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Through 5 editions, Pediatric Nephrology has become the standard reference text for students, trainees, practicing physicians (Pediatricians, Nephrologists, Internists, and Urologists), sub-specialists, and allied health professionals seeking information about Children's Kidney Diseases. It is global in perspective and reflects the international group of editors, who are well-recognized world's experts in Pediatric Nephrology. In a single text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases. These chapters, grouped by major disease categories, utilize molecular and cellular pathophysiology of disease to provide unique and comprehensive information of the current state of the art on all known childhood kidney diseases. Each chapter makes new genetic information easily understandable for the practitioner, and uses many algorithms and diagrams to describe appropriate clinical evaluation of symptoms, differential diagnosis, specific diagnostics, and currently available therapies. The text is not only found in University/Hospital libraries, but on the shelves of sub-specialists, pediatricians, internists, urologists, and extensively in the clinics where it is used during clinical encounters with childhood kidney disease.

Child --- Infant --- Kidney Diseases --- Urinary Tract Infections --- Infection, Urinary Tract --- Infections, Urinary Tract --- Tract Infection, Urinary --- Tract Infections, Urinary --- Urinary Tract Infection --- Disease, Kidney --- Diseases, Kidney --- Kidney Disease --- Nephrology --- Renal Replacement Therapy --- Infants --- Children --- Minors

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Child. --- Infant. --- Kidney Diseases. --- Urinary Tract Infections. --- Infection, Urinary Tract --- Infections, Urinary Tract --- Tract Infection, Urinary --- Tract Infections, Urinary --- Urinary Tract Infection --- Disease, Kidney --- Diseases, Kidney --- Kidney Disease --- Nephrology --- Renal Replacement Therapy --- Infants --- Children --- Minors --- Pediatric nephrology --- Child --- Infant --- Kidney Diseases --- Urinary Tract Infections --- Kidney diseases in children --- Childhood diseases --- Children's diseases --- Diseases of children --- Juvenile diseases --- Pediatrics --- Diseases

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Disorders of the central and peripheral nerve systems have severe effects on gut function. Hence, people who have sustained spinal cord injury and multiple sclerosis, Parkinson’s disease, or spina bifida patients may suffer from severe bowel symptoms, including constipation, incontinence to stools, difficult bowel evacuation, or pain. For the present book, a number of international experts have described how disorders of the nerve system affect bowel function, how to assess and treat bowel symptoms, and how the bacterial composition of the bowel may be affected.

Medicine --- Neurology & clinical neurophysiology --- laxatives --- constipation --- adults --- prevalence --- utilisation --- gut microbiota --- spina bifida --- transanal irrigation --- urinary tract infection --- SCI --- MENTOR --- NBD --- fecal incontinence --- Parkinson’s disease --- autonomic --- gastrointestinal --- alpha-synuclein --- parasympathetic --- neurogenic bowel dysfunction --- low anterior resection syndrome --- faecal incontinence --- chronic constipation --- bowel dysfunction --- quality of life --- spinal cord injury --- multiple sclerosis --- pharmacological --- systematic review --- neurogenic bowel --- treatment assessment --- bowel function --- exoskeletal walking --- difficulty with evacuation --- neostigmine --- glycopyrrolate --- iontophoresis --- autonomic dysfunction --- motility --- investigations --- manometry --- breath test --- imaging --- diabetes mellitus --- postprandial hypotension --- food ingestion --- ambulatory blood pressure measurement --- cohort study --- pediatric --- children --- adolescent --- anorectal malformation --- cerebral palsy --- acute rehabilitation --- opioids --- SCI bowel management

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Bacterial resistance to known and currently used antibiotics represents a growing issue worldwide. It poses a major problem in the treatment of infectious diseases in general and hospital-acquired infections in particular. This is in part due to the overuse and misuse of antibiotics in past decades, which led to the selection of highly resistant bacteria and even so-called superbugs – multidrug-resistant (MDR) bacteria. Nosocomial infections, particularly, are often caused by MDR bacterial pathogens and the treatment of such infections is very complicated and extensive, often leading to various side effects, including adverse effects on the natural human microbiome. At the same time, the development of novel antibiotics is lagging with very few new ones in the pipeline. Finding viable alternatives to treat such infections may help to overcome these therapeutic issues. This publication brings novel developments in the field of bacterial resistance, mainly in the hospital settings, adequate antibiotic therapy, and identification of compounds useful to battle this growing issue.

