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Immunology. Immunopathology --- Zoohistology. Zoocytology --- Antibody diversity --- Antibody Diversity --- 616.9 --- Diversity, Antibody --- Germ line theory --- Immunoglobulin diversity --- Somatic mutation theory --- Clonal selection theory --- Immunogenetics --- Gene rearrangement --- Immunoglobulins --- Immunospecificity --- Communicable diseases. Infectious and contagious diseases, fevers --- 616.9 Communicable diseases. Infectious and contagious diseases, fevers

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This book includes 17 papers published in the Special Issue/Article Collection “New Insights in the Genetics and Genomics of adrenocortical tumors and pheochromocytomas” including an editorial, 10 research papers and six review articles. Adrenal tumors represent a hot topic in contemporary endocrine oncology. Significant advancements in the genetics of genomics of these tumors have been made in recent years, and these articles give a useful and comprehensive overview of these issues. Questions regarding molecular pathogenesis, diagnosis (biomarkers) and even treatment are discussed in the papers written by international leaders of the field. Manuscripts are focused on three main topics: i. primary aldosteronism (the most common cause of secondary endocrine hypertension), ii. adrenocortical cancer and iii. pheochromocytoma/paraganglioma, which are the tumors with the highest heritability in humans. The book is edited by Prof. Peter Igaz (Department of Endocrinology, Faculty of Medicine, Semmelweis University).

pheochromocytoma --- paraganglioma --- genetics --- non-coding RNA --- malignancy --- biomarker --- treatment --- adaptive metabolism --- adrenal gland --- conn adenoma --- fatty acid metabolism --- ferroptosis --- hyperaldosteronism --- metabolic reprogramming --- β-oxidation --- PPARα --- tumor microenvironment --- Next Generation Sequencing --- hereditary cancer --- endocrine tumor syndrome --- KCNJ5 somatic mutation --- pulse wave velocity --- aldosterone-producing adenoma --- adrenalectomy --- propensity score matching --- arterial stiffness --- pheochromocytomas --- paragangliomas --- mutations --- susceptibility genes --- driver mutations --- hereditary --- germline --- somatic --- environment --- variants --- tumor suppressor genes --- metastatic --- RNAseq --- next generation sequencing --- adrenocortical carcinoma --- in silico analysis --- machine learning --- bioinformatic clustering --- biomarker prediction --- aldosterone producing adenoma --- ATP2B3 --- K416-F418delinsN mutation --- primary aldosteronism --- PPGL --- telomeres --- TERT --- ATRX --- NOP10 --- prognostic biomarker --- ALT --- phaeochromocytoma --- cancer --- mitochondrial complex II --- zebrafish --- therapy --- drug discovery --- redox balance pathway --- Vitamin C --- mitotane --- H295 strains --- microRNA --- aldosterone --- circulating --- adrenocortical --- transcriptomics --- epigenetics --- metabolomics --- epidemiology --- genetic analysis --- mortality --- surveillance --- TP53 R337H --- genetic testing --- adrenocortical tumor --- neonatal screening --- screening --- adenoma --- adrenal --- tissue --- artificial intelligence --- neural network --- n/a

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This book includes 17 papers published in the Special Issue/Article Collection “New Insights in the Genetics and Genomics of adrenocortical tumors and pheochromocytomas” including an editorial, 10 research papers and six review articles. Adrenal tumors represent a hot topic in contemporary endocrine oncology. Significant advancements in the genetics of genomics of these tumors have been made in recent years, and these articles give a useful and comprehensive overview of these issues. Questions regarding molecular pathogenesis, diagnosis (biomarkers) and even treatment are discussed in the papers written by international leaders of the field. Manuscripts are focused on three main topics: i. primary aldosteronism (the most common cause of secondary endocrine hypertension), ii. adrenocortical cancer and iii. pheochromocytoma/paraganglioma, which are the tumors with the highest heritability in humans. The book is edited by Prof. Peter Igaz (Department of Endocrinology, Faculty of Medicine, Semmelweis University).

