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BIOGENIC POLYAMINES --- INTESTINES --- RATS --- BOMBESIN --- SPERMIDINE --- GROWTH AND DEVELOPMENT --- BIOGENIC POLYAMINES --- INTESTINES --- RATS --- BOMBESIN --- SPERMIDINE --- GROWTH AND DEVELOPMENT
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Polyamines are small aliphatic polycations which have been involved in key stress and developmental processes in plants. In the recent years, compelling genetic and molecular evidences point to polyamines as essential metabolites required for resistance to drought, freezing, salinity, oxidative stress among other type of abiotic and biotic stresses. In addition to their role as stress-protective compounds, polyamines participate in key developmental processes mediated by specific signaling pathways or in cross-regulation with other plant hormones. Our Research Topic aims to integrate the multiple stress and developmental regulatory functions of polyamines in plants under a genetic, molecular and evolutionary perspective with special focus on signaling networks, mechanisms of action and metabolism regulation.
Polyamines. --- Plant polymers. --- stress --- Spermine --- Thermospermine --- Spermidine --- ROS --- Transglutaminase --- Putrescine --- Polyamines --- Biopolymers --- Phytochemicals --- Aliphatic compounds --- Amines --- Imines
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Polyamines are small organic compounds found in all living organisms. In recent years, there have been many exciting advances in our understanding of plant polyamines, such as the determination of the biosynthetic and catabolic pathways of plant polyamines and the identification of the roles that plant polyamines play in cellular processes. This Special Issue contains six original research papers and three review articles, providing valuable insights and information for future polyamine-related research.
polyamine oxidase --- norspermidine --- thermospermine --- Selaginella lepidophylla --- Arabidopsis thaliana mutant --- polyamines --- spermidine --- nonsense-mediated decay --- no-go decay --- non-stop decay --- quality control --- translation --- copper amine oxidases --- H2O2 --- ROS --- ABA --- stomatal closure --- back conversion pathway --- polyamine catabolism --- stress response --- terminal catabolism pathway --- Ranunculus biternatus --- Ranunculus pseudotrullifolius --- Ranunculus moseleyi --- secondary metabolite variation --- amines --- quercetins --- natural populations --- environment --- redundancy --- sub-Antarctic plants --- Arabidopsis --- phloem --- rice --- spermine --- xylem --- nitrogen metabolism --- abiotic and biotic stress --- hydrogen peroxide --- antioxidant machinery --- heat shock proteins --- heat stress --- polyamine oxidases --- PA acetylation --- PA oxidation --- PA back-conversion --- putrescine --- tomato --- spermidine synthase --- fruit shape --- cell division --- cell expansion --- copper amine oxidase
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Polyamines are small organic compounds found in all living organisms. In recent years, there have been many exciting advances in our understanding of plant polyamines, such as the determination of the biosynthetic and catabolic pathways of plant polyamines and the identification of the roles that plant polyamines play in cellular processes. This Special Issue contains six original research papers and three review articles, providing valuable insights and information for future polyamine-related research.
