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Medical sciences --- Medical innovations --- Medicine --- Translational Medical Research. --- Research

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The aim of this Research Topic was to collate articles describing prediction of outcomes of pre- and perinatal lesions leading to cerebral palsy, basic research in animal models and human subjects, and ideas for, and trials of, interventions in the first two years of life.CP arises from insults to the sensorimotor cortex, subcortical axon tracts and subplate. The aetiology is complex and often multifactorial. The outcome is not simply a loss of voluntary control due to disruption of descending pathways, but also involves abnormal development of reflex and corticospinal circuitry. CP may be viewed as aberrant plasticity in response to a lesion, indeed, abnormalities in movement are subtle at first but develop subsequently. It is misleading to suppose that developmental mechanisms are self-reparative. The challenge is to understand activitydependent fine tuning of neural circuitry during normal development and to find how to promote desirable plasticity whilst limiting undesirable effects following developmental lesions. However, before proposing interventions, we have to develop our ability to predict the severity of neonatal insults.We solicited a variety of articles, including long and short reviews, original research and opinion pieces, from both basic scientists and clinicians. Likewise we, as editors, have complementary knowledge and experience in this area. Anna Basu is an academic pediatric neurologist and Gavin Clowry is a developmental neuroscientist.

Cerebral palsy. --- outcome prediction --- Early Intervention --- Translational Medical Research --- diagnosis --- Cerebral Palsy --- outcome prediction --- Early Intervention --- Translational Medical Research --- diagnosis --- Cerebral Palsy

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Medical sciences --- Medical innovations --- Medicine --- Translational Medical Research. --- Medical innovations. --- Medical sciences. --- Medicine --- Research --- Research.

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Medicine --- Biomedical Research. --- Translational Medical Research. --- Therapies, Investigational. --- Research --- Research. --- Medicine - General --- Translational Research, Biomedical.

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This new edition continues to provide basic, comprehensive coverage of key methods in categorical data analysis with multiple variables. Maintaining the same nontechnical, user-friendly approach, coverage has been added to this second edition to take the topic of categorical data analysis into a more applied direction.

Multivariate analysis --- Biometry --- Models, Theoretical --- Research Design --- Translational Medical Research --- methods --- methods