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Over the last few decades, remarkable progress has been made in understanding the aetiology and pathophysiology of diseases and many new theories emphasize the importance of the small bowel ‘ecosystem’ in the pathogenesis of acute and chronic illness. Emerging factors such as microbiome, stem cells, innate intestinal immunity and the enteric nervous system along with mucosal and endothelial barriers have key role in the development of gastrointestinal and extra-intestinal diseases. Therefore, the small intestine is considered key player in metabolic disease development, including diabetes mellitus, and other diet-related disorders such as celiac and non-celiac enteropathies. Another major field is drug metabolism and its interaction with microbiota. Moreover, the emergence of gut-brain, gut-liver and gut-blood barriers points toward the important role of small intestine in the pathogenesis of common disorders, such as liver disease, hypertension and neurodegenerative disease. However, the small bowel remains an organ that is difficult to fully access and assess and accurate diagnosis often poses a clinical challenge. Eventually, the therapeutic potential remains untapped. Therefore, it is due time to direct our interest towards the small intestine and unravel the interplay between small-bowel and other gastrointestinal (GI) and non-GI related maladies.

Research & information: general --- Biology, life sciences --- capsule endoscopy --- Crohn’s disease --- mucosal healing --- small bowel --- gut brain axis --- microbiota --- functional gastrointestinal disorders --- inflammatory bowel disease (IBD) --- adult stem cells --- surgical site infections (SSIs) --- probiotics --- prebiotics --- synbiotics --- surgery --- adverse events --- meta-analysis --- systematic review --- hyperspectral imaging --- multispectral imaging --- clinical diagnosis --- biomedical optical imaging --- gastroenterology --- medical diagnostic imaging --- small-bowel mass --- small-bowel bulge --- video capsule endoscopy --- cystic fibrosis --- gut microbiota --- intestinal inflammation --- fecal calprotectin --- dysbiosis index --- celiac disease --- biomarker --- serology --- enteropathy --- n/a --- colon cancer --- cancer risk --- collagenous colitis --- lung cancer --- microscopic colitis --- skin cancer --- squamous cell carcinoma --- Crohn's disease

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Over the last few decades, remarkable progress has been made in understanding the aetiology and pathophysiology of diseases and many new theories emphasize the importance of the small bowel ‘ecosystem’ in the pathogenesis of acute and chronic illness. Emerging factors such as microbiome, stem cells, innate intestinal immunity and the enteric nervous system along with mucosal and endothelial barriers have key role in the development of gastrointestinal and extra-intestinal diseases. Therefore, the small intestine is considered key player in metabolic disease development, including diabetes mellitus, and other diet-related disorders such as celiac and non-celiac enteropathies. Another major field is drug metabolism and its interaction with microbiota. Moreover, the emergence of gut-brain, gut-liver and gut-blood barriers points toward the important role of small intestine in the pathogenesis of common disorders, such as liver disease, hypertension and neurodegenerative disease. However, the small bowel remains an organ that is difficult to fully access and assess and accurate diagnosis often poses a clinical challenge. Eventually, the therapeutic potential remains untapped. Therefore, it is due time to direct our interest towards the small intestine and unravel the interplay between small-bowel and other gastrointestinal (GI) and non-GI related maladies.

Research & information: general --- Biology, life sciences --- capsule endoscopy --- Crohn's disease --- mucosal healing --- small bowel --- gut brain axis --- microbiota --- functional gastrointestinal disorders --- inflammatory bowel disease (IBD) --- adult stem cells --- surgical site infections (SSIs) --- probiotics --- prebiotics --- synbiotics --- surgery --- adverse events --- meta-analysis --- systematic review --- hyperspectral imaging --- multispectral imaging --- clinical diagnosis --- biomedical optical imaging --- gastroenterology --- medical diagnostic imaging --- small-bowel mass --- small-bowel bulge --- video capsule endoscopy --- cystic fibrosis --- gut microbiota --- intestinal inflammation --- fecal calprotectin --- dysbiosis index --- celiac disease --- biomarker --- serology --- enteropathy --- colon cancer --- cancer risk --- collagenous colitis --- lung cancer --- microscopic colitis --- skin cancer --- squamous cell carcinoma --- capsule endoscopy --- Crohn's disease --- mucosal healing --- small bowel --- gut brain axis --- microbiota --- functional gastrointestinal disorders --- inflammatory bowel disease (IBD) --- adult stem cells --- surgical site infections (SSIs) --- probiotics --- prebiotics --- synbiotics --- surgery --- adverse events --- meta-analysis --- systematic review --- hyperspectral imaging --- multispectral imaging --- clinical diagnosis --- biomedical optical imaging --- gastroenterology --- medical diagnostic imaging --- small-bowel mass --- small-bowel bulge --- video capsule endoscopy --- cystic fibrosis --- gut microbiota --- intestinal inflammation --- fecal calprotectin --- dysbiosis index --- celiac disease --- biomarker --- serology --- enteropathy --- colon cancer --- cancer risk --- collagenous colitis --- lung cancer --- microscopic colitis --- skin cancer --- squamous cell carcinoma

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This Special Issue is dedicated to neuroendocrine neoplasms (NENs), a category of malignancy that demonstrates wide clinical heterogeneity, posing major challenges in diagnosis and management. There have been significant advances in the field of NEN genomics, pathology, imaging, and treatment over the past five years. NENs are examples of rare tumours (although their incidence and prevalence are increasing) where international collaborative efforts have allowed the generation of high-level evidence to guide optimal patient-centred care. This issue presents both reviews and original papers to provide comprehensive state-of-the-art understanding of this fascinating disease.

small bowel neuroendocrine tumours --- pancreatic neuroendocrine tumours --- liver metastases --- midgut --- meta-analysis --- neuroendocrine tumors --- carcinoid heart disease --- carcinoid syndrome --- somatostatin analogues --- metastases --- multidisciplinary --- management --- outcome --- grading --- staging --- neuroendocrine neoplasms --- chemotherapy --- temozolomide --- metronomic treatment --- second-line --- NOTCH --- cancer-driven genes --- mutational mechanism --- germline mutations --- small cell lung carcinoma --- pancreatic NET --- small bowel NET --- medullary thyroid carcinoma --- malignant castration-resistant prostatic cells --- quality performance indicators --- QPIs --- cancer care --- neuroendocrine tumour --- NETs --- modified Delphi --- CommNETs --- pancreatic neuroendocrine neoplasms --- neuroendocrine tumor --- long-term functional outcomes --- pancreatectomy --- diabetes mellitus --- pancreatic exocrine insufficiency --- body mass index --- parenchyma-sparing surgery --- neuroendocrine tumours --- curative surgery --- resection --- follow-up --- guidelines --- relapse --- recurrence --- risk factor --- mixed non-neuroendocrine neuroendocrine neoplasms --- MiNENs --- mixed adeno-neuroendocrine carcinoma --- MANEC --- 2017 WHO classification --- 2019 WHO classification