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The book is a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration. One of the most ambitious aspirations of modern medical science is the possibility of regenerating any damaged part of the body, including skeletal muscle. This desire has prompted clinicians and researchers to search for innovative technologies aimed at replacing organs and tissues that are compromised. In this context, the papers, collected in this book, addressing a specific aspects of muscle homeostasis and regeneration under physiopathologic conditions, will help us to better understand the underlying mechanisms of muscle healing and will help to design more appropriate therapeutic approaches to improve muscle regeneration and to counteract muscle diseases.

Research & information: general --- Biology, life sciences --- lysine --- mTORC1 --- satellite cells --- proliferation --- skeletal muscle growth --- muscle satellite cell --- transthyretin --- thyroid hormone --- myogenesis --- exosomes --- skeletal muscle --- genotype --- genetic variation --- muscle phenotypes --- sarcopenia --- aging --- calcium homeostasis --- hibernation --- mitochondria --- sarcoplasmic reticulum --- Acvr1b --- Tgfbr1 --- myostatin --- Col1a1 --- fibrosis --- atrophy --- IGF2R --- muscle homeostasis --- inflammation --- muscular dystrophy --- pericytes --- macrophages --- Nfix --- phagocytosis --- RhoA-ROCK1 --- splicing isoforms --- CRISPR-Cas9 --- exon deletion --- NF-Y --- muscle differentiation --- C2C12 cells --- denervation --- neuromuscular junction --- heavy resistance exercise --- acetylcholine receptor --- cell culture --- neonatal myosin --- neural cell adhesion molecule --- biomarkers --- mitophagy --- mitochondrial dynamics --- mitochondrial quality control --- mitochondrial-derived vesicles (MDVs) --- mitochondrial-lysosomal axis --- Hibernation --- electron microscopy --- immunocytochemistry --- α-smooth muscle actin --- confocal microscopy --- connexin 43 --- connexin 26 --- gap junctions --- myofibroblasts --- Platelet-Rich Plasma --- transforming growth factor (TGF)-β1 --- muscle regeneration --- inflammatory response --- cell precursors --- experimental methods --- stem cell markers --- muscles --- heterotopic ossification --- skeletal muscle stem and progenitor cells --- HO precursors --- muscle atrophy --- septicemia --- mitochondrial fusion --- mitochondrial fission --- iPSC --- extracellular vesicles --- Drosophila --- muscle --- genetic control --- muscle diversification --- fascicle --- myofiber --- myofibril --- sarcomere --- hypertrophy --- hyperplasia --- splitting --- radial growth --- longitudinal growth --- exercise --- muscle stem cells --- stem cells niche --- neuromuscular disorders --- Duchenne muscular dystrophy --- pharmacological approach --- single-cell --- mass cytometry --- skeletal muscle regeneration --- skeletal muscle homeostasis --- fibro/adipogenic progenitors --- myogenic progenitors --- muscle populations --- evolution --- metazoans --- differentiation --- transdifferentiation --- muscle precursors --- regenerative medicine --- stem cells --- FAPs --- tissue niche --- growth factors --- muscle pathology

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Even today, cardiovascular diseases are the main cause of death worldwide, and therapeutic approaches are very restricted. Due to the limited regenerative capabilities of terminally differentiated cardiomyocytes post injury, new strategies to treat cardiac patients are urgently needed. Post myocardial injury, resident fibroblasts begin to generate the extracellular matrix, resulting in fibrosis, and finally, cardiac failure. Recently, preclinical investigations and clinical trials raised hope in stem cell-based approaches, to be an effective therapy option for these diseases. So far, several types of stem cells have been identified to be promising candidates to be applied for treatment: cardiac progenitor cells, bone marrow derived stem cells, embryonic and induced pluripotent stem cells, as well as their descendants. Furthermore, the innovative techniques of direct cardiac reprogramming of cells offered promising options for cardiovascular research, in vitro and in vivo. Hereby, the investigation of underlying and associated mechanisms triggering the therapeutic effects of stem cell application is of particular importance to improve approaches for heart patients. This Special Issue of Cells provides the latest update in the rapidly developing field of regenerative medicine in cardiology.

