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This book addresses chemical and biological aspects related to sesquiterpene lactones (STLs). Experts in different fields have been invited to contribute on this class of compound's chemistry, isolation and identification, biological activities (antibacterial, antifungal, antiviral, antitrypanosomal, antileishmanial,antiplasmodial, antiproliferative and antiinflammatory), synthesis, biosynthesis, derivatization and QSAR analysis. Taxonomic and chemotaxonomic aspects related to the Asteraceae family are also contributed. The book begins by describing the chemical characteristics of STLs, their classification in different skeleton types, synthesis, distribution in nature and their most important biological properties. An overview of the group's main representatives, based on their importance for human health, as well as an update of the most recently isolated STLs, follow. The authors also provide an overview of the most common methods described in the literature for the extraction, purification, identification and structure elucidation of STLs, while also highlighting more recently developed methods. Furthermore, experts in the field provide an in-depth discussion of the most commonly employed in vitro and in vivo antiprotozoal assays against the different stages of parasites, as well as STLs' properties as anticancer agents in numerous cancer cell lines and animal models. Lastly, the book presents examples of the in vitro and in vivo activity of STLs and their mechanism of antiprotozoal action, together with an analysis of ultrastructural alterations, observed using TEM techniques. The book is aimed at scientists working on natural products: both those investigating this particular group of compounds and those who wish to further explore its potential as new drugs for medical conditions such as protozoal diseases and cancer.
Chemistry. --- Pharmacology. --- Organic chemistry. --- Medicinal chemistry. --- Biochemistry. --- Medicinal Chemistry. --- Pharmacology/Toxicology. --- Organic Chemistry. --- Biochemistry, general. --- Pharmaceutical chemistry. --- Sesquiterpene lactones. --- Chemistry, Organic. --- Organic chemistry --- Chemistry --- Lactones --- Sesquiterpenes --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry --- Toxicology. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Toxicology --- Composition --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Physiological effect
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Nature represents an amazing source of inspiration, since it produces a great diversity of natural compounds selected by evolution, which exhibit multiple biological activities and applications. A large and very active research field is dedicated to identifying biosynthesized compounds, to improve/develop new methodologies, to produce/reuse natural compounds, and to assess their potential for pharmaceutical, cosmetic and food industries, among others, and additionally, to understand their mechanism of action. This book is dedicated to presenting the most recent results on the development of natural compounds’ applications. Ten original research works, organized by applications, and two reviews are included. Each of them contributes to the knowledge advance, insofar as they present new applications for known products, new methodologies to obtain new products, or the evaluation of a given application, with the applications related to health promotion being the most frequently considered. These works are significant contributions and reinforce the dynamic field of natural products’ applications.
Medicine --- amino acid metabolism --- carvacrol --- metabolomics data --- oxidative stress --- Penicillium digitatum --- Prangos pabularia Lindl. --- volatile oil --- PTP-1B --- osthole --- 5-pentylcyclohexa-1,3-diene --- antidiabetic activity --- chalcones --- aldol condensation --- biological activity --- flavanones --- cytotoxic --- antioxidant --- anticholinesterase --- Maytenus --- celastroloids --- semisynthesis --- antibacterial activity --- structure–activity relationship --- rosemary --- rosmarinic acid --- anticancer --- antidiabetic --- cardioprotective --- Helianthus annuus --- Helianthus strumosus --- Aspergillus niger --- Candida albicans --- Cryptococcus neoformans --- α-pinene --- oleracone --- flavonoid --- anti-aging --- longevity --- Portulaca oleracea L. --- Caenorhabditis elegans --- total synthesis --- pimenta d’água --- Candida --- fungistatic effect --- inhibition of dimorphism --- GC/MS --- colorectal cancer --- Salviae miltiorrhizae radix --- apoptosis --- honey --- propolis --- phenolic compounds --- wound-healing activity --- NHDF cells --- Asteraceae --- sesquiterpene lactones --- alantolactone --- arglabin --- parthenolide --- thapsigargin --- in vivo study --- anti-inflammatory --- almond --- byproducts --- chlorogenic acid --- design of experiment --- phenolic acids --- ultrasound-assisted extraction --- natural compounds --- therapeutic applications --- essential oils --- antimicrobial --- antitumor --- SAR
Choose an application
Nature represents an amazing source of inspiration, since it produces a great diversity of natural compounds selected by evolution, which exhibit multiple biological activities and applications. A large and very active research field is dedicated to identifying biosynthesized compounds, to improve/develop new methodologies, to produce/reuse natural compounds, and to assess their potential for pharmaceutical, cosmetic and food industries, among others, and additionally, to understand their mechanism of action. This book is dedicated to presenting the most recent results on the development of natural compounds’ applications. Ten original research works, organized by applications, and two reviews are included. Each of them contributes to the knowledge advance, insofar as they present new applications for known products, new methodologies to obtain new products, or the evaluation of a given application, with the applications related to health promotion being the most frequently considered. These works are significant contributions and reinforce the dynamic field of natural products’ applications.
