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colloidal systems --- foams and gels and emulsions --- molecular surfactants --- fluid dynamics --- adsorption and interfacial dynamics --- rheology --- experimental as well as theoretical aspects on interfacial phenomena --- colloidal systems --- properties of colloidal systems such as rheology and material properties --- properties of solutions of surface active molecules --- self-assembling phenomena and aggregates in solution --- Chemistry --- Colloids --- Interfaces (Physical sciences) --- Surface chemistry --- Colloids. --- Dispersoids --- Gels --- Hydrogels --- Sols --- Amorphous substances --- Chemistry, Physical and theoretical --- Diffusion --- Matter --- Micelles --- Particles --- Rheology --- Solution (Chemistry) --- Surfaces (Physics) --- Properties

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The new frontier of pharmaceutical sciences is gene therapy, which is the use of molecules able to interact directly with the expression of the genetic material of the patient as well as of the disease-causing guest (bacteria, virus, parasites, and tumor cells). Among the molecules of interest for gene therapy, a relevant role is played by small interfering RNA (siRNA) molecules able to interfere with the expression of genes of interest for some diseases. However, siRNA molecules, even if they are powerful as drugs, are difficult to deliver since they are sensitive to enzymes present in plasma and they are large and negatively charged, so are difficult to administer into the cell nuclei, since the cell walls are scarcely permeable to large molecules and are also negatively charged. Therefore, the focus of research on siRNA-based therapies is their delivery, which can be performed by chemical modification, association with aptamers or polycations, or embedding them into properly designed liposomes. This book is centered on the more recent development in siRNA delivery techniques toward the clinical applications of this potent class of drugs.

oligonucleotide delivery --- light-activated release --- intracellular release --- liposome --- indocyanine green --- drug co-delivery --- methotrexate --- siRNA --- antitumor effect --- mixed micelles --- targeted delivery system --- cationic liposome --- folate --- folate receptor --- cationic cholesterol derivative --- siRNA delivery --- gene knockdown --- tumor-targeting --- VEGFA --- VEGFR1 --- endoglin --- peptide --- angiogenesis --- gene silencing --- migration --- proliferation --- endothelial cells --- RNAi therapeutics --- amphiphilic dendrons --- PAMAM dendrimers --- self-assembling --- nanovectors --- covalent dendrimers --- NABDs --- liposomes --- clinical trials --- drug delivery --- nanoparticle --- carbonate apatite --- ERBB2 --- AKT --- breast cancer --- ovarian cancer --- polymer --- lipid --- delivery --- poly(ethylene) imine --- PEI --- RNA --- tyrosine-modification --- tumor xenograft --- magnetic nanoparticle --- iron oxide --- BCL2 --- BIRC5/survivin --- oral cancer --- aptamers --- cancer --- nanoparticles --- STAT6 --- polyaspartamide --- pegylation --- polyamine --- polyplexes --- asthma --- n/a

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Objects of nanotechnology such as micro- and nanoparticles are very interesting due to their unique properties. This reprint will be useful to scientists of diverse backgrounds, i.e., material science, organic and inorganic chemistry, biochemistry, and biology.

Technology: general issues --- electropolymerization --- poly(Azure B) --- poly(proflavine) --- DNA sensor --- doxorubicin determination --- electrochemical impedance spectroscopy --- calix[4]arene --- NHC complex --- Suzuki–Miyaura coupling --- DPPC vesicles --- heparin/protamine particles --- hepatocyte --- intravenous injection --- lacZ protein --- nanoparticles --- protein delivery --- self-assembling --- antiviral agent --- nanoparticle --- coronavirus --- viral mechanism of entry --- antiviral mechanism --- therapeutic approaches --- SARS-CoV-2 --- COVID-19 --- polyol synthesis --- rhodium nanoparticles --- surfactants --- role of additives --- morphology control --- toxicity --- bio-imaging --- X-ray fluorescence --- contrast agent --- XFCT --- nanomaterials --- 2D nanostructures --- thiacalix[4]arene --- terpenoids --- geraniol --- X-ray crystal analysis --- 2D monomolecular-layer nanosheets --- polymorphism --- silica --- polystyrene --- maghemite supraparticles --- patchy particles --- seeded-growth emulsion polymerization --- solvent-induced self-assembly --- pillar[5]arene --- tetrazole --- drug delivery systems --- fluorescein --- ceria --- nanorods --- nanosheets --- nanozyme --- biomolecule --- template --- catalysis --- anti-oxidant --- oxygen radicals --- lithium iron phosphate --- hydrothermal synthesis --- heating rate --- morphology --- crystallinity and purity --- polyelectrolyte multilayers --- encapsulation --- calcium carbonate --- drug delivery --- shrinkage --- layered oxides --- perovskites --- bismuth titanates --- exfoliation --- coating --- silver nanoparticles --- AgNPs --- synthesis --- separation --- purification --- n/a --- Suzuki-Miyaura coupling

