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"In consultation with Consulting Editor, Dr. Helen Boucher, Dr. Mossad has created an issue that provides a very current look at the prevention of infections in the solid organ transplant patient. Top authors in the field have contributed clinical reviews on the following topics: Is this organ donor safe; Immunization of solid organ transplant candidates & recipients; Safe living following solid organ transplantation; Strategies for Antimicrobial Stewardship in solid organ transplant recipients; Multi drug resistant bacterial infections in solid organ transplant candidates and recipients; Yeast infections in solid organ transplant recipients; Mold infections in solid organ transplant recipients; Endemic mycoses in solid organ transplant recipients; Prevention and treatment of cytomegalovirus infections in solid organ transplant recipients; Management of BK polyomavirus infection in kidney & pancreas transplant recipients; Prevention and treatment of clostridium difficile-associated diarrhea in solid organ transplant recipients; Management of viral hepatitis in solid organ transplant recipients; Prevention and management of tuberculosis in solid organ transplant recipients; Management of mycobacteria other than tuberculosis in solid organ transplant recipients; Management of strongyloidiasis in solid organ transplant recipients; and Transplantation in HIV infected patients. Readers will come away with the clinical information and evidence they need to improve outcomes of the organ transplant patient." -- provided by the publisher
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This book provides a comprehensive guide to successful kidney transplantation in the highly regulated environment of today. It covers the history of kidney transplant to highlight innovations that have made kidney transplantation so successful as well as the new deceased donor kidney allocation strategy and postulates what types of changes might occur with this new policy. The book highlights special areas of nephrology concern in kidney transplantation, especially diseases likely to recur following transplant. It deals with many of the medications used in kidney transplantation including different commonly used antirejection protocols. It also provides a complete reference on the various operations involved in kidney transplantation. The text includes detailed pictures and surgical technique sections on cadaveric kidney transplantation and living kidney transplantation. It includes information on living kidney donation surgery with a chapter dedicated to the minimally invasive techniques that have been popularized in the last fifteen years. Some coverage on open living kidney donation is presented. Included in this section is discussions of how to handle certain operative challenges like severe atherosclerosis, venous sclerosis and various urinary system aberrancies. Comprehensive coverage of common surgical complications is presented including management of urinary strictures, urinary leaks, lymphoceles, vascular problems following transplant, and what steps should be taken when an early kidney transplant biopsy is necessary. It also covers in detail what is required for maintenance of health after kidney transplantation including the major risks for graft loss as well as what disease processes kidney transplant patients are particularly vulnerable to.
Surgical transplantation. --- Nephrology. --- Transplant Surgery.
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Contemporary Liver Transplantation provides a comprehensive review of the most crucial and provocative aspects of liver transplantation. It represents a unique source of information and guidance for the current generation of transplant surgeons that evolved from being pure clinicians into savvy administrators knowledgeable in every regulatory aspect governing transplantation. The book contains 35 chapters covering every single aspect of the surgical operation in the donors as well as the recipients of liver transplants. The pre-operative work-up, as well as the post-operative immunosuppression management, and the treatment of recurrent diseases are addressed in detail. Single chapters are dedicated to controversial issues like transplantation in patients diagnosed with NASH, transplantation for patients diagnosed with HCC beyond Milan criteria, and usage of HIV positive donors. Dedicated chapters on HCV, HCC, FHF, and NASH will make this book a unique resource for any health care provider part of the multidisciplinary liver transplant team. The book goes beyond the analysis of the formal medical and surgical aspects of liver transplantation and introduces deep knowledge on key aspects of contemporary transplant programs, such as: physical rehabilitation, palliative care, pregnancy, the multiple requirements of regulatory agencies ruling transplantation, quality measurements for transplant programs, finance and liability. The book is organized in 9 sections focusing on each key aspect of liver transplantation. Contemporary Liver Transplantation addresses the need and the questions of of the multidisciplinary group involved including surgeons, Hepatologists , anesthesiologists, infectious disease specialists, radiologists, transplant coordinators, financial specialists, epidemiologists and administrators.
Surgical transplantation. --- Hepatology. --- Transplant Surgery.
