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612:796 --- 612:796 Fysiologie van de sport --- Fysiologie van de sport --- Musculoskeletal system --- Muscle, Skeletal --- physiology --- physiopathology --- Musculoskeletal System. --- Appareil locomoteur --- Muscles --- Muscle, Striated --- Musculoskeletal System --- Anatomy --- Tissues --- Tissue --- Anatomies --- Anterior Tibial Muscle --- Gastrocnemius Muscle --- Muscle, Voluntary --- Plantaris Muscle --- Skeletal Muscle --- Soleus Muscle --- Muscle, Anterior Tibial --- Muscle, Gastrocnemius --- Muscle, Plantaris --- Muscle, Soleus --- Muscles, Skeletal --- Muscles, Voluntary --- Skeletal Muscles --- Tibial Muscle, Anterior --- Voluntary Muscle --- Voluntary Muscles --- Musculoskeletal Systems --- System, Musculoskeletal --- Systems, Musculoskeletal --- Musculoskeletal Development --- Striated Muscle --- Muscles, Striated --- Striated Muscles --- Muscle Tissue --- Muscle --- Muscle Tissues --- Tissue, Muscle --- Tissues, Muscle --- Skeletal Muscle Enlargement --- Muscle, Skeletal - physiology --- Muscle, Skeletal - physiopathology

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This book describes the diverse roles that growth factors and cytokines play in skeletal muscle. The extracellular environment has profound effects on the biology of skeletal muscle. The soluble portion of this environment includes a rich milieu of growth factors and cytokines which have been shown to regulate virtually all facets of the response of skeletal muscle to external stimuli, whether it be exercise induced metabolic shifts, remodeling in response to trauma or loading of the ongoing pathology associated with neuromuscular disease. The chapters included in this work illustrate growth factors that directly affect skeletal muscle cells and those which influence non-muscle cells that contribute to the biology of skeletal muscle as a whole tissue. The current state of the art, with the advent of systems biology, allows for the delineation of signaling networks which are regulated by suites of growth factors. This is in stark contrast to early more traditional studies, which only examined the effects of isolated growth factors on the activity of skeletal muscle precursor cells in tissue culture. The work presented in this volume ranges from reviewing and analyzing the roles of individual growth factors in detail, to the complex interplay of multiple soluble factors in the control of muscle functional, and dysfunctional states. The material covered in this volume will particularly suit readers from a range of research fields spanning general muscle biology and physiology, and those working on diseases and conditions affecting skeletal muscle both directly and indirectly.

Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Muscles --- Musculoskeletal system. --- Muscle cells. --- Regeneration. --- Myocytes --- Locomotor system --- Musculo-skeletal system --- Skeletomuscular system --- Cells --- Cytokines. --- Human physiology. --- Biochemistry. --- Cytokines and Growth Factors. --- Human Physiology. --- Medical Biochemistry. --- Human biology --- Medical sciences --- Physiology --- Human body --- Cellular immunity --- Immune response --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Regulation --- Composition --- Muscle, Skeletal. --- Intercellular Signaling Peptides and Proteins. --- Growth Factors --- Paracrine Peptide Factors --- Paracrine Protein Factors --- Peptide Factors, Paracrine --- Paracrine Communication --- Peptide Hormones --- Anterior Tibial Muscle --- Gastrocnemius Muscle --- Muscle, Voluntary --- Plantaris Muscle --- Skeletal Muscle --- Soleus Muscle --- Muscle, Anterior Tibial --- Muscle, Gastrocnemius --- Muscle, Plantaris --- Muscle, Soleus --- Muscles, Skeletal --- Muscles, Voluntary --- Skeletal Muscles --- Tibial Muscle, Anterior --- Voluntary Muscle --- Voluntary Muscles --- Growth factors. --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides

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Starting from a kinase of interest, AMP-activated protein kinase (AMPK) has gone far beyond an average biomolecule. Being expressed in all mammalian cell types and probably having a counterpart in every eukaryotic cell, AMPK has attracted interest in virtually all areas of biological research. Structural and biophysical insights have greatly contributed to a molecular understanding of this kinase. From good old protein biochemistry to modern approaches, such as systems biology and advanced microscopy, all disciplines have provided important information. Thus, multiple links to cellular events and subcellular localizations have been established. Moreover, the crucial involvement of AMPK in human health and disease has been evidenced. AMPK accordingly has moved from an interesting enzyme to a pharmacological target. However, despite our extensive current knowledge about AMPK, the growing community is busier than ever. This book provides a snapshot of recent and current AMPK research with an emphasis on work providing molecular insight, including but not limited to novel physiological and pathological functions, or regulatory mechanisms. Up-to-date reviews and research articles are included.

