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Book
Families
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ISBN: 9781509518425 9781509518432 1509518436 1509518428 Year: 2024 Publisher: Cambridge: Polity press,

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Abstract

In this accessible and engagingly written book, Vanessa May invites readers into the rich world of thought, research and study of the highly diverse phenomenon of families and family life. The book explores what is and has been understood by ‘family’ in different sociocultural contexts and how family life intersects with social spheres such as the state, the labour market and the economy. Alongside broad social developments such as (post)colonialism and austerity and their connections with changing family patterns, the book engages interdisciplinary work on time, embodiment and materiality in order to offer a multidimensional perspective on the day-to-day lives of families. Drawing from research in the Global North and the Global South, the text carefully considers how people approach the study of families and thus offers insight into the shape of mainstream family studies today


Book
Tribological Performance of Artificial Joints
Authors: ---
ISBN: 3039210793 3039210785 9783039210794 Year: 2019 Publisher: Basel, Switzerland : MDPI,

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Abstract

Joint replacement is a very successful medical treatment. However, the survivorship of the implants could be adversely affected due to the loss of materials in the form of particles or ions as the bearing surfaces articulate against earch other. The consequent tissue and immune response to the wear products, remain one of the key factors of their failure. Tribology has been defined as the science and technology of interacting surfaces in relative motion and all related wear products (e.g., particles, ions, etc.). Over the last few decades, in an attempt to understand and improve joint replacement technology, the tribological performance of several material combinations have been studied experimentally and assessed clinically. In addition, research has focused on the biological effects and long term consequences of wear products. Improvements have been made in manufacturing processes, precision engineering capabilities, device designs and materials properties in order to minimize wear and friction and maximize component longevity in vivo. This book investigates the in vivo and in vitro performance of the orthopaedic implants and their advanced bearings. Contributions are solicited from the researchers working in the field of biotribology and bioengineering


Book
New Advances on Zika Virus Research
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Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.

Keywords

microRNAs --- antivirals --- reverse genetics --- nucleic acid computation --- viral pathogenesis --- plaque reduction neutralization test --- clinical trials --- viral genetic variation --- viral fitness --- pregnancy --- type I IFN antagonist --- prM-E proteins --- eye --- replicon --- antiviral responses --- Bacterial artificial chromosome --- gene expression --- NS1 protein --- viral permissiveness --- ZIKV–host interactions --- reporter virus --- viral persistence --- blood-retinal barrier --- virus like particles --- emerging arbovirus --- Non-human primates --- heme-oxygenase 1 --- mosquito surveillance --- antiviral compounds --- ZIKV-associated neurologic disorders --- external quality assessment --- outbreak control --- therapeutics --- cryptic promoter silencing --- testis --- neurons --- mutagenesis --- RNA-seq --- microsphere immunoassay --- host-directed antivirals --- molecular diagnostics --- Bayesian analyses --- astrocytomas --- Full-length cDNA infectious clones --- viral pathogenicity --- neural progenitor cells --- full-length molecular clone --- antiviral --- multiplex nucleic acid detection --- Asian-lineage --- nucleic acid strand exchange --- IgA --- African-lineage --- vaccines --- Zika --- research models and tools --- immune response --- IgG avidity tests --- polymerase chain reaction --- Asian lineage --- sexual transmission --- TLR7/8 --- neuropathogenesis --- cross-reactions --- genetic variability --- mosquito --- ZIKV --- infectious cDNA --- prostate --- host genetic variation --- monoclonal antibodies --- optimised --- anti-viral immunity --- QCMD --- arbovirus --- FSS13025 --- MR766 --- NS5 --- EQA --- testicular cells --- virus attachment --- flavivirus --- mosquito-borne flavivirus --- dsRNA --- boolean logic-processing nucleic acid probes --- Ziks virus --- viral replication --- Aedes aegypti --- infection --- natural history --- infectious RNA --- zika virus --- chimeric viruses --- subgenomic replicon --- replication --- human brain glial cells --- microglia cells --- hepatocytes --- bacterial artificial chromosome --- detoxification and immune system responses --- testes --- dengue viruses --- Zika virus --- insecticide resistance --- NS2A protein --- plasmid toxicity --- cell surface receptors --- serology --- viral evolution --- laboratory preparedness --- flaviviruses --- Tet-inducible --- dengue virus --- diagnosis --- assay standardization --- infectious clone --- ELISA --- innate response --- congenital Zika syndrome --- secondary infections --- apoptosis --- viral survival --- ocular --- validated --- rhesus macaques --- neuroinflammation --- placenta cells --- NHP --- Zika virus (ZIKV) --- point-of-care diagnostics --- isothermal nucleic acid amplification --- microcephaly --- cytopathic effects --- indirect immunofluorescence --- fetal infection --- therapy --- siRNA --- viral counteraction --- neural cells --- silvestrol --- eIF4A


Book
New Advances on Zika Virus Research
Authors: ---
Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.

