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ROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that ROS at low concentrations act as signaling molecules, leading to the regulation of physiological functions. Moreover, several interventions that increase ROS generation activate stress-adaptive responses that extend the lifespan. It was also shown that excessive use of antioxidants can counter the beneficial effects of ROS. Currently, much progress has been made in understanding the role of ROS in human diseases and aging, as well as in the regulation of physiological functions, and in identifying the signaling pathways involved in ROS. However, much remains to be understood about the mutual interactions among signaling pathways underlying organisms’ adaptive responses, their modifications (which occur during aging), and some disease states. The aim of this Special Issue is to underline the effects of ROS production and antioxidant treatment in living organisms, focusing on their impact on health, disease, and aging.

CTCL --- apoptosis --- cell viability --- c-FLIP --- XIAP --- artemisinin --- SH-SY5Y cells --- hippocampal neurons --- H2O2 --- AMPK pathway --- atherosclerosis --- sphingomyelin synthase 2 --- endothelial dysfunction --- endoplasmic reticulum stress --- β-catenin --- insulin resistance --- cancer --- cardiovascular disease --- neurodegenerative disorders --- exercise --- mitochondria --- oxidative stress --- PGC-1 --- Nrf2 --- UCPs --- ROS --- light --- DNA damage --- evolution --- D-box --- cavefish --- Spalax --- trimethylamine N-oxide --- cardiomyocytes --- cardiotoxicity --- mitochondrial membrane potential --- CORM-2 --- NADPH oxidase --- AP-1 --- HO-1 --- Renal cell carcinoma (RCC) --- reactive oxygen species (ROS) --- glutathione (GSH) metabolism --- cancer therapy --- clear cell RCC --- papillary RCC --- chromophobe RCC --- sarcopenia --- reactive oxygen species --- redox signaling --- antioxidant supplementation --- protein aggregation --- redox --- proteinopathy --- peroxiredoxins --- tumorigenesis --- ROS scavengers --- n/a

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ROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that ROS at low concentrations act as signaling molecules, leading to the regulation of physiological functions. Moreover, several interventions that increase ROS generation activate stress-adaptive responses that extend the lifespan. It was also shown that excessive use of antioxidants can counter the beneficial effects of ROS. Currently, much progress has been made in understanding the role of ROS in human diseases and aging, as well as in the regulation of physiological functions, and in identifying the signaling pathways involved in ROS. However, much remains to be understood about the mutual interactions among signaling pathways underlying organisms’ adaptive responses, their modifications (which occur during aging), and some disease states. The aim of this Special Issue is to underline the effects of ROS production and antioxidant treatment in living organisms, focusing on their impact on health, disease, and aging.

Research & information: general --- Biology, life sciences --- CTCL --- apoptosis --- cell viability --- c-FLIP --- XIAP --- artemisinin --- SH-SY5Y cells --- hippocampal neurons --- H2O2 --- AMPK pathway --- atherosclerosis --- sphingomyelin synthase 2 --- endothelial dysfunction --- endoplasmic reticulum stress --- β-catenin --- insulin resistance --- cancer --- cardiovascular disease --- neurodegenerative disorders --- exercise --- mitochondria --- oxidative stress --- PGC-1 --- Nrf2 --- UCPs --- ROS --- light --- DNA damage --- evolution --- D-box --- cavefish --- Spalax --- trimethylamine N-oxide --- cardiomyocytes --- cardiotoxicity --- mitochondrial membrane potential --- CORM-2 --- NADPH oxidase --- AP-1 --- HO-1 --- Renal cell carcinoma (RCC) --- reactive oxygen species (ROS) --- glutathione (GSH) metabolism --- cancer therapy --- clear cell RCC --- papillary RCC --- chromophobe RCC --- sarcopenia --- reactive oxygen species --- redox signaling --- antioxidant supplementation --- protein aggregation --- redox --- proteinopathy --- peroxiredoxins --- tumorigenesis --- ROS scavengers

