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Polyphenols are a heterogeneous group of bioactive compounds mainly found in plant-based foods. Numerous clinical and epidemiological studies have led to the result that polyphenol intake may protect against chronic diseases such as cardiovascular and neurodegenerative diseases, cancer, or type 2 diabetes, to name some. Polyphenol intake estimation can be obtained through food frequency questionnaires and nutritional biomarkers, both having their own advantages and disadvantages. Although the association between these bioactive compounds and health seems irrefutable, many questions remain still unanswered. For instance, more studies are needed to identify possible interactions and effect-modulating variables, such as smoking habit, body mass index, sex, alcohol, hormones, other foods, etc. Moreover, intestinal microbiota seems to play an important role in the metabolism of polyphenols, but it is still unclear how.

Research & information: general --- Biology, life sciences --- polyphenols --- metabolic syndrome --- Mediterranean diet --- glignans --- stilbenes --- HDL-cholesterol --- polyphenol --- diabetes --- flavonoids --- catechins --- black sorghum --- platelets --- platelet microparticles --- atherosclerosis --- rice bran --- phenolic extracts --- β-cell function --- gene expression --- insulin secretion --- sleep disorders --- sleep duration --- urinary phytoestrogens --- concentration–response --- NHANES --- cognition --- attention --- memory --- brain --- mangiferin --- mango leaf extract --- non-alcoholic fatty liver disease --- obesity --- lipid metabolism --- metabolic regulation --- adipose tissue --- fruits --- berries --- vegetables --- dark chocolate --- psychological well-being --- depression --- physical health --- mental health --- isoflavones --- soy --- dietary flavonoids --- lignans --- flaxseeds --- endocrine --- stages of life --- estrogenic --- health --- nursing home --- residential care --- aging --- menu --- phenolic acids --- n/a --- concentration-response

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Polyphenols are a heterogeneous group of bioactive compounds mainly found in plant-based foods. Numerous clinical and epidemiological studies have led to the result that polyphenol intake may protect against chronic diseases such as cardiovascular and neurodegenerative diseases, cancer, or type 2 diabetes, to name some. Polyphenol intake estimation can be obtained through food frequency questionnaires and nutritional biomarkers, both having their own advantages and disadvantages. Although the association between these bioactive compounds and health seems irrefutable, many questions remain still unanswered. For instance, more studies are needed to identify possible interactions and effect-modulating variables, such as smoking habit, body mass index, sex, alcohol, hormones, other foods, etc. Moreover, intestinal microbiota seems to play an important role in the metabolism of polyphenols, but it is still unclear how.

Research & information: general --- Biology, life sciences --- polyphenols --- metabolic syndrome --- Mediterranean diet --- glignans --- stilbenes --- HDL-cholesterol --- polyphenol --- diabetes --- flavonoids --- catechins --- black sorghum --- platelets --- platelet microparticles --- atherosclerosis --- rice bran --- phenolic extracts --- β-cell function --- gene expression --- insulin secretion --- sleep disorders --- sleep duration --- urinary phytoestrogens --- concentration-response --- NHANES --- cognition --- attention --- memory --- brain --- mangiferin --- mango leaf extract --- non-alcoholic fatty liver disease --- obesity --- lipid metabolism --- metabolic regulation --- adipose tissue --- fruits --- berries --- vegetables --- dark chocolate --- psychological well-being --- depression --- physical health --- mental health --- isoflavones --- soy --- dietary flavonoids --- lignans --- flaxseeds --- endocrine --- stages of life --- estrogenic --- health --- nursing home --- residential care --- aging --- menu --- phenolic acids --- polyphenols --- metabolic syndrome --- Mediterranean diet --- glignans --- stilbenes --- HDL-cholesterol --- polyphenol --- diabetes --- flavonoids --- catechins --- black sorghum --- platelets --- platelet microparticles --- atherosclerosis --- rice bran --- phenolic extracts --- β-cell function --- gene expression --- insulin secretion --- sleep disorders --- sleep duration --- urinary phytoestrogens --- concentration-response --- NHANES --- cognition --- attention --- memory --- brain --- mangiferin --- mango leaf extract --- non-alcoholic fatty liver disease --- obesity --- lipid metabolism --- metabolic regulation --- adipose tissue --- fruits --- berries --- vegetables --- dark chocolate --- psychological well-being --- depression --- physical health --- mental health --- isoflavones --- soy --- dietary flavonoids --- lignans --- flaxseeds --- endocrine --- stages of life --- estrogenic --- health --- nursing home --- residential care --- aging --- menu --- phenolic acids

