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Book
Systems Analytics and Integration of Big Omics Data
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ISBN: 3039287451 3039287443 Year: 2020 Publisher: MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

A “genotype"" is essentially an organism's full hereditary information which is obtained from its parents. A ""phenotype"" is an organism's actual observed physical and behavioral properties. These may include traits such as morphology, size, height, eye color, metabolism, etc. One of the pressing challenges in computational and systems biology is genotype-to-phenotype prediction. This is challenging given the amount of data generated by modern Omics technologies. This “Big Data” is so large and complex that traditional data processing applications are not up to the task. Challenges arise in collection, analysis, mining, sharing, transfer, visualization, archiving, and integration of these data. In this Special Issue, there is a focus on the systems-level analysis of Omics data, recent developments in gene ontology annotation, and advances in biological pathways and network biology. The integration of Omics data with clinical and biomedical data using machine learning is explored. This Special Issue covers new methodologies in the context of gene–environment interactions, tissue-specific gene expression, and how external factors or host genetics impact the microbiome.

Keywords

precision medicine informatics --- n/a --- drug sensitivity --- chromatin modification --- cell lines --- biocuration --- neurodegeneration --- multivariate analysis --- artificial intelligence --- epigenetics --- missing data --- sequencing --- clinical data --- class imbalance --- integrative analytics --- algorithm development for network integration --- deep phenotype --- non-omics data --- feature selection --- Gene Ontology --- miRNA–gene expression networks --- omics data --- plot visualization --- Alzheimer’s disease --- tissue classification --- epidemiological data --- proteomic analysis --- genotype --- RNA expression --- indirect effect --- multi-omics --- dementia --- multiomics integration --- data integration --- phenomics --- network topology analysis --- challenges --- transcriptome --- enrichment analysis --- regulatory genomics --- scalability --- heterogeneous data --- systemic lupus erythematosus --- database --- microtubule-associated protein tau --- disease variants --- genomics --- joint modeling --- distance correlation --- annotation --- phenotype --- direct effect --- curse of dimensionality --- gene–environment interactions --- logic forest --- machine learning --- KEGG pathways --- multivariate causal mediation --- amyloid-beta --- bioinformatics pipelines --- support vector machine --- pharmacogenomics --- candidate genes --- tissue-specific expressed genes --- cognitive impairment --- causal inference --- miRNA-gene expression networks --- Alzheimer's disease --- gene-environment interactions


Book
Tumors of the central nervous system : meningiomas and schwannomas
Author:
ISBN: 940072893X 9786613697646 9400728948 1280787252 Year: 2012 Publisher: Dordrecht [Netherlands] : Springer,

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This seventh volume of the essential series covering practices and developments relating to CNS tumors zeroes in on those found in the brain. Detailed dossiers on meningioma and schwannoma tumors cover aspects including diagnosis, therapy and prognosis. The text delivers vital insights into the molecular pathways related to brain tumor biology, including a detailed analysis of the roles played in neoplasm formation by E-cadherin gene instability, carbonic anhydrase 11, urokinase plasminogen activator, and Wnt signaling. Further research into their influence in the process could prompt the development of effective anti-cancer drugs.   The contributions also show how perfusion magnetic resonance imaging helps physicians differentiate between subtypes of meningiomas, and analyze the influence of molecular genetics and epigenetic mechanisms on schwannoma tumors. Among the diagnostic processes outlined are those for recognizing incidentally discovered meningioma, cystic papillary meningioma, facial nerve schwannoma, vestibular schwannoma, and intermediate nerve schwannoma. This book presents treatments for atypical, oncocytic, intracranial, and cavernous meningiomas, as well as guides to therapeutic methods ranging from neurosurgery and gamma-knife radiosurgery to vestibular schwannoma interventions such as retrosigmoidal craniotomy and immunotherapy. This authoritative volume once again provides invaluable and tightly focused source material for medical professionals committed to placing the latest theories and techniques at the service of those they care for.

Keywords

Central Nervous System Neoplasms -- pathology. --- Neoplasms, Nerve Tissue -- pathology. --- Neoplasms, Nervous Tissue -- classification. --- Tumors -- Classification. --- Neuroendocrine Tumors --- Nervous System Neoplasms --- Neoplasms, Vascular Tissue --- Neoplasms, Nerve Tissue --- Nerve Sheath Neoplasms --- Neuroma --- Meningeal Neoplasms --- Neuroectodermal Tumors --- Neoplasms by Histologic Type --- Peripheral Nervous System Neoplasms --- Neoplasms by Site --- Nervous System Diseases --- Neoplasms, Germ Cell and Embryonal --- Neoplasms --- Diseases --- Peripheral Nervous System Diseases --- Neuromuscular Diseases --- Central Nervous System Neoplasms --- Neurilemmoma --- Meningioma --- Medicine --- Surgery & Anesthesiology --- Health & Biological Sciences --- Surgery - General and By Type --- Oncology --- Meningioma. --- Acoustic neuroma. --- Central nervous system --- Cancer. --- Acoustic neurilemmonma --- Acoustic neurilemoma --- Acoustic neurinoma --- Neurilemmoma, Acoustic --- Neurilemoma, Acoustic --- Neurinoma, Acoustic --- Schwannoma, Vestibular --- Vestibular schwannoma --- Medicine. --- Cancer research. --- Laboratory medicine. --- Drug resistance. --- Neurosciences. --- Radiology. --- Biomedicine. --- Cancer Research. --- Laboratory Medicine. --- Drug Resistance. --- Diagnostic Radiology. --- Radiological physics --- Physics --- Radiation --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Resistance to drugs --- Pharmacology --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Pathology --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Physicians --- Acoustic nerve --- Neuromas --- Brain --- Tumors --- Oncology. --- Medical laboratories. --- Drug interactions. --- Radiology, Medical. --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Interactions, Drug --- Drugs --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Side effects

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