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Jöbsis was the first to describe the in vivo application of near-infrared spectroscopy (NIRS), also called diffuse optical spectroscopy (DOS). NIRS was originally designed for the clinical monitoring of tissue oxygenation, and today it has also become a useful tool for neuroimaging studies (functional near-infrared spectroscopy, fNIRS). However, difficulties in the selective and quantitative measurements of tissue hemoglobin (Hb), which have been central in the NIRS field for over 40 years, remain to be solved. To overcome these problems, time-domain (TD) and frequency-domain (FD) measurements have been tried. Presently, a wide range of NIRS instruments are available, including commonly available commercial instruments for continuous wave (CW) measurements, based on the modified Beer–Lambert law (steady-state domain measurements). Among these measurements, the TD measurement is the most promising approach, although compared with CW and FD measurements, TD measurements are less common, due to the need for large and expensive instruments with poor temporal resolution and limited dynamic range. However, thanks to technological developments, TD measurements are increasingly being used in research, and also in various clinical settings. This Special Issue highlights issues at the cutting edge of TD DOS and diffuse optical tomography (DOT). It covers all aspects related to TD measurements, including advances in hardware, methodology, the theory of light propagation, and clinical applications.

Medicine --- Neurosciences --- breast cancer --- diffuse optical spectroscopy --- chemotherapy --- time-domain spectroscopy --- near-infrared spectroscopy --- radiative transfer equation --- diffusion equation --- biological tissue --- time-domain instruments --- light propagation in tissue --- optical properties of tissue --- diffuse optical tomography --- fluorescence diffuse optical tomography --- time-resolved spectroscopy --- NIRS --- diffuse optics --- time-domain --- time-resolved --- brain oxygenation --- tissue saturation --- scattering --- absorption --- 3-hour sitting --- near infrared time-resolved spectroscopy --- compression stocking --- tissue oxygenation --- extracellular water --- intracellular water --- circumference --- gastrocnemius --- neonate --- vaginal delivery --- cerebral blood volume --- cerebral hemoglobin oxygen saturation --- near-infrared time-resolved spectroscopy --- near infrared spectroscopy --- aging --- prefrontal cortex --- TRS --- magnetic resonance imaging --- brain atrophy --- VSRAD --- optical pathlength --- hemoglobin --- cognitive function --- time-domain NIRS --- null source-detector separation --- brain --- noninvasive --- subcutaneous white adipose tissue --- tissue total hemoglobin --- diffuse light --- inverse problems --- optical tomography --- inverse problem --- datatypes --- diffusion approximation --- highly forward scattering of photons --- diffusion and delta-Eddington approximations --- characteristic length and time scales of photon transport --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Jöbsis was the first to describe the in vivo application of near-infrared spectroscopy (NIRS), also called diffuse optical spectroscopy (DOS). NIRS was originally designed for the clinical monitoring of tissue oxygenation, and today it has also become a useful tool for neuroimaging studies (functional near-infrared spectroscopy, fNIRS). However, difficulties in the selective and quantitative measurements of tissue hemoglobin (Hb), which have been central in the NIRS field for over 40 years, remain to be solved. To overcome these problems, time-domain (TD) and frequency-domain (FD) measurements have been tried. Presently, a wide range of NIRS instruments are available, including commonly available commercial instruments for continuous wave (CW) measurements, based on the modified Beer–Lambert law (steady-state domain measurements). Among these measurements, the TD measurement is the most promising approach, although compared with CW and FD measurements, TD measurements are less common, due to the need for large and expensive instruments with poor temporal resolution and limited dynamic range. However, thanks to technological developments, TD measurements are increasingly being used in research, and also in various clinical settings. This Special Issue highlights issues at the cutting edge of TD DOS and diffuse optical tomography (DOT). It covers all aspects related to TD measurements, including advances in hardware, methodology, the theory of light propagation, and clinical applications.

Medicine --- Neurosciences --- breast cancer --- diffuse optical spectroscopy --- chemotherapy --- time-domain spectroscopy --- near-infrared spectroscopy --- radiative transfer equation --- diffusion equation --- biological tissue --- time-domain instruments --- light propagation in tissue --- optical properties of tissue --- diffuse optical tomography --- fluorescence diffuse optical tomography --- time-resolved spectroscopy --- NIRS --- diffuse optics --- time-domain --- time-resolved --- brain oxygenation --- tissue saturation --- scattering --- absorption --- 3-hour sitting --- near infrared time-resolved spectroscopy --- compression stocking --- tissue oxygenation --- extracellular water --- intracellular water --- circumference --- gastrocnemius --- neonate --- vaginal delivery --- cerebral blood volume --- cerebral hemoglobin oxygen saturation --- near-infrared time-resolved spectroscopy --- near infrared spectroscopy --- aging --- prefrontal cortex --- TRS --- magnetic resonance imaging --- brain atrophy --- VSRAD --- optical pathlength --- hemoglobin --- cognitive function --- time-domain NIRS --- null source-detector separation --- brain --- noninvasive --- subcutaneous white adipose tissue --- tissue total hemoglobin --- diffuse light --- inverse problems --- optical tomography --- inverse problem --- datatypes --- diffusion approximation --- highly forward scattering of photons --- diffusion and delta-Eddington approximations --- characteristic length and time scales of photon transport --- breast cancer --- diffuse optical spectroscopy --- chemotherapy --- time-domain spectroscopy --- near-infrared spectroscopy --- radiative transfer equation --- diffusion equation --- biological tissue --- time-domain instruments --- light propagation in tissue --- optical properties of tissue --- diffuse optical tomography --- fluorescence diffuse optical tomography --- time-resolved spectroscopy --- NIRS --- diffuse optics --- time-domain --- time-resolved --- brain oxygenation --- tissue saturation --- scattering --- absorption --- 3-hour sitting --- near infrared time-resolved spectroscopy --- compression stocking --- tissue oxygenation --- extracellular water --- intracellular water --- circumference --- gastrocnemius --- neonate --- vaginal delivery --- cerebral blood volume --- cerebral hemoglobin oxygen saturation --- near-infrared time-resolved spectroscopy --- near infrared spectroscopy --- aging --- prefrontal cortex --- TRS --- magnetic resonance imaging --- brain atrophy --- VSRAD --- optical pathlength --- hemoglobin --- cognitive function --- time-domain NIRS --- null source-detector separation --- brain --- noninvasive --- subcutaneous white adipose tissue --- tissue total hemoglobin --- diffuse light --- inverse problems --- optical tomography --- inverse problem --- datatypes --- diffusion approximation --- highly forward scattering of photons --- diffusion and delta-Eddington approximations --- characteristic length and time scales of photon transport