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Metabolic syndrome has been the topic of countless publications. It still remains a subject of debate and some experts have even questioned its clinical relevance. Its diagnosis is nevertheless predictive of an increased risk of type 2 diabetes and cardiovascular disease even in the absence of traditional risk factors. Many years ago, our team made the point that the most prevalent form of metabolic syndrome was linked to abdominal obesity, which can be found even among individuals who are not considered obese by body weight standards. Imaging techniques such as computed tomography and magnetic resonance imaging have revealed the link between regional body fat partitioning and cardiometabolic risk. Visceral obesity is the most dangerous form of obesity, with subcutaneous obesity being associated with lower health risk. We have proposed that excess visceral fat may be a marker of subcutaneous adipose tissue dysfunction not being able to serve as a metabolic sink, causing lipid accumulation at undesired sites, a condition described as ectopic fat deposition. Among the effective approaches to prevent, delay, or manage metabolic syndrome, lifestyle changes are the key elements, with an emphasis on the importance of healthy global dietary patterns, regular physical activity, and adequate sleep quality.

Humanities --- Social interaction --- trimethylamine N-oxide (TMAO) --- obesity --- visceral adiposity index (VAI) --- fatty liver index (FLI) --- metabolic syndrome (MetS) --- healthy lifestyle score --- metabolic syndrome --- SUN cohort --- branched-chain amino acids --- acylcarnitines --- dietary protein sources --- meat --- metabolite profiling --- diet --- pediatric obesity --- nonalcoholic fatty liver disease --- saliva --- metabolomics --- gas-chromatography mass spectrometry --- anthropometric indexes --- diagnosis criteria --- adolescents --- bone mineral density --- insulin resistance --- bone health --- osteoporosis --- atherosclerotic cardiovascular disease --- visceral fat accumulation --- universal public health screening program --- health check-up --- health guidance --- city planning --- carbohydrate --- polyunsaturated fat --- monounsaturated fat --- saturated fat --- fish oil --- meta-analyses --- lipids --- glucose --- blood pressure --- breastfeeding duration --- birth weight --- cardiorespiratory fitness --- cardiovascular disease --- exercise training --- linseed --- secoisolariciresinol diglucoside --- high-carbohydrate --- high-fat diet --- anthropometric indices --- cardiometabolic risk --- elderly --- risk --- pediatric --- adolescent --- sugar-sweetened beverages --- weight gain --- type 2 diabetes --- older adults --- macronutrient intake --- dietary intake --- fat intake --- endocannabinoids --- endocannabinoidome --- microbiome --- fructose --- hypertriglyceridemia --- metabolism --- sleep --- sleep apnea --- sleep habit --- sleep duration --- chronotype --- social jetlag --- ethnicity --- prevention --- lifestyle --- cardiometabolic --- exercise --- abdominal obesity --- energy balance --- caloric restriction --- non-alcoholic fatty liver disease --- physical activity --- saturated fatty acids --- diet quality --- dietary guidelines --- n/a

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Metabolic syndrome has been the topic of countless publications. It still remains a subject of debate and some experts have even questioned its clinical relevance. Its diagnosis is nevertheless predictive of an increased risk of type 2 diabetes and cardiovascular disease even in the absence of traditional risk factors. Many years ago, our team made the point that the most prevalent form of metabolic syndrome was linked to abdominal obesity, which can be found even among individuals who are not considered obese by body weight standards. Imaging techniques such as computed tomography and magnetic resonance imaging have revealed the link between regional body fat partitioning and cardiometabolic risk. Visceral obesity is the most dangerous form of obesity, with subcutaneous obesity being associated with lower health risk. We have proposed that excess visceral fat may be a marker of subcutaneous adipose tissue dysfunction not being able to serve as a metabolic sink, causing lipid accumulation at undesired sites, a condition described as ectopic fat deposition. Among the effective approaches to prevent, delay, or manage metabolic syndrome, lifestyle changes are the key elements, with an emphasis on the importance of healthy global dietary patterns, regular physical activity, and adequate sleep quality.