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Sarcopenia represents the decline in skeletal muscle mass and function with age, characterized by the muscle fiber's quality, strength, muscle endurance, and metabolic ability decreasing, as well as the fat and connective tissue growing.Reduction of muscle strength with aging leads to loss of functional capacity, causing disability, mortality, and other adverse health outcomes. Because of the increase of the proportion of elderly in the population, sarcopenia-related morbidity will become an increasing area of health care resource utilization.Diagnostic screening consists of individuation of body composition, assessed by DEXA, anthropometry, bioelectrical impedance, MRI, or CT scan. Management is possible with resistance training exercise and vibration therapy, nutritional supplements, and pharmacological treatment.The book includes articles from different nationalities, treating the experimental and medical applications of sarcopenia. The consequences of sarcopenia in frailty are treated in relation to other associated pathologies or lesions, as femoral neck fractures and hepatocellular carcinoma.

muscle-mass --- sleep efficiency --- sleep duration --- insomnia --- sarcopenia --- quality of life --- osteoporosis --- postmenopausal women --- sedentary behaviour --- aged --- exercise --- motivation --- hepatoma --- myokine --- decorin --- walking distance --- survival --- muscle strength --- resistance training --- randomized controlled trial --- nutritional status --- nutritional screening tools --- hospitalized older patients --- resistance exercise training --- muscle regulatory factors --- deconditioning --- skeletal muscle --- elderly --- hypertrophy --- multimorbidity --- polypathological patients --- frailty --- oxidative stress --- telomere length --- apoptosis --- spirometry --- urea --- fatigue --- respiratory system --- skeletal muscles --- lipids --- transaminases --- falls --- resistance exercise --- vibration --- electrical stimulation --- hip fracture --- diagnosis --- treatment --- prevention --- dual-energy X-ray absorptiometry --- bisphosphonate --- β-hydroxy-β-methylbutyrate --- exercise intervention --- fall risk --- balance --- anxiety --- depression --- sleep quality --- type 2 diabetes --- physical activity --- muscle mass --- protein intake --- accelerometer --- aerobic exercise training --- mitochondria --- endurance --- fractures --- ageing fractures --- complications --- recovery --- rehabilitation --- nutritional supplements --- physical therapy --- cognition --- brain-body cross-talk --- older persons --- prevalence --- physical functional performance --- epidemiologic studies --- aging --- panoramic ultrasound --- echogenicity --- specific force --- isokinetic dynamometry --- muscle quality --- strength --- older adults --- diagnostic criteria --- clinical

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Metabolic syndrome has been the topic of countless publications. It still remains a subject of debate and some experts have even questioned its clinical relevance. Its diagnosis is nevertheless predictive of an increased risk of type 2 diabetes and cardiovascular disease even in the absence of traditional risk factors. Many years ago, our team made the point that the most prevalent form of metabolic syndrome was linked to abdominal obesity, which can be found even among individuals who are not considered obese by body weight standards. Imaging techniques such as computed tomography and magnetic resonance imaging have revealed the link between regional body fat partitioning and cardiometabolic risk. Visceral obesity is the most dangerous form of obesity, with subcutaneous obesity being associated with lower health risk. We have proposed that excess visceral fat may be a marker of subcutaneous adipose tissue dysfunction not being able to serve as a metabolic sink, causing lipid accumulation at undesired sites, a condition described as ectopic fat deposition. Among the effective approaches to prevent, delay, or manage metabolic syndrome, lifestyle changes are the key elements, with an emphasis on the importance of healthy global dietary patterns, regular physical activity, and adequate sleep quality.

