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Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.

HOTAIR --- neurosciences --- sleep disturbance --- positron emission tomography (PET) --- vitamin B complex --- neurodegeneration --- Tau --- miR-15/107 --- default-mode network --- complement receptor 1 --- neuronal differentiation --- epigenetics --- brain glucose metabolism --- oligomerization --- genetic risk --- A?O receptors --- prion --- ryanodine receptor --- type 3 diabetes --- complement --- cognitive behavioral therapy for insomnia --- cognitive function --- epigenome-wide association study --- Alzheimer’s disease --- calcium signaling --- ?-secretase --- tau --- Prolyl isomerases --- NEAT1 --- complement C3b/C4b receptor --- proteostasis --- amyloid beta --- yeast --- slow-wave sleep --- amyloid ? --- nutrition --- 4 --- protein aggregation --- apolipoprotein E --- dementia --- MALAT1 --- inositol 1 --- lncRNAs --- molecular biology --- methylenetetrahydrofolate reductase MTHFR gene --- 5-trisphosphate receptor --- CR1 density --- miR-34c --- aggregation --- heat shock protein --- dendritic spine --- S-adenosylmethionine --- beta amyloid --- ion channel --- inflammation --- sleep fragmentation --- cystathionine-?-lyase CTH gene --- DNA methylation --- heat shock response --- microglia --- drug target discovery --- amyloid-? oligomer --- therapy --- CR1 length polymorphism --- methylome --- APOE gene --- ubiquitin --- magnetic resonance imaging (MRI) --- neuronal degeneration --- type 2 diabetes --- Pin1 --- mild cognitive impairment --- dairy products --- endoplasmic reticulum --- oxidative stress --- Hispanics --- CDK5R1

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Fatigue --- Automotive medicine --- Dyssomnias --- Sleep --- Technology, Industry, and Agriculture --- Signs and Symptoms --- Sleep Disorders --- Psychophysiology --- Nervous System Physiological Processes --- Pathological Conditions, Signs and Symptoms --- Neurologic Manifestations --- Technology, Industry, Agriculture --- Psychological Phenomena and Processes --- Mental Disorders --- Nervous System Diseases --- Diseases --- Nervous System Physiological Phenomena --- Psychiatry and Psychology --- Musculoskeletal and Neural Physiological Phenomena --- Phenomena and Processes --- Sleep Deprivation --- Transportation --- Medicine --- Health & Biological Sciences --- Transportation Medicine & Physiology --- Psychologic Processes --- Psychologic Processes and Principles --- Psychological Processes --- Phenomena, Psychological --- Processes, Psychologic --- Processes, Psychological --- Psychological Phenomenas --- Psychological Processe --- Focal Neurologic Deficits --- Manifestations, Neurologic --- Manifestations, Neurological --- Neurologic Dysfunction --- Neurologic Findings --- Neurologic Manifestation --- Neurologic Signs --- Neurologic Symptoms --- Neurological Manifestations --- Neurologic Deficits --- Neurologic Signs and Symptoms --- Deficit, Focal Neurologic --- Deficit, Neurologic --- Deficits, Focal Neurologic --- Deficits, Neurologic --- Dysfunction, Neurologic --- Dysfunctions, Neurologic --- Finding, Neurologic --- Findings, Neurologic --- Focal Neurologic Deficit --- Manifestation, Neurologic --- Manifestation, Neurological --- Neurologic Deficit --- Neurologic Deficit, Focal --- Neurologic Deficits, Focal --- Neurologic Dysfunctions --- Neurologic Finding --- Neurologic Sign --- Neurologic Symptom --- Neurological Manifestation --- Sign, Neurologic --- Signs, Neurologic --- Symptom, Neurologic --- Symptoms, Neurologic --- Nervous System --- Symptoms and General Pathology --- Nervous System Physiological Concepts --- Nervous System Physiological Phenomenon --- Nervous System Physiological Process --- Physiology, Nervous System --- Nervous System Physiologic Processes --- Nervous System Physiology --- System Physiology, Nervous --- Mind-Body Relationship (Physiology) --- Physiologic Psychology --- Physiological Psychology --- Psychology, Physiologic --- Mind-Body Relations (Physiology) --- Psychology, Physiological --- Mind Body Relations (Physiology) --- Mind Body Relationship (Physiology) --- Mind-Body Relation (Physiology) --- Mind-Body Relationships (Physiology) --- Physiologic