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Stacking machines --- Hoisting machinery --- Materials handling. --- Law and legislation --- United States.

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For the past 40 years, metal-based drugs have been widely used for the treatment of cancer. Cisplatin and follow-up drugs carboplatin (ParaplatinTM) and oxaliplatin (EloxatinTM) have been the gold standard for metallodrugs in clinical settings as antineoplastic agents. While effective, these drugs (either alone or in combination therapy) have faced a number of clinical challenges resulting from their limited spectrum of activity, high toxicity leading to significant side effects, resistance, poor water solubility, low bioavailability and short circulating time. In the past 10 years, various unconventional non-platinum metal-based agents have emerged as a potential alternative for cancer treatment. These compounds are highly effective and selective in cancers resistant to cisplatin and other chemotherapeutic agents. Research in this area has recently exploded with a relevant number of patents and clinical trials, in addition to reports in scientific journals. Furthermore, in parallel to the synthesis of coordination and organometallic compounds comprising many different metals and unconventional platinum-based derivatives, researchers are focused on optimizing mechanistic and pharmacological features of promising drug candidates. This Special Issue aims to highlight the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting and delivery strategies aimed at improving their pharmacological profile.

?–? stacking --- encapsulation --- n/a --- oxindolimine–metal complexes --- cyclodextrin --- platinum iodido complexes --- distribution coefficient --- antiproliferative activity --- anticancer agents --- nanotubes --- ruthenium --- platinum --- Log kw --- nanoparticles --- drug discovery --- metal complex --- metallodrugs --- isatin-derived ligands --- anticancer drug --- upconverting nanoparticles --- pyridine benzimidazole --- dendrimers --- liposomes --- thiophene --- angiogenesis --- micelles --- HSA oxidation --- platinum(IV) --- imaging --- chromatographic lipophilicity parameter --- amidophosphine --- copper and iron chelators in cancer --- Log P --- biomacromolecules --- bones --- DNA cleavage --- stopped-flow spectroscopy --- silver --- phosphonates --- transmetalation --- metallomics --- MRI --- fluorescence quenching --- partition coefficient --- gold fingers --- anticancer --- HSA binding --- gold --- ?0 --- targeting --- metastasis --- DNA interaction --- antimigration --- cytotoxicity --- HPLC --- ruthenium complexes --- zinc finger proteins --- Gold(III) complexes --- aquaporins --- antiproliferative --- protein-DNA recognition --- photoactivation --- lipophilicity --- cancer --- 1-methylcytosine --- PET --- ?-? stacking --- oxindolimine-metal complexes

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This book describes unconventional noncovalent interactions and analyzes their importance for crystal growth in organic and hybrid organic–inorganic systems. Several examples illustrate how the combination of theory and experiment allows rationalizing the strength and directionality of noncovalent interactions. This book elegantly describes the results of a survey of X-ray structures of main group element compounds (M = Sn, Pb As, Sb, Bi, and Te) exhibiting intermolecular M•••Se noncovalent interactions in one of its chapters. Moreover, it provides a consistent description of noncovalent interactions, covering most groups of the periodic table. The interactions are described and discussed using their trivial names. That is, a comprehensive and accurate description is provided for alkali, alkaline earth, regium, spodium, triel, tetrel, pnictogen, chalcogen, halogen, and aerogen bonding interactions. No other book is available covering such an extensive number of interactions and examples where these interactions are relevant. relevant.

Research & information: general --- Biology, life sciences --- non-covalent interactions --- regium bonds --- silver(I) --- coinage metals --- pyrazolates --- phosphines --- halogen bonding --- hydrogen bonding sigma-hole interactions --- theoretical studies --- characterizations --- noncovalent interactions --- Lewis acids --- Lewis bases --- spodium bonds --- σ/π-hole interactions --- EDTA --- 2,6-diaminopurine --- cadmium --- co-crystal --- H-bonding --- π–π stacking --- triazinane --- 1,3,5-Triazacyclohexane --- Hirshfeld surface analysis --- DFT study --- C–H···π interaction --- hybridization of a nitrogen atom in sulfonamides --- molecular cocrystal --- sandwiched-layer structure --- C–I···F halogen bonds --- π···π stacking interactions --- PBE0-D3(BJ) calculations --- secondary bonding --- supramolecular --- crystal engineering --- tetrel bonding --- pnictogen bonding --- chalcogen bonding --- selenium --- structural chemistry --- main group elements --- π–hole interaction --- substituent effects --- vibrational spectroscopy --- local vibrational mode theory --- direct measure for π–hole interaction strength --- noncovalent interaction --- hydrogen bonding --- nickel --- Schiff bases --- crystallography --- σ-hole --- π-hole --- crystal growth --- supramolecular chemistry --- σ-hole interactions --- self-assembly --- scanning tunneling microscopy

