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Skin Neoplasms. --- Cancer of the Skin --- Neoplasms, Skin --- Cancer of Skin --- Skin Cancer --- Cancer, Skin --- Cancers, Skin --- Neoplasm, Skin --- Skin Cancers --- Skin Neoplasm --- Skin --- Cancer --- Cancer. --- Cutis --- Integument (Skin) --- Beauty, Personal --- Body covering (Anatomy)

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Pathological dermatology --- Oncology. Neoplasms --- Skin Neoplasms. --- Skin --- -Cutis --- Integument (Skin) --- Beauty, Personal --- Body covering (Anatomy) --- Cancer of the Skin --- Neoplasms, Skin --- Cancer of Skin --- Skin Cancer --- Cancer, Skin --- Cancers, Skin --- Neoplasm, Skin --- Skin Cancers --- Skin Neoplasm --- Tumors --- -Atlases --- Atlases. --- -Tumors --- Skin Neoplasms --- Cutis --- Tumors&delete& --- Atlases

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Pathological dermatology --- Pathological anatomy and histology --- Skin Diseases. --- Skin Manifestations. --- Skin Neoplasms. --- Cancer of the Skin --- Neoplasms, Skin --- Cancer of Skin --- Skin Cancer --- Cancer, Skin --- Cancers, Skin --- Neoplasm, Skin --- Skin Cancers --- Skin Neoplasm --- Manifestation, Skin --- Manifestations, Skin --- Skin Manifestation --- Skin --- Skin Diseases --- Dermatosis --- Dermatoses --- Disease, Skin --- Diseases, Skin --- Skin Disease --- Dermatology --- Skin manifestations --- Skin neoplasms --- Diseases. --- Skin manifestations. --- Skin neoplasms. --- Skin and Subcutaneous Tissue Disorders --- Skin Manifestations --- Skin Neoplasms

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The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this Special Issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting mTOR pathway is a promising strategy to fight against certain human diseases.

mTOR --- histone deacetylase --- prostate cancer --- integrins --- adhesion --- invasion --- cell metabolism --- T cells --- Foxp3 --- Acute Lymphoblastic leukemia --- targeted therapy --- metabolism --- cell signalling --- mTOR signalling --- head and neck cancer --- mutant genes --- biomarkers --- targeted therapies --- clinical trials --- cancers --- inhibitors --- photodynamic therapy --- PI3K --- Akt --- skin cancers --- phytochemicals --- melanoma --- basal cell carcinoma --- squamous cell carcinoma --- Merkel cell carcinoma --- TNBC --- eribulin --- PI3K/AKT/mTOR --- everolimus --- combination --- synergy --- mTOR signaling --- tissue regeneration --- neuron --- muscle --- liver --- intestine --- hematologic malignancies --- regulatory T cells --- tumor

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Cosmetic products undergo nowadays rigorous Quality Control testing to ensure that they are safe and stable and that their claims are substantiated by scientifically robust data. Quality Control tests used in the pharmaceutical industry can be applicable also for cosmetic formulations. However, claim substantiation testing is unique to cosmetic products. To enable time- and cost-effective quality control testing, assessment methodologies constantly keep evolving. This Special Issue includes manuscripts that explore all stages of Quality Control testing for cosmetic products, i.e., (1) physicochemical stability testing; (2) microbial stability testing; (3) efficacy testing including objective/subjective claim substantiation testing and the evaluation of sensorial properties; (4) toxicological/safety testing with emphasis on current and evolving methodologies that replace animal testing.

Research & information: general --- Chemistry --- Physical chemistry --- safety --- cosmetics --- botanicals --- toxicology --- TTC --- solar elastosis --- collagen type I --- solar radiation --- non-melanoma skin cancers --- photoaging --- tattoos --- permanent makeup --- PMU --- colorants --- pigments --- cosmetic product safety --- non-animal-testing methodologies --- dermal absorption --- skin irritation --- skin sensitization --- genotoxicity --- endocrine disruptors --- active compounds --- assay --- cosmeceutics --- functional cosmetics --- HPLC-UV --- labelling --- retinoids --- tocopherol --- ubiquinone --- β carotene --- stability testing --- stability protocol --- accelerated ageing --- shelf life --- minimally disruptive formulas --- direct to consumer --- retail model --- sensory testing --- refractive index --- critical wavelength --- turbidity --- skin hydration --- creams --- safety --- cosmetics --- botanicals --- toxicology --- TTC --- solar elastosis --- collagen type I --- solar radiation --- non-melanoma skin cancers --- photoaging --- tattoos --- permanent makeup --- PMU --- colorants --- pigments --- cosmetic product safety --- non-animal-testing methodologies --- dermal absorption --- skin irritation --- skin sensitization --- genotoxicity --- endocrine disruptors --- active compounds --- assay --- cosmeceutics --- functional cosmetics --- HPLC-UV --- labelling --- retinoids --- tocopherol --- ubiquinone --- β carotene --- stability testing --- stability protocol --- accelerated ageing --- shelf life --- minimally disruptive formulas --- direct to consumer --- retail model --- sensory testing --- refractive index --- critical wavelength --- turbidity --- skin hydration --- creams