Fabry disease --- human embryonic stem cells --- CRISPR/Cas9 genomic editing --- Mass spectrometry proteomic analysis --- hypertrophic cardiomyopathy --- disease model --- physical exercise --- cardiac cellular regeneration --- microRNA (miR) --- Akt signaling --- cardiomyocyte proliferation --- cardiac hypertrophy --- cardioprotection --- myocarditis --- inflammation --- leukocytes --- cardiomyocytes --- multi-electrode-array --- micro-electrode-array --- MEA --- drug/toxicity screening --- field potential --- arrhythmia --- electrocardiography --- cardiac regeneration --- stem cells --- iPSC --- PSC --- ESC --- cardiovascular disease --- regeneration --- cardiac progenitor cells --- induced pluripotent stem cells --- transdifferentiation --- direct reprogramming --- genetic engineering --- cardiac tissue engineering --- biomaterials --- 18F-FDG PET --- cardiac induced cells --- cardiac function --- non-invasive imaging --- human pluripotent stem cell --- ventricular --- maturation --- bone marrow stem cells --- angiogenesis --- myocardial infarction --- human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) --- iPS cells --- big conductance calcium activated potassium channel (BK) --- Maxi-K --- slo1 --- KCa1.1 --- iberiotoxin --- long QT syndrome --- mesenchymal stromal cells (MSC) --- mRNA --- miRNA --- cardiac reprogramming --- cardiac differentiation --- cardiovascular diseases --- adult stem cells --- myocardial infraction --- 3D printing --- 3D model --- bioprinting --- cardiovascular medicine --- heart --- myocardium --- heart valves --- vascular graft --- endothelialization --- tissue engineering --- decorin --- fibronectin --- electrospinning --- endothelial progenitor cells --- bioreactor --- biostable polyurethane --- MicroRNA --- Mir-133 --- coronary heart disease --- biomarker --- meta-analysis

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The book is a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration. One of the most ambitious aspirations of modern medical science is the possibility of regenerating any damaged part of the body, including skeletal muscle. This desire has prompted clinicians and researchers to search for innovative technologies aimed at replacing organs and tissues that are compromised. In this context, the papers, collected in this book, addressing a specific aspects of muscle homeostasis and regeneration under physiopathologic conditions, will help us to better understand the underlying mechanisms of muscle healing and will help to design more appropriate therapeutic approaches to improve muscle regeneration and to counteract muscle diseases.

Research & information: general --- Biology, life sciences --- lysine --- mTORC1 --- satellite cells --- proliferation --- skeletal muscle growth --- muscle satellite cell --- transthyretin --- thyroid hormone --- myogenesis --- exosomes --- skeletal muscle --- genotype --- genetic variation --- muscle phenotypes --- sarcopenia --- aging --- calcium homeostasis --- hibernation --- mitochondria --- sarcoplasmic reticulum --- Acvr1b --- Tgfbr1 --- myostatin --- Col1a1 --- fibrosis --- atrophy --- IGF2R --- muscle homeostasis --- inflammation --- muscular dystrophy --- pericytes --- macrophages --- Nfix --- phagocytosis --- RhoA-ROCK1 --- splicing isoforms --- CRISPR-Cas9 --- exon deletion --- NF-Y --- muscle differentiation --- C2C12 cells --- denervation --- neuromuscular junction --- heavy resistance exercise --- acetylcholine receptor --- cell culture --- neonatal myosin --- neural cell adhesion molecule --- biomarkers --- mitophagy --- mitochondrial dynamics --- mitochondrial quality control --- mitochondrial-derived vesicles (MDVs) --- mitochondrial-lysosomal axis --- Hibernation --- electron microscopy --- immunocytochemistry --- α-smooth muscle actin --- confocal microscopy --- connexin 43 --- connexin 26 --- gap junctions --- myofibroblasts --- Platelet-Rich Plasma --- transforming growth factor (TGF)-β1 --- muscle regeneration --- inflammatory response --- cell precursors --- experimental methods --- stem cell markers --- muscles --- heterotopic ossification --- skeletal muscle stem and progenitor cells --- HO precursors --- muscle atrophy --- septicemia --- mitochondrial fusion --- mitochondrial fission --- iPSC --- extracellular vesicles --- Drosophila --- muscle --- genetic control --- muscle diversification --- fascicle --- myofiber --- myofibril --- sarcomere --- hypertrophy --- hyperplasia --- splitting --- radial growth --- longitudinal growth --- exercise --- muscle stem cells --- stem cells niche --- neuromuscular disorders --- Duchenne muscular dystrophy --- pharmacological approach --- single-cell --- mass cytometry --- skeletal muscle regeneration --- skeletal muscle homeostasis --- fibro/adipogenic progenitors --- myogenic progenitors --- muscle populations --- evolution --- metazoans --- differentiation --- transdifferentiation --- muscle precursors --- regenerative medicine --- stem cells --- FAPs --- tissue niche --- growth factors --- muscle pathology