Psychologies --- Psychologies, Physiologic --- Relation, Mind-Body (Physiology) --- Relations, Mind-Body (Physiology) --- Relationship, Mind-Body (Physiology) --- Relationships, Mind-Body (Physiology) --- Psychosomatic Medicine --- Mind-Body Relations, Metaphysical --- Long Sleeper Syndrome --- Short Sleep Phenotype --- Short Sleeper Syndrome --- Sleep-Related Neurogenic Tachypnea --- Subwakefullness Syndrome --- Disorder, Sleep --- Disorder, Sleep Wake --- Disorders, Sleep --- Disorders, Sleep Wake --- Long Sleeper Syndromes --- Neurogenic Tachypnea, Sleep-Related --- Neurogenic Tachypneas, Sleep-Related --- Phenotype, Short Sleep --- Phenotypes, Short Sleep --- Short Sleep Phenotypes --- Short Sleeper Syndromes --- Sleep Disorder --- Sleep Phenotypes, Short --- Sleep Related Neurogenic Tachypnea --- Sleep Wake Disorder --- Sleep-Related Neurogenic Tachypneas --- Sleeper Syndrome, Long --- Sleeper Syndrome, Short --- Sleeper Syndromes, Long --- Sleeper Syndromes, Short --- Subwakefullness Syndromes --- Syndrome, Long Sleeper --- Syndrome, Short Sleeper --- Syndrome, Subwakefullness --- Syndromes, Long Sleeper --- Syndromes, Short Sleeper --- Syndromes, Subwakefullness --- Tachypnea, Sleep-Related Neurogenic --- Tachypneas, Sleep-Related Neurogenic --- Wake Disorder, Sleep --- Wake Disorders, Sleep --- Sleep Hygiene --- Symptoms and Signs --- Sleep Habits --- Sleeping Habit --- Sleeping Habits --- Habit, Sleep --- Habit, Sleeping --- Habits, Sleep --- Habits, Sleeping --- Sleep Habit --- Sleepiness --- Adjustment Sleep Disorder --- Environmental Sleep Disorder --- Limit-Setting Sleep Disorder --- Nocturnal Eating-Drinking Syndrome --- Sleep Disorder, Adjustment --- Sleep Disorder, Environmental --- Sleep Disorder, Limit-Setting --- Sleep Disorders, Extrinsic --- Adjustment Sleep Disorders --- Dyssomnia --- Eating-Drinking Syndrome, Nocturnal --- Eating-Drinking Syndromes, Nocturnal --- Environmental Sleep Disorders --- Extrinsic Sleep Disorder --- Extrinsic Sleep Disorders --- Limit Setting Sleep Disorder --- Limit-Setting Sleep Disorders --- Nocturnal Eating Drinking Syndrome --- Nocturnal Eating-Drinking Syndromes --- Sleep Disorder, Extrinsic --- Sleep Disorder, Limit Setting --- Sleep Disorders, Adjustment --- Sleep Disorders, Environmental --- Sleep Disorders, Limit-Setting --- Syndrome, Nocturnal Eating-Drinking --- Syndromes, Nocturnal Eating-Drinking --- Automobile driving, Medical aspects of --- Transportation medicine --- Exhaustion --- Lassitude --- Tiredness --- Weariness --- Physiology --- Symptoms --- Rest --- Commuting --- Asthenia --- Physical Exertion --- Inadequate Sleep --- Insufficient Sleep --- Insufficient Sleep Syndrome --- REM Sleep Deprivation --- Sleep Debt --- Sleep Fragmentation --- Sleep Insufficiency --- Deprivation, REM Sleep --- Deprivation, Sleep --- Fragmentation, Sleep --- Insufficiencies, Sleep --- Insufficiency, Sleep --- Insufficient Sleep Syndromes --- Sleep Deprivation, REM --- Sleep Insufficiencies --- Sleep, Inadequate --- Sleep, Insufficient --- Syndrome, Insufficient Sleep --- Musculoskeletal and Neural Physiological Concepts --- Musculoskeletal and Neural Physiological Phenomenon --- Musculoskeletal and Neural Physiology --- Nervous System Disorders --- Neurological Disorders --- Neurologic Disorders --- Disease, Nervous System --- Diseases, Nervous System --- Disorder, Nervous System --- Disorder, Neurologic --- Disorder, Neurological --- Disorders, Nervous System --- Disorders, Neurologic --- Disorders, Neurological --- Nervous System Disease --- Nervous System Disorder --- Neurologic Disorder --- Neurological Disorder --- Neurology --- Behavior Disorders --- Diagnosis, Psychiatric --- Mental Disorders, Severe --- Psychiatric Diagnosis --- Mental Illness --- Psychiatric Diseases --- Psychiatric Disorders --- Psychiatric Illness --- Illness, Mental --- Mental Disorder --- Mental Disorder, Severe --- Mental Illnesses --- Psychiatric Disease --- Psychiatric Disorder --- Psychiatric Illnesses --- Severe Mental Disorder --- Severe Mental Disorders --- Mentally Ill Persons --- Congresses --- physiology --- Sleep Deprivation. --- Transportation. --- prevention & control. --- Transport. Traffic --- Personnel management