n/a --- HDACs --- transcription --- epigenetics --- spermatozoa --- par complex --- A769662 --- MDCK --- skeletal muscle --- AID --- phosphorylation --- energy metabolism --- monocytes --- autophagy --- CML --- liver --- hindlimb suspension --- pregnancy --- preeclampsia --- gestational diabetes mellitus --- CaMKK2 --- assisted reproduction techniques --- nutrient-sensing signals --- sonic hedgehog --- protein acetylation --- glycogen storage disease --- AMPK --- adenosine monophosphate-activated protein kinase --- AICAR --- indirect calorimetry --- IL-1? --- MyHC I(?) --- HDAC4/5 --- endothelial cells --- infection --- hepatocyte --- p70S6K --- lipid metabolism --- host defense --- exercise --- kidney disease --- heat shock protein --- ?RIM --- mycobacteria --- activation loop --- developmental origins of health and disease (DOHaD) --- CREB --- TAK1 --- metabolic-inflammation --- phenylephrine --- AMP-activated protein kinase (AMPK) --- KATs --- 2-methoxyestradiol --- DNA methylation --- NLRP3 --- pump --- ?-linker --- steatosis --- AMPK kinase --- stress --- endothelial nitric-oxide synthase --- vasodilation --- adherent junctions --- epithelial cells --- glycogen --- Akt --- synaptic activation --- cellular energy sensing --- glucose uptake --- transporter --- co-expression --- atrophy --- nutrigenomics --- motility --- vasoconstriction --- fatty acid oxidation --- oxidative stress --- AS160 --- membrane --- histone modification --- sirtuin 1 (SIRT1) --- chromatin remodeling --- insulin signalling --- dietary fatty acids --- ULK --- CMML --- adaptive thermogenesis --- mTOR --- MDS --- mechanical unloading --- AML --- endothelial function --- medulloblastoma --- PKA --- adipose tissue --- NAD⁺ --- membranes --- nutrition --- ZO-1 --- TBC1D4 --- adipocyte --- soluble Adenylyl cyclase --- metabolism --- renin-angiotensin system --- energy utilization --- proteasome --- differentiation --- signaling --- peroxisome proliferator-activated receptor gamma coactivator 1-? (PGC1?) --- hypertrophy --- AMP-activated protein kinase --- metabolic disease --- LKB1 --- soleus muscle --- macrophages --- Immediate early genes --- CBS --- beiging --- motor endplate remodeling --- ionomycin --- nectin-afadin --- tight junctions --- resveratrol --- protein kinase B --- regrowth --- mitochondria --- protein synthesis --- energy deficiency --- catechol-O-methyltransferase --- fiber-type --- microarrays --- carrier --- acetyl-CoA --- hypertension --- 3T3-L1 --- hypothalamus --- food intake --- benign

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612:796 --- Fysiologie van de sport --- 612:796 Fysiologie van de sport --- Human Activities --- Musculoskeletal Physiological Processes --- Muscles --- Muscle, Striated --- Biological Processes --- Physiological Processes --- Biological Phenomena --- Musculoskeletal Physiological Phenomena --- Musculoskeletal System --- Anthropology, Education, Sociology and Social Phenomena --- Physiological Phenomena --- Phenomena and Processes --- Anatomy --- Tissues --- Musculoskeletal and Neural Physiological Phenomena --- Muscle, Skeletal --- Adaptation, Physiological --- Exercise --- Adaptation, Biological --- Musculoskeletal Physiologic Process --- Musculoskeletal Physiological Concepts --- Musculoskeletal Physiological Phenomenon --- Physiology, Musculoskeletal --- Musculoskeletal Physiologic Processes --- Musculoskeletal Physiological Process --- Musculoskeletal Physiology --- Concept, Musculoskeletal Physiological --- Concepts, Musculoskeletal Physiological --- Musculoskeletal Physiological Concept --- Phenomena, Musculoskeletal Physiological --- Phenomenon, Musculoskeletal Physiological --- Physiologic Process, Musculoskeletal --- Physiologic Processes, Musculoskeletal --- Process, Musculoskeletal Physiologic --- Process, Musculoskeletal Physiological --- Processes, Musculoskeletal Physiologic --- Processes, Musculoskeletal Physiological --- Activities, Human --- Activity, Human --- Human Activity --- Animal Assisted Therapy --- Adaptation, Biologic --- Biological Adaptation --- Biologic Adaptation --- Acute Exercise --- Exercise Training --- Aerobic Exercise --- Exercise, Aerobic --- Exercise, Isometric --- Exercise, Physical --- Isometric Exercise --- Physical Activity --- Activities, Physical --- Activity, Physical --- Acute Exercises --- Aerobic Exercises --- Exercise Trainings --- Exercise, Acute --- Exercises --- Exercises, Acute --- Exercises, Aerobic --- Exercises, Isometric --- Exercises, Physical --- Isometric Exercises --- Physical Activities --- Physical Exercise --- Physical Exercises --- Training, Exercise --- Trainings, Exercise --- Exercise Therapy --- Physical Exertion --- Physical Fitness --- Sports --- Exercise Movement Techniques --- Adaptation, Physiologic --- Adaptations, Physiologic --- Adaptations, Physiological --- Adaptive Plasticity --- Phenotypic Plasticity --- Physiological Adaptation --- Physiologic Adaptation --- Physiologic Adaptations --- Physiological Adaptations --- Plasticity, Adaptive --- Plasticity, Phenotypic --- Anterior Tibial Muscle --- Gastrocnemius Muscle --- Muscle, Voluntary --- Plantaris Muscle --- Skeletal Muscle --- Soleus Muscle --- Muscle, Anterior Tibial --- Muscle, Gastrocnemius --- Muscle, Plantaris --- Muscle, Soleus --- Muscles, Skeletal --- Muscles, Voluntary --- Skeletal Muscles --- Tibial Muscle, Anterior --- Voluntary Muscle --- Voluntary Muscles --- Musculoskeletal and Neural Physiological Concepts --- Musculoskeletal and Neural Physiological Phenomenon --- Musculoskeletal and Neural Physiology --- Tissue --- Anatomies --- Physiological Concepts --- Physiological Phenomenon --- Physiological Process --- Concept, Physiological --- Concepts, Physiological --- Phenomena, Physiological --- Phenomenas, Physiological --- Phenomenon, Physiological --- Physiological Concept --- Process, Physiological --- Processes, Physiological --- Musculoskeletal Systems --- System, Musculoskeletal --- Systems, Musculoskeletal --- Musculoskeletal Development --- Biologic Phenomena --- Biological Phenomenon --- Biological Process --- Phenomena, Biological --- Phenomena, Biologic --- Phenomenon, Biological --- Process, Biological --- Processes, Biological --- Striated Muscle --- Muscles, Striated --- Striated Muscles --- Muscle Tissue --- Muscle --- Muscle Tissues --- Tissue, Muscle --- Tissues, Muscle --- physiology --- Skeletal Muscle Enlargement

