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Based on the highly successful first edition of Prostate Biopsy: Indications, Techniques, and Complications, this new volume presents new concepts that have emerged in answer to current questions from its audience. Many new perspectives and technologies are presented, many from the authors’ internationally recognized work on the topic. Substantial developments in techniques and complications are explored in detail. The chapter authors comprise a complete spectrum of specialists in their respective subject areas. All authors are internationally accepted as the premier authorities on their chosen topics. Prostate Cancer Diagnosis: PSA, Biopsy, and Beyond presents new data on the controversial issue of PSA screening and thresholds as indication to perform biopsy. Office based transrectal saturation biopsy is covered in detail. Other topics explored include template guided biopsy and image-guided biopsy as well as a completely new paradigm for prevention of complications. Prostate Cancer Diagnosis: PSA, Biopsy, and Beyond will be of great value and utility to all practicing urologists. .
Medicine. --- Prostate -- Cancer -- Diagnosis. --- Prostate -- Cancer -- Treatment. --- Prostate --- Prostatic Secretory Proteins --- Kallikreins --- Genital Neoplasms, Male --- Early Diagnosis --- Diagnostic Techniques, Surgical --- Tumor Markers, Biological --- Specimen Handling --- Surgical Procedures, Operative --- Prostatic Diseases --- Antigens, Neoplasm --- Cytodiagnosis --- Laboratory Techniques and Procedures --- Antigens --- Urogenital Neoplasms --- Serine Endopeptidases --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Genital Diseases, Male --- Diagnosis --- Biological Markers --- Diagnostic Techniques and Procedures --- Seminal Plasma Proteins --- Male Urogenital Diseases --- Proteins --- Serine Proteases --- Neoplasms by Site --- Biological Factors --- Endopeptidases --- Diseases --- Peptide Hydrolases --- Chemicals and Drugs --- Amino Acids, Peptides, and Proteins --- Neoplasms --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Prostate-Specific Antigen --- Prostatic Neoplasms --- Biopsy --- Early Detection of Cancer --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Medical screening. --- Diagnosis. --- Mass medical screening --- Mass screening, Medical --- Medical examinations --- Screening, Medical --- Oncology. --- Medicine & Public Health. --- Medicine/Public Health, general. --- Diagnostic services --- Health risk assessment --- Oncology . --- Tumors --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Health Workforce
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Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes
Research & information: general --- Biology, life sciences --- Streptomyces --- biogeography --- comparative genomics --- diversification --- secondary metabolite biosynthetic gene clusters --- SMGC --- natural products --- streptomyces --- rishirilide --- biosynthesis --- polyketides --- polynucleotide phosphorylase --- ribonuclease --- regulation --- promoter --- RNA decay --- polyadenylation --- (p)ppGpp --- antibiotic --- antibiotics --- geomicrobiology --- Illumina sequencing --- microbiome diversity --- Actinobacteria --- Cave microbiology --- secondary metabolite --- rare Actinobacteria --- Amycolatopsis --- unculturability --- siderophore --- glycopeptide antibiotics --- dbv cluster --- regulatory genes --- StrR --- LAL --- LuxR solo --- dalbavancin --- A40926 --- Streptomyces lividans --- secretion pathways --- secretory proteins --- signal peptides --- actinomycetes --- teicoplanin --- van resistance genes --- Streptomyces tsukubaensis --- tacrolimus --- FK506 --- omics --- screening --- secondary metabolism --- differentiation --- elicitors --- morphology --- liquid cultures --- metagenomics --- rare actinomycetes --- dereplication --- metabolomics --- genome mining --- secondary metabolites --- novel compounds --- physicochemical screening --- physical and chemical properties --- structural diversity --- biological activity --- Actinoallomurus --- antibiotics polyethers --- lysolipin --- minimal PKS II --- cyclases --- benz[a]naphthacene quinone --- tridecaketide --- aromatic polyketide --- pentacyclic angular polyphenol --- extended polyketide chain --- actinobacteria --- β-lactamase --- resistance --- β-lactamase inhibitor --- polyketide synthases --- acyltransferases --- engineering --- new bioactive compounds --- symbiosis --- drug discovery --- chemical ecology --- culture-based approaches --- strain --- specialized metabolites --- biosynthetic gene cluster --- n/a
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Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes
