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Biosensing and bioimaging techniques largely promote the accurate diagnosis of intractable diseases, such as cancers, on the basis of specific molecular targets, or as-called biomarkers. To realize the assays with ultrahigh sensitivity and selectivity, the wide application of molecular biology and nanotechnology are of great necessity. Both directions may offer effective signal amplification strategies, as well as inhibition of cross-reaction interference. Therefore, this Special Issue, “Biosensing and Bioimaging: Trends and Perspective”, highlights the recent developments in intelligent biomolecule/nanostructure-based probes for bioimaging and biosensing applications. It consists of five peer-reviewed papers that cover current hot topics, such as biodegradable materials, DNA assembly, shRNA delivery and chimeric proteins, which will provide a unique perspective of advanced biosensing and bioimaging techniques.

Medicine --- Pharmacology --- Chagas disease --- immunoassays --- chimeric proteins --- stability --- biodegradable materials --- metal-organic framework --- metal ion nodes --- multimode imaging --- theranostic nano-platforms --- MCF-7 cells --- electrochemistry --- 2-D materials --- signal amplification --- DNA assembly --- bio-responsive fluorescent complexes --- shRNA delivery --- LncRNA MALAT1 --- cancer cells bioimaging --- therapeutics --- autophagy --- biosensor --- microfluidics --- organ-on-a-chip --- lung model --- lung-on-a-chip --- Chagas disease --- immunoassays --- chimeric proteins --- stability --- biodegradable materials --- metal-organic framework --- metal ion nodes --- multimode imaging --- theranostic nano-platforms --- MCF-7 cells --- electrochemistry --- 2-D materials --- signal amplification --- DNA assembly --- bio-responsive fluorescent complexes --- shRNA delivery --- LncRNA MALAT1 --- cancer cells bioimaging --- therapeutics --- autophagy --- biosensor --- microfluidics --- organ-on-a-chip --- lung model --- lung-on-a-chip

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Biosensing and bioimaging techniques largely promote the accurate diagnosis of intractable diseases, such as cancers, on the basis of specific molecular targets, or as-called biomarkers. To realize the assays with ultrahigh sensitivity and selectivity, the wide application of molecular biology and nanotechnology are of great necessity. Both directions may offer effective signal amplification strategies, as well as inhibition of cross-reaction interference. Therefore, this Special Issue, “Biosensing and Bioimaging: Trends and Perspective”, highlights the recent developments in intelligent biomolecule/nanostructure-based probes for bioimaging and biosensing applications. It consists of five peer-reviewed papers that cover current hot topics, such as biodegradable materials, DNA assembly, shRNA delivery and chimeric proteins, which will provide a unique perspective of advanced biosensing and bioimaging techniques.

Chagas disease --- immunoassays --- chimeric proteins --- stability --- biodegradable materials --- metal-organic framework --- metal ion nodes --- multimode imaging --- theranostic nano-platforms --- MCF-7 cells --- electrochemistry --- 2-D materials --- signal amplification --- DNA assembly --- bio-responsive fluorescent complexes --- shRNA delivery --- LncRNA MALAT1 --- cancer cells bioimaging --- therapeutics --- autophagy --- biosensor --- microfluidics --- organ-on-a-chip --- lung model --- lung-on-a-chip

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The recent global events of the SARS-CoV-2 pandemic in 2020 have alerted the world to the urgent need to develop fast, sensitive, simple, and inexpensive analytical tools that are capable of carrying out a large number of quantitative analyses, not only in centralized laboratories and core facilities but also on site and for point-of-care applications. In particular, in the case of immunological tests, the required sensitivity and specificity is often lacking when carrying out large-scale screening using decentralized methods, while a centralized laboratory with qualified personnel is required for providing quantitative and reliable responses. The advantages typical of electrochemical and optical biosensors (low cost and easy transduction) can nowadays be complemented in terms of improved sensitivity by combining electrochemistry (EC) with optical techniques such as electrochemiluminescence (ECL), EC/surface-enhanced Raman spectroscopy (SERS), and EC/surface plasmon resonance (SPR). This Special Issue addresses existing knowledge gaps and aids in exploring new approaches, solutions, and applications for opto-electrochemical biosensors in the quantitative detection of disease markers, such as cancer biomarkers proteins and allergens, and pathogenic agents such as viruses. Included are seven peer-reviewed papers that cover a range of subjects and applications related to the strategies developed for early diagnosis.