amino acid metabolism --- carvacrol --- metabolomics data --- oxidative stress --- Penicillium digitatum --- Prangos pabularia Lindl. --- volatile oil --- PTP-1B --- osthole --- 5-pentylcyclohexa-1,3-diene --- antidiabetic activity --- chalcones --- aldol condensation --- biological activity --- flavanones --- cytotoxic --- antioxidant --- anticholinesterase --- Maytenus --- celastroloids --- semisynthesis --- antibacterial activity --- structure–activity relationship --- rosemary --- rosmarinic acid --- anticancer --- antidiabetic --- cardioprotective --- Helianthus annuus --- Helianthus strumosus --- Aspergillus niger --- Candida albicans --- Cryptococcus neoformans --- α-pinene --- oleracone --- flavonoid --- anti-aging --- longevity --- Portulaca oleracea L. --- Caenorhabditis elegans --- total synthesis --- pimenta d’água --- Candida --- fungistatic effect --- inhibition of dimorphism --- GC/MS --- colorectal cancer --- Salviae miltiorrhizae radix --- apoptosis --- honey --- propolis --- phenolic compounds --- wound-healing activity --- NHDF cells --- Asteraceae --- sesquiterpene lactones --- alantolactone --- arglabin --- parthenolide --- thapsigargin --- in vivo study --- anti-inflammatory --- almond --- byproducts --- chlorogenic acid --- design of experiment --- phenolic acids --- ultrasound-assisted extraction --- natural compounds --- therapeutic applications --- essential oils --- antimicrobial --- antitumor --- SAR
Choose an application
Nature represents an amazing source of inspiration, since it produces a great diversity of natural compounds selected by evolution, which exhibit multiple biological activities and applications. A large and very active research field is dedicated to identifying biosynthesized compounds, to improve/develop new methodologies, to produce/reuse natural compounds, and to assess their potential for pharmaceutical, cosmetic and food industries, among others, and additionally, to understand their mechanism of action. This book is dedicated to presenting the most recent results on the development of natural compounds’ applications. Ten original research works, organized by applications, and two reviews are included. Each of them contributes to the knowledge advance, insofar as they present new applications for known products, new methodologies to obtain new products, or the evaluation of a given application, with the applications related to health promotion being the most frequently considered. These works are significant contributions and reinforce the dynamic field of natural products’ applications.
Medicine --- amino acid metabolism --- carvacrol --- metabolomics data --- oxidative stress --- Penicillium digitatum --- Prangos pabularia Lindl. --- volatile oil --- PTP-1B --- osthole --- 5-pentylcyclohexa-1,3-diene --- antidiabetic activity --- chalcones --- aldol condensation --- biological activity --- flavanones --- cytotoxic --- antioxidant --- anticholinesterase --- Maytenus --- celastroloids --- semisynthesis --- antibacterial activity --- structure–activity relationship --- rosemary --- rosmarinic acid --- anticancer --- antidiabetic --- cardioprotective --- Helianthus annuus --- Helianthus strumosus --- Aspergillus niger --- Candida albicans --- Cryptococcus neoformans --- α-pinene --- oleracone --- flavonoid --- anti-aging --- longevity --- Portulaca oleracea L. --- Caenorhabditis elegans --- total synthesis --- pimenta d’água --- Candida --- fungistatic effect --- inhibition of dimorphism --- GC/MS --- colorectal cancer --- Salviae miltiorrhizae radix --- apoptosis --- honey --- propolis --- phenolic compounds --- wound-healing activity --- NHDF cells --- Asteraceae --- sesquiterpene lactones --- alantolactone --- arglabin --- parthenolide --- thapsigargin --- in vivo study --- anti-inflammatory --- almond --- byproducts --- chlorogenic acid --- design of experiment --- phenolic acids --- ultrasound-assisted extraction --- natural compounds --- therapeutic applications --- essential oils --- antimicrobial --- antitumor --- SAR --- amino acid metabolism --- carvacrol --- metabolomics data --- oxidative stress --- Penicillium digitatum --- Prangos pabularia Lindl. --- volatile oil --- PTP-1B --- osthole --- 5-pentylcyclohexa-1,3-diene --- antidiabetic activity --- chalcones --- aldol condensation --- biological activity --- flavanones --- cytotoxic --- antioxidant --- anticholinesterase --- Maytenus --- celastroloids --- semisynthesis --- antibacterial activity --- structure–activity relationship --- rosemary --- rosmarinic acid --- anticancer --- antidiabetic --- cardioprotective --- Helianthus annuus --- Helianthus strumosus --- Aspergillus niger --- Candida albicans --- Cryptococcus neoformans --- α-pinene --- oleracone --- flavonoid --- anti-aging --- longevity --- Portulaca oleracea L. --- Caenorhabditis elegans --- total synthesis --- pimenta d’água --- Candida --- fungistatic effect --- inhibition of dimorphism --- GC/MS --- colorectal cancer --- Salviae miltiorrhizae radix --- apoptosis --- honey --- propolis --- phenolic compounds --- wound-healing activity --- NHDF cells --- Asteraceae --- sesquiterpene lactones --- alantolactone --- arglabin --- parthenolide --- thapsigargin --- in vivo study --- anti-inflammatory --- almond --- byproducts --- chlorogenic acid --- design of experiment --- phenolic acids --- ultrasound-assisted extraction --- natural compounds --- therapeutic applications --- essential oils --- antimicrobial --- antitumor --- SAR
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