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Meninges --- Tuberculosis, Meningeal --- Tuberculosis. --- TB Meningitis --- Tubercular Meningitis --- Tuberculosis Meningitis --- Tuberculous Hypertrophic Pachymeningitis --- Meningitis, Tuberculous --- Hypertrophic Pachymeningitides, Tuberculous --- Hypertrophic Pachymeningitis, Tuberculous --- Meningeal Tuberculoses --- Meningeal Tuberculosis --- Meningitides, Tubercular --- Meningitides, Tuberculosis --- Meningitides, Tuberculous --- Meningitis, Tubercular --- Meningitis, Tuberculosis --- Pachymeningitides, Tuberculous Hypertrophic --- Pachymeningitis, Tuberculous Hypertrophic --- TB Meningitides --- Tubercular Meningitides --- Tuberculoses, Meningeal --- Tuberculosis Meningitides --- Tuberculous Hypertrophic Pachymeningitides --- Tuberculous Meningitides --- Tuberculous Meningitis --- lemac

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Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in biology. This editorial mini-review summarizes the Special Issue, which includes four review articles and 10 original articles that highlight the versatile roles of MMPs, ADAMs, and ADAMTSs, in normal physiology as well as in neoplastic and destructive processes in tissue. In addition, we briefly discuss the unambiguous involvement of MMPs in wound healing.

hemagglutinin-B --- transwell co-cultures --- matrix metalloproteinases --- TNF-α --- matrix metalloproteinase --- peritoneal mesothelial cell --- gastric cancer --- metastatic dissemination --- MT4-MMP --- cancer --- diseases --- aggrecan --- aggrecanase --- ADAMTS --- cartilage --- arthritis --- MMP-2 --- MMP-9 --- inhibitor --- allodynia --- caspase-3 --- neuropathic --- pain --- dorsal root ganglion --- spinal nerve ligation --- tuberculosis --- tuberculous meningitis --- HIV-TB-associated IRIS --- extracellular matrix breakdown --- adult --- pediatric --- lung --- central nervous system --- matrix-metalloproteinase --- monocytes --- inflammation --- phagocytosis --- apoptosis --- blood sampling --- anticoagulants --- high-molecular-weight heparin --- IL-16 --- sICAM-1 --- IL-8 --- T cells --- a disintegrin and metalloproteinase --- EMMPRIN --- CD147 --- ectodomain shedding --- MMPs --- PTMs --- glycosylation --- phosphorylation --- glycosaminoglycans --- interleukin --- IL-6 --- IL-11 --- trans-signaling --- metalloproteases --- ADAM --- MMP --- meprin --- matrix metalloproteinases (MMPs) --- protease --- signaling --- invasion --- chemokine --- cytokine --- proteomics --- interferon --- Agkistrodon venom --- metalloproteinase --- fibrinogen --- antithrombotic --- metabolomics --- extracellular matrix --- cytokines --- proteinases --- interstitial collagens --- wound healing

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This timely collection of expert papers draws attention to the global burden of meningitis and the challenges faced by the WHO’s roadmap to defeat meningitis by 2030. The three main goals of the meningitis roadmap are to eliminate epidemics of bacterial meningitis, reduce cases and deaths from vaccine-preventable bacterial meningitis, and reduce disability and improve quality of life after meningitis of any cause. This book includes a wide range of original research and reviews on epidemiology and vaccination of bacterial meningitis that have direct relevance to advancing the goals of the roadmap.

Research & information: general --- Biology, life sciences --- meningitis --- child mortality --- neonatal sepsis --- global health --- global health estimates --- modelling --- Streptococcus pneumoniae --- Haemophilus influenzae --- Neisseria meningitidis --- bacterial meningitis --- S. pneumoniae --- N. meningitidis --- H. influenzae --- S. agalactiae --- conjugate vaccines --- post-vaccine surveillance --- vaccine --- Africa --- mathematical modelling --- susceptibility --- invasive bacterial infections --- complement --- genetic factors --- Streptococcus agalactiae --- group B streptococci --- capsule --- meningococcal group --- nongroupable --- meningococcal carriage --- invasive meningococcal disease --- meningococcal urethritis --- neonatal infections --- epidemiology --- antibiotic resistance --- etiologic diagnosis --- enterovirus --- group B Streptococcus --- neurological sequelae --- hearing loss --- seizure --- epilepsy --- hydrocephalus --- focal neurological deficit --- corticosteroid --- dexamethasone --- invasive pneumococcal disease --- pneumococcal conjugate vaccines --- serotypes --- vaccine impact --- pneumococcal meningitis --- serotype distribution --- PCV impact --- global --- meta-analysis --- surveillance --- meningococcus --- pneumococcus --- Hib --- group B streptococcus --- conjugate vaccine --- rapid diagnostic test --- national reference laboratory --- cerebrospinal fluid --- Niger --- Burkina Faso --- tuberculosis --- tuberculous meningitis --- TBM --- children --- impact of Hib conjugate vaccine --- Hia --- NTHi --- burden --- social and economic costs --- WHO meningitis roadmap --- disability