gold nanoparticles --- doxycycline --- tetracycline --- SPR biosensor --- signal amplification --- clinical diagnosis --- microRNA --- electrochemical biosensor --- catalysts --- RedOx indicator --- cancer biomarker --- electrochemical immune platform --- human ST2 --- plasma --- pancreatic cancer --- collagen type I --- 4,4′-thiobisbenzenethiol --- nanogold --- electrochemical impedance spectroscopy --- surface plasmon resonance --- half antibody --- medical diagnostic devices --- peptide --- antifouling --- protease --- biomarker --- bioreceptor --- SARS-CoV-2 detection --- nasopharyngeal swab --- saliva --- serum --- droplets --- amperometric biosensor --- neural esterase --- acetylcholinesterase --- inhibition --- organophosphate --- design --- optimization --- mathematical model --- flux control --- dimensionless --- n/a --- 4,4'-thiobisbenzenethiol

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The recent global events of the SARS-CoV-2 pandemic in 2020 have alerted the world to the urgent need to develop fast, sensitive, simple, and inexpensive analytical tools that are capable of carrying out a large number of quantitative analyses, not only in centralized laboratories and core facilities but also on site and for point-of-care applications. In particular, in the case of immunological tests, the required sensitivity and specificity is often lacking when carrying out large-scale screening using decentralized methods, while a centralized laboratory with qualified personnel is required for providing quantitative and reliable responses. The advantages typical of electrochemical and optical biosensors (low cost and easy transduction) can nowadays be complemented in terms of improved sensitivity by combining electrochemistry (EC) with optical techniques such as electrochemiluminescence (ECL), EC/surface-enhanced Raman spectroscopy (SERS), and EC/surface plasmon resonance (SPR). This Special Issue addresses existing knowledge gaps and aids in exploring new approaches, solutions, and applications for opto-electrochemical biosensors in the quantitative detection of disease markers, such as cancer biomarkers proteins and allergens, and pathogenic agents such as viruses. Included are seven peer-reviewed papers that cover a range of subjects and applications related to the strategies developed for early diagnosis.

Research & information: general --- Biology, life sciences --- Biochemistry --- gold nanoparticles --- doxycycline --- tetracycline --- SPR biosensor --- signal amplification --- clinical diagnosis --- microRNA --- electrochemical biosensor --- catalysts --- RedOx indicator --- cancer biomarker --- electrochemical immune platform --- human ST2 --- plasma --- pancreatic cancer --- collagen type I --- 4,4′-thiobisbenzenethiol --- nanogold --- electrochemical impedance spectroscopy --- surface plasmon resonance --- half antibody --- medical diagnostic devices --- peptide --- antifouling --- protease --- biomarker --- bioreceptor --- SARS-CoV-2 detection --- nasopharyngeal swab --- saliva --- serum --- droplets --- amperometric biosensor --- neural esterase --- acetylcholinesterase --- inhibition --- organophosphate --- design --- optimization --- mathematical model --- flux control --- dimensionless --- n/a --- 4,4'-thiobisbenzenethiol

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The present book is devoted to all aspects of biosensing in a very broad definition, including, but not limited to, biomolecular composition used in biosensors (e.g., biocatalytic enzymes, DNAzymes, abiotic nanospecies with biocatalytic features, bioreceptors, DNA/RNA, aptasensors, etc.), physical signal transduction mechanisms (e.g., electrochemical, optical, magnetic, etc.), engineering of different biosensing platforms, operation of biosensors in vitro and in vivo (implantable or wearable devices), self-powered biosensors, etc. The biosensors can be represented with analogue devices measuring concentrations of analytes and binary devices operating in the YES/NO format, possibly with logical processing of input signals. Furthermore, the book is aimed at attracting young scientists and introducing them to the field, while providing newcomers with an enormous collection of literature references.

