Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book provides a comprehensive guide to successful kidney transplantation in the highly regulated environment of today. It covers the history of kidney transplant to highlight innovations that have made kidney transplantation so successful as well as the new deceased donor kidney allocation strategy and postulates what types of changes might occur with this new policy. The book highlights special areas of nephrology concern in kidney transplantation, especially diseases likely to recur following transplant. It deals with many of the medications used in kidney transplantation including different commonly used antirejection protocols. It also provides a complete reference on the various operations involved in kidney transplantation. The text includes detailed pictures and surgical technique sections on cadaveric kidney transplantation and living kidney transplantation. It includes information on living kidney donation surgery with a chapter dedicated to the minimally invasive techniques that have been popularized in the last fifteen years. Some coverage on open living kidney donation is presented. Included in this section is discussions of how to handle certain operative challenges like severe atherosclerosis, venous sclerosis and various urinary system aberrancies. Comprehensive coverage of common surgical complications is presented including management of urinary strictures, urinary leaks, lymphoceles, vascular problems following transplant, and what steps should be taken when an early kidney transplant biopsy is necessary. It also covers in detail what is required for maintenance of health after kidney transplantation including the major risks for graft loss as well as what disease processes kidney transplant patients are particularly vulnerable to.

Surgical transplantation. --- Nephrology. --- Transplant Surgery.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the transplanted tissues. Thus, there is a great medical need to understand the complex network of immune system interactions that lead to transplant rejection so that new strategies of intervention can be determined that will redirect the system toward transplant acceptance while preserving immune competence against offending agents. In the past 20 years, the discovery and growing understanding of the positive and negative regulators of the activation of the immune system have fostered new interventional procedures targeting one or the other. While pre-clinical results proved the validity of these strategies, their clinical implementation has been troublesome. These results underscore the need for additional methods to determine the most effective interventions to prevent long-term transplant rejection. New tools of genomics, proteomics and metabolomics are being implemented in powerful analyses that promise the development of better, safer personalized treatments. In parallel, theoretical modeling has emerged as a tool that transcends investigations of individual mechanistic processes and instead unravels the relevant mechanisms of complex systems such as the immune response triggered by a transplant. In this way, theoretical models can be used to identify important behavior that arises from complex systems and thereby delineate emergent properties of biological systems that could not be identified studying single components. Employing this approach, interdisciplinary collaborations among immunologists, mathematicians, and system biologists will yield novel perspectives in the development of more effective strategies of intervention. The aim of this Research Topic is to demonstrate how new insight and methods from theoretical and experimental studies of the immune response can aid in identifying new research directions in transplant immunology. First, techniques from various theoretical and experimental studies with applications to the immune response will be reviewed to determine how they can be adapted to explore the complexity of transplant rejection. Second, recent advances in the acquisition and mining of large data sets related to transplant genomics, proteomics, and metabolomics will be discussed in the context of their predictive power and potential for optimizing and personalizing patient treatment. Last, new perspectives will be offered on the integration of computational immune modeling with transplant and omics data to establish more effective strategies of intervention that promote transplant tolerance.

systems biology --- theoretical modeling --- transplant immunology --- biomarkers --- big data and bioinformatics --- transplant rejection --- transplant tolerance --- mechanistic models --- systems biology --- theoretical modeling --- transplant immunology --- biomarkers --- big data and bioinformatics --- transplant rejection --- transplant tolerance --- mechanistic models

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the transplanted tissues. Thus, there is a great medical need to understand the complex network of immune system interactions that lead to transplant rejection so that new strategies of intervention can be determined that will redirect the system toward transplant acceptance while preserving immune competence against offending agents. In the past 20 years, the discovery and growing understanding of the positive and negative regulators of the activation of the immune system have fostered new interventional procedures targeting one or the other. While pre-clinical results proved the validity of these strategies, their clinical implementation has been troublesome. These results underscore the need for additional methods to determine the most effective interventions to prevent long-term transplant rejection. New tools of genomics, proteomics and metabolomics are being implemented in powerful analyses that promise the development of better, safer personalized treatments. In parallel, theoretical modeling has emerged as a tool that transcends investigations of individual mechanistic processes and instead unravels the relevant mechanisms of complex systems such as the immune response triggered by a transplant. In this way, theoretical models can be used to identify important behavior that arises from complex systems and thereby delineate emergent properties of biological systems that could not be identified studying single components. Employing this approach, interdisciplinary collaborations among immunologists, mathematicians, and system biologists will yield novel perspectives in the development of more effective strategies of intervention. The aim of this Research Topic is to demonstrate how new insight and methods from theoretical and experimental studies of the immune response can aid in identifying new research directions in transplant immunology. First, techniques from various theoretical and experimental studies with applications to the immune response will be reviewed to determine how they can be adapted to explore the complexity of transplant rejection. Second, recent advances in the acquisition and mining of large data sets related to transplant genomics, proteomics, and metabolomics will be discussed in the context of their predictive power and potential for optimizing and personalizing patient treatment. Last, new perspectives will be offered on the integration of computational immune modeling with transplant and omics data to establish more effective strategies of intervention that promote transplant tolerance.

systems biology --- theoretical modeling --- transplant immunology --- biomarkers --- big data and bioinformatics --- transplant rejection --- transplant tolerance --- mechanistic models

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book is a comprehensive and easy-to-access guide not only in the diagnosis of the various types of liver disease but in the management of specific disorders, including the particular nuances of the care of the patient with liver disease. It provides a resource to the practitioner caring for patients with liver disease for addressing everyday questions posed by patients and their families, as well as referring physicians, in a manner that can easily be conveyed. The spectrum covered includes appropriate testing and disease monitoring of patients, use of medications, supplements, alternative therapies and alcohol, operative risk assessment, implementation of health maintenance for patients with chronic liver disease and cirrhosis, identification and management of particular complications of cirrhosis, and appropriate referral for liver transplantation, as well as management of special populations. Written by experts in the field, Liver Disorders: A Point of Care Clinical Guide is a valuable resource for clinicians who treat patients with a variety of liver disorders. .

Hepatology. --- Gastroenterology . --- Surgical transplantation. --- Gastroenterology. --- Transplant Surgery.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This book is a comprehensive and easy-to-access guide not only in the diagnosis of the various types of liver disease but in the management of specific disorders, including the particular nuances of the care of the patient with liver disease. It provides a resource to the practitioner caring for patients with liver disease for addressing everyday questions posed by patients and their families, as well as referring physicians, in a manner that can easily be conveyed. The spectrum covered includes appropriate testing and disease monitoring of patients, use of medications, supplements, alternative therapies and alcohol, operative risk assessment, implementation of health maintenance for patients with chronic liver disease and cirrhosis, identification and management of particular complications of cirrhosis, and appropriate referral for liver transplantation, as well as management of special populations. Written by experts in the field, Liver Disorders: A Point of Care Clinical Guide is a valuable resource for clinicians who treat patients with a variety of liver disorders. .

Hepatology. --- Gastroenterology . --- Surgical transplantation. --- Gastroenterology. --- Transplant Surgery.