Streptomyces --- biogeography --- comparative genomics --- diversification --- secondary metabolite biosynthetic gene clusters --- SMGC --- natural products --- streptomyces --- rishirilide --- biosynthesis --- polyketides --- polynucleotide phosphorylase --- ribonuclease --- regulation --- promoter --- RNA decay --- polyadenylation --- (p)ppGpp --- antibiotic --- antibiotics --- geomicrobiology --- Illumina sequencing --- microbiome diversity --- Actinobacteria --- Cave microbiology --- secondary metabolite --- rare Actinobacteria --- Amycolatopsis --- unculturability --- siderophore --- glycopeptide antibiotics --- dbv cluster --- regulatory genes --- StrR --- LAL --- LuxR solo --- dalbavancin --- A40926 --- Streptomyces lividans --- secretion pathways --- secretory proteins --- signal peptides --- actinomycetes --- teicoplanin --- van resistance genes --- Streptomyces tsukubaensis --- tacrolimus --- FK506 --- omics --- screening --- secondary metabolism --- differentiation --- elicitors --- morphology --- liquid cultures --- metagenomics --- rare actinomycetes --- dereplication --- metabolomics --- genome mining --- secondary metabolites --- novel compounds --- physicochemical screening --- physical and chemical properties --- structural diversity --- biological activity --- Actinoallomurus --- antibiotics polyethers --- lysolipin --- minimal PKS II --- cyclases --- benz[a]naphthacene quinone --- tridecaketide --- aromatic polyketide --- pentacyclic angular polyphenol --- extended polyketide chain --- actinobacteria --- β-lactamase --- resistance --- β-lactamase inhibitor --- polyketide synthases --- acyltransferases --- engineering --- new bioactive compounds --- symbiosis --- drug discovery --- chemical ecology --- culture-based approaches --- strain --- specialized metabolites --- biosynthetic gene cluster --- n/a
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Beyond being the most important natural compound source, actinomycetes are the origin of up to two-thirds of all clinically used antibiotics. Currently, new antimicrobials are urgently needed, as infections caused by antibiotic-resistant pathogens are on the rise. In the identification of new antibiotics, many scientists are currently investigating biosynthetic aspects of antibiotic production in actinomycetes. Since the emergence of next-generation sequencing technologies, the field of antibiotics research has experienced a remarkable revival. These bacteria have the potential to produce more antibiotics than previously thought possible. Some antibiotics are produced in standard media, while others require the presence of a specific signaling molecule in the medium. Others, however, are only produced when the native regulation of the biosynthesis gene cluster is overruled. This book covers topics in the field of antibiotic-producing actinomycetes. The following tops are addressed: - Approaches to access novel antibiotic producers for novel natural compounds - Omics and genome mining approaches for the discovery of novel natural compounds - Analyses and genetic engineering of antibiotic biosynthesis - Regulation of the secondary metabolism in actinomycetes
Research & information: general --- Biology, life sciences --- Streptomyces --- biogeography --- comparative genomics --- diversification --- secondary metabolite biosynthetic gene clusters --- SMGC --- natural products --- streptomyces --- rishirilide --- biosynthesis --- polyketides --- polynucleotide phosphorylase --- ribonuclease --- regulation --- promoter --- RNA decay --- polyadenylation --- (p)ppGpp --- antibiotic --- antibiotics --- geomicrobiology --- Illumina sequencing --- microbiome diversity --- Actinobacteria --- Cave microbiology --- secondary metabolite --- rare Actinobacteria --- Amycolatopsis --- unculturability --- siderophore --- glycopeptide antibiotics --- dbv cluster --- regulatory genes --- StrR --- LAL --- LuxR solo --- dalbavancin --- A40926 --- Streptomyces lividans --- secretion pathways --- secretory proteins --- signal peptides --- actinomycetes --- teicoplanin --- van resistance genes --- Streptomyces tsukubaensis --- tacrolimus --- FK506 --- omics --- screening --- secondary metabolism --- differentiation --- elicitors --- morphology --- liquid cultures --- metagenomics --- rare actinomycetes --- dereplication --- metabolomics --- genome mining --- secondary metabolites --- novel compounds --- physicochemical screening --- physical and chemical properties --- structural diversity --- biological activity --- Actinoallomurus --- antibiotics polyethers --- lysolipin --- minimal PKS II --- cyclases --- benz[a]naphthacene quinone --- tridecaketide --- aromatic polyketide --- pentacyclic angular polyphenol --- extended polyketide chain --- actinobacteria --- β-lactamase --- resistance --- β-lactamase inhibitor --- polyketide synthases --- acyltransferases --- engineering --- new bioactive compounds --- symbiosis --- drug discovery --- chemical ecology --- culture-based approaches --- strain --- specialized metabolites --- biosynthetic gene cluster --- Streptomyces --- biogeography --- comparative genomics --- diversification --- secondary