Technology: general issues --- metabolite sensors --- sensor biocompatibility --- ion selective electrodes --- foreign body reaction --- O2 --- glucose --- lactate --- biosensors --- bioelectrochemistry --- photo-biosensors --- enzyme --- biocatalysis --- electrochemical biosensors --- real-time --- continuous operation --- reagentless --- reusable --- calibration-free --- antibiofouling --- biosensor --- biomimetic membranes --- membrane-bound enzymes --- electrodes --- sulfur-containing nanomaterials --- metallic sulfide nanomaterials --- sulfur-containing quantum dots --- enzyme-based biosensors --- direct electron transfer (DET) --- redox enzymes --- nanostructured electrodes --- protein film voltammetry (PFV) --- glucose biosensors --- nanoporous metals --- nanoporous gold --- graphene --- carbon nanotube --- ordered mesoporous carbon --- additive manufacturing --- heme --- peroxidases --- semiconductors --- peroxidase mimics --- DNA assay --- nucleic acid --- isothermal --- signal amplification --- restriction endonuclease --- wearable biosensors --- metabolism --- remote monitoring --- sweat --- microfluidic --- 3D printing --- nanoparticle --- nanocomposite --- nanozyme --- synthesis --- catalytic properties --- nano-peroxidase --- nanooxidase --- nanolaccase --- electronanocatalyst --- amperometric (bio)sensors --- POC --- microfluidics --- immunosensor --- cancer --- biomarkers --- electrochemical DNA sensor --- nucleic acid sensor --- DNA --- RNA --- pathogen sensing --- 2D-materials --- field-effect transistor --- transition metal dichalcogenides --- black phosphorus --- phosphorene --- hexagonal boron nitride --- transition metal oxides --- current-potential curve --- multi-enzymatic cascades --- multianalyte detection --- mass-transfer-controlled amperometric response --- potentiometric coulometry --- MXenes --- 2D nanomaterials --- wearables --- electrochemistry --- bacteria --- electrochemical ELISA --- electrochemical immunoassays --- electrochemical aptamer-based assays --- chemical sensor --- field effect --- capacitive EIS sensor --- pH sensor --- enzyme biosensor --- label-free detection --- charged molecules --- DNA biosensor --- protein detection --- forensics --- biometrics --- cybersecurity --- fingerprints --- blood --- cipher --- non-invasive biosensors --- human physiological fluids --- tears --- saliva --- urine --- metabolite sensors --- sensor biocompatibility --- ion selective electrodes --- foreign body reaction --- O2 --- glucose --- lactate --- biosensors --- bioelectrochemistry --- photo-biosensors --- enzyme --- biocatalysis --- electrochemical biosensors --- real-time --- continuous operation --- reagentless --- reusable --- calibration-free --- antibiofouling --- biosensor --- biomimetic membranes --- membrane-bound enzymes --- electrodes --- sulfur-containing nanomaterials --- metallic sulfide nanomaterials --- sulfur-containing quantum dots --- enzyme-based biosensors --- direct electron transfer (DET) --- redox enzymes --- nanostructured electrodes --- protein film voltammetry (PFV) --- glucose biosensors --- nanoporous metals --- nanoporous gold --- graphene --- carbon nanotube --- ordered mesoporous carbon --- additive manufacturing --- heme --- peroxidases --- semiconductors --- peroxidase mimics --- DNA assay --- nucleic acid --- isothermal --- signal amplification --- restriction endonuclease --- wearable biosensors --- metabolism --- remote monitoring --- sweat --- microfluidic --- 3D printing --- nanoparticle --- nanocomposite --- nanozyme --- synthesis --- catalytic properties --- nano-peroxidase --- nanooxidase --- nanolaccase --- electronanocatalyst --- amperometric (bio)sensors --- POC --- microfluidics --- immunosensor --- cancer --- biomarkers --- electrochemical DNA sensor --- nucleic acid sensor --- DNA --- RNA --- pathogen sensing --- 2D-materials --- field-effect transistor --- transition metal dichalcogenides --- black phosphorus --- phosphorene --- hexagonal boron nitride --- transition metal oxides --- current-potential curve --- multi-enzymatic cascades --- multianalyte detection --- mass-transfer-controlled amperometric response --- potentiometric coulometry --- MXenes --- 2D nanomaterials --- wearables --- electrochemistry --- bacteria --- electrochemical ELISA --- electrochemical immunoassays --- electrochemical aptamer-based assays --- chemical sensor --- field effect --- capacitive EIS sensor --- pH sensor --- enzyme biosensor --- label-free detection --- charged molecules --- DNA biosensor --- protein detection --- forensics --- biometrics --- cybersecurity --- fingerprints --- blood --- cipher --- non-invasive biosensors --- human physiological fluids --- tears --- saliva --- urine