VRE --- GIT --- hemato-oncological patients --- clonality --- antibiotic stewardship --- resistance --- consumption of antibiotics --- clonal spread --- Enterococcus faecium --- Enterococcus faecalis --- linezolid resistance --- 23S rRNA --- optrA --- carbapenem-resistant Klebsiella pneumoniae --- carbapenem-resistant Acinetobacter baumannii --- N-acetylcysteine --- septic shock --- critically ill patients --- newborn --- infection --- bacteria --- antibiotic therapy --- hops --- C. difficile --- rat model --- Staphylococcus aureus --- MRSA --- spa typing --- MLST --- SCCmec typing --- clonal analysis --- epidemiology --- cancer patients --- duration of treatment --- colistin --- propensity score analysis --- multidrug-resistant Acinetobacter baumannii --- urinary tract infections --- UTIs --- MDR --- Escherichia coli --- Klebsiella --- uropathogens --- AMR --- antibiotic resistance --- ESBL-producing Klebsiella pneumoniae --- urinary tract infection --- clinical impact --- economic impact --- ventilator-associated pneumonia --- Klebsiella spp. --- Escherichia spp. --- pulsed-field gel electrophoresis (PFGE) --- endogenous infection --- methicillin-resistant --- porcine model --- methicillin-resistant Staphylococcus aureus (MRSA) --- long term care facilities (LTCF) --- multidrug resistance (MDR) --- enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR) --- ESBL --- PCR --- primer --- antimicrobial resistance --- infection prevention and control --- antimicrobial stewardship --- hospital --- cluster analysis --- principal component analysis

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Bacterial resistance to known and currently used antibiotics represents a growing issue worldwide. It poses a major problem in the treatment of infectious diseases in general and hospital-acquired infections in particular. This is in part due to the overuse and misuse of antibiotics in past decades, which led to the selection of highly resistant bacteria and even so-called superbugs – multidrug-resistant (MDR) bacteria. Nosocomial infections, particularly, are often caused by MDR bacterial pathogens and the treatment of such infections is very complicated and extensive, often leading to various side effects, including adverse effects on the natural human microbiome. At the same time, the development of novel antibiotics is lagging with very few new ones in the pipeline. Finding viable alternatives to treat such infections may help to overcome these therapeutic issues. This publication brings novel developments in the field of bacterial resistance, mainly in the hospital settings, adequate antibiotic therapy, and identification of compounds useful to battle this growing issue.

Medicine --- Epidemiology & medical statistics --- VRE --- GIT --- hemato-oncological patients --- clonality --- antibiotic stewardship --- resistance --- consumption of antibiotics --- clonal spread --- Enterococcus faecium --- Enterococcus faecalis --- linezolid resistance --- 23S rRNA --- optrA --- carbapenem-resistant Klebsiella pneumoniae --- carbapenem-resistant Acinetobacter baumannii --- N-acetylcysteine --- septic shock --- critically ill patients --- newborn --- infection --- bacteria --- antibiotic therapy --- hops --- C. difficile --- rat model --- Staphylococcus aureus --- MRSA --- spa typing --- MLST --- SCCmec typing --- clonal analysis --- epidemiology --- cancer patients --- duration of treatment --- colistin --- propensity score analysis --- multidrug-resistant Acinetobacter baumannii --- urinary tract infections --- UTIs --- MDR --- Escherichia coli --- Klebsiella --- uropathogens --- AMR --- antibiotic resistance --- ESBL-producing Klebsiella pneumoniae --- urinary tract infection --- clinical impact --- economic impact --- ventilator-associated pneumonia --- Klebsiella spp. --- Escherichia spp. --- pulsed-field gel electrophoresis (PFGE) --- endogenous infection --- methicillin-resistant --- porcine model --- methicillin-resistant Staphylococcus aureus (MRSA) --- long term care facilities (LTCF) --- multidrug resistance (MDR) --- enterobacterial repetitive intergenic consensus-polymerase chain reaction (ERIC-PCR) --- ESBL --- PCR --- primer --- antimicrobial resistance --- infection prevention and control --- antimicrobial stewardship --- hospital --- cluster analysis --- principal component analysis