metabolite biosynthetic gene clusters --- SMGC --- natural products --- streptomyces --- rishirilide --- biosynthesis --- polyketides --- polynucleotide phosphorylase --- ribonuclease --- regulation --- promoter --- RNA decay --- polyadenylation --- (p)ppGpp --- antibiotic --- antibiotics --- geomicrobiology --- Illumina sequencing --- microbiome diversity --- Actinobacteria --- Cave microbiology --- secondary metabolite --- rare Actinobacteria --- Amycolatopsis --- unculturability --- siderophore --- glycopeptide antibiotics --- dbv cluster --- regulatory genes --- StrR --- LAL --- LuxR solo --- dalbavancin --- A40926 --- Streptomyces lividans --- secretion pathways --- secretory proteins --- signal peptides --- actinomycetes --- teicoplanin --- van resistance genes --- Streptomyces tsukubaensis --- tacrolimus --- FK506 --- omics --- screening --- secondary metabolism --- differentiation --- elicitors --- morphology --- liquid cultures --- metagenomics --- rare actinomycetes --- dereplication --- metabolomics --- genome mining --- secondary metabolites --- novel compounds --- physicochemical screening --- physical and chemical properties --- structural diversity --- biological activity --- Actinoallomurus --- antibiotics polyethers --- lysolipin --- minimal PKS II --- cyclases --- benz[a]naphthacene quinone --- tridecaketide --- aromatic polyketide --- pentacyclic angular polyphenol --- extended polyketide chain --- actinobacteria --- β-lactamase --- resistance --- β-lactamase inhibitor --- polyketide synthases --- acyltransferases --- engineering --- new bioactive compounds --- symbiosis --- drug discovery --- chemical ecology --- culture-based approaches --- strain --- specialized metabolites --- biosynthetic gene cluster
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Prostate cancer is the most frequently diagnosed non-cutaneous malignancy in men, and the second leading cause of male cancer-related mortality in the United States. The last decade has seen unprecedented progress in the detection, prognosis, treatment and prevention of prostate cancer. These advances have been driven largely by an increased understanding of the underlying biochemistry, molecular biology and genetics of the disease. New cell and animal models have been developed that recapitulate the natural progression of prostate cancer. New technologies have allowed scientists to view in detail the genomic, proteomic, metabolomics and other –omic universe of cancer cells and tissues. This has resulted in a greater understanding of the pathophysiology of the disease.
Prostate -- Cancer -- Diet therapy. --- Prostate -- Cancer -- Genetic aspects. --- Prostate -- Cancer -- Molecular aspects. --- Prostate --- Exocrine Glands --- Cell Physiological Processes --- Neoplastic Processes --- Prostatic Diseases --- Genital Neoplasms, Male --- Genitalia, Male --- Prostatic Secretory Proteins --- Tumor Markers, Biological --- Kallikreins --- Antigens, Neoplasm --- Biochemical Processes --- Proteins --- Seminal Plasma Proteins --- Genital Diseases, Male --- Neoplasms --- Biochemical Phenomena --- Biological Markers --- Pathologic Processes --- Genitalia --- Serine Endopeptidases --- Tissues --- Cell Physiological Phenomena --- Chemical Processes --- Antigens --- Amino Acids, Peptides, and Proteins --- Urogenital Neoplasms --- Neoplasms by Site --- Phenomena and Processes --- Chemical Phenomena --- Male Urogenital Diseases --- Biological Factors --- Endopeptidases --- Urogenital System --- Anatomy --- Diseases --- Chemicals and Drugs --- Serine Proteases --- Pathological Conditions, Signs and Symptoms --- Peptide Hydrolases --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Signal Transduction --- Prostatic Neoplasms --- Neoplasm Proteins --- Prostate-Specific Antigen --- Cell Transformation, Neoplastic --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer --- Genetics. --- Cancer. --- Medicine. --- Cancer research. --- Medical biochemistry. --- Proteins. --- Cell biology. --- Systems biology. --- Biological systems. --- Biomedicine. --- Cancer Research. --- Medical Biochemistry. --- Cell Biology. --- Protein Science. --- Receptors. --- Biological Networks, Systems Biology. --- Biosystems --- Systems, Biological --- Biology --- System theory --- Systems biology --- Computational biology --- Bioinformatics --- Biological systems --- Molecular biology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Pathology --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Philosophy --- Embryology --- Mendel's law --- Adaptation (Biology) --- Breeding --- Chromosomes --- Heredity --- Mutation (Biology) --- Variation (Biology) --- Oncology. --- Biochemistry. --- Cytology. --- Cell receptors. --- Systems Biology. --- Cell membrane receptors --- Cell surface receptors --- Receptors, Cell --- Binding sites (Biochemistry) --- Cell membranes --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Tumors --- Composition --- Proteins .