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Integrative omics of plants in response to stress conditions play more crucial roles in the post-genomic era. High-quality genomic data provide more deeper understanding of how plants to survive under environmental stresses. This book is focused on concluding the recent progress in the Protein and Proteome Atlas in plants under different stresses. It covers various aspects of plant protein ranging from agricultural proteomics, structure and function of proteins, and approaches for protein identification and quantification.

phosphoproteomics --- GLU1 --- somatic embryogenesis --- CHA-SQ-1 --- nitrogen fertilizer --- chilling stress --- differentially abundant proteins --- ATP synthase --- photosynthetic parameters --- photosynthesis --- constitutive splicing --- phosphorylation --- Jatropha curcas --- plants under stress --- postharvest freshness --- Alternanthera philoxeroides --- rubber latex --- Millettia pinnata --- molecular and biochemical basis --- filling kernel --- drought stress --- comparative proteomic analysis --- domain --- micro-exons --- phylogeny --- phos-tagTM --- E. angustifolia --- root cell elongation --- ABA --- pollen abortion --- lncRNA --- transcriptome --- radish --- redox homeostasis --- Nelumbo nucifera --- sugar beet --- shotgun proteomics --- proteomes --- high-temperature stress --- post-genomics era --- model plant --- salt tolerance --- miRNA --- wheat --- physiological response --- stress --- visual proteome map --- transcriptional dynamics --- leaf --- maize --- Dunaliella salina --- phosphatidylinositol --- S-adenosylmethionine decarboxylase --- Gossypium hirsutum --- flavonoid biosynthesis --- phosphatase --- wood vinegar --- heat shock proteins --- silicate limitation --- purine metabolism --- natural rubber biosynthesis --- ancient genes --- cotton --- rubber grass --- abiotic stress --- heat stress --- maturation --- low-temperature stress --- molecular basis --- transcriptome sequencing --- ROS scavenging --- widely targeted metabolomics --- transdifferentiation --- seed development --- alternative splicing --- cultivars --- inositol --- salt stress --- chlorophyll fluorescence parameters --- proteome --- carbon fixation --- AGPase --- transcript-metabolite network --- molecular mechanisms --- Triticum aestivum L. --- Zea mays L. --- ROS --- label-free quantification --- woody oilseed plants --- heat-sensitive spinach variety --- MIPS --- quantitative proteomics --- regulated mechanism --- two-dimensional gel electrophoresis --- potassium --- glutathione --- Salinity stress --- integrated omics --- diatom --- ATP synthase CF1 alpha subunit (chloroplast) --- root --- proteome atlas --- brittle-2 --- mass spectrometry --- genomics --- Taraxacum kok-saghyz --- cytomorphology --- proteomics --- arbuscular mycorrhizal fungi --- signaling pathway --- proteomic --- loss-of-function mutant --- rice --- seedling --- wucai --- leaf sheath --- root and shoot --- antioxidant enzyme --- exon-intron structure diversity --- isobaric tags for relative and absolute quantitation --- regulation and metabolism --- concerted network --- drought --- heat response --- VIGS --- iTRAQ --- nitrogen use efficiency (NUE) --- stem