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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

smooth muscle cells (SMCs) --- pericytes --- Alzheimer's disease --- small vessel disease --- vascular cognitive impairment --- mural cells

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Neurosciences --- smooth muscle cells (SMCs) --- pericytes --- Alzheimer's disease --- small vessel disease --- vascular cognitive impairment --- mural cells

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The present special issue will lead you to discover the association between cerebrovascular events, cognitive impairment and atrial fibrillation, through update reviews and original articles exploring the pathophysiological mechanisms underpinning this association and describing the latest results in term of stroke prevention in AF. An interesting scientific journey that reflects the recent advances in pharmacological treatments and interventional procedures involving both mind and heart.

Medicine --- memory loss --- antioxidant --- neuroprotective --- acetylcholinesterase inhibitor --- molecular docking --- atrial --- fibrillation --- venous --- thrombosis --- anticoagulation --- perception --- chronic obstructive pulmonary disease --- atrial fibrillation --- cardiovascular risk --- outcome --- prognosis --- novel oral anticoagulants --- prosthetic valve replacement --- subclinical atrial fibrillation --- stroke --- ischemic cerebral events --- catheter ablation --- screening --- cognitive impairment --- atrial fibrillation ablation --- iatrogenic interatrial septum defect --- paradoxical embolism --- anticoagulant interruption --- cardioversion --- oral anticoagulation therapy --- left atrial appendage thrombosis --- transesophageal echocardiography --- IL1B --- IL1RN --- polymorphism --- inflammation --- cognitive decline --- rhythm control --- microbleeds --- cerebral ischemia --- diabetes mellitus --- metformin --- thiazolidinediones --- GLP-1 receptor agonists --- SGLT-2 inhibitors --- atrial high rate episodes --- NOACs --- non vitamin K oral anticoagulants --- oral anticoagulation --- intracerebral hemorrhage --- cerebral small vessel disease --- brain MRI --- circulating biomarkers --- direct oral anticoagulants (DOACs) --- atrial fibrillation (AF) --- electrical cardioversion (EC) --- surgical cryoablation --- left atrial function --- minimally invasive mitral valve repair --- echocardiography --- aneurysmal subarachnoid hemorrhage --- interdisciplinary setting --- metabolic syndrome --- obesity --- dementia --- memory loss --- antioxidant --- neuroprotective --- acetylcholinesterase inhibitor --- molecular docking --- atrial --- fibrillation --- venous --- thrombosis --- anticoagulation --- perception --- chronic obstructive pulmonary disease --- atrial fibrillation --- cardiovascular risk --- outcome --- prognosis --- novel oral anticoagulants --- prosthetic valve replacement --- subclinical atrial fibrillation --- stroke --- ischemic cerebral events --- catheter ablation --- screening --- cognitive impairment --- atrial fibrillation ablation --- iatrogenic interatrial septum defect --- paradoxical embolism --- anticoagulant interruption --- cardioversion --- oral anticoagulation therapy --- left atrial appendage thrombosis --- transesophageal echocardiography --- IL1B --- IL1RN --- polymorphism --- inflammation --- cognitive decline --- rhythm control --- microbleeds --- cerebral ischemia --- diabetes mellitus --- metformin --- thiazolidinediones --- GLP-1 receptor agonists --- SGLT-2 inhibitors --- atrial high rate episodes --- NOACs --- non vitamin K oral anticoagulants --- oral anticoagulation --- intracerebral hemorrhage --- cerebral small vessel disease --- brain MRI --- circulating biomarkers --- direct oral anticoagulants (DOACs) --- atrial fibrillation (AF) --- electrical cardioversion (EC) --- surgical cryoablation --- left atrial function --- minimally invasive mitral valve repair --- echocardiography --- aneurysmal subarachnoid hemorrhage --- interdisciplinary setting --- metabolic syndrome --- obesity --- dementia