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More than one in six men will develop prostate cancer in their lifetime. In recent years there has been an explosion of information regarding PSA screening and biomarkers for the disease. In Prostate Cancer Screening, Second Edition, the world’s leading experts on prostate cancer detection update the first edition with the latest findings. The book incorporates a series of thoughtful and cutting-edge works from the world’s experts in prostate cancer screening, ranging from the current status quo of prostate cancer screening across the globe to consensus on optimal utilization of the traditional PSA and DRE tests, to cutting-edge research in new biomarkers, biomeasures, and extended risk algorithms for prostate cancer. An additional chapter covers family-based linkage analysis as well as possible pitfalls in prostate cancer biomarker evaluation studies. Timely and authoritative, Prostate Cancer Screening, Second Edition, is an essential text for urologists, oncologists and family physicians, as well as researchers in the biomarker industry who seek methods to better develop and support markers and measures of prostate cancer.
Medical screening. --- Prostate --Cancer --Diagnosis. --- Prostate --- Medical screening --- Mass Screening --- Prostate-Specific Antigen --- Prostatic Neoplasms --- Diagnostic Techniques and Procedures --- Antigens, Neoplasm --- Tumor Markers, Biological --- Diagnostic Services --- Kallikreins --- Health Surveys --- Public Health Practice --- Prostatic Diseases --- Genital Neoplasms, Male --- Prostatic Secretory Proteins --- Urogenital Neoplasms --- Biological Markers --- Public Health --- Genital Diseases, Male --- Preventive Health Services --- Diagnosis --- Serine Endopeptidases --- Antigens --- Data Collection --- Seminal Plasma Proteins --- Male Urogenital Diseases --- Health Care Evaluation Mechanisms --- Environment and Public Health --- Endopeptidases --- Proteins --- Community Health Services --- Biological Factors --- Epidemiologic Methods --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Health Services --- Neoplasms by Site --- Serine Proteases --- Quality of Health Care --- Diseases --- Chemicals and Drugs --- Neoplasms --- Peptide Hydrolases --- Amino Acids, Peptides, and Proteins --- Health Care --- Investigative Techniques --- Health Care Facilities, Manpower, and Services --- Hydrolases --- Health Care Quality, Access, and Evaluation --- Enzymes --- Enzymes and Coenzymes --- Oncology --- Public Health - General --- Urology & Nephrology --- Medicine --- Health & Biological Sciences --- Cancer --- Diagnosis. --- Mass medical screening --- Mass screening, Medical --- Medical examinations --- Screening, Medical --- Medicine. --- Health informatics. --- Oncology. --- Urology. --- Epidemiology. --- Medicine & Public Health. --- Medicine/Public Health, general. --- Health Informatics. --- Public health --- Genitourinary organs --- Tumors --- Clinical informatics --- Health informatics --- Medical information science --- Information science --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Data processing --- Diagnostic services --- Health risk assessment --- Oncology . --- Medical records --- Data processing. --- EHR systems --- EHR technology --- EHRs (Electronic health records) --- Electronic health records --- Electronic medical records --- EMR systems --- EMRs (Electronic medical records) --- Information storage and retrieval systems --- Medical care --- Health Workforce
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