trimethylamine N-oxide (TMAO) --- obesity --- visceral adiposity index (VAI) --- fatty liver index (FLI) --- metabolic syndrome (MetS) --- healthy lifestyle score --- metabolic syndrome --- SUN cohort --- branched-chain amino acids --- acylcarnitines --- dietary protein sources --- meat --- metabolite profiling --- diet --- pediatric obesity --- nonalcoholic fatty liver disease --- saliva --- metabolomics --- gas-chromatography mass spectrometry --- anthropometric indexes --- diagnosis criteria --- adolescents --- bone mineral density --- insulin resistance --- bone health --- osteoporosis --- atherosclerotic cardiovascular disease --- visceral fat accumulation --- universal public health screening program --- health check-up --- health guidance --- city planning --- carbohydrate --- polyunsaturated fat --- monounsaturated fat --- saturated fat --- fish oil --- meta-analyses --- lipids --- glucose --- blood pressure --- breastfeeding duration --- birth weight --- cardiorespiratory fitness --- cardiovascular disease --- exercise training --- linseed --- secoisolariciresinol diglucoside --- high-carbohydrate --- high-fat diet --- anthropometric indices --- cardiometabolic risk --- elderly --- risk --- pediatric --- adolescent --- sugar-sweetened beverages --- weight gain --- type 2 diabetes --- older adults --- macronutrient intake --- dietary intake --- fat intake --- endocannabinoids --- endocannabinoidome --- microbiome --- fructose --- hypertriglyceridemia --- metabolism --- sleep --- sleep apnea --- sleep habit --- sleep duration --- chronotype --- social jetlag --- ethnicity --- prevention --- lifestyle --- cardiometabolic --- exercise --- abdominal obesity --- energy balance --- caloric restriction --- non-alcoholic fatty liver disease --- physical activity --- saturated fatty acids --- diet quality --- dietary guidelines --- n/a

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Metabolic syndrome has been the topic of countless publications. It still remains a subject of debate and some experts have even questioned its clinical relevance. Its diagnosis is nevertheless predictive of an increased risk of type 2 diabetes and cardiovascular disease even in the absence of traditional risk factors. Many years ago, our team made the point that the most prevalent form of metabolic syndrome was linked to abdominal obesity, which can be found even among individuals who are not considered obese by body weight standards. Imaging techniques such as computed tomography and magnetic resonance imaging have revealed the link between regional body fat partitioning and cardiometabolic risk. Visceral obesity is the most dangerous form of obesity, with subcutaneous obesity being associated with lower health risk. We have proposed that excess visceral fat may be a marker of subcutaneous adipose tissue dysfunction not being able to serve as a metabolic sink, causing lipid accumulation at undesired sites, a condition described as ectopic fat deposition. Among the effective approaches to prevent, delay, or manage metabolic syndrome, lifestyle changes are the key elements, with an emphasis on the importance of healthy global dietary patterns, regular physical activity, and adequate sleep quality.

Humanities --- Social interaction --- trimethylamine N-oxide (TMAO) --- obesity --- visceral adiposity index (VAI) --- fatty liver index (FLI) --- metabolic syndrome (MetS) --- healthy lifestyle score --- metabolic syndrome --- SUN cohort --- branched-chain amino acids --- acylcarnitines --- dietary protein sources --- meat --- metabolite profiling --- diet --- pediatric obesity --- nonalcoholic fatty liver disease --- saliva --- metabolomics --- gas-chromatography mass spectrometry --- anthropometric indexes --- diagnosis criteria --- adolescents --- bone mineral density --- insulin resistance --- bone health --- osteoporosis --- atherosclerotic cardiovascular disease --- visceral fat accumulation --- universal public health screening program --- health check-up --- health guidance --- city planning --- carbohydrate --- polyunsaturated fat --- monounsaturated fat --- saturated fat --- fish oil --- meta-analyses --- lipids --- glucose --- blood pressure --- breastfeeding duration --- birth weight --- cardiorespiratory fitness --- cardiovascular disease --- exercise training --- linseed --- secoisolariciresinol diglucoside --- high-carbohydrate --- high-fat diet --- anthropometric indices --- cardiometabolic risk --- elderly --- risk --- pediatric --- adolescent --- sugar-sweetened beverages --- weight gain --- type 2 diabetes --- older adults --- macronutrient intake --- dietary intake --- fat intake --- endocannabinoids --- endocannabinoidome --- microbiome --- fructose --- hypertriglyceridemia --- metabolism --- sleep --- sleep apnea --- sleep habit --- sleep duration --- chronotype --- social jetlag --- ethnicity --- prevention --- lifestyle --- cardiometabolic --- exercise --- abdominal obesity --- energy balance --- caloric restriction --- non-alcoholic fatty liver disease --- physical activity --- saturated fatty acids --- diet quality --- dietary guidelines