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Defoe, Daniel, -- 1661?-1731 -- Brief state of the question between the printed and painted callicoes, and the woollen and silk manufacture --- Wool industry -- Great Britain -- Early works to 1800 --- Silk industry -- Great Britain -- Early works to 1800 --- Textile industry -- Great Britain -- Early works to 1800 --- Steele, Richard, -- Sir, -- 1672-1729 -- Spinster, in defence of the woollen manufactures

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Although sphingolipids are ubiquitous components of cellular membranes, their abundance in cells is generally lower than glycerolipids or cholesterol, representing less than 20% of total lipid mass. Following their discovery in the brain—which contains the largest amounts of sphingolipids in the body—and first description in 1884 by J.L.W. Thudichum, sphingolipids have been overlooked for almost a century, perhaps due to their complexity and enigmatic nature. When sphingolipidoses were discovered, a series of inherited diseases caused by enzyme mutations involved in sphingolipid degradation returned to the limelight. The essential breakthrough came decades later, in the 1990s, with the discovery that sphingolipids were not just structural elements of cellular membranes but intra- and extracellular signaling molecules. It turned out that their lipid backbones, including ceramide and sphingosine-1-phosphate, had selective physiological functions. Thus, sphingolipids emerged as essential players in several pathologies including cancer, diabetes, neurodegenerative disorders, and autoimmune diseases. The present volume reflects upon the unexpectedly eclectic functions of sphingolipids in health, disease, and therapy. This fascinating lipid class will continue to be the subject of up-and-coming future discoveries, especially with regard to new therapeutic strategies.

Research & information: general --- Biology, life sciences --- S1P receptor --- inflammation --- S1P transporter --- spinster homolog 2 --- barrier dysfunction --- anxiety --- depression --- sphingolipids --- sphingomyelinase --- ceramidase --- Smpd1 --- acid sphingomyelinase --- forebrain --- depressive-like behavior --- anxiety-like behavior --- ceramide --- ceramides --- ceramidases --- neurodegenerative diseases --- infectious diseases --- sphingosine 1-phoshate --- sphingosine 1-phosphate receptor --- S1P1-5 --- sphingosine 1-phosphate metabolism --- sphingosine 1-phosphate antagonistst/inhibitors --- sphingosine 1-phosphate signaling --- stroke --- multiple sclerosis --- neurodegeneration --- fingolimod --- Sphingosine-1-phosphate --- obesity --- type 2 diabetes --- insulin resistance --- pancreatic β cell fate --- hypothalamus --- sphingosine-1-phosphate --- ischemia/reperfusion --- cardioprotection --- vasoconstriction --- coronary flow --- myocardial function --- myocardial infarct --- albumin --- type 1 diabetes --- beta-cells --- islets --- insulin --- cytokines --- S1P --- animal models --- cystic fibrosis --- autophagy --- myriocin --- Aspergillus fumigatus --- CLN3 disease --- Cln3Δex7/8 mice --- flupirtine --- allyl carbamate derivative --- apoptosis --- cancer --- gangliosides --- immunotherapy --- metastasis --- phenotype switching --- sphingosine 1-phosphate --- Sphingosine 1-phosphate (S1P) --- S1P-lyase (SGPL1) --- tau --- calcium --- histone acetylation --- hippocampus --- cortex --- astrocytes --- neurons --- sphingosine kinase --- G-protein-coupled receptors --- Gαq/11 --- sphingosine kinase 1 --- SK1 --- microRNA --- transcription factor --- hypoxia --- long non-coding RNA --- S1P receptor --- inflammation --- S1P transporter --- spinster homolog 2 --- barrier dysfunction --- anxiety --- depression --- sphingolipids --- sphingomyelinase --- ceramidase --- Smpd1 --- acid sphingomyelinase --- forebrain --- depressive-like behavior --- anxiety-like behavior --- ceramide --- ceramides --- ceramidases --- neurodegenerative diseases --- infectious diseases --- sphingosine 1-phoshate --- sphingosine 1-phosphate receptor --- S1P1-5 --- sphingosine 1-phosphate metabolism --- sphingosine 1-phosphate antagonistst/inhibitors --- sphingosine 1-phosphate signaling --- stroke --- multiple sclerosis --- neurodegeneration --- fingolimod --- Sphingosine-1-phosphate --- obesity --- type 2 diabetes --- insulin resistance --- pancreatic β cell fate --- hypothalamus --- sphingosine-1-phosphate --- ischemia/reperfusion --- cardioprotection --- vasoconstriction --- coronary flow --- myocardial function --- myocardial infarct --- albumin --- type 1 diabetes --- beta-cells --- islets --- insulin --- cytokines --- S1P --- animal models --- cystic fibrosis --- autophagy --- myriocin --- Aspergillus fumigatus --- CLN3 disease --- Cln3Δex7/8 mice --- flupirtine --- allyl carbamate derivative --- apoptosis --- cancer --- gangliosides --- immunotherapy --- metastasis --- phenotype switching --- sphingosine 1-phosphate --- Sphingosine 1-phosphate (S1P) --- S1P-lyase (SGPL1) --- tau --- calcium --- histone acetylation --- hippocampus --- cortex --- astrocytes --- neurons --- sphingosine kinase --- G-protein-coupled receptors --- Gαq/11 --- sphingosine kinase 1 --- SK1 --- microRNA --- transcription factor --- hypoxia --- long non-coding RNA