Research & information: general --- Biology, life sciences --- polyamine oxidase --- norspermidine --- thermospermine --- Selaginella lepidophylla --- Arabidopsis thaliana mutant --- polyamines --- spermidine --- nonsense-mediated decay --- no-go decay --- non-stop decay --- quality control --- translation --- copper amine oxidases --- H2O2 --- ROS --- ABA --- stomatal closure --- back conversion pathway --- polyamine catabolism --- stress response --- terminal catabolism pathway --- Ranunculus biternatus --- Ranunculus pseudotrullifolius --- Ranunculus moseleyi --- secondary metabolite variation --- amines --- quercetins --- natural populations --- environment --- redundancy --- sub-Antarctic plants --- Arabidopsis --- phloem --- rice --- spermine --- xylem --- nitrogen metabolism --- abiotic and biotic stress --- hydrogen peroxide --- antioxidant machinery --- heat shock proteins --- heat stress --- polyamine oxidases --- PA acetylation --- PA oxidation --- PA back-conversion --- putrescine --- tomato --- spermidine synthase --- fruit shape --- cell division --- cell expansion --- copper amine oxidase --- polyamine oxidase --- norspermidine --- thermospermine --- Selaginella lepidophylla --- Arabidopsis thaliana mutant --- polyamines --- spermidine --- nonsense-mediated decay --- no-go decay --- non-stop decay --- quality control --- translation --- copper amine oxidases --- H2O2 --- ROS --- ABA --- stomatal closure --- back conversion pathway --- polyamine catabolism --- stress response --- terminal catabolism pathway --- Ranunculus biternatus --- Ranunculus pseudotrullifolius --- Ranunculus moseleyi --- secondary metabolite variation --- amines --- quercetins --- natural populations --- environment --- redundancy --- sub-Antarctic plants --- Arabidopsis --- phloem --- rice --- spermine --- xylem --- nitrogen metabolism --- abiotic and biotic stress --- hydrogen peroxide --- antioxidant machinery --- heat shock proteins --- heat stress --- polyamine oxidases --- PA acetylation --- PA oxidation --- PA back-conversion --- putrescine --- tomato --- spermidine synthase --- fruit shape --- cell division --- cell expansion --- copper amine oxidase
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Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis. Dysregulation of these multifaceted polyamine functions contribute to multiple disease processes, thus their metabolism and function have been targeted for preventive or therapeutic intervention. The correlation between elevated polyamine levels and cancer is well established, and ornithine decarboxylase, the rate-limiting biosynthetic enzyme in the production of putrescine, is a bona fide transcriptional target of the Myc oncogene. Furthermore, induced polyamine catabolism contributes to carcinogenesis that is associated with certain forms of chronic infection and/or inflammation through the production of reactive oxygen species. These and other characteristics specific to cancer cells have led to the development of polyamine-based agents and inhibitors aimed at exploiting the polyamine metabolic pathway for chemotherapeutic and chemopreventive benefit. In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases including Alzheimer’s and Parkinson’s, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines are known to decrease with age. As in cancer, polyamine-based therapies for these conditions are an area of active investigation. With recent advances in immunotherapy, interest has increased regarding polyamine-associated modulation of immune responses, as well as potential immunoregulation of polyamine metabolism, the results of which could have relevance to multiple disease processes. The goal of this Special Issue of Medical Sciences is to present the most recent advances in polyamine research as it relates to health, disease, and/or therapy.
protein synthesis in cancer --- neuroblastoma --- epigenetics --- Drosophila imaginal discs --- pneumococcal pneumonia --- transgenic mice --- spermidine/spermine N1-acetyl transferase --- ?-difluoromethylornithine --- MYC --- skeletal muscle --- protein expression --- curcumin --- colorectal cancer --- autophagy --- human embryonic kidney 293 (HEK293) --- melanoma --- tumor immunity --- Snyder-Robinson Syndrome --- Streptococcus pneumoniae --- B-lymphocytes --- autoimmunity --- spermine oxidase --- cell differentiation --- diferuloylmethane --- immunity --- antizyme --- transgenic mouse --- polyamine --- hirsutism --- chemoprevention --- CRISPR --- transglutaminase --- polyamine analogs --- NF-?B --- spermine synthase --- atrophy --- aging --- oxidative stress --- mast cells --- African sleeping sickness --- pancreatic ductal adenocarcinoma --- eflornithine --- carcinogenesis --- ornithine decarboxylase --- polyamine transport inhibitor --- putrescine --- neutrophils --- spermidine --- untranslated region --- spermine --- polyphenol --- M2 macrophages --- polyamine transport system --- metabolism --- difluoromethylorthinine --- DFMO --- antizyme inhibitors --- capsule --- polyamine transport --- eosinophils --- MCF-7 cells --- difluoromethylornithine --- polyamine metabolism --- mutant BRAF --- polyamines --- cadaverine --- proteomics --- airway smooth muscle cells --- breast cancer --- X-linked intellectual disability --- complementation --- T-lymphocytes --- bis(ethyl)polyamine analogs --- antizyme 1 --- cancer --- osteosarcoma
