Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The recent cloning and identification of a large number of serotonin (5-HT) receptors-a major family of therapeutic targets-holds out the possibility of developing novel, subtype-selective 5-HT receptor agonists and antagonists for use as psychiatric, cardiovascular, and neurological medications. In The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics, leading experts comprehensively examine our current understanding of the molecular and structural biology of 5-HT receptors and their pharmacological use. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction. Comprehensive and state of the art, The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics provides an illuminating "snapshot" of the 5-HT receptor field today and prospects for the future, taking it from the genomic to a systems level of understanding.

Serotonin --- Serotoninergic mechanisms. --- Physiological effect. --- Receptors. --- Serotonergic mechanisms --- Sympathetic nervous system --- 5-HT (Neurotransmitter) --- Hydroxytryptamine --- Neurotransmitters --- Tryptamine --- Pharmacy. --- Chemistry --- Medicine --- Drugs --- Materia medica --- Pharmacology

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Human biochemistry --- Electrochemical analysis --- Physiology of nerves and sense organs --- $ Brain neurochemical analysis --- $ Neurotransmitters analysis --- $ Catecholamine activity in the brain --- $ Serotonergic mechanisms --- Neurotransmitters --- Neurochemistry --- Voltammetry --- Perfusion (Physiology) --- Analysis --- Congresses --- Technique --- Behavior --- Brain Chemistry --- Perfusion --- BEHAVIOR --- BRAIN CHEMISTRY --- ELECTROCHEMISTRY --- NEUROCHEMISTRY --- PERFUSION --- Congresses. --- drug effects --- congresses. --- methods --- Drug effects --- Methods --- Brain chemistry --- Electrochemistry --- Perfusion (physiology) --- Neurotransmitters - Analysis - Congresses --- Neurochemistry - Technique - Congresses --- Voltammetry - Congresses --- Perfusion (Physiology) - Congresses

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Antidepressants --- Serotoninergic mechanisms --- Serotonin uptake inhibitors --- Mental Disorders --- Serotonin Antagonists --- 5-HT uptake inhibitors --- 5-Hydroxytryptamine uptake inhibitors --- Inhibitors, Serotonic uptake --- Reuptake inhibitors, Serotonin --- Serotonin reuptake inhibitors --- Uptake inhibitors, Serotonin --- Neurotransmitter uptake inhibitors --- Serotonergic mechanisms --- Sympathetic nervous system --- Antidepressive agents --- Energizers, Psychic --- Psychic energizers --- Psychotropic drugs --- Depression, Mental --- drug therapy --- therapeutic use --- Chemotherapy

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This Special Edition Issue on the “Pathogenesis and Treatment of Chronic Pruritus” contains an overview of various known causes of chronic pruritus and emerging therapeutics. Chronic pruritus is an itch that lasts longer than six weeks, and is associated with a variety of dermatologic, systemic, neurologic, and psychiatric etiologies. Itch negatively impacts patient quality of life, and has devastating psychosocial consequences. The manuscripts published in this Special Issue are also a showcase of the current understanding of the pathogenesis of chronic pruritus, along with its epidemiology, diagnostic workup, and therapeutic approaches used to treat chronic pruritus. A special focus is also placed on prurigo nodularis, a severely pruritic chronic inflammatory skin disease.

Medicine --- dupilumab --- IL-4 --- IL-13 --- pruritus --- chronic pruritus of unknown origin --- prurigo nodularis --- uremic pruritus --- lichen planus --- eosinophilic dermatosis of hematologic malignancy --- chronic pruritus --- mirtazapine --- chronic --- itch --- refractory --- treatment --- noradrenergic --- serotonergic --- antihistaminergic --- antidepressant --- skin --- atopic dermatitis --- ceramide --- pine tar --- drug-induced --- medication-related --- epidemiology --- inpatient --- disease burden --- national inpatient sample --- medical dermatology --- systematic review --- prurigo --- nodularis --- atopic --- dermatitis --- race --- gender --- comorbidities --- demographics --- pediatric --- children --- malignancy --- cancer --- neoplasm --- ion channels --- cell signaling --- Cav3.2 calcium channel --- RT-PCR --- wounds --- itch in wounds --- itch management --- aprepitant --- erlotinib --- EGFR --- epidermal growth factor receptor --- NK1R --- neurokinin1-receptor --- mycosis fungoides --- psoriasis --- associations --- lymphomatoid papulosis --- lymphoma --- racial differences --- nodular prurigo --- neuropathy --- therapeutic --- pathogenesis

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This Special Edition Issue on the “Pathogenesis and Treatment of Chronic Pruritus” contains an overview of various known causes of chronic pruritus and emerging therapeutics. Chronic pruritus is an itch that lasts longer than six weeks, and is associated with a variety of dermatologic, systemic, neurologic, and psychiatric etiologies. Itch negatively impacts patient quality of life, and has devastating psychosocial consequences. The manuscripts published in this Special Issue are also a showcase of the current understanding of the pathogenesis of chronic pruritus, along with its epidemiology, diagnostic workup, and therapeutic approaches used to treat chronic pruritus. A special focus is also placed on prurigo nodularis, a severely pruritic chronic inflammatory skin disease.

dupilumab --- IL-4 --- IL-13 --- pruritus --- chronic pruritus of unknown origin --- prurigo nodularis --- uremic pruritus --- lichen planus --- eosinophilic dermatosis of hematologic malignancy --- chronic pruritus --- mirtazapine --- chronic --- itch --- refractory --- treatment --- noradrenergic --- serotonergic --- antihistaminergic --- antidepressant --- skin --- atopic dermatitis --- ceramide --- pine tar --- drug-induced --- medication-related --- epidemiology --- inpatient --- disease burden --- national inpatient sample --- medical dermatology --- systematic review --- prurigo --- nodularis --- atopic --- dermatitis --- race --- gender --- comorbidities --- demographics --- pediatric --- children --- malignancy --- cancer --- neoplasm --- ion channels --- cell signaling --- Cav3.2 calcium channel --- RT-PCR --- wounds --- itch in wounds --- itch management --- aprepitant --- erlotinib --- EGFR --- epidermal growth factor receptor --- NK1R --- neurokinin1-receptor --- mycosis fungoides --- psoriasis --- associations --- lymphomatoid papulosis --- lymphoma --- racial differences --- nodular prurigo --- neuropathy --- therapeutic --- pathogenesis