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London (Watford) Spring-Water Company : report to the directors
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Year: 1850 Publisher: London J. Weale

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Digital
Review of the report by the General Board of Health on the supply of water to the metropolis : contained in a report to the directors of the London (Watford) Spring Water Company

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Clay-Based Pharmaceutical Formulations and Drug Delivery Systems
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Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design.

Keywords

Medicine --- hydrochlorothiazide --- cyclodextrins --- sepiolite --- nanoclay --- dissolution rate --- tablet --- electrospinning --- chitosan --- chondroitin sulfate --- scaffolds --- montmorillonite --- halloysite --- fibroblasts proliferation --- immune response --- glycosaminoglycans --- antimicrobial properties --- palygorskite --- spring water --- hydrogel --- fibroblast --- biocompatibility --- wound healing --- mesoporous clay --- Neusilin --- aeroperl --- liquisolid technique --- glyburide --- dissolution improvement --- hydrotalcite --- ketoprofen --- hybrid --- photostability --- hydrogel film --- bioadhesion --- heavy metal --- hazardous element --- element mobility --- clay minerals --- toxicity --- palygorksite --- proliferation --- Franz cell --- bioactive elements --- praziquantel --- drug --- organic solvents --- in vitro dissolution tests --- cytotoxicity --- targeted drug delivery --- halloysite nanotube --- osteosarcoma --- methotrexate --- surface modification --- hydrochlorothiazide --- cyclodextrins --- sepiolite --- nanoclay --- dissolution rate --- tablet --- electrospinning --- chitosan --- chondroitin sulfate --- scaffolds --- montmorillonite --- halloysite --- fibroblasts proliferation --- immune response --- glycosaminoglycans --- antimicrobial properties --- palygorskite --- spring water --- hydrogel --- fibroblast --- biocompatibility --- wound healing --- mesoporous clay --- Neusilin --- aeroperl --- liquisolid technique --- glyburide --- dissolution improvement --- hydrotalcite --- ketoprofen --- hybrid --- photostability --- hydrogel film --- bioadhesion --- heavy metal --- hazardous element --- element mobility --- clay minerals --- toxicity --- palygorksite --- proliferation --- Franz cell --- bioactive elements --- praziquantel --- drug --- organic solvents --- in vitro dissolution tests --- cytotoxicity --- targeted drug delivery --- halloysite nanotube --- osteosarcoma --- methotrexate --- surface modification


Book
Clay-Based Pharmaceutical Formulations and Drug Delivery Systems
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design.


Book
Clay-Based Pharmaceutical Formulations and Drug Delivery Systems
Author:
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

This book includes recent advances in the use of clays in the design of medicinal products and medicinal devices. The pharmaceutical applications of nanoclays are far ranging, because of their distinct advantages: they are versatile (possess a wide range of mechanical, chemical and physical properties) and available at reasonable costs. Some special clays (mainly kaolinite, halloysite, montmorillonite, saponite, hectorite, palygorskite and sepiolite), as well as semi-synthetic (organoclays) or synthetic (double layer hydroxides) derivatives, are very useful materials for modulating drug delivery. In the last decade, several actives have been loaded onto nanoclays and similar inorganic excipients to increase solubility, improve stability, reduce toxicity, and enhance bioavailability, with a consequent increase in therapeutic response. Polymer/clay nanocomposites with synergic properties have been developed, showing improved mechanical properties with respect to the pristine polymer matrices and allowing modified release of loaded actives. Moreover, nanoclays have very recently demonstrated positive effects on the proliferation and migration of fibroblasts. The development of clay-based medicinal products and medicinal devices requires experience in the fields of both clay structure and properties and pharmaceutical technology design.


Book
Monitoring Land Subsidence Using Remote Sensing
Authors: --- ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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In this book are reported nine works related to land subsidence monitoring using remote sensing techniques. Land subsidence is a common phenomenon in many regions of the world, where it causes degradation of local ecosystems and disruption of economic activities. Its effects are more evident in densely populated areas in particular in low-lying territories such as river deltas and coastal areas where the combination of land subsidence and sea level rise increases the flooding risk. For this reason, the monitoring of ground deformations is a crucial step to obtain important information for the development of risk mitigation strategies. In the presented papers, the characteristics of land subsidence occurring in different study areas are described, and recent developments in the used methodologies for the monitoring of the ground displacements are discussed and validated also by means of ground-based data. Moreover, advantages and disadvantages of the adopted techniques are highlighted. The outcomes of these research works can provide national and local authorities with useful information for the implementation of integrated monitoring systems in the areas most affected by land subsidence.


