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There has been much speculation about a possible antibiotic Armageddon; this would be the result of having untreatable post-operative infections, and similarly untreatable complications after chemotherapy. The now famous “O’Neill Report” (https://amr-review.org/) suggests that more people could die from resistant bacterial infections by 2050 than from cancer. We are still learning about all the subtle drivers of antibiotic resistance, and realizing that we need a single “whole of health” co-ordinated policy. We ingest what we sometimes feed to animals. There do not seem to be any new classes of antibiotics on our horizon. Perhaps something that has been around “forever” will come to our rescue—bacteriophages! Nevertheless, we have to do things differently, use antibiotics appropriately, for the correct indication, for the correct duration and with the correct dose, and with that, practice good antibiotic stewardship. Whilst by no means comprehensive, this book does cover some of the many topics of antibiotic stewardship. It also addresses some of the older antibiotics, some new combinations, and even some new agents. Last, and by no means least, there are two excellent articles on bacteriophages.

Antimicrobial resistance --- antibiotics --- antimicrobial stewardship --- inappropriate prescribing --- days of therapy --- Start Smart then Focus --- piperine --- piperlongumine --- antibacterial --- antifungal --- synergy --- non-target feed --- florfenicol --- thiamfenicol --- chloramfenicol --- HPLC–MS/MS --- validation --- swine --- out-of-hours care --- primary care --- quality of care --- quality indicators --- practitioners cooperative --- antibiotic stewardship --- fluoroquinolones --- guidelines --- urinary tract infections --- quality improvement --- general practitioners --- guideline --- health inequalities --- health equity assessment tool --- public health --- Enterobacteriaceae --- carbapenem-resistant --- CRE --- antibiotic resistance --- antimicrobials --- bacteriophages --- biofilms --- novel antimicrobials --- Antibiotics --- resistance --- broad-spectrum agents --- hospital epidemiology --- antibiotic utilization --- infection control --- infection prevention --- Pseudomonas aeruginosa --- Acinetobacter baumannii --- extended-spectrum beta-lactamases --- carbapenem-resistant Enterobacteriaceae --- methicillin-resistant Staphylococcus aureus --- clinical trials --- infectious disease --- phage therapy --- silver complexes --- camphorimine --- anti-Candida activity --- antifungals --- antibacterials --- efflux inhibitors --- efflux pumps --- erm(41) --- mutations --- mycobacteria --- verapamil --- actinomycetes --- bioactivity --- polyketides --- polyketide synthases --- biosynthesis --- antimicrobial resistance --- economic evaluation --- cost-utility analysis --- cost-effectiveness analysis --- policy analysis --- One Health --- Singapore --- antibiotic prescribing --- implementation --- behavior change --- stakeholder consultation --- n/a --- HPLC-MS/MS

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A collection of essential research articles and scientific reviews covering some of the most pertinent and topical areas of study that currently constitute Inorganic Chemistry in the early 21st century.

Research & information: general --- Chemistry --- Inorganic chemistry --- cyanoguanidine --- silver --- crystal structure --- chemical bonding --- CuII --- pyridine amides --- pyrazine amide --- amino benzamides --- EPR spectroscopy --- lanthanides --- Schiff base --- synthetic strategies --- single-molecule magnets --- Atomic Layer Deposition --- Ni catalyst --- reforming catalyst --- thermodynamics --- metallopharmaceuticals --- cancer stem cells --- copper --- bioinorganic chemistry --- medicinal inorganic chemistry --- reactive oxygen species --- metal-carbonyl complexes --- [FeFe]-hydrogenases --- density functional theory --- time-dependent DFT --- organometallic photochemistry --- crystalline borosilicate --- actinides --- supercritical hydrothermal synthesis --- waste forms --- thorium --- rhenium --- ruthenium --- metal–metal bonds --- uranium --- ceria --- hydrothermal --- catalysis --- nanomaterials --- crystallisation --- 4,2′:6′,4″-terpyridine --- 3,2′:6′,3″-terpyridine --- coordination polymer --- isomers --- lithium --- potassium --- Nacnac --- β-diketiminate --- tricyclohexylphenyl --- steric bulk --- silver complexes --- permanganates --- perchlorates --- perrhenate --- pyridine --- structure --- spectroscopy --- thermal behavior --- heterogenous catalyst --- metal–organic framework (MOF) --- olefin epoxidation --- carbon dioxide cycloaddition --- f-element --- lanthanide --- actinide --- multidentate ligand --- macrocycle --- ammonothermal synthesis --- fluoride --- aluminum --- speciation --- equilibria --- thermodynamic stability --- peptides --- multivariate linear regression --- poisoning effect of polar monomers --- Brookhart-type catalysts --- Zintl clusters --- X-ray crystallography --- Density Functional Theory --- n/a --- metal-metal bonds --- 4,2':6',4"-terpyridine --- 3,2':6',3"-terpyridine --- metal-organic framework (MOF)