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Le staphylocoque doré est une des bactéries la plus présente dans notre environnement et elle peut causer diverses pathologies. L'Homme a mis au point des molécules biocides afin de contrer les bactéries pathogènes qui constitue la classe des antibiotiques. A cause de la résistance bactérienne, les antibiotiques ont des applications de plus en plus limitées et il est nécessaire de trouver des alternatives. Une alternative est l'utilisation de peptide antimicrobien et un peptide antimicrobien en particulier est la Pro3-TL. Néanmoins, ces peptides ne peuvent pas être administrés directement par voie orale, il est donc nécessaire d'encapsuler ceux-ci dans des microgels afin de les protéger des enzymes de la sphère intestinale. Par soucis environnemental, ces microgels sont synthétisés en CO2 supercritique qui est une technique permettant de se passer de solvant. Néanmoins, un agent de stabilisation doit être préalablement synthétisé afin de permettre la bonne dispersion de ces microgels. Cet agent de stabilisation possède une partie poly(oxyde d'éthylène) (PEO) et une partie poly(acrylate de perfluorodécyle) (PFDA) avec, entre ces deux parties, un groupement photo-clivable qui aura sont importance dans la suite. Une fois ces microgels synthétisés, des tests antibactériens vont être effectués afin de déterminer la cinétique de relargage du peptide au travers les pores du microgels. Dans un deuxième temps, grâce au clivage du bloc fluoré, il est possible de réalisé une amination réductrice, à la surface des microgels, entre l'amine terminale d'un peptide et l'aldéhyde formée à la surface des microgels lors du clivage de la partie fluorée. Il sera donc possible de cibler spécifiquement les staphylocoques dorés en greffant un peptide de ciblage à leur surface.

Microgels --- Staphylococcus Aureus --- Supercritical carbon dioxide --- Antibacterial peptide --- Physique, chimie, mathématiques & sciences de la terre > Chimie

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This Special Issue is a compilation of the recent advances in thermal fluid engineering related to supercritical CO2 power cycle development. The supercritical CO2 power cycle is considered to be one of the most promising power cycles for distributed power generation, waste heat recovery, and a topping cycle of coal, nuclear, and solar thermal heat sources. While the cycle benefits from dramatic changes in CO2 thermodynamic properties near the critical point, design, and analysis of the power cycle and its major components also face certain challenges due to the strong real gas effect and extreme operating conditions. This Special Issue will present a series of recent research results in heat transfer and fluid flow analyses and experimentation so that the accumulated knowledge can accelerate the development of this exciting future power cycle technology.

History of engineering & technology --- emergency diesel generator --- supercritical carbon dioxide cycle --- waste heat recovery system --- bottoming cycle --- re-compression Brayton cycle --- carbon dioxide --- supercritical --- thermodynamic --- exergy --- cycle simulation --- design point analysis --- radial-inflow turbine --- supercritical carbon dioxide --- air --- rotor solidity --- aerodynamic performance --- centrifugal compressor --- aerodynamic optimization design --- numerical simulation --- radial turbine --- utility-scale --- turbomachinery design --- NET Power --- supercritical CO2 --- heat exchanger --- flow analysis --- thermal stress analysis --- LCoE --- CSP --- concentrated-solar power --- axial turbine design --- micro-scale turbomachinery design --- emergency diesel generator --- supercritical carbon dioxide cycle --- waste heat recovery system --- bottoming cycle --- re-compression Brayton cycle --- carbon dioxide --- supercritical --- thermodynamic --- exergy --- cycle simulation --- design point analysis --- radial-inflow turbine --- supercritical carbon dioxide --- air --- rotor solidity --- aerodynamic performance --- centrifugal compressor --- aerodynamic optimization design --- numerical simulation --- radial turbine --- utility-scale --- turbomachinery design --- NET Power --- supercritical CO2 --- heat exchanger --- flow analysis --- thermal stress analysis --- LCoE --- CSP --- concentrated-solar power --- axial turbine design --- micro-scale turbomachinery design

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This Special Issue is a compilation of the recent advances in thermal fluid engineering related to supercritical CO2 power cycle development. The supercritical CO2 power cycle is considered to be one of the most promising power cycles for distributed power generation, waste heat recovery, and a topping cycle of coal, nuclear, and solar thermal heat sources. While the cycle benefits from dramatic changes in CO2 thermodynamic properties near the critical point, design, and analysis of the power cycle and its major components also face certain challenges due to the strong real gas effect and extreme operating conditions. This Special Issue will present a series of recent research results in heat transfer and fluid flow analyses and experimentation so that the accumulated knowledge can accelerate the development of this exciting future power cycle technology.

emergency diesel generator --- supercritical carbon dioxide cycle --- waste heat recovery system --- bottoming cycle --- re-compression Brayton cycle --- carbon dioxide --- supercritical --- thermodynamic --- exergy --- cycle simulation --- design point analysis --- radial-inflow turbine --- supercritical carbon dioxide --- air --- rotor solidity --- aerodynamic performance --- centrifugal compressor --- aerodynamic optimization design --- numerical simulation --- radial turbine --- utility-scale --- turbomachinery design --- NET Power --- supercritical CO2 --- heat exchanger --- flow analysis --- thermal stress analysis --- LCoE --- CSP --- concentrated-solar power --- axial turbine design --- micro-scale turbomachinery design --- n/a