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Breathing Exercises. --- Athletic Performance --- Respiratory Muscles --- Breathing exercises. --- Athletes --- Respiratory muscles --- Sports --- Exercise. --- Exercices respiratoires --- Entraînement (Sports) --- Appareil respiratoire --- Exercice --- physiology. --- Training of. --- Physiology --- Physiological aspects. --- Muscles --- Physiologie --- Aspect physiologique --- Breathing exercises --- Exercise --- Exercise Movement Techniques --- Muscle, Skeletal --- Mind-Body Therapies --- Physical Therapy Modalities --- Recreation --- Complementary Therapies --- Leisure Activities --- Therapeutics --- Musculoskeletal System --- Human Activities --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Anatomy --- Anthropology, Education, Sociology and Social Phenomena --- Breathing Exercises --- Public Health --- Health & Biological Sciences --- Public Health - General --- Training of --- Physiological aspects --- Respiratory Muscle --- Ventilatory Muscles --- Muscle, Respiratory --- Muscle, Ventilatory --- Muscles, Respiratory --- Muscles, Ventilatory --- Ventilatory Muscle --- Thoracic Wall --- Sports Performance --- Athletic Performances --- Performance, Athletic --- Performance, Sports --- Performances, Athletic --- Performances, Sports --- Sports Performances --- Psychomotor Performance --- Respiratory Muscle Training --- Exercise, Breathing --- Muscle Training, Respiratory --- Training, Respiratory Muscle --- Respiration --- Respiratory Therapy --- Anatomies --- Activities, Human --- Activity, Human --- Human Activity --- Animal Assisted Therapy --- Musculoskeletal Systems --- System, Musculoskeletal --- Systems, Musculoskeletal --- Musculoskeletal Development --- Therapy --- Treatment --- Therapeutic --- Therapies --- Treatments --- Disease --- Leisure --- Activities, Leisure --- Activity, Leisure --- Leisure Activity --- Leisures --- Alternative Therapies --- Therapy, Alternative --- Therapy, Complementary --- Alternative Medicine --- Complementary Medicine --- Medicine, Alternative --- Medicine, Complementary --- Therapies, Alternative --- Therapies, Complementary --- Recreations --- Muscle Tissue --- Muscle --- Muscle Tissues --- Tissue, Muscle --- Tissues, Muscle --- Group Physiotherapy --- Neurological Physiotherapy --- Neurophysiotherapy --- Physical Therapy Techniques --- Physiotherapy (Techniques) --- Group Physiotherapies --- Modalities, Physical Therapy --- Modality, Physical Therapy --- Physical Therapy Modality --- Physical Therapy Technique --- Physiotherapies (Techniques) --- Physiotherapies, Group --- Physiotherapy, Group --- Physiotherapy, Neurological --- Techniques, Physical Therapy --- Postoperative Care --- Physical Therapist Assistants --- Athletics --- Athletic --- Sport --- Exercise Therapy --- Physical Exertion --- Mind-Body Medicine --- Mind Body Medicine --- Mind Body Therapies --- Mind-Body Therapy --- Therapies, Mind-Body --- Therapy, Mind-Body --- Spiritual Therapies --- Anterior Tibial Muscle --- Gastrocnemius Muscle --- Muscle, Voluntary --- Plantaris Muscle --- Skeletal Muscle --- Soleus Muscle --- Muscle, Anterior Tibial --- Muscle, Gastrocnemius --- Muscle, Plantaris --- Muscle, Soleus --- Muscles, Skeletal --- Muscles, Voluntary --- Skeletal Muscles --- Tibial Muscle, Anterior --- Voluntary Muscle --- Voluntary Muscles --- Exercise Movement Technics --- Pilates Training --- Pilates-Based Exercises --- Exercises, Pilates-Based --- Movement Techniques, Exercise --- Pilates Based Exercises --- Training, Pilates --- Physical activity --- Warm-up --- Workouts (Exercise) --- Health --- Physical education and training --- Field sports --- Pastimes --- Games --- Outdoor life --- Respiratory organs --- Sports persons --- Sportspeople --- Sportspersons --- Sports personnel --- Breath work --- Breathwork --- therapy --- Physical Therapy --- Physical Therapies --- Therapy, Physical --- Skeletal Muscle Enlargement