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Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving coordinated waves of DNA methylation/demethylation, histone modification, and the replacement and removal that occurs before, during, and after meiosis. This Special Issue will draw together papers that address all aspects of chromatin organization and dynamics in the male germ line, in humans, and in model organisms. In particular, we will invite authors to discuss novel methods for studying germline chromatin structure, the interplay between chromatin structure and susceptibility to DNA damage and mutation, chromatin modifications associated with epigenetic inheritance in the early embryo, and the impact this work has for understanding natural fertility and improving assisted reproduction techniques.

Research & information: general --- Biology, life sciences --- mouse sperm chromatin --- chromosome organization --- nuclear-3D-parameters --- spermiogenesis --- chromatin remodeling --- DNA double-strand breaks --- genetic instability --- mutations --- sperm DNA damage --- DNA fragmentation --- infertility --- assisted reproduction --- miscarriage --- implantation --- nuclear organization --- sperm --- morphometrics --- chromosome painting --- nucleoli --- NOR --- chromosome associations --- meiotic prophase --- spermatocytes --- Mus m. domesticus --- Robertsonian chromosomes --- chromosome translocation --- Y chromosome --- testis --- spermatogenesis --- SLY --- mouse --- oxidative stress --- reactive oxygen species --- chromatin --- DNA oxidation --- male infertility --- spermatozoa --- chromosomes --- chromosome territories --- centromeres --- male germ cells --- telomeres --- reproductive aging --- nuclear organisation --- epigenetic inheritance --- histone retention --- in vitro fertilisation

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving coordinated waves of DNA methylation/demethylation, histone modification, and the replacement and removal that occurs before, during, and after meiosis. This Special Issue will draw together papers that address all aspects of chromatin organization and dynamics in the male germ line, in humans, and in model organisms. In particular, we will invite authors to discuss novel methods for studying germline chromatin structure, the interplay between chromatin structure and susceptibility to DNA damage and mutation, chromatin modifications associated with epigenetic inheritance in the early embryo, and the impact this work has for understanding natural fertility and improving assisted reproduction techniques.

Research & information: general --- Biology, life sciences --- mouse sperm chromatin --- chromosome organization --- nuclear-3D-parameters --- spermiogenesis --- chromatin remodeling --- DNA double-strand breaks --- genetic instability --- mutations --- sperm DNA damage --- DNA fragmentation --- infertility --- assisted reproduction --- miscarriage --- implantation --- nuclear organization --- sperm --- morphometrics --- chromosome painting --- nucleoli --- NOR --- chromosome associations --- meiotic prophase --- spermatocytes --- Mus m. domesticus --- Robertsonian chromosomes --- chromosome translocation --- Y chromosome --- testis --- spermatogenesis --- SLY --- mouse --- oxidative stress --- reactive oxygen species --- chromatin --- DNA oxidation --- male infertility --- spermatozoa --- chromosomes --- chromosome territories --- centromeres --- male germ cells --- telomeres --- reproductive aging --- nuclear organisation --- epigenetic inheritance --- histone retention --- in vitro fertilisation --- mouse sperm chromatin --- chromosome organization --- nuclear-3D-parameters --- spermiogenesis --- chromatin remodeling --- DNA double-strand breaks --- genetic instability --- mutations --- sperm DNA damage --- DNA fragmentation --- infertility --- assisted reproduction --- miscarriage --- implantation --- nuclear organization --- sperm --- morphometrics --- chromosome painting --- nucleoli --- NOR --- chromosome associations --- meiotic prophase --- spermatocytes --- Mus m. domesticus --- Robertsonian chromosomes --- chromosome translocation --- Y chromosome --- testis --- spermatogenesis --- SLY --- mouse --- oxidative stress --- reactive oxygen species --- chromatin --- DNA oxidation --- male infertility --- spermatozoa --- chromosomes --- chromosome territories --- centromeres --- male germ cells --- telomeres --- reproductive aging --- nuclear organisation --- epigenetic inheritance --- histone retention --- in vitro fertilisation

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• Reference Manager
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Do you care about your environment and your health? Contamination by hazardous substances in environmental matrices, including landfills, oil fields, and manufacturing and industrial sites, represents a global concern and needs to be remediated since it poses a serious risk to the environment and human health. Particular attention should also be paid to the use of medical devices and recent developments in the use of nanoparticles expressed as drug delivery systems designed to treat a wide variety of diseases. This Special Issue collects a compilation of articles that strongly demonstrate the continuous efforts made in developing advanced and safe nanomaterial-based technologies for nano-remediation and for drug delivery and other biomedical applications. It covers the most recent advances in the safe nanomaterials synthesis field as well as in environmental applications, in the use of restorative materials, drug delivery and other clinical applications, in order to lay the foundations for a cleaner and healthier future.

lipid nanoparticles --- cryo transmission electron microscopy --- atomic force microscopy --- bicelle --- micelle --- liposome --- UO22+ --- salicyladazine --- fluorescence --- mesoporous silica --- multifunctional nanoemulsions --- targeted delivery --- cancer --- Trojan horse effect --- B[a]P --- nC60 --- co-exposure --- mussels --- DNA damage --- proteomics --- pitch --- activated carbon fiber --- evaporated fuel --- hydrocarbon emissions --- magnetic nanoparticles --- human bone marrow-derived mesenchymal stem cells --- membrane fluidity --- focal adhesion --- cytoskeletal abnormality --- nanomaterials --- organisms suitable for simple and rapid ecotoxicity testing SSRET --- ecotoxicological test batteries --- ecotoxicology --- graphite powder --- graphene oxide --- reduced graphene oxide --- Chenopodium album --- anticancer --- antimicrobial --- sperm DNA damage --- titanium dioxide nanoparticles --- cadmium --- oxidative stress --- male infertility --- cellulose-based nanosponges --- zinc --- seawater --- ecotoxicity --- effect-based approach --- remediation --- Chlorella vulgaris --- silver nanoparticles --- growth inhibition --- chlorophyll-a content --- morphological changes --- bioaccumulation --- crystalline structure --- scanning electron microscopy --- porosity --- glass ionomer cement --- cytotoxicity --- TiO2 NPs --- applications --- wastewater treatment --- agro-environment --- exposure pathways --- bacterial resistance --- boar --- microbiological analyses --- nanoparticles --- semen --- nanostructured materials --- sorption --- organic dyes --- nanocellulose --- micronucleus --- nuclear morphology alteration --- cellular proliferation --- zebra mussel (Dreissena polymorpha) --- polysaccharide-based nanosponge --- nanoremediation --- n/a