Medicine --- pheochromocytoma --- paraganglioma --- genetics --- non-coding RNA --- malignancy --- biomarker --- treatment --- adaptive metabolism --- adrenal gland --- conn adenoma --- fatty acid metabolism --- ferroptosis --- hyperaldosteronism --- metabolic reprogramming --- β-oxidation --- PPARα --- tumor microenvironment --- Next Generation Sequencing --- hereditary cancer --- endocrine tumor syndrome --- KCNJ5 somatic mutation --- pulse wave velocity --- aldosterone-producing adenoma --- adrenalectomy --- propensity score matching --- arterial stiffness --- pheochromocytomas --- paragangliomas --- mutations --- susceptibility genes --- driver mutations --- hereditary --- germline --- somatic --- environment --- variants --- tumor suppressor genes --- metastatic --- RNAseq --- next generation sequencing --- adrenocortical carcinoma --- in silico analysis --- machine learning --- bioinformatic clustering --- biomarker prediction --- aldosterone producing adenoma --- ATP2B3 --- K416-F418delinsN mutation --- primary aldosteronism --- PPGL --- telomeres --- TERT --- ATRX --- NOP10 --- prognostic biomarker --- ALT --- phaeochromocytoma --- cancer --- mitochondrial complex II --- zebrafish --- therapy --- drug discovery --- redox balance pathway --- Vitamin C --- mitotane --- H295 strains --- microRNA --- aldosterone --- circulating --- adrenocortical --- transcriptomics --- epigenetics --- metabolomics --- epidemiology --- genetic analysis --- mortality --- surveillance --- TP53 R337H --- genetic testing --- adrenocortical tumor --- neonatal screening --- screening --- adenoma --- adrenal --- tissue --- artificial intelligence --- neural network

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Hereditary hemorrhagic telangiectasia (HHT) is an inherited disease that affects the blood vessels, and is characterized by direct connections between arteries and veins with no intervening capillaries. These abnormal vessels may appear in the skin as tiny red dilated blood vessels in the mouth, lips, fingers and toes. The presence of these vascular lesions in the mucosa can lead to spontaneous and recurrent nose bleeding, typically beginning in mid-childhood, and this is the most common clinical manifestation of HHT, occurring in over 90% of patients. Gastrointestinal bleeding, derived from mucocutaneous vascular lesions, affects approximately 25% of patients, almost always presenting after the age of 50. Chronic nasal and gastrointestinal bleeding can cause iron-deficiency anemia, and current therapeutic strategies are trying to minimize iron and blood transfusions. HHT patients also present large vascular lesions, known as arteriovenous malformations, that occur in internal organs like lungs, liver, and brain, and may result in life-threatening complications often related to the shunting of blood. This book not only highlights the current knowledge regarding diagnosis and treatment of HHT, but also the newest insights in the molecular basis of HHT, the understanding of which is essential for the development of new medicines or therapeutic strategies.

Research & information: general --- hereditary hemorrhagic telangiectasia --- rare diseases --- telangiectasis --- transforming growth factor-beta (TGF-β) --- Smad pathway --- gastrointestinal bleeding --- epistaxis --- nosebleeds --- tacrolimus --- nasal ointment --- genetic disease --- rare disease --- hereditary hemorrhagic telangiectasia (HHT) --- telangiectases --- mechanical damage --- sun-induced trauma --- vascular malformations --- Endoglin --- activin-receptor-like kinase 1 --- Hereditary Hemorrhagic Telangiectasia --- antithrombotic therapy --- anticoagulants --- antiplatelets --- bleeding --- safety --- HHT --- ALK1 --- endoglin --- raloxifene --- bazedoxifene --- tranexamic acid --- propranolol --- FK506 --- etamsylate --- N-acetylcysteine --- pulmonary arteriovenous malformations --- transcatheter embolotherapy --- screening --- guidelines --- Hereditary hemorrhagic telangiectasia --- pediatrics --- genotype–phenotype correlation --- arteriovenous malformation --- ENG --- ACVRL1 --- SMAD4 --- microRNA --- biomarker --- plasma --- arteriovenous malformations (AVMs) --- angiogenesis --- activin receptor-like kinase 1 (ALK1) --- transforming growth factor beta (TGF-β) --- bone morphogenetic protein (BMP) --- propranolol gel --- epistaxis severity score --- nasal endoscopy --- antiangiogenic properties --- non-coding RNAs --- microRNAs --- long non-coding RNAs --- biomarkers --- endothelial cells --- hereditary hemorrhagic telangiectasia (HHT), second-hit --- arteriovenous malformation (AVM) --- Smad4 --- inflammation --- shear stress --- vascular injury --- somatic mutation --- cell adhesion --- vascular endothelial growth factor (VEGF) --- telangiectasia --- hereditary hemorrhagic --- survival --- life expectancy --- pulmonary arteriovenous malformation --- contrast enhanced magnetic resonance angiography --- liver --- MRI --- ultrasound --- AVM --- bevacizumab --- Osler–Weber–Rendu --- hereditary hemorrhagic telangiectasia/HHT/osler’s disease --- cerebral ischemic lesions --- catheter based embolization therapy