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Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the transplanted tissues. Thus, there is a great medical need to understand the complex network of immune system interactions that lead to transplant rejection so that new strategies of intervention can be determined that will redirect the system toward transplant acceptance while preserving immune competence against offending agents. In the past 20 years, the discovery and growing understanding of the positive and negative regulators of the activation of the immune system have fostered new interventional procedures targeting one or the other. While pre-clinical results proved the validity of these strategies, their clinical implementation has been troublesome. These results underscore the need for additional methods to determine the most effective interventions to prevent long-term transplant rejection. New tools of genomics, proteomics and metabolomics are being implemented in powerful analyses that promise the development of better, safer personalized treatments. In parallel, theoretical modeling has emerged as a tool that transcends investigations of individual mechanistic processes and instead unravels the relevant mechanisms of complex systems such as the immune response triggered by a transplant. In this way, theoretical models can be used to identify important behavior that arises from complex systems and thereby delineate emergent properties of biological systems that could not be identified studying single components. Employing this approach, interdisciplinary collaborations among immunologists, mathematicians, and system biologists will yield novel perspectives in the development of more effective strategies of intervention. The aim of this Research Topic is to demonstrate how new insight and methods from theoretical and experimental studies of the immune response can aid in identifying new research directions in transplant immunology. First, techniques from various theoretical and experimental studies with applications to the immune response will be reviewed to determine how they can be adapted to explore the complexity of transplant rejection. Second, recent advances in the acquisition and mining of large data sets related to transplant genomics, proteomics, and metabolomics will be discussed in the context of their predictive power and potential for optimizing and personalizing patient treatment. Last, new perspectives will be offered on the integration of computational immune modeling with transplant and omics data to establish more effective strategies of intervention that promote transplant tolerance.
systems biology --- theoretical modeling --- transplant immunology --- biomarkers --- big data and bioinformatics --- transplant rejection --- transplant tolerance --- mechanistic models --- systems biology --- theoretical modeling --- transplant immunology --- biomarkers --- big data and bioinformatics --- transplant rejection --- transplant tolerance --- mechanistic models
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Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the transplanted tissues. Thus, there is a great medical need to understand the complex network of immune system interactions that lead to transplant rejection so that new strategies of intervention can be determined that will redirect the system toward transplant acceptance while preserving immune competence against offending agents. In the past 20 years, the discovery and growing understanding of the positive and negative regulators of the activation of the immune system have fostered new interventional procedures targeting one or the other. While pre-clinical results proved the validity of these strategies, their clinical implementation has been troublesome. These results underscore the need for additional methods to determine the most effective interventions to prevent long-term transplant rejection. New tools of genomics, proteomics and metabolomics are being implemented in powerful analyses that promise the development of better, safer personalized treatments. In parallel, theoretical modeling has emerged as a tool that transcends investigations of individual mechanistic processes and instead unravels the relevant mechanisms of complex systems such as the immune response triggered by a transplant. In this way, theoretical models can be used to identify important behavior that arises from complex systems and thereby delineate emergent properties of biological systems that could not be identified studying single components. Employing this approach, interdisciplinary collaborations among immunologists, mathematicians, and system biologists will yield novel perspectives in the development of more effective strategies of intervention. The aim of this Research Topic is to demonstrate how new insight and methods from theoretical and experimental studies of the immune response can aid in identifying new research directions in transplant immunology. First, techniques from various theoretical and experimental studies with applications to the immune response will be reviewed to determine how they can be adapted to explore the complexity of transplant rejection. Second, recent advances in the acquisition and mining of large data sets related to transplant genomics, proteomics, and metabolomics will be discussed in the context of their predictive power and potential for optimizing and personalizing patient treatment. Last, new perspectives will be offered on the integration of computational immune modeling with transplant and omics data to establish more effective strategies of intervention that promote transplant tolerance.