Humanities --- Social interaction --- trimethylamine N-oxide (TMAO) --- obesity --- visceral adiposity index (VAI) --- fatty liver index (FLI) --- metabolic syndrome (MetS) --- healthy lifestyle score --- metabolic syndrome --- SUN cohort --- branched-chain amino acids --- acylcarnitines --- dietary protein sources --- meat --- metabolite profiling --- diet --- pediatric obesity --- nonalcoholic fatty liver disease --- saliva --- metabolomics --- gas-chromatography mass spectrometry --- anthropometric indexes --- diagnosis criteria --- adolescents --- bone mineral density --- insulin resistance --- bone health --- osteoporosis --- atherosclerotic cardiovascular disease --- visceral fat accumulation --- universal public health screening program --- health check-up --- health guidance --- city planning --- carbohydrate --- polyunsaturated fat --- monounsaturated fat --- saturated fat --- fish oil --- meta-analyses --- lipids --- glucose --- blood pressure --- breastfeeding duration --- birth weight --- cardiorespiratory fitness --- cardiovascular disease --- exercise training --- linseed --- secoisolariciresinol diglucoside --- high-carbohydrate --- high-fat diet --- anthropometric indices --- cardiometabolic risk --- elderly --- risk --- pediatric --- adolescent --- sugar-sweetened beverages --- weight gain --- type 2 diabetes --- older adults --- macronutrient intake --- dietary intake --- fat intake --- endocannabinoids --- endocannabinoidome --- microbiome --- fructose --- hypertriglyceridemia --- metabolism --- sleep --- sleep apnea --- sleep habit --- sleep duration --- chronotype --- social jetlag --- ethnicity --- prevention --- lifestyle --- cardiometabolic --- exercise --- abdominal obesity --- energy balance --- caloric restriction --- non-alcoholic fatty liver disease --- physical activity --- saturated fatty acids --- diet quality --- dietary guidelines --- trimethylamine N-oxide (TMAO) --- obesity --- visceral adiposity index (VAI) --- fatty liver index (FLI) --- metabolic syndrome (MetS) --- healthy lifestyle score --- metabolic syndrome --- SUN cohort --- branched-chain amino acids --- acylcarnitines --- dietary protein sources --- meat --- metabolite profiling --- diet --- pediatric obesity --- nonalcoholic fatty liver disease --- saliva --- metabolomics --- gas-chromatography mass spectrometry --- anthropometric indexes --- diagnosis criteria --- adolescents --- bone mineral density --- insulin resistance --- bone health --- osteoporosis --- atherosclerotic cardiovascular disease --- visceral fat accumulation --- universal public health screening program --- health check-up --- health guidance --- city planning --- carbohydrate --- polyunsaturated fat --- monounsaturated fat --- saturated fat --- fish oil --- meta-analyses --- lipids --- glucose --- blood pressure --- breastfeeding duration --- birth weight --- cardiorespiratory fitness --- cardiovascular disease --- exercise training --- linseed --- secoisolariciresinol diglucoside --- high-carbohydrate --- high-fat diet --- anthropometric indices --- cardiometabolic risk --- elderly --- risk --- pediatric --- adolescent --- sugar-sweetened beverages --- weight gain --- type 2 diabetes --- older adults --- macronutrient intake --- dietary intake --- fat intake --- endocannabinoids --- endocannabinoidome --- microbiome --- fructose --- hypertriglyceridemia --- metabolism --- sleep --- sleep apnea --- sleep habit --- sleep duration --- chronotype --- social jetlag --- ethnicity --- prevention --- lifestyle --- cardiometabolic --- exercise --- abdominal obesity --- energy balance --- caloric restriction --- non-alcoholic fatty liver disease --- physical activity --- saturated fatty acids --- diet quality --- dietary guidelines

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Metabolic syndrome has been the topic of countless publications. It still remains a subject of debate and some experts have even questioned its clinical relevance. Its diagnosis is nevertheless predictive of an increased risk of type 2 diabetes and cardiovascular disease even in the absence of traditional risk factors. Many years ago, our team made the point that the most prevalent form of metabolic syndrome was linked to abdominal obesity, which can be found even among individuals who are not considered obese by body weight standards. Imaging techniques such as computed tomography and magnetic resonance imaging have revealed the link between regional body fat partitioning and cardiometabolic risk. Visceral obesity is the most dangerous form of obesity, with subcutaneous obesity being associated with lower health risk. We have proposed that excess visceral fat may be a marker of subcutaneous adipose tissue dysfunction not being able to serve as a metabolic sink, causing lipid accumulation at undesired sites, a condition described as ectopic fat deposition. Among the effective approaches to prevent, delay, or manage metabolic syndrome, lifestyle changes are the key elements, with an emphasis on the importance of healthy global dietary patterns, regular physical activity, and adequate sleep quality.

trimethylamine N-oxide (TMAO) --- obesity --- visceral adiposity index (VAI) --- fatty liver index (FLI) --- metabolic syndrome (MetS) --- healthy lifestyle score --- metabolic syndrome --- SUN cohort --- branched-chain amino acids --- acylcarnitines --- dietary protein sources --- meat --- metabolite profiling --- diet --- pediatric obesity --- nonalcoholic fatty liver disease --- saliva --- metabolomics --- gas-chromatography mass spectrometry --- anthropometric indexes --- diagnosis criteria --- adolescents --- bone mineral density --- insulin resistance --- bone health --- osteoporosis --- atherosclerotic cardiovascular disease --- visceral fat accumulation --- universal public health screening program --- health check-up --- health guidance --- city planning --- carbohydrate --- polyunsaturated fat --- monounsaturated fat --- saturated fat --- fish oil --- meta-analyses --- lipids --- glucose --- blood pressure --- breastfeeding duration --- birth weight --- cardiorespiratory fitness --- cardiovascular disease --- exercise training --- linseed --- secoisolariciresinol diglucoside --- high-carbohydrate --- high-fat diet --- anthropometric indices --- cardiometabolic risk --- elderly --- risk --- pediatric --- adolescent --- sugar-sweetened beverages --- weight gain --- type 2 diabetes --- older adults --- macronutrient intake --- dietary intake --- fat intake --- endocannabinoids --- endocannabinoidome --- microbiome --- fructose --- hypertriglyceridemia --- metabolism --- sleep --- sleep apnea --- sleep habit --- sleep duration --- chronotype --- social jetlag --- ethnicity --- prevention --- lifestyle --- cardiometabolic --- exercise --- abdominal obesity --- energy balance --- caloric restriction --- non-alcoholic fatty liver disease --- physical activity --- saturated fatty acids --- diet quality --- dietary guidelines --- n/a