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Objects of nanotechnology such as micro- and nanoparticles are very interesting due to their unique properties. This reprint will be useful to scientists of diverse backgrounds, i.e., material science, organic and inorganic chemistry, biochemistry, and biology.

electropolymerization --- poly(Azure B) --- poly(proflavine) --- DNA sensor --- doxorubicin determination --- electrochemical impedance spectroscopy --- calix[4]arene --- NHC complex --- Suzuki–Miyaura coupling --- DPPC vesicles --- heparin/protamine particles --- hepatocyte --- intravenous injection --- lacZ protein --- nanoparticles --- protein delivery --- self-assembling --- antiviral agent --- nanoparticle --- coronavirus --- viral mechanism of entry --- antiviral mechanism --- therapeutic approaches --- SARS-CoV-2 --- COVID-19 --- polyol synthesis --- rhodium nanoparticles --- surfactants --- role of additives --- morphology control --- toxicity --- bio-imaging --- X-ray fluorescence --- contrast agent --- XFCT --- nanomaterials --- 2D nanostructures --- thiacalix[4]arene --- terpenoids --- geraniol --- X-ray crystal analysis --- 2D monomolecular-layer nanosheets --- polymorphism --- silica --- polystyrene --- maghemite supraparticles --- patchy particles --- seeded-growth emulsion polymerization --- solvent-induced self-assembly --- pillar[5]arene --- tetrazole --- drug delivery systems --- fluorescein --- ceria --- nanorods --- nanosheets --- nanozyme --- biomolecule --- template --- catalysis --- anti-oxidant --- oxygen radicals --- lithium iron phosphate --- hydrothermal synthesis --- heating rate --- morphology --- crystallinity and purity --- polyelectrolyte multilayers --- encapsulation --- calcium carbonate --- drug delivery --- shrinkage --- layered oxides --- perovskites --- bismuth titanates --- exfoliation --- coating --- silver nanoparticles --- AgNPs --- synthesis --- separation --- purification --- n/a --- Suzuki-Miyaura coupling

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Recently, stem cells have been drawing increasing interest in basic and translational research that aims to understand stem cell biology and generate new therapies for various disorders. Many stem cells can be cultured in 2D relatively easily using tissue culture plastic. However, many of these cultures do not represent the natural conditions of stem cells in the body. In the body, microenvironments include numerous supporting cells and molecules. Therefore, researchers and clinicians have sought ideal stem cell preparations for basic research and clinical applications, which may be attainable through 3D culture of stem cells. The 3D cultures mimic the conditions of the natural environment of stem cells better, as cells in 3D cultures exhibit many unique and desirable characteristics that could be beneficial for therapeutic interventions. 3D stem cell cultures may employ supporting structures, such as various matrices or scaffolds, in addition to stem cells, to support complex structures. This book brings together recent research on 3D cultures of various stem cells to increase the basic understanding of stem cell culture techniques and also to highlight stem cell preparations for possible novel therapeutic applications.

Research & information: general --- Biology, life sciences --- hematopoiesis --- hematopoietic stem cells --- stem cell culture --- 2D culture --- 3D culture --- embryonic stem cells --- three-dimensional --- self-assembling scaffold --- pluripotency --- culture conditions --- expansion --- growth --- niche --- human cortical progenitors --- silicon pillars --- cell growth --- hiPSC-derived neural progenitors --- cerebral cortex --- carcinogen --- protein phosphatase 2A (PP2A) --- intestinal tumor --- intestinal organoid --- Lgr5+ crypt stem cell --- mouse embryonic stem cell --- differentiation protocol --- ureteric bud progenitor cells --- 3D kidney organoids --- intestinal organoids --- canine intestine --- differentiation --- organoid culture --- induced pluripotent stem cells --- neurospheres --- neurite outgrowth --- neurotoxicity --- hBM-MSCs --- cytokines --- tenogenic markers --- cyclic strain --- 3D microenvironment --- PLGA carriers --- bioreactor --- cardiac microtissues --- iPSC-derived cardiomyocytes --- cardiac fibroblasts --- cardiac fibrosis --- cardiac rhythm --- TGF-β signalling --- drug screening --- in vitro model --- stem cell --- 3D --- culture condition --- regenerative medicine --- scaffold --- organoid --- adipose tissue-derived mesenchymal stem cells --- stromal vascular fraction --- platelet rich plasma --- platelet concentrates --- veterinary regenerative medicine