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Asthma is a common complex and heterogeneous respiratory disease with an increasing prevalence in developed countries. Asthma is a disease consisting of different phenotypes that are driven by different mechanistic pathways (endotypes). The recognition of these phenotypes and endotypes is central to asthma management entailing prognostic and therapeutic implications. It is acknowledged that despite optimal treatment, many patients are poorly controlled, highlighting the need for phenotype-guided treatments. In this context, the emergence of novel therapies (monoclonal antibody therapy, bronchial thermoplasty) is paving the way for personalized asthma therapy. A better understanding of disease pathogenesis may enable the identification of biomarkers, mediators, novel therapeutic targets, and treatable traits. Further molecular phenotyping or endotyping of asthma will be necessary to tailor new therapeutic strategies. The present Special Issue on Asthma aims to provide the current knowledge on phenotypes and endotypes in appreciating and managing the heterogeneous condition that is asthma.

asthma --- lactic acidosis --- hyperchloremic acidosis --- hypocapnia --- hypercapnia --- wheezing --- bronchial biopsies --- symptom persistence --- clinical remission --- eosinophil --- adhesion --- viability --- proliferation --- airway smooth muscle cell --- pulmonary fibroblast --- phenotype --- acute severe asthma exacerbation --- near fatal asthma --- severe asthma --- inflammation --- interleukin-5 (IL-5) --- anti-IL-5 --- interleukin-4 --- airway remodeling --- matrix metalloproteinases-9 --- tissue inhibitor of metalloproteinase-1 --- alveolar macrophages --- lung function --- bronchodilation --- resistance --- obstruction --- reproducible --- spirometry --- obstructive sleep apnea --- bronchial asthma --- alternative overlap syndrome --- exacerbation --- reactive oxygen species --- PBMC --- mitochondrial function --- innate immunity --- immune regulation --- NLRP3 --- IL-1β --- allergic airway inflammation --- microbiome --- pathogenesis --- immune responses --- PreDicta --- preschool --- FeNO --- asthma-specific quality of life --- chronic rhinitis --- disease-specific quality of life --- health-related quality of Life (HRQLQ) --- children --- longitudinal study

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Medical practice is a mixture of science and art, technique and humanism. The importance of human beings is more obvious in medicine than in any other field. At the center of medical care is the patient, and at its base and that of the entire medical system is the relationship that is established between the patient and the medical staff. Overspecialization is a big component of modern medicine, with professionals working in increasingly narrow fields, which makes patients routinely treated by multidisciplinary teams. This draws attention to the importance of appropriate relationships between members of the medical team for the success of the therapeutic approach. In the context of technological progress in medicine, the need to relate to the humanistic values of the medical profession and the complexity of the medical act in which technical aspects are intertwined with cultural, ethical, legal, psychological, and sociological issues becomes increasingly clear. This Special Issue is dedicated to the humanistic values of medical practice. It includes articles that approach various aspects of the so-called humanistic medicine, drawing a picture of what contemporary medicine should strive for.

Humanities --- Social interaction --- avoidance learning --- neck pain --- workplace --- employment --- fear --- exercise --- attitude --- accidents --- disability --- obstetrics and gynecology --- physicians --- stress --- medical practice --- psychosomatic symptoms --- continuing education --- SARS-CoV-2 --- pandemics --- fear of COVID 19 --- HIV --- cardiovascular disease --- metabolic syndrome --- HAART --- Framingham risk score --- students --- medicine --- healthcare --- lifestyle --- body image --- social network --- self-esteem --- body mass index --- physical health --- domestic violence --- physician–patient relationship --- dental medical students’ opinion --- teenager --- sex education --- sexual health --- pregnancy --- teenage pregnancy --- sexually transmitted diseases --- contraception --- communication --- head and neck cancer --- quality of life --- psychosocial --- interventions --- asthma --- asthma therapy --- severe asthma --- patient behaviour --- patient attitudes --- length of the visit --- patient satisfaction --- health status --- appointments and schedules --- general practice --- adult --- aging --- primary care --- Borderline Personality Disorder --- depression --- perfectionism --- obsessive-compulsive symptoms --- fearfulness --- dependency --- psycho-emotional moods --- behavioral problems --- academic performance --- COVID-19 pandemic --- medical malpractice --- complaints --- doctor --- Romania --- socio-demographic characteristics --- professional characteristics --- institutional characteristics --- embodiment --- empathy --- humanism --- medical education