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Analytical chemistry --- Analyse instrumentale --- Instrumental analysis --- Instrumentele analyse --- Flow injection analysis --- Chemistry, Analytic --- Chemistry, Physical and theoretical --- Flow injection technique --- Flow method (Analytical chemistry) --- Rapid flow technique --- Stopped flow technique

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Flow Analysis (FA) offers a very convenient and fast approach to enhance and automate 'preliminary steps' of analysis (sample dissolution, pretreatments, preconcentrations, etc.) for atomic spectrometric detectors (ASD). Moreover, flow manifolds can ease the well-known problem of sample introduction/presentation to atomisers or even expand the classical scope of atomic/elemental information, characterizing atomic spectrometry, into the realm of molecules and metal-compounds analysis (e.g. by resorting to coupled separation techniques). All these facts could explain both the extraordinary inter

Spectrometric and optical chemical analysis --- fysicochemie --- Atomic spectroscopy. --- Flow injection analysis. --- Flow injection technique --- Flow method (Analytical chemistry) --- Rapid flow technique --- Stopped flow technique --- Instrumental analysis --- Spectroscopy, Atomic --- Spectrum analysis

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Chemical oceanography. --- Flow injection analysis. --- Marine sediments. --- Bottom deposits (Oceanography) --- Bottom sediments (Oceanography) --- Deep-sea deposits --- Deposits, Deep-sea --- Marine deposits --- Sediments, Marine --- Ocean bottom --- Sedimentation and deposition --- Submarine geology --- Sediments (Geology) --- Flow injection technique --- Flow method (Analytical chemistry) --- Rapid flow technique --- Stopped flow technique --- Instrumental analysis --- Marine chemistry --- Oceanography --- Water chemistry

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For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals. Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. This Special Issue aims to highlight the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting and delivery strategies aimed at improving their pharmacological profile.

?–? stacking --- encapsulation --- n/a --- oxindolimine–metal complexes --- cyclodextrin --- platinum iodido complexes --- distribution coefficient --- antiproliferative activity --- anticancer agents --- nanotubes --- ruthenium --- platinum --- Log kw --- nanoparticles --- drug discovery --- metal complex --- metallodrugs --- isatin-derived ligands --- anticancer drug --- upconverting nanoparticles --- pyridine benzimidazole --- dendrimers --- liposomes --- thiophene --- angiogenesis --- micelles --- HSA oxidation --- platinum(IV) --- imaging --- chromatographic lipophilicity parameter --- amidophosphine --- copper and iron chelators in cancer --- Log P --- biomacromolecules --- bones --- DNA cleavage --- stopped-flow spectroscopy --- silver --- phosphonates --- transmetalation --- metallomics --- MRI --- fluorescence quenching --- partition coefficient --- gold fingers --- anticancer --- HSA binding --- gold --- ?0 --- targeting --- metastasis --- DNA interaction --- antimigration --- cytotoxicity --- HPLC --- ruthenium complexes --- zinc finger proteins --- Gold(III) complexes --- aquaporins --- antiproliferative --- protein-DNA recognition --- photoactivation --- lipophilicity --- cancer --- 1-methylcytosine --- PET --- ?-? stacking --- oxindolimine-metal complexes

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This book covers the most recent research trends and applications of Pharmaceutical Analytical Chemistry. The included topics range from the adulteration of dietary supplements, to the determination of drugs in biological samples with the aim to investigate their pharmacokinetic properties.

Research & information: general --- growth hormone --- long-acting Fc-fusion recombinant human growth hormone --- method validation --- cell-based bioassay --- reporter gene assay --- pharmacokinetics --- tissue distribution --- alnustone --- rats --- LC-MS/MS --- inflammatory bowel disease --- fixed-dose combination --- biomimetic chromatography --- thiopurine immunosuppressants --- folic acid --- doxorubicin --- hernandezine --- pharmacokinetic study --- drug-drug interaction --- gardneramine --- monoterpenoid indole alkaloid --- memantine --- rimantadine --- amantadine --- zone fluidics --- o-phthalaldehyde --- derivatization --- stopped-flow --- quality control --- anwuligan --- rat --- optode --- polyhexamethylene biguanide hydrochloride --- lactone-rhodamine B --- contact-lens detergent --- dietary supplement --- adulteration --- low-field NMR --- multivariate analysis --- steroids --- Partial Least Squares regression --- in vitro permeability --- predictive model --- ketamine --- norketamine --- high throughput bar adsorptive microextraction --- LVI-GC-MS(SIM) --- urine --- baricitinib --- UPLC-MS/MS --- irbersartan