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Dysregulation of Wnt signaling is known to be associated with various cancers. As such, identification of novel Wnt pathway targets in cancer and better characterization of already-known targets present exciting, emerging opportunities for cancer treatment. In this Special Issue, we feature papers which discuss the role of Wnt signaling and associated targets in cancer metabolism, tumor immune response, and tumor microenvironment. Papers discussing a range of Wnt-mediated cancers, including those of the colon, liver, pancreas, synovium, bladder, etc., are included.

Medicine --- Pharmacology --- Wnt signaling --- synovial sarcoma --- TNIK --- NCB-0846 --- MYC --- hepatitis B virus --- HBV --- cancer --- liver cancer --- β-catenin --- TCF/LEF --- pancreatic cancer --- pancreatic stellate cells --- CBP --- p300 --- pancreatitis --- fibrosis --- just-right signaling --- APC --- colorectal cancer --- RNA-binding proteins --- Musashi --- drug discovery --- Notch signaling --- cancer therapy --- fungi secondary metabolite derivative --- microenvironment --- Wnt --- AML --- drug target --- signaling --- colorectal --- porcupine --- R-spondin --- serrated --- immunotherapy --- wnt --- vitamin D --- colon cancer --- L1 --- Wnt target genes --- cell adhesion --- NF-κB --- invasion and metastasis --- cancer stem cells --- EMT --- Lgr5 --- Wnt/beta-catenin signaling --- angiogenesis --- anti-angiogenic therapy --- gastrointestinal cancers --- therapeutic targeting of Wnt signaling --- β-catenin paradox --- molecular targeting --- urothelial cancer --- immune checkpoint inhibitor --- immunotherapy resistance --- IBD --- colitis --- β-catenin mutations --- tumor metabolism --- tumor immunology --- molecular therapeutics --- precision medicine --- astrocytic brain tumors --- DKKs --- GSK3β --- Wnt signaling --- synovial sarcoma --- TNIK --- NCB-0846 --- MYC --- hepatitis B virus --- HBV --- cancer --- liver cancer --- β-catenin --- TCF/LEF --- pancreatic cancer --- pancreatic stellate cells --- CBP --- p300 --- pancreatitis --- fibrosis --- just-right signaling --- APC --- colorectal cancer --- RNA-binding proteins --- Musashi --- drug discovery --- Notch signaling --- cancer therapy --- fungi secondary metabolite derivative --- microenvironment --- Wnt --- AML --- drug target --- signaling --- colorectal --- porcupine --- R-spondin --- serrated --- immunotherapy --- wnt --- vitamin D --- colon cancer --- L1 --- Wnt target genes --- cell adhesion --- NF-κB --- invasion and metastasis --- cancer stem cells --- EMT --- Lgr5 --- Wnt/beta-catenin signaling --- angiogenesis --- anti-angiogenic therapy --- gastrointestinal cancers --- therapeutic targeting of Wnt signaling --- β-catenin paradox --- molecular targeting --- urothelial cancer --- immune checkpoint inhibitor --- immunotherapy resistance --- IBD --- colitis --- β-catenin mutations --- tumor metabolism --- tumor immunology --- molecular therapeutics --- precision medicine --- astrocytic brain tumors --- DKKs --- GSK3β

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The Special Issue ‘Physical Metallurgy of High Manganese Steels’ addresses the highly fascinating class of manganese-alloyed steels with manganese contents well above 3 mass%. The book gathers manuscripts from internationally recognized researchers with stimulating new ideas and original results. It consists of fifteen original research papers. Seven contributions focus on steels with manganese contents above 12 mass%. These contributions cover fundamental aspects of process-microstrcuture-properties relationships with processes ranging from cold and warm rolling over deep rolling to heat treatment. Novel findings regarding the fatigue and fracture behavior, deformation mechanisms, and computer-aided design are presented. Additionally, the Special Issue also reflects the current trend of reduced Mn content (3-12 mass%) in advanced high strength steels (AHSS). Eight contributions were dedicated to these alloys, which are often referred to as 3rd generation AHSS, medium manganese steels or quenching and partitioning (Q&P/Q+P) steels. The interplay between advanced processing, mainly novel annealing variants, and microstructure evolution has been addressed using computational and experimental approaches. A deeper understanding of strain-rate sensitivity, hydrogen embrittlement, phase transformations, and the consequences for the materials’ properties has been developed. Hence, the topics included are manifold, fundamental-science oriented and, at the same time, relevant to industrial application.

n/a --- TRIP --- microstructure --- medium-manganese steel --- dislocation density --- V alloying --- ultrafine grains --- intercritical annealing --- medium manganese steel --- fracture --- precipitations --- twinning induced plasticity --- deformation behavior --- fatigue --- austenite-reversed-transformation --- medium-manganese --- Lüders band --- medium-Mn steel --- fatigue behavior --- alloy design --- austenitic high nitrogen steel (HNS) --- high-entropy alloys --- mechanical properties --- retained austenite --- high-manganese steel --- localized deformation --- phase transformation --- austenite stability --- processing --- strain-hardening behavior --- TWIP steel --- recrystallization annealing --- damage --- strengthening --- cold rolling --- ultrafine-grained microstructure --- serrated flow --- multiscale simulation --- deformation twinning --- annealing --- high-Mn steels --- corrosion resistance --- TWIP --- quenching and partitioning --- high manganese steel --- lightweight --- residual stresses --- in-situ DIC tensile tests --- crash box --- deep rolling --- high strength steel --- plastic deformation --- MMn steel X20CrNiMnVN18-5-10 --- neutron diffraction --- phase field simulation --- dynamic strain aging --- cold deformation --- near surface properties --- P steel --- continuous annealing --- texture --- hydrogen embrittlement --- hot-stamping --- warm rolling --- strain-rate sensitivity --- austenite reversion --- D&amp --- forging --- high-manganese steels --- grain refinement --- double soaking

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This book is a collection of several unique articles on the current state of research on complex concentrated alloys, as well as their compelling future opportunities in wide ranging applications. Complex concentrated alloys consist of multiple principal elements and represent a new paradigm in structural alloy design. They show a range of exceptional properties that are unachievable in conventional alloys, including high strength–ductility combination, resistance to oxidation, corrosion/wear resistance, and excellent high-temperature properties. The research articles, reviews, and perspectives are intended to provide a wholistic view of this multidisciplinary subject of interest to scientists and engineers.

high-entropy alloy --- laser cladding --- microstructure --- slurry erosion --- Nb/SiC composite material --- hot pressing sintering --- mechanical property --- corrosion --- surface degradation --- wear --- high entropy alloys --- complex concentrated alloys --- potentiodynamic polarization --- erosion-corrosion --- slurry-erosion --- oxidation wear --- highly wear resistant coatings --- multi-principal element alloys --- computational models --- first-principles calculations --- molecular dynamics --- phases --- properties --- dislocation nucleation --- activation volume --- activation energy --- nano-indentation --- high/medium entropy alloys --- spark plasma sintering --- pressure --- mechanical properties --- high-entropy --- high pressure --- high pressure torsion --- diamond anvil cells --- CoCrFeMnNi high entropy alloys --- additive manufacturing --- corrosion behavior --- non-equilibrium microstructure --- micro-pores --- high-entropy alloys --- corrosion resistance --- wear resistance --- serrated flow --- thermal coarsening --- actuators --- phase transformation --- nanoporous metals and alloys --- AlCoCrFeNi2.1 --- CCA --- HEA --- aging --- precipitates --- tribology --- creep --- stress exponent --- data analysis --- n/a