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Oath of allegiance, 1606. --- James - I, - King of England, - 1566-1625. - Triplici nodo, triplex cuneus.

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Judgment Day --- Oath of allegiance, 1606 --- James - I, - King of England, - 1566-1625. - Triplici nodo, triplex cuneus

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Church and state --- Oath of allegiance, 1606. --- James - I, - King of England, - 1566-1625. - Triplici nodo, triplex cuneus.

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Ungenutzte Potenziale von Holz entdecken Wood is usually perceived as a "traditional" material. However, the properties of this material have now for some time made it possible to design free shapes and highly complex structures. Today, the wood laboratory of the EPF Lausanne, which was originally founded by Julius Natterer, is testing the production of origami structures, ribbed shells, fabric structures and curved panels under the guidance of Professor Weinand using digital calculation and computer-aided processing methods. The research results are tested in prototypes, which demonstrate the potential applications in large-scale timber buildings. By exploring the hitherto unused potential of wood as a construction material, this book provides an exciting and inspiring outlook on a new generation of timber buildings.

Construction en bois --- Conception assistée par ordinateur --- 691 --- 691.1 --- Bouwmaterialen (architectuur) --- Hout --- Houtconstructies --- 72.04 --- 692.4 --- Architectuurdetails --- Overkappingen --- Building, Wooden --- Wooden-frame buildings --- Structural frames --- Constructions à ossature de bois --- Charpentes --- Constructions à ossature de bois --- wood [plant material] --- Building materials. Building technology --- Artificial intelligence. Robotics. Simulation. Graphics --- Architecture --- computer-aided design --- architecture [discipline] --- 691.11 --- Houtconstructies ; houtarchitectuur ; details --- Bouwmaterialen ; hout ; houten spanten ; triplex ; multiplex --- Houtbouw --- Bouwmaterialen ; hout --- Construction en bois. --- Conception assistée par ordinateur. --- Building, Wooden. --- Timber. --- Forest production --- Building materials --- Forest products --- Lumber trade --- Forests and forestry --- Lumber --- Tree farms --- Trees --- Wood --- Conception assistée par ordinateur --- computer-aided design [process] --- digitale ontwerptechnieken

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This book compiles four review articles and four research papers that highlight recent developments in the field of peptide nucleic acid (PNA) chemistry and biomedicine. The review articles encompass a variety of fields related to PNA, emphasizing the versatility of this DNA mimic. Two excellent reviews detail the use of PNA for molecular diagnostics of miRNAs and genetic point mutations (SNPs). Another review provides a comprehensive analysis of the various approaches for gene editing using chemically modified PNA molecules. Lastly, PNA molecules are elegantly described as effective (antisense) antimicrobial agents in the final review. The high binding affinity of PNA to complementary DNA and RNA is highlighted in three research articles. Two articles show how PNA molecules act as splice modulating and RNA masking molecules, separately. In another contribution, the high affinity and achiral characteristics of PNAs are used to developed a stable L-DNA-based catalytic hairpin assembly. Lastly, chemically-modified PNA molecules are shown to be superior probes for SNP detection. Altogether, these studies illustrate how PNA molecules may be useful for a variety of biomedical applications as either therapeutic or diagnostic agents.

RNA structure --- strand invasion --- antisense --- PNA --- exon skipping --- exon inclusion --- oligonucleotides --- peptide nucleic acid (PNA) --- antibacterials --- RNA --- PNA transporters --- conjugates --- bacterial resistance --- peptide nucleic acids --- triplex --- gene editing --- structure --- recombination --- repair --- nanoparticles --- β-thalassemia --- cystic fibrosis --- peptide nucleic acid --- tolane --- single nucleotide polymorphism --- influenza virus --- drug resistance --- peptide nucleic acids (PNAs) --- single-nucleotide polymorphism (SNP) --- polymerase chain reaction (PCR) --- cancer. --- catalytic hairpin assembly (CHA) --- strand-displacement reaction --- l-DNA --- microRNA --- fluorescence --- templated reactions --- light-triggered --- electrochemical biosensors --- colorimetric detection --- Peptide nucleic acids --- PNA-masking --- microRNAs --- miR-145-5p --- miRNA targeting --- delivery --- CFTR --- n/a