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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Science: general issues --- Physiology --- Cutaneous wound healing --- Skin Regeneration --- Skin substitutes --- engineered scaffolds --- Cutaneous wound healing --- Skin Regeneration --- Skin substitutes --- engineered scaffolds

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Why This Volume? The title of this volume reads like an oxymoron.After all, it is well known that,whether animal or human,adults do not spontaneously regenerate any of their organs that have been lost to accidental trauma or to surgery. If mammals could somehow regenerate organs such as the skin of a hand lost to a burn or a breast lost to mastectomy, scars should not ?ll the anato- cal site of the lost organ; instead,a regrown organ should emerge.If reg- eration were possible, treatments might also be developed for potentially lethal degenerative conditions such as a scarred heart muscle or a cirrhotic liver. The concept of induced organ regeneration in adults is relatively new. The deliberate modi?cation of healing to achieve regrowth of lost tissue structures does not follow directly from current mainstream paradigms of biological research.The ?rst tentative recognition that the healing process could be modi?ed to induce regeneration of the dermis, a tissue that does not spontaneously regenerate in adults, appeared in reports published in the early 1980s. Eventually, other organs, including peripheral nerves and the eye conjunctiva, were induced to regenerate in anatomical wounds known to be incapable of supporting spontaneous regeneration. The data on induced regeneration are scattered in a variety of journals, book chapters,abstracts,and theses.It is time to marshal the extensive e- dence.This is the main reason for writing this volume.

Nerves --- Regeneration (Biology). --- Skin --- Regeneration. --- Nerves -- Regeneration. --- Skin -- Regeneration. --- Integumentary System Physiological Phenomena --- Nerve Regeneration --- Skin Physiological Phenomena --- Peripheral Nerves --- Regeneration (Biology) --- Medicine. --- Molecular biology. --- Dermatology. --- Neurology. --- Medicine & Public Health. --- Medicine/Public Health, general. --- Molecular Medicine. --- Neurology . --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Medicine --- Nervous system --- Neuropsychiatry --- Health Workforce --- Diseases

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New approaches to deal with the growing concern associated with antibiotic-resistant bacteria are in great demand. For many years, antibiotics have widely been employed to treat infections. However, their excessive consumption and misuse have accelerated the rise of antibiotic-resistant microorganisms, which constitute a major challenge to global health. The antibiotic crisis is now a general concern; therefore, alternative biomolecules or drug delivery systems to treat infections are urgently needed. From natural extracts to traditional medicine remedies, to newly engineered nanocapsules and nanoparticles, to bio-based, biodegradable delivery platforms, many systems to fight infections are explored in this book.

Research & information: general --- Chemistry --- nanoparticles --- 4-Nerolidylcatechol --- antifungals --- Microsporum canis --- polycaprolactone --- nanoprecipitation --- silver nanoparticles --- green synthesis method --- Catharanthus roseus --- Azadirachta indica --- multidrug-resistant bacteria --- wound healing --- nosocomial infection --- plant extract --- grapefruit seed extract --- antibacterial activity --- fiber-hydrogel composite --- biodegradable polymers --- skin regeneration --- drug delivery platforms --- controlled release --- tetramycin --- antimicrobial activity --- kiwifruit disease --- conventional antibiotics --- storage quality --- gold nanoparticles --- flavonoids --- Gram-negative bacteria --- DNA gyrase --- in silico --- multidrug-resistant Acinetobacter baumannii (MDR-AB) --- hypertonic saline --- antibiotics --- biofilm --- aerosol delivery --- ultrahigh-throughput screening --- live biosensors --- antibiotic discovery --- gram-negative pathogens --- microfluidic droplet cocultivation --- efficient promoters --- polymyxins --- colistin biosynthetic gene cluster --- single cell --- multi-omics --- quercetin --- magnesium-doped calcium silicate --- osteogenic activity --- bone regeneration and nanofiber scaffold --- bulk-tank milk --- mastitis --- methicillin --- milk --- goat --- somatic cell counts --- staphylococcus --- tetracycline --- total bacterial counts --- prosthetic joint infection --- local prevention --- allicin --- chitosan --- Sphaerotheca sp. --- antibiotic --- Rosa roxburghii --- cyclic diphenylphosphonate --- quinoline --- DNA gyrase inhibitor --- molecular docking --- magnesium ion --- nanoparticles --- 4-Nerolidylcatechol --- antifungals --- Microsporum canis --- polycaprolactone --- nanoprecipitation --- silver nanoparticles --- green synthesis method --- Catharanthus roseus --- Azadirachta indica --- multidrug-resistant bacteria --- wound healing --- nosocomial infection --- plant extract --- grapefruit seed extract --- antibacterial activity --- fiber-hydrogel composite --- biodegradable polymers --- skin regeneration --- drug delivery platforms --- controlled release --- tetramycin --- antimicrobial activity --- kiwifruit disease --- conventional antibiotics --- storage quality --- gold nanoparticles --- flavonoids --- Gram-negative bacteria --- DNA gyrase --- in silico --- multidrug-resistant Acinetobacter baumannii (MDR-AB) --- hypertonic saline --- antibiotics --- biofilm --- aerosol delivery --- ultrahigh-throughput screening --- live biosensors --- antibiotic discovery --- gram-negative pathogens --- microfluidic droplet cocultivation --- efficient promoters --- polymyxins --- colistin biosynthetic gene cluster --- single cell --- multi-omics --- quercetin --- magnesium-doped calcium silicate --- osteogenic activity --- bone regeneration and nanofiber scaffold --- bulk-tank milk --- mastitis --- methicillin --- milk --- goat --- somatic cell counts --- staphylococcus --- tetracycline --- total bacterial counts --- prosthetic joint infection --- local prevention --- allicin --- chitosan --- Sphaerotheca sp. --- antibiotic --- Rosa roxburghii --- cyclic diphenylphosphonate --- quinoline --- DNA gyrase inhibitor --- molecular docking --- magnesium ion