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Dear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection Editor

soy --- isoflavones --- mammary tumor prevention --- rodent models --- chemical carcinogens --- transgenic mice --- Zebrafish --- Drosophila --- rats --- mice --- NPM-1 --- FLT3 ITD --- ETO-1 --- IDH1/2 --- neural stem cells --- brain and nervous system cancers --- neurogenic niches --- radiotherapy --- sparing of neurogenic regions --- carcinoma --- consensus molecular subtypes --- intestine --- oncogenes --- signaling cascades --- tumor suppressors --- tumorigenesis --- MPN (myeloproliferative neoplasms) --- zebrafish --- iPSCs --- JAK2 --- MPL --- CALR --- thrombosis --- ubiquitin–proteasome system --- cancer --- mouse model --- gene inactivation --- colorectal cancer --- mouse models --- microbiota --- antitumor immunity --- melanoma --- mutation --- genetics --- animal model --- swine --- MeLiM --- progression --- spontaneous regression --- devitalization --- metaplasia --- Cdx --- animal models --- epigenetics --- xenotransplantation --- drug screen --- pre-clinical cancer model --- non-mouse models --- gene editing --- stem cells --- solid tumors --- hematologic malignancies

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Dear Readers, Understanding the pathological mechanisms involved in human diseases and their possible treatment has been historically based on comparative analysis of diverse animal species that share a similar genetic, physiological and behavioural composition. The ancient Greeks were the first to use animals as models for anatomy and physiology, and this was consequently adopted by other cultures and led to important discoveries. In recent years, there have been many efforts to understand and fight cancer through new revolutionary personalized treatments and wider screenings that help diagnose and treat cancer. A fundamental part of this effort is to develop suitable cancer animal models that simulate the different disease variants and their progression. Ranging from tumor-derived xenografts to genetically engineered models, a wide variety of systems are applied for this purpose, and many technological breakthroughs are changing the way cancer is studied and analyzed. In this Special Issue, we collected a set of research articles and reviews that focus on the generation of cancer animal models that are used for understanding the disease and contribute to designing and testing new drugs for cancer prevention or treatment. Vladimir Korinek Collection Editor

Research & information: general --- Biology, life sciences --- soy --- isoflavones --- mammary tumor prevention --- rodent models --- chemical carcinogens --- transgenic mice --- Zebrafish --- Drosophila --- rats --- mice --- NPM-1 --- FLT3 ITD --- ETO-1 --- IDH1/2 --- neural stem cells --- brain and nervous system cancers --- neurogenic niches --- radiotherapy --- sparing of neurogenic regions --- carcinoma --- consensus molecular subtypes --- intestine --- oncogenes --- signaling cascades --- tumor suppressors --- tumorigenesis --- MPN (myeloproliferative neoplasms) --- zebrafish --- iPSCs --- JAK2 --- MPL --- CALR --- thrombosis --- ubiquitin–proteasome system --- cancer --- mouse model --- gene inactivation --- colorectal cancer --- mouse models --- microbiota --- antitumor immunity --- melanoma --- mutation --- genetics --- animal model --- swine --- MeLiM --- progression --- spontaneous regression --- devitalization --- metaplasia --- Cdx --- animal models --- epigenetics --- xenotransplantation --- drug screen --- pre-clinical cancer model --- non-mouse models --- gene editing --- stem cells --- solid tumors --- hematologic malignancies

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This Special Issue contains review articles focusing on several lymphoma entities included in the current WHO classification. The aim of the book is to guide the readers in understanding the evolution of lymphoma classification. The clinicopathological entities described in this issue have been analyzed through the molecular mechanisms involved in their pathogenesis.

Medicine --- lymphomas in PLWH --- KSHV/HHV8 --- EBV --- lymphoma classification --- management --- cART --- HLX --- HOXB9 --- NFIB --- PBX1 --- STAT3 --- TLX2 --- autoimmune hemolytic anemia --- cold agglutinin --- B-cell lymphoproliferative disorder --- lymphomagenesis --- methylation --- histone modification --- indolent --- T-cell --- NK-cell --- lymphoproliferative disorder --- gastrointestinal tract --- genetics --- cell of origin --- T follicular helper cells --- TFH lymphoma --- angioimmunoblastic T-cell lymphoma --- follicular T-cell lymphoma --- peripheral T-cell lymphoma of T-follicular helper immunophenotype --- peripheral T-cell lymphoma --- primary cutaneous B-cell lymphoma --- primary cutaneous marginal zone B-cell lymphoma --- primary cutaneous follicle centre lymphoma --- primary cutaneous diffuse large B-cell lymphoma, leg-type --- primary cutaneous diffuse large B-cell lymphoma, not otherwise specified --- intravascular B-cell lymphoma --- EBV+ mucocutaneous ulcer --- Burkitt lymphoma --- epidemiology --- Plasmodium falciparum --- Epstein Barr virus --- registry studies --- multimodal cancer --- non-Hodgkin lymphoma --- HIV/AIDS --- follicular lymphoma --- in situ follicular neoplasia --- FL transformation --- FL in young patients --- diffuse large B-cell lymphoma NOS --- high grade B-cell lymphoma --- lymphoma --- gene expression profiling --- tumor microenvironment --- diagnostics --- centrocytic lymphoma --- intermediate lymphocytic lymphoma --- Jaffe --- mantle cell lymphoma --- mantle zone lymphoma --- cyclin D1 --- lymphomas --- people living with HIV --- tumor prevention in people living with HIV --- KSHV --- BCL2 rearrangement --- genetic alterations --- histological transformation --- targeted therapies --- transformed follicular lymphoma --- lymphoproliferative neoplasms of uncertain biological significance --- monoclonal B-cell lymphocytosis --- “in situ” follicular neoplasia --- “in situ” mantle cell neoplasia --- atypical germinal centers --- large B-cell lymphoma with IRF4 rearrangement --- “in situ” high-grade B lymphomas --- Hodgkin lymphoma