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Industrial chemistry --- Chemistry of natural organic substances --- Surface chemistry --- Animal biochemistry --- Nutritionary hygiene. Diet --- fysicochemie --- Pharmacotechnology. Preparations --- Gelatin --- Collagen --- Collagène --- 665.931.7 --- 678.567 --- Gelatine --- Proteins --- Collogen --- Extracellular matrix proteins --- Connective tissues --- Keratin. Gelatin (collagen). Other scleroproteins --- 678.567 Keratin. Gelatin (collagen). Other scleroproteins --- 665.931.7 Gelatin --- Collagène
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Molecular Conformation --- Biopolymers --- Extracellular Matrix Proteins --- Amino Acids, Peptides, and Proteins --- Polymers --- Scleroproteins --- Molecular Structure --- Biochemical Phenomena --- Macromolecular Substances --- Chemical Phenomena --- Collagen --- Elastin --- Protein Conformation --- Proteins --- Protein Structure, Secondary --- Molecular Conformation. --- Biopolymers. --- Extracellular Matrix Proteins. --- Amino Acids, Peptides, and Proteins. --- Polymers. --- Scleroproteins. --- Molecular Structure. --- Biochemical Phenomena. --- Macromolecular Substances. --- Chemical Phenomena. --- Collagen. --- Elastin. --- Protein Conformation. --- Proteins. --- Protein Structure, Secondary.
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Collagen. --- Collagène --- Chemistry. --- Chemistry, Organic. --- Organic Chemistry. --- Collagen --- Biopolymers --- Extracellular Matrix Proteins --- Polymers --- Scleroproteins --- Proteins --- Macromolecular Substances --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Biochemistry --- Chemistry --- Physical Sciences & Mathematics --- 547.96 --- 547.96 Proteins --- Macromolecular Complexes --- Macromolecular Compounds --- Macromolecular Compounds and Complexes --- Complexes, Macromolecular --- Compounds, Macromolecular --- Substances, Macromolecular --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Polymer --- Matrix Proteins, Extracellular --- Proteins, Extracellular Matrix --- Biopolymer --- Avicon --- Avitene --- Collagen Felt --- Collagen Fleece --- Collagenfleece --- Collastat --- Dermodress --- Microfibril Collagen Hemostat --- Pangen --- Zyderm --- alpha-Collagen --- Collagen Hemostat, Microfibril --- alpha Collagen --- Organic chemistry --- Fibrous Proteins --- Organic chemistry.
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Cells require interactions with extracellular matrix (ECM) components in order to undergo normal morphogenesis with respect to organogenesis. ECM plays a significant role in regulating numerous cellular functions, like cell shape, adhesion, migration, proliferation, polarity, differentiation and apoptosis. In pathological conditions such as cancer, increased synthesis of certain ECM components and/or increased breakdown with consequent generation of ECM cleavage products can contribute to cancer growth and progression. That many growth factors (i.e. FGF, VEGF) are stored in the ECM milieu and are released upon protease-dependent cleavage further confirms the importance of ECM in regulating cell functions. Cell-Extracellular Matrix Interactions in Cancer describes how ECM creates a niche for tumor formation and the contribution of ECM components and their respective receptors in the development and spread of cancer.
Cancer -- Pathophysiology. --- Extracellular matrix proteins. --- Neoplasms -- Physiopathology. --- Cancer --- Extracellular matrix proteins --- Scleroproteins --- Diseases --- Cell Physiological Processes --- Cell Communication --- Neoplasms --- Extracellular Matrix Proteins --- Proteins --- Cell Physiological Phenomena --- Amino Acids, Peptides, and Proteins --- Phenomena and Processes --- Chemicals and Drugs --- Medicine --- Oncology --- Health & Biological Sciences --- Pathophysiology --- Pathophysiology. --- Matrix proteins --- Medicine. --- Cancer research. --- Pharmacology. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Pharmacology/Toxicology. --- Oncology. --- Cytology. --- Toxicology. --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Tumors --- Toxicology --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Cancer research --- Physiological effect
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The cyclic ovary can be seen as a site of tissue damage, repair and precisely controlled tissue homeostasis, as long ovulation and luteolysis can be compared with acute and chronic inflammation. Innate immunity appears to be a powerful force in the endocrine system, representing a novel concept. In this monograph, remarkable evidence is given for the immune-privileged ovary being an implant on the chicken chorioallantoic membrane with an areactive mesenchyme. Mild to severe tissue damages due to follicular atresia, follicular rupture, or intraovarian oocyte release do no lasting harm. The most exciting part relates to the analysis of cytokeratin-positive (CK+) cells, comparing the fate mapping of this cell type from the fetal ovary to the adult organ. Findings on toll-like receptor 4 regulation and interferon-gamma-dependent positive effects indicate that CK+ cells from human preovulatory follicles and bovine corpora lutea have similarities with nonlymphoid dendritic cells, a discovery that has the makings of a top story in basic and clinical research on the ovary.
Dendritic cells. --- Natural immunity. --- Ovaries. --- Chordata --- Scleroproteins --- Adnexa Uteri --- Mononuclear Phagocyte System --- Antigen-Presenting Cells --- Intermediate Filament Proteins --- Gonads --- Immunity --- Epithelial Cells --- Immune System --- Cells --- Animals --- Biopolymers --- Genitalia --- Cytoskeletal Proteins --- Genitalia, Female --- Immune System Phenomena --- Proteins --- Endocrine Glands --- Dendritic Cells --- Keratins --- Vertebrates --- Ovary --- Immunity, Innate --- Anatomy --- Hemic and Immune Systems --- Eukaryota --- Urogenital System --- Endocrine System --- Amino Acids