systems biology --- theoretical modeling --- transplant immunology --- biomarkers --- big data and bioinformatics --- transplant rejection --- transplant tolerance --- mechanistic models
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Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the transplanted tissues. Thus, there is a great medical need to understand the complex network of immune system interactions that lead to transplant rejection so that new strategies of intervention can be determined that will redirect the system toward transplant acceptance while preserving immune competence against offending agents. In the past 20 years, the discovery and growing understanding of the positive and negative regulators of the activation of the immune system have fostered new interventional procedures targeting one or the other. While pre-clinical results proved the validity of these strategies, their clinical implementation has been troublesome. These results underscore the need for additional methods to determine the most effective interventions to prevent long-term transplant rejection. New tools of genomics, proteomics and metabolomics are being implemented in powerful analyses that promise the development of better, safer personalized treatments. In parallel, theoretical modeling has emerged as a tool that transcends investigations of individual mechanistic processes and instead unravels the relevant mechanisms of complex systems such as the immune response triggered by a transplant. In this way, theoretical models can be used to identify important behavior that arises from complex systems and thereby delineate emergent properties of biological systems that could not be identified studying single components. Employing this approach, interdisciplinary collaborations among immunologists, mathematicians, and system biologists will yield novel perspectives in the development of more effective strategies of intervention. The aim of this Research Topic is to demonstrate how new insight and methods from theoretical and experimental studies of the immune response can aid in identifying new research directions in transplant immunology. First, techniques from various theoretical and experimental studies with applications to the immune response will be reviewed to determine how they can be adapted to explore the complexity of transplant rejection. Second, recent advances in the acquisition and mining of large data sets related to transplant genomics, proteomics, and metabolomics will be discussed in the context of their predictive power and potential for optimizing and personalizing patient treatment. Last, new perspectives will be offered on the integration of computational immune modeling with transplant and omics data to establish more effective strategies of intervention that promote transplant tolerance.
systems biology --- theoretical modeling --- transplant immunology --- biomarkers --- big data and bioinformatics --- transplant rejection --- transplant tolerance --- mechanistic models
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This updated, full-color 4th edition features a greatly expanded surgical focus for a practical guide to corneal surgery. The expert guidance of internationally renowned editors provides you with authoritative and current coverage that takes you from an in-depth exploration corneal function as related to corneal surgery through to the correction of refractive errors. New chapters ensure that you stay up-to-date on the latest developments in the field. This easy-to-use, state-of-the-art resource has been reorganized to focus strictly on surgery to provide you with more coverage of recent surgic
Cornea --- Surgery. --- Transplantation. --- Corneal transplant --- Keratoplasty
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This book is a comprehensive and easy-to-access guide not only in the diagnosis of the various types of liver disease but in the management of specific disorders, including the particular nuances of the care of the patient with liver disease. It provides a resource to the practitioner caring for patients with liver disease for addressing everyday questions posed by patients and their families, as well as referring physicians, in a manner that can easily be conveyed. The spectrum covered includes appropriate testing and disease monitoring of patients, use of medications, supplements, alternative therapies and alcohol, operative risk assessment, implementation of health maintenance for patients with chronic liver disease and cirrhosis, identification and management of particular complications of cirrhosis, and appropriate referral for liver transplantation, as well as management of special populations. Written by experts in the field, Liver Disorders: A Point of Care Clinical Guide is a valuable resource for clinicians who treat patients with a variety of liver disorders. .
Hepatology. --- Gastroenterology . --- Surgical transplantation. --- Gastroenterology. --- Transplant Surgery.
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Intestinal transplantation remains on the cutting edge of solid organ transplantation. Each potential recipient provides a unique case of intestinal failure with individual intricacies requiring the combined efforts of a complex multidisciplinary team in order to achieve success. Contemporary Small Bowel Transplantation covers all aspects of intestinal transplantation in a manner accessible to all providers and provides specific guidance for those that may come in contact with this field and these patients. The text provides an understanding of the critical pre-operative evaluation, thorough descriptions of each surgical procedure and postoperative management. Areas such as infectious disease, nutrition and graft versus host disease will be addressed in detail. Key controversies and administrative issues unique to intestinal transplantation are covered. Contemporary Small Bowel Transplantation provides critical guidance for the new transplant surgeon, gastroenterologist or administrator as they navigate the challenging field of intestinal transplantation.
Surgical transplantation. --- Gastroenterology . --- Transplant Surgery. --- Gastroenterology.
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This book is a comprehensive and easy-to-access guide not only in the diagnosis of the various types of liver disease but in the management of specific disorders, including the particular nuances of the care of the patient with liver disease. It provides a resource to the practitioner caring for patients with liver disease for addressing everyday questions posed by patients and their families, as well as referring physicians, in a manner that can easily be conveyed. The spectrum covered includes appropriate testing and disease monitoring of patients, use of medications, supplements, alternative therapies and alcohol, operative risk assessment, implementation of health maintenance for patients with chronic liver disease and cirrhosis, identification and management of particular complications of cirrhosis, and appropriate referral for liver transplantation, as well as management of special populations. Written by experts in the field, Liver Disorders: A Point of Care Clinical Guide is a valuable resource for clinicians who treat patients with a variety of liver disorders. .
Hepatology. --- Gastroenterology . --- Surgical transplantation. --- Gastroenterology. --- Transplant Surgery.
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