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Due to their lightweight and high specific strength, Mg-based alloys are considered as substitutes to their heavier counterparts in applications in which corrosion is non-relevant and weight saving is of importance. Furthermore, due to the biocompatibility of Mg, some alloys with controlled corrosion rates are used as degradable implant materials in the medical sector. The typical processing route of Mg parts incorporates a casting step and, subsequently, a thermo–mechanical treatment. In order to achieve the desired macroscopic properties and thus fulfill the service requirements, thorough knowledge of the relationship between the microstructure, the processing steps, and the resulting property profile is necessary. This Special Issue covers in situ and ex situ experimental and computational investigations of the behavior under thermo–mechanical load of Mg-based alloys utilizing modern characterization and simulation techniques. The papers cover investigations on the effect of rare earth additions on the mechanical properties of different Mg alloys, including the effect of long-period stacking-ordered (LPSO) structures, and the experimental and computational investigation of the effect of different processing routes.

Technology: general issues --- magnesium alloys --- long period stacking ordered structures (LPSO) --- synchrotron radiation diffraction --- magnesium alloy --- low-speed extrusion --- microstructure evolution --- mechanical properties --- thermomechanical processing --- calcium addition --- disintegrated melt deposition --- processing map --- formability --- initial texture --- deformation mechanism --- texture evolution --- ductile damage --- GTN model --- magnesium --- in-situ --- deformation mechanisms --- deformation behaviour --- restoration mechanisms --- electron microscopy --- characterisation --- in-situ diffraction --- Mg-LPSO alloys --- neutron diffraction --- EBSD --- dislocation slip --- twinning --- magnesium alloys --- long period stacking ordered structures (LPSO) --- synchrotron radiation diffraction --- magnesium alloy --- low-speed extrusion --- microstructure evolution --- mechanical properties --- thermomechanical processing --- calcium addition --- disintegrated melt deposition --- processing map --- formability --- initial texture --- deformation mechanism --- texture evolution --- ductile damage --- GTN model --- magnesium --- in-situ --- deformation mechanisms --- deformation behaviour --- restoration mechanisms --- electron microscopy --- characterisation --- in-situ diffraction --- Mg-LPSO alloys --- neutron diffraction --- EBSD --- dislocation slip --- twinning

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Due to their lightweight and high specific strength, Mg-based alloys are considered as substitutes to their heavier counterparts in applications in which corrosion is non-relevant and weight saving is of importance. Furthermore, due to the biocompatibility of Mg, some alloys with controlled corrosion rates are used as degradable implant materials in the medical sector. The typical processing route of Mg parts incorporates a casting step and, subsequently, a thermo–mechanical treatment. In order to achieve the desired macroscopic properties and thus fulfill the service requirements, thorough knowledge of the relationship between the microstructure, the processing steps, and the resulting property profile is necessary. This Special Issue covers in situ and ex situ experimental and computational investigations of the behavior under thermo–mechanical load of Mg-based alloys utilizing modern characterization and simulation techniques. The papers cover investigations on the effect of rare earth additions on the mechanical properties of different Mg alloys, including the effect of long-period stacking-ordered (LPSO) structures, and the experimental and computational investigation of the effect of different processing routes.

Technology: general issues --- magnesium alloys --- long period stacking ordered structures (LPSO) --- synchrotron radiation diffraction --- magnesium alloy --- low-speed extrusion --- microstructure evolution --- mechanical properties --- thermomechanical processing --- calcium addition --- disintegrated melt deposition --- processing map --- formability --- initial texture --- deformation mechanism --- texture evolution --- ductile damage --- GTN model --- magnesium --- in-situ --- deformation mechanisms --- deformation behaviour --- restoration mechanisms --- electron microscopy --- characterisation --- in-situ diffraction --- Mg-LPSO alloys --- neutron diffraction --- EBSD --- dislocation slip --- twinning --- n/a