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The current demand for healthy and sustainable foods has encouraged the development of new alternatives, even in traditional products. Improved foods may be produced by reducing the amount of some ingredients, adding new ones, or replacing traditionally used ingredients for others. By reformulating their products, manufacturers can offer healthier choices for an ever-growing number of consumers interested in maintaining a balanced diet. In addition, market demand for more sustainable foods contributes to a lower environmental impact in their production. In this regard, current areas of interest include the production of foods using a lower amount of inputs, as well as the utilization of food by-products to improve the amount and quality of available foods. Another aspect to be considered is that not all consumers are willing to eat foods produced with new ingredients or novel technologies. Hence, the development of innovations in food products should take into account the influence of the so-called consumer food neophobia. For this reason, papers dealing with the consumer acceptance of these food innovations are also welcome. Thus, the aim of this Special Issue of Foods is to provide documents focused on the production of healthier and more sustainable foods by using novel ingredients, food by-products, or new production processes.
Business strategy --- melon-seed oil --- fruit waste --- tocopherols --- tocotrienols --- unsaturated fatty acids --- screw press --- tree nuts --- chemical composition --- proteins --- carbohydrates --- minerals --- phytochemicals --- polyphenols --- antioxidants --- volatile compounds --- saffron --- crocetin --- obesity --- agri-food marketing --- consumer behaviour --- economic and social crisis --- health --- innovation --- GM foods --- food labelling --- soybean oil --- willingness to pay --- choice experiment --- LC-mass spectrometry --- antioxidant capacity --- vacuum impregnation --- polyphenolic profile --- lulo fruit juice --- spermidine --- food innovation --- chia --- flax --- proximate composition --- sesame --- poppy --- product innovation --- process innovation --- neophobia --- food technology neophobia --- wine neophobia scale --- ham --- slices --- Crocus sativus L. --- pH --- color --- sensorial quality --- safranal --- pulsed electric fields --- pecan nut oil --- oil extraction yield --- microstructural analysis --- oil stability --- enzyme activity --- novel foods --- functional food --- food by-product --- sustainability --- food neophobia --- melon-seed oil --- fruit waste --- tocopherols --- tocotrienols --- unsaturated fatty acids --- screw press --- tree nuts --- chemical composition --- proteins --- carbohydrates --- minerals --- phytochemicals --- polyphenols --- antioxidants --- volatile compounds --- saffron --- crocetin --- obesity --- agri-food marketing --- consumer behaviour --- economic and social crisis --- health --- innovation --- GM foods --- food labelling --- soybean oil --- willingness to pay --- choice experiment --- LC-mass spectrometry --- antioxidant capacity --- vacuum impregnation --- polyphenolic profile --- lulo fruit juice --- spermidine --- food innovation --- chia --- flax --- proximate composition --- sesame --- poppy --- product innovation --- process innovation --- neophobia --- food technology neophobia --- wine neophobia scale --- ham --- slices --- Crocus sativus L. --- pH --- color --- sensorial quality --- safranal --- pulsed electric fields --- pecan nut oil --- oil extraction yield --- microstructural analysis --- oil stability --- enzyme activity --- novel foods --- functional food --- food by-product --- sustainability --- food neophobia
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The current demand for healthy and sustainable foods has encouraged the development of new alternatives, even in traditional products. Improved foods may be produced by reducing the amount of some ingredients, adding new ones, or replacing traditionally used ingredients for others. By reformulating their products, manufacturers can offer healthier choices for an ever-growing number of consumers interested in maintaining a balanced diet. In addition, market demand for more sustainable foods contributes to a lower environmental impact in their production. In this regard, current areas of interest include the production of foods using a lower amount of inputs, as well as the utilization of food by-products to improve the amount and quality of available foods. Another aspect to be considered is that not all consumers are willing to eat foods produced with new ingredients or novel technologies. Hence, the development of innovations in food products should take into account the influence of the so-called consumer food neophobia. For this reason, papers dealing with the consumer acceptance of these food innovations are also welcome. Thus, the aim of this Special Issue of Foods is to provide documents focused on the production of healthier and more sustainable foods by using novel ingredients, food by-products, or new production processes.
