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Uterine Cervical Neoplasms. --- Cancer of Cervix --- Cancer of the Cervix --- Cancer of the Uterine Cervix --- Cervical Cancer --- Cervical Neoplasms --- Cervix Cancer --- Cervix Neoplasms --- Neoplasms, Cervical --- Neoplasms, Cervix --- Uterine Cervical Cancer --- Cancer, Cervix --- Cancer, Uterine Cervical --- Cancers, Cervix --- Cancers, Uterine Cervical --- Cervical Cancer, Uterine --- Cervical Cancers, Uterine --- Cervical Neoplasm --- Cervical Neoplasm, Uterine --- Cervical Neoplasms, Uterine --- Cervix Neoplasm --- Neoplasm, Cervical --- Neoplasm, Cervix --- Neoplasm, Uterine Cervical --- Neoplasms, Uterine Cervical --- Uterine Cervical Cancers --- Uterine Cervical Neoplasm --- Uterine Cervical Dysplasia --- Cervical Intraepithelial Neoplasia --- Cervix uteri --- Uterine Cervical Neoplasms --- Cervical cancer --- Cancer --- Cancer, Cervical --- Cervical Cancers

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Personalised medicine is the next step in healthcare, especially when applied to genetically diverse diseases such as cancers. Naturally, a host of methods need to evolve alongside this, in order to allow the practice and implementation of individual treatment regimens. One of the major tasks for the development of personalised treatment of cancer is the identification and validation of a comprehensive, robust, and reliable panel of biomarkers that guide the clinicians to provide the best treatment to patients. This is indeed important with regards to radiotherapy; not only do biomarkers allow for the assessment of treatability, tumour response, and the radiosensitivity of healthy tissue of the treated patient. Furthermore, biomarkers should allow for the evaluation of the risks of developing adverse late effects as a result of radiotherapy such as second cancers and non-cancer effects, for example cardiovascular injury and cataract formation. Knowledge of all of these factors would allow for the development of a tailored radiation therapy regime. This Special Issue of the Journal of Personalised Medicine covers the topic of Radiation Response Biomarkers in the context of individualised cancer treatments, and offers an insight into some of the further evolution of radiation response biomarkers, their usefulness in guiding clinicians, and their application in radiation therapy.

carbon-ion radiotherapy --- head-and-neck tumors --- squamous cell carcinoma --- radiosensitivity --- relative biological effectiveness --- lung cancer --- radiotherapy --- radiotherapy monitoring --- radiation-induced lung injury --- RILI --- pneumonitis --- radiation-induced lung fibrosis --- RILF --- circulating biomarkers --- microRNA --- micronuclei --- uterine cervical cancer --- cGAS --- STING --- abscopal effect --- immunotherapy --- PBMCS --- micronucleus assay --- biological dosimetry --- human blood --- genotoxicity tests --- ionizing radiation --- biomarkers --- dicentric assay --- gamma H2AX foci assay --- health surveillance analyses --- clonogenic assays --- methods --- plating --- cancer --- radiation --- head and neck cancer --- exosomes --- serum --- metabolomics --- GC/MS --- biodosimetry --- chromosome aberrations --- normal tissue toxicity --- predictive tests --- normal tissue --- biomarker --- protein --- immune infiltrate --- stroma --- tumour microenvironment --- proteomics --- telomeres --- chromosomal instability --- inversions --- prostate cancer --- IMRT --- machine learning --- individual radiosensitivity --- late effects --- personalized medicine --- liquid biopsy --- circulating tumour cells --- extracellular vesicles --- microRNAs --- immune system --- inflammation --- n/a

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This book discusses the application of probabilistics to the investigation of mechanical systems. The book shows, for example, how random function theory can be applied directly to the investigation of random processes in the deflection of cam profiles, pitch or gear teeth, pressure in pipes, etc. The author also deals with some other technical applications of probabilistic theory, including, amongst others, those relating to pneumatic and hydraulic mechanisms and roller bearings. Many of the aspects are illustrated by examples of applications of the techniques under discussion.