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Hereditary hemorrhagic telangiectasia (HHT) is an inherited disease that affects the blood vessels, and is characterized by direct connections between arteries and veins with no intervening capillaries. These abnormal vessels may appear in the skin as tiny red dilated blood vessels in the mouth, lips, fingers and toes. The presence of these vascular lesions in the mucosa can lead to spontaneous and recurrent nose bleeding, typically beginning in mid-childhood, and this is the most common clinical manifestation of HHT, occurring in over 90% of patients. Gastrointestinal bleeding, derived from mucocutaneous vascular lesions, affects approximately 25% of patients, almost always presenting after the age of 50. Chronic nasal and gastrointestinal bleeding can cause iron-deficiency anemia, and current therapeutic strategies are trying to minimize iron and blood transfusions. HHT patients also present large vascular lesions, known as arteriovenous malformations, that occur in internal organs like lungs, liver, and brain, and may result in life-threatening complications often related to the shunting of blood. This book not only highlights the current knowledge regarding diagnosis and treatment of HHT, but also the newest insights in the molecular basis of HHT, the understanding of which is essential for the development of new medicines or therapeutic strategies.

hereditary hemorrhagic telangiectasia --- rare diseases --- telangiectasis --- transforming growth factor-beta (TGF-β) --- Smad pathway --- gastrointestinal bleeding --- epistaxis --- nosebleeds --- tacrolimus --- nasal ointment --- genetic disease --- rare disease --- hereditary hemorrhagic telangiectasia (HHT) --- telangiectases --- mechanical damage --- sun-induced trauma --- vascular malformations --- Endoglin --- activin-receptor-like kinase 1 --- Hereditary Hemorrhagic Telangiectasia --- antithrombotic therapy --- anticoagulants --- antiplatelets --- bleeding --- safety --- HHT --- ALK1 --- endoglin --- raloxifene --- bazedoxifene --- tranexamic acid --- propranolol --- FK506 --- etamsylate --- N-acetylcysteine --- pulmonary arteriovenous malformations --- transcatheter embolotherapy --- screening --- guidelines --- Hereditary hemorrhagic telangiectasia --- pediatrics --- genotype–phenotype correlation --- arteriovenous malformation --- ENG --- ACVRL1 --- SMAD4 --- microRNA --- biomarker --- plasma --- arteriovenous malformations (AVMs) --- angiogenesis --- activin receptor-like kinase 1 (ALK1) --- transforming growth factor beta (TGF-β) --- bone morphogenetic protein (BMP) --- propranolol gel --- epistaxis severity score --- nasal endoscopy --- antiangiogenic properties --- non-coding RNAs --- microRNAs --- long non-coding RNAs --- biomarkers --- endothelial cells --- hereditary hemorrhagic telangiectasia (HHT), second-hit --- arteriovenous malformation (AVM) --- Smad4 --- inflammation --- shear stress --- vascular injury --- somatic mutation --- cell adhesion --- vascular endothelial growth factor (VEGF) --- telangiectasia --- hereditary hemorrhagic --- survival --- life expectancy --- pulmonary arteriovenous malformation --- contrast enhanced magnetic resonance angiography --- liver --- MRI --- ultrasound --- AVM --- bevacizumab --- Osler–Weber–Rendu --- hereditary hemorrhagic telangiectasia/HHT/osler’s disease --- cerebral ischemic lesions --- catheter based embolization therapy