Business strategy --- melon-seed oil --- fruit waste --- tocopherols --- tocotrienols --- unsaturated fatty acids --- screw press --- tree nuts --- chemical composition --- proteins --- carbohydrates --- minerals --- phytochemicals --- polyphenols --- antioxidants --- volatile compounds --- saffron --- crocetin --- obesity --- agri-food marketing --- consumer behaviour --- economic and social crisis --- health --- innovation --- GM foods --- food labelling --- soybean oil --- willingness to pay --- choice experiment --- LC-mass spectrometry --- antioxidant capacity --- vacuum impregnation --- polyphenolic profile --- lulo fruit juice --- spermidine --- food innovation --- chia --- flax --- proximate composition --- sesame --- poppy --- product innovation --- process innovation --- neophobia --- food technology neophobia --- wine neophobia scale --- ham --- slices --- Crocus sativus L. --- pH --- color --- sensorial quality --- safranal --- pulsed electric fields --- pecan nut oil --- oil extraction yield --- microstructural analysis --- oil stability --- enzyme activity --- novel foods --- functional food --- food by-product --- sustainability --- food neophobia
Choose an application
The current demand for healthy and sustainable foods has encouraged the development of new alternatives, even in traditional products. Improved foods may be produced by reducing the amount of some ingredients, adding new ones, or replacing traditionally used ingredients for others. By reformulating their products, manufacturers can offer healthier choices for an ever-growing number of consumers interested in maintaining a balanced diet. In addition, market demand for more sustainable foods contributes to a lower environmental impact in their production. In this regard, current areas of interest include the production of foods using a lower amount of inputs, as well as the utilization of food by-products to improve the amount and quality of available foods. Another aspect to be considered is that not all consumers are willing to eat foods produced with new ingredients or novel technologies. Hence, the development of innovations in food products should take into account the influence of the so-called consumer food neophobia. For this reason, papers dealing with the consumer acceptance of these food innovations are also welcome. Thus, the aim of this Special Issue of Foods is to provide documents focused on the production of healthier and more sustainable foods by using novel ingredients, food by-products, or new production processes.
melon-seed oil --- fruit waste --- tocopherols --- tocotrienols --- unsaturated fatty acids --- screw press --- tree nuts --- chemical composition --- proteins --- carbohydrates --- minerals --- phytochemicals --- polyphenols --- antioxidants --- volatile compounds --- saffron --- crocetin --- obesity --- agri-food marketing --- consumer behaviour --- economic and social crisis --- health --- innovation --- GM foods --- food labelling --- soybean oil --- willingness to pay --- choice experiment --- LC-mass spectrometry --- antioxidant capacity --- vacuum impregnation --- polyphenolic profile --- lulo fruit juice --- spermidine --- food innovation --- chia --- flax --- proximate composition --- sesame --- poppy --- product innovation --- process innovation --- neophobia --- food technology neophobia --- wine neophobia scale --- ham --- slices --- Crocus sativus L. --- pH --- color --- sensorial quality --- safranal --- pulsed electric fields --- pecan nut oil --- oil extraction yield --- microstructural analysis --- oil stability --- enzyme activity --- novel foods --- functional food --- food by-product --- sustainability --- food neophobia
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