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Azoospermia, defined as the absence of sperm in the ejaculate after examination of the centrifuged specimens, affects about 1% of the male population and 10–15% of infertile men. In about two-thirds of cases, this is caused by severe spermatogenic dysfunction, and it is commonly termed “nonobstructive azoospermia” (NOA) to differentiate it from the less severe form of azoospermia caused by the obstruction of the seminal tract (obstructive azoospermia—OA), the latter affecting the remaining one-third of cases. Managing patients with NOA is challenging due to the severity of spermatogenic dysfunction and the lack of medical treatments, with surgical retrieval of testicular sperm being the only way of enabling some of these patients to father their own biological children. In-depth clinical knowledge is key for supporting clinical reasoning and decision making when counselling patients with NOA, and surgical skill is required to maximize the outcome of surgical procedures that aim to retrieve testicular sperm. The present book is a collection of scientific papers published in a Special Issue of the Journal of Clinical Medicine, authored by some of the most influential researchers in the field. The Special Issue, and thus also this book, were conceived to provide early career reproductive urologists and endocrinologists with an update of the scientific evidence in the field, together with surgical tips.

Medicine --- Pharmacology --- nonobstructive azoospermia --- micro-TESE --- FSH treatment --- hormonal treatment --- testosterone level --- microdissection testicular sperm extraction --- non-obstructive azoospermia --- management --- infertility --- intracytoplasmic sperm injection --- testicular azoospermia --- sperm selection --- sperm --- cryopreservation --- in vitro maturation --- azoospermia --- diagnosis --- male infertility --- spermatogenic failure --- testis biopsy --- sperm retrieval --- genetic testing --- endocrine evaluation --- review --- hypogonadism --- Sertoli cell-only syndrome --- testicular spermatozoa --- processing --- microfluidics --- new technologies --- genetics --- exome --- WES --- Y chromosome --- cancer --- NOA --- genes --- general health --- ICSI --- offspring health --- microTESE --- prediction model --- nonobstructive azoospermia --- micro-TESE --- FSH treatment --- hormonal treatment --- testosterone level --- microdissection testicular sperm extraction --- non-obstructive azoospermia --- management --- infertility --- intracytoplasmic sperm injection --- testicular azoospermia --- sperm selection --- sperm --- cryopreservation --- in vitro maturation --- azoospermia --- diagnosis --- male infertility --- spermatogenic failure --- testis biopsy --- sperm retrieval --- genetic testing --- endocrine evaluation --- review --- hypogonadism --- Sertoli cell-only syndrome --- testicular spermatozoa --- processing --- microfluidics --- new technologies --- genetics --- exome --- WES --- Y chromosome --- cancer --- NOA --- genes --- general health --- ICSI --- offspring health --- microTESE --- prediction model

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Nowadays, assisted reproductive technologies (ARTs) have a pivotal role not only in achieving fertilization in subfertile animals, but they are also involved in the management of the herd, decreasing disease spread and even allowing offspring sex selection. Nonetheless, there are differences between species or even within species that have led researchers worldwide to focus on those differences in order to bypass these specific difficulties. This Special Issue, titled “The Era of Assisted Reproductive Technologies Tailored to the Specific Necessities of Species, Industry and Case Reports” and published in Animals, is composed of 12 original manuscripts and three reviews that offer an overview of current and future ARTs used to improve reproductive outcomes, mainly focused on farm animals, such as horse, pig, bovine, rabbit and ovine species. Thus, the Special Issue covers information from the classical point of view, including comparative studies of different semen extenders, to the most advanced technologies of sperm selection by thermotaxis or chemoattractants, as well as the improvement of sperm features by red light irradiation. The female and embryo contributions to ART outcomes are also covered, for instance, with a study that improves our knowledge by the metabolomic description of follicular fluid composition or the description of better culture conditions of oocytes. In brief, this Special Issue provides a balanced overview of emerging techniques and technologies used to preserve, improve, rescue or even create fertility for domestic farm animals with high economic impact.

Medicine --- IVM --- oocytes --- equine --- metabolomic --- embryo transfer --- reproductive fluids --- pregnancy --- vitrification --- calving --- selection programme --- embryo vitrification --- Gompertz growth curve --- biobanking --- reproductive performance --- stallion sperm --- capacitation --- penicillamine --- thermotaxis --- selection --- BMP15 --- ram --- semen --- semen freezing --- semen extender --- stallions --- semen quality --- fertilizing ability --- Tris --- boar spermatozoa --- perfluorinated compounds --- PFHxS --- PFOS --- spermatozoa toxicology --- glucocorticoid receptor --- gene expression --- RT-qPCR --- seminal plasma --- female genital tract --- rabbit --- spermatozoa --- oocyte --- in vitro fertilization --- extracellular vesicles --- assisted reproductive technologies --- embryo --- oocyte competence --- livestock production --- assisted reproductive technology --- embryo development --- micromanipulation --- in vitro production --- nanoparticles --- liposomes --- exosomes --- cryopreservation --- sheep --- ovary storage --- transport --- in vitro embryo production --- sperm selection --- chemotaxis --- IVF --- IVC --- porcine --- cryopreserved sperm --- sperm–oviduct interaction --- ARTs --- equines --- horse --- sperm --- red light irradiation --- extender --- straw --- IVM --- oocytes --- equine --- metabolomic --- embryo transfer --- reproductive fluids --- pregnancy --- vitrification --- calving --- selection programme --- embryo vitrification --- Gompertz growth curve --- biobanking --- reproductive performance --- stallion sperm --- capacitation --- penicillamine --- thermotaxis --- selection --- BMP15 --- ram --- semen --- semen freezing --- semen extender --- stallions --- semen quality --- fertilizing ability --- Tris --- boar spermatozoa --- perfluorinated compounds --- PFHxS --- PFOS --- spermatozoa toxicology --- glucocorticoid receptor --- gene expression --- RT-qPCR --- seminal plasma --- female genital tract --- rabbit --- spermatozoa --- oocyte --- in vitro fertilization --- extracellular vesicles --- assisted reproductive technologies --- embryo --- oocyte competence --- livestock production --- assisted reproductive technology --- embryo development --- micromanipulation --- in vitro production --- nanoparticles --- liposomes --- exosomes --- cryopreservation --- sheep --- ovary storage --- transport --- in vitro embryo production --- sperm selection --- chemotaxis --- IVF --- IVC --- porcine --- cryopreserved sperm --- sperm–oviduct interaction --- ARTs --- equines --- horse --- sperm --- red light irradiation --- extender --- straw