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The memoirs of Hortense (1646-1699) and of Marie (1639-1715) Mancini, nieces of the powerful Cardinal Mazarin and members of the court of Louis XIV, represent the earliest examples in France of memoirs published by women under their own names during their lifetimes. Both unhappily married-Marie had also fled the aftermath of her failed affair with the king-the sisters chose to leave their husbands for life on the road, a life quite rare for women of their day. Through their writings, the Mancinis sought to rehabilitate their reputations and reclaim the right to define their public images themselves, rather than leave the stories of their lives to the intrigues of the court-and to their disgruntled ex-husbands. First translated in 1676 and 1678 and credited largely to male redactors, the two memoirs reemerge here in an accessible English translation that chronicles the beginnings of women's rights to personal independence within the confines of an otherwise circumscribed early modern aristocratic society.

BIOGRAPHY & AUTOBIOGRAPHY / General. --- Mazarin, Hortense Mancini, --- Mancini, Maria, --- Mancini, Anna Maria --- M. L. D. M. --- M., M. L. D. --- Mancini, Hortense, --- Mazarin, Hortense Mancini de La Porte, --- Mazarin, --- Mazarine, --- Mazarine, Hortense Mancini, --- Mazzarino, Ortensia Mancini, --- France --- Bro-C'hall --- Fa-kuo --- Fa-lan-hsi --- Faguo --- Falanxi --- Falanxi Gongheguo --- Faransā --- Farānsah --- França --- Francia (Republic) --- Francija --- Francja --- Francland --- Francuska --- Franis --- Franḳraykh --- Frankreich --- Frankrig --- Frankrijk --- Frankrike --- Frankryk --- Fransa --- Fransa Respublikası --- Franse --- Franse Republiek --- Frant︠s︡ --- Frant︠s︡ Uls --- Frant︠s︡ii︠a︡ --- Frantsuzskai︠a︡ Rėspublika --- Frantsyi︠a︡ --- Franza --- French Republic --- Frencisc Cynewīse --- Frenska republika --- Furansu --- Furansu Kyōwakoku --- Gallia --- Gallia (Republic) --- Gallikē Dēmokratia --- Hyãsia --- Parancis --- Peurancih --- Phransiya --- Pransiya --- Pransya --- Prantsusmaa --- Pʻŭrangsŭ --- Ranska --- República Francesa --- Republica Franzesa --- Republika Francuska --- Republiḳah ha-Tsarfatit --- Republikang Pranses --- République française --- Tsarfat --- Tsorfat --- Γαλλική Δημοκρατία --- Γαλλία --- Франц --- Франц Улс --- Французская Рэспубліка --- Францыя --- Франция --- Френска република --- פראנקרייך --- צרפת --- רפובליקה הצרפתית --- فرانسه --- فرنسا --- フランス --- フランス共和国 --- 法国 --- 法蘭西 --- 法蘭西共和國 --- 프랑스 --- France (Provisional government, 1944-1946) --- History --- Court and courtiers --- hortense, marie, mancini, cardinal, mazarin, louis xiv, france, french, history, historical, biography, autobiography, journal, diary, spinster, affair, husband, divorce, feminism, traveling, reputation, public, image, identity, intrigue, 1600s, translation, academic, scholarly, research, literature, literary, college, university, textbook, womens rights, woman, feminist, liberty, independence, aristocratic, early modern.