Keywords

microRNAs --- antivirals --- reverse genetics --- nucleic acid computation --- viral pathogenesis --- plaque reduction neutralization test --- clinical trials --- viral genetic variation --- viral fitness --- pregnancy --- type I IFN antagonist --- prM-E proteins --- eye --- replicon --- antiviral responses --- Bacterial artificial chromosome --- gene expression --- NS1 protein --- viral permissiveness --- ZIKV–host interactions --- reporter virus --- viral persistence --- blood-retinal barrier --- virus like particles --- emerging arbovirus --- Non-human primates --- heme-oxygenase 1 --- mosquito surveillance --- antiviral compounds --- ZIKV-associated neurologic disorders --- external quality assessment --- outbreak control --- therapeutics --- cryptic promoter silencing --- testis --- neurons --- mutagenesis --- RNA-seq --- microsphere immunoassay --- host-directed antivirals --- molecular diagnostics --- Bayesian analyses --- astrocytomas --- Full-length cDNA infectious clones --- viral pathogenicity --- neural progenitor cells --- full-length molecular clone --- antiviral --- multiplex nucleic acid detection --- Asian-lineage --- nucleic acid strand exchange --- IgA --- African-lineage --- vaccines --- Zika --- research models and tools --- immune response --- IgG avidity tests --- polymerase chain reaction --- Asian lineage --- sexual transmission --- TLR7/8 --- neuropathogenesis --- cross-reactions --- genetic variability --- mosquito --- ZIKV --- infectious cDNA --- prostate --- host genetic variation --- monoclonal antibodies --- optimised --- anti-viral immunity --- QCMD --- arbovirus --- FSS13025 --- MR766 --- NS5 --- EQA --- testicular cells --- virus attachment --- flavivirus --- mosquito-borne flavivirus --- dsRNA --- boolean logic-processing nucleic acid probes --- Ziks virus --- viral replication --- Aedes aegypti --- infection --- natural history --- infectious RNA --- zika virus --- chimeric viruses --- subgenomic replicon --- replication --- human brain glial cells --- microglia cells --- hepatocytes --- bacterial artificial chromosome --- detoxification and immune system responses --- testes --- dengue viruses --- Zika virus --- insecticide resistance --- NS2A protein --- plasmid toxicity --- cell surface receptors --- serology --- viral evolution --- laboratory preparedness --- flaviviruses --- Tet-inducible --- dengue virus --- diagnosis --- assay standardization --- infectious clone --- ELISA --- innate response --- congenital Zika syndrome --- secondary infections --- apoptosis --- viral survival --- ocular --- validated --- rhesus macaques --- neuroinflammation --- placenta cells --- NHP --- Zika virus (ZIKV) --- point-of-care diagnostics --- isothermal nucleic acid amplification --- microcephaly --- cytopathic effects --- indirect immunofluorescence --- fetal infection --- therapy --- siRNA --- viral counteraction --- neural cells --- silvestrol --- eIF4A


Book
New Advances on Zika Virus Research
Authors: ---
Year: 2019 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Export citation

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Bookmark

Abstract

Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.

Keywords

microRNAs --- antivirals --- reverse genetics --- nucleic acid computation --- viral pathogenesis --- plaque reduction neutralization test --- clinical trials --- viral genetic variation --- viral fitness --- pregnancy --- type I IFN antagonist --- prM-E proteins --- eye --- replicon --- antiviral responses --- Bacterial artificial chromosome --- gene expression --- NS1 protein --- viral permissiveness --- ZIKV–host interactions --- reporter virus --- viral persistence --- blood-retinal barrier --- virus like particles --- emerging arbovirus --- Non-human primates --- heme-oxygenase 1 --- mosquito surveillance --- antiviral compounds --- ZIKV-associated neurologic disorders --- external quality assessment --- outbreak control --- therapeutics --- cryptic promoter silencing --- testis --- neurons --- mutagenesis --- RNA-seq --- microsphere immunoassay --- host-directed antivirals --- molecular diagnostics --- Bayesian analyses --- astrocytomas --- Full-length cDNA infectious clones --- viral pathogenicity --- neural progenitor cells --- full-length molecular clone --- antiviral --- multiplex nucleic acid detection --- Asian-lineage --- nucleic acid strand exchange --- IgA --- African-lineage --- vaccines --- Zika --- research models and tools --- immune response --- IgG avidity tests --- polymerase chain reaction --- Asian lineage --- sexual transmission --- TLR7/8 --- neuropathogenesis --- cross-reactions --- genetic variability --- mosquito --- ZIKV --- infectious cDNA --- prostate --- host genetic variation --- monoclonal antibodies --- optimised --- anti-viral immunity --- QCMD --- arbovirus --- FSS13025 --- MR766 --- NS5 --- EQA --- testicular cells --- virus attachment --- flavivirus --- mosquito-borne flavivirus --- dsRNA --- boolean logic-processing nucleic acid probes --- Ziks virus --- viral replication --- Aedes aegypti --- infection --- natural history --- infectious RNA --- zika virus --- chimeric viruses --- subgenomic replicon --- replication --- human brain glial cells --- microglia cells --- hepatocytes --- bacterial artificial chromosome --- detoxification and immune system responses --- testes --- dengue viruses --- Zika virus --- insecticide resistance --- NS2A protein --- plasmid toxicity --- cell surface receptors --- serology --- viral evolution --- laboratory preparedness --- flaviviruses --- Tet-inducible --- dengue virus --- diagnosis --- assay standardization --- infectious clone --- ELISA --- innate response --- congenital Zika syndrome --- secondary infections --- apoptosis --- viral survival --- ocular --- validated --- rhesus macaques --- neuroinflammation --- placenta cells --- NHP --- Zika virus (ZIKV) --- point-of-care diagnostics --- isothermal nucleic acid amplification --- microcephaly --- cytopathic effects --- indirect immunofluorescence --- fetal infection --- therapy --- siRNA --- viral counteraction --- neural cells --- silvestrol --- eIF4A

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