin --- glutamic acid methyl ester --- solid-phase peptide synthesis --- antifungal --- anticancer --- target identification --- kaempferol --- docking --- DARTS --- Src --- breast cancer --- butein --- frondoside-A --- STAT3 --- angiogenesis --- invasion --- viability --- tumor growth --- marine fungi --- Cosmospora sp. --- soudanone --- Magnaporthe oryzae --- co-culture --- phytopathogen --- molecular networking --- metabolomics --- bispecific antibody --- Trypsiligase --- click chemistry --- biorthogonal chemistry --- antibody engineering --- n/a --- the Bcl-2-Beclin 1 complex