Book
Monitoring Land Subsidence Using Remote Sensing
Authors: --- ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

In this book are reported nine works related to land subsidence monitoring using remote sensing techniques. Land subsidence is a common phenomenon in many regions of the world, where it causes degradation of local ecosystems and disruption of economic activities. Its effects are more evident in densely populated areas in particular in low-lying territories such as river deltas and coastal areas where the combination of land subsidence and sea level rise increases the flooding risk. For this reason, the monitoring of ground deformations is a crucial step to obtain important information for the development of risk mitigation strategies. In the presented papers, the characteristics of land subsidence occurring in different study areas are described, and recent developments in the used methodologies for the monitoring of the ground displacements are discussed and validated also by means of ground-based data. Moreover, advantages and disadvantages of the adopted techniques are highlighted. The outcomes of these research works can provide national and local authorities with useful information for the implementation of integrated monitoring systems in the areas most affected by land subsidence.


Book
Monitoring Land Subsidence Using Remote Sensing
Authors: --- ---
Year: 2021 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

In this book are reported nine works related to land subsidence monitoring using remote sensing techniques. Land subsidence is a common phenomenon in many regions of the world, where it causes degradation of local ecosystems and disruption of economic activities. Its effects are more evident in densely populated areas in particular in low-lying territories such as river deltas and coastal areas where the combination of land subsidence and sea level rise increases the flooding risk. For this reason, the monitoring of ground deformations is a crucial step to obtain important information for the development of risk mitigation strategies. In the presented papers, the characteristics of land subsidence occurring in different study areas are described, and recent developments in the used methodologies for the monitoring of the ground displacements are discussed and validated also by means of ground-based data. Moreover, advantages and disadvantages of the adopted techniques are highlighted. The outcomes of these research works can provide national and local authorities with useful information for the implementation of integrated monitoring systems in the areas most affected by land subsidence.

Keywords

Research & information: general --- land subsidence --- IPTA --- land-use --- water resource utilization --- groundwater change --- deformation --- geology --- Gävle --- InSAR --- PSI --- precise levelling --- sentinel-1 --- subsidence --- Sweden --- ALOS/PALSAR --- time series analysis --- SBAS --- hot spring water --- hydrothermal fluids --- Hakone Volcano --- satellite geodesy --- radar interferometry --- persistent scatterers --- distributed scatterers --- orbit combination --- Sentinel-1 --- cavern field --- salt deposit --- geophysical modeling --- underground gas storage --- GNSS --- ground movement --- subsidence monitoring --- integrated numerical simulation --- Dubrovnik --- satellite altimetry --- tide gauges --- vertical land motion --- DInSAR --- mining-induced tremors --- land surface deformation --- Upper Silesian Coal Basin --- Interferometry --- SNAP-StaMPS --- Ground deformation --- Po River Delta --- integrated monitoring --- time-series analysis --- land subsidence --- IPTA --- land-use --- water resource utilization --- groundwater change --- deformation --- geology --- Gävle --- InSAR --- PSI --- precise levelling --- sentinel-1 --- subsidence --- Sweden --- ALOS/PALSAR --- time series analysis --- SBAS --- hot spring water --- hydrothermal fluids --- Hakone Volcano --- satellite geodesy --- radar interferometry --- persistent scatterers --- distributed scatterers --- orbit combination --- Sentinel-1 --- cavern field --- salt deposit --- geophysical modeling --- underground gas storage --- GNSS --- ground movement --- subsidence monitoring --- integrated numerical simulation --- Dubrovnik --- satellite altimetry --- tide gauges --- vertical land motion --- DInSAR --- mining-induced tremors --- land surface deformation --- Upper Silesian Coal Basin --- Interferometry --- SNAP-StaMPS --- Ground deformation --- Po River Delta --- integrated monitoring --- time-series analysis

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