Mechanical movements --- Machine design --- Probabilities --- Uterine Cervical Diseases --- Uterine Cervical Neoplasms --- Colposcopy --- Cancer of Cervix --- Cancer of the Cervix --- Cancer of the Uterine Cervix --- Cervical Cancer --- Cervical Neoplasms --- Cervix Cancer --- Cervix Neoplasms --- Neoplasms, Cervical --- Neoplasms, Cervix --- Uterine Cervical Cancer --- Cancer, Cervix --- Cancer, Uterine Cervical --- Cancers, Cervix --- Cancers, Uterine Cervical --- Cervical Cancer, Uterine --- Cervical Cancers, Uterine --- Cervical Neoplasm --- Cervical Neoplasm, Uterine --- Cervical Neoplasms, Uterine --- Cervix Neoplasm --- Neoplasm, Cervical --- Neoplasm, Cervix --- Neoplasm, Uterine Cervical --- Neoplasms, Uterine Cervical --- Uterine Cervical Cancers --- Uterine Cervical Neoplasm --- Uterine Cervical Dysplasia --- Cervical Intraepithelial Neoplasia --- Colposcopic Surgery --- Surgery, Colposcopic --- Colposcopic Surgical Procedures --- Surgical Procedures, Colposcopic --- Colposcopic Surgeries --- Colposcopic Surgical Procedure --- Colposcopies --- Procedure, Colposcopic Surgical --- Procedures, Colposcopic Surgical --- Surgeries, Colposcopic --- Surgical Procedure, Colposcopic --- Cervix Uteri --- Vagina --- Colposcopes --- Cervix Diseases --- Cervical Disease, Uterine --- Cervical Diseases, Uterine --- Cervix Disease --- Disease, Cervix --- Disease, Uterine Cervical --- Diseases, Cervix --- Diseases, Uterine Cervical --- Uterine Cervical Disease --- Probability --- Statistical inference --- Combinations --- Mathematics --- Chance --- Least squares --- Mathematical statistics --- Risk --- Machinery --- Engineering design --- Mechanisms (Machinery) --- Kinematics --- Mechanical engineering --- Mechanics --- Motion --- Gearing --- Statistical methods --- pathology --- Design --- Design and construction --- Engineering --- Applications of probabilities --- Conferences - Meetings --- Plates (Engineering) --- Shells (Engineering) --- Elastic plates and shells. --- Elastic shells --- Plates, Elastic --- Shells, Elastic --- Elastic waves --- Elasticity --- Plasticity --- Structural shells --- Elastic plates and shells --- Structural analysis (Engineering) --- Disks (Mechanics) --- Panels --- Structural plates --- Mechanical movements. --- Probabilities. --- Statistical methods. --- Surfaces (Technology) --- Classical mechanics --- Newtonian mechanics --- Physics --- Dynamics --- Quantum theory --- Differential equations, Nonlinear --- Numerical analysis --- Nonlinear differential equations --- Nonlinear theories --- Data processing. --- Numerical solutions. --- Cancer, Cervical --- Cervical Cancers

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This book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance. Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response. Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases.

Oncology  . --- Gynecology . --- Cancer research. --- Cell biology. --- Oncology. --- Gynecology. --- Cancer Research. --- Cell Biology. --- Cell biology --- Cellular biology --- Biology --- Cells --- Cancer research --- Gynaecology --- Medicine --- Generative organs, Female --- Tumors --- Diseases --- Cancer. --- Gynecologic cancer --- Cancer in women --- Genital Neoplasms, Female. --- Ovarian Neoplasms. --- Uterine Cervical Neoplasms. --- Cancer of Cervix --- Cancer of the Cervix --- Cancer of the Uterine Cervix --- Cervical Cancer --- Cervical Neoplasms --- Cervix Cancer --- Cervix Neoplasms --- Neoplasms, Cervical --- Neoplasms, Cervix --- Uterine Cervical Cancer --- Cancer, Cervix --- Cancer, Uterine Cervical --- Cancers, Cervix --- Cancers, Uterine Cervical --- Cervical Cancer, Uterine --- Cervical Cancers, Uterine --- Cervical Neoplasm --- Cervical Neoplasm, Uterine --- Cervical Neoplasms, Uterine --- Cervix Neoplasm --- Neoplasm, Cervical --- Neoplasm, Cervix --- Neoplasm, Uterine Cervical --- Neoplasms, Uterine Cervical --- Uterine Cervical Cancers --- Uterine Cervical Neoplasm --- Uterine Cervical Dysplasia --- Cervical Intraepithelial Neoplasia --- Cancer of the Ovary --- Neoplasms, Ovarian --- Ovary Cancer --- Ovary Neoplasms --- Cancer of Ovary --- Ovarian Cancer --- Cancer, Ovarian --- Cancer, Ovary --- Cancers, Ovarian --- Cancers, Ovary --- Neoplasm, Ovarian --- Neoplasm, Ovary --- Neoplasms, Ovary --- Ovarian Cancers --- Ovarian Neoplasm --- Ovary Cancers --- Ovary Neoplasm --- Germinoma --- Female Genital Neoplasms --- Neoplasms, Female Genital --- Neoplasms, Gynecologic --- Gynecologic Neoplasms --- Female Genital Neoplasm --- Genital Neoplasm, Female --- Gynecologic Neoplasm --- Neoplasm, Female Genital --- Neoplasm, Gynecologic --- Cancer, Cervical --- Cervical Cancers --- Càncer --- Malalties de l'aparell genital femení --- Càncer d'ovari --- Càncer d'úter --- Càncer de matriu --- Càncer uterí --- Malalties uterines --- Càncer d'endometri --- Càncer de coll uterí --- Càncer d'ovaris --- Malalties ginecològiques --- Malalties de l'aparell genital --- Endometriosi --- Fibromiomes uterins --- Malalties de la vagina --- Malalties de la vulva --- Malalties de les trompes de Fal·lopi --- Malalties de l'ovari --- Ginecologia --- Carcinoma --- Carcinosi --- Càncer d'ossos --- Càncer de cap --- Càncer de coll --- Càncer de bufeta --- Càncer de fetge --- Càncer de laringe --- Càncer de mama --- Càncer de pàncrees --- Càncer de pell --- Càncer de pròstata --- Càncer de pulmó --- Càncer de ronyó --- Càncer de tiroide --- Càncer gastrointestinal --- Càncer ginecològic --- Càncer en els adolescents --- Càncer en els infants --- Medicaments antineoplàstics --- Melanoma --- Leucèmia --- Sarcoma --- Carcinògens --- Cèl·lules canceroses --- Cirurgia oncològica --- Infermeria oncològica --- Malalts de càncer --- Metàstasi --- Oncologia