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Biopolymers including natural (e.g., polysaccharides, proteins, gums, natural rubbers, bacterial polymers), synthetic (e.g., aliphatic polyesters and polyphosphoester), and biocomposites are of paramount interest in regenerative medicine, due to their availability, processability, and low toxicity. Moreover, the structuration of biopolymer-based materials at the nano- and microscale along with their chemical properties are crucial in the engineering of advanced carriers for drug products. Finally, combination products including or based on biopolymers for controlled drug release offer a powerful solution to improve the tissue integration and biological response of these materials. Understanding the drug delivery mechanisms, efficiency, and toxicity of such systems may be useful for regenerative medicine and pharmaceutical technology. The main aim of the Special Issue on “Biopolymers in Drug Delivery and Regenerative Medicine” is to gather recent findings and current advances on biopolymer research for biomedical applications, particularly in regenerative medicine, wound healing, and drug delivery. Contributions to this issue can be as original research or review articles and may cover all aspects of biopolymer research, ranging from the chemical synthesis and characterization of modified biopolymers, their processing in different morphologies and hierarchical structures, as well as their assessment for biomedical uses.

curcumin --- pectin aerogels --- chitosan coating --- burst release --- controlled release --- Keratose --- drug-coated balloon --- paclitaxel --- drug delivery --- pre-clinical --- peripheral arterial disease --- endovascular --- cellulose phosphate --- cellulose phosphate aerogel --- interconnected porosity --- supercritical carbon dioxide --- tetrabutylammonium fluoride --- TBAF/DMSO --- polysaccharide --- κ-carrageenan --- dexamethasone --- electrochemical active deliver system --- doping agent --- charged molecule --- conductive polymers --- colorectal cancer --- antioxidants --- 5-fluorouracil --- polymer nanomaterials --- nanocapsules --- chemotherapy --- cryogel --- starch --- NMR spectroscopy --- morphology --- drug release --- polysaccharides --- hydrogels --- prilling --- droplets --- ionotropic gelation --- drying --- xerogels --- cryogels --- aerogels --- lipid microparticles --- PGSS® --- supercritical CO2 --- modeling --- solvent-free technology --- biomaterials --- porous materials --- biomimetic --- multi-stimulation --- tissue engineering --- n/a

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The extraction and exploration of cellulose-based polymers is an exciting area of research. For many years, wood (especially from bleached kraft wood pulp) was considered the main source of cellulosic compounds because of its abundance in nature. However, in the past decade, researchers have been devoted to finding alternatives to extract cellulose from byproducts of agricultural crops and/or textile wastes, which are both highly available at a very reduced raw material cost. This book brings together original research that details the recent progresses and new developments in this field, and how this research is contributing to a circular economy.

Research & information: general --- Physics --- citrus sinensis --- nano-fibrillated cellulose --- silver nanoparticles --- acid hydrolysis --- heavy metal sorption --- anaerobic digestion --- biofuel --- biomass --- cotton-based waste --- closed-loop --- lignocellulose --- textile waste --- cellulose nanofibre --- green materials --- biopolymers --- environmental --- recycled newspaper --- composite laminates --- water resistance --- high strength --- cotton wastes --- textile --- nanomaterials --- cellulose nanocrystal --- extraction methods --- environmental application --- regenerated cellulose fiber --- Au NP --- controllably assembled --- SERS --- dimetridazole --- cellulose hydrogel --- thermo-responsive --- sustained release --- silver sulfadiazine --- burn wound --- polymer --- carpet fiber --- direct analysis in real time --- time of flight --- mass spectrometry --- function switching --- oleamide --- cellulose nanofibers isolation --- carpet wastes --- supercritical carbon dioxide --- enhanced properties --- recovery of cellulose --- textile fibers --- eco-efficiency --- circular economy --- textile industry --- citrus sinensis --- nano-fibrillated cellulose --- silver nanoparticles --- acid hydrolysis --- heavy metal sorption --- anaerobic digestion --- biofuel --- biomass --- cotton-based waste --- closed-loop --- lignocellulose --- textile waste --- cellulose nanofibre --- green materials --- biopolymers --- environmental --- recycled newspaper --- composite laminates --- water resistance --- high strength --- cotton wastes --- textile --- nanomaterials --- cellulose nanocrystal --- extraction methods --- environmental application --- regenerated cellulose fiber --- Au NP --- controllably assembled --- SERS --- dimetridazole --- cellulose hydrogel --- thermo-responsive --- sustained release --- silver sulfadiazine --- burn wound --- polymer --- carpet fiber --- direct analysis in real time --- time of flight --- mass spectrometry --- function switching --- oleamide --- cellulose nanofibers isolation --- carpet wastes --- supercritical carbon dioxide --- enhanced properties --- recovery of cellulose --- textile fibers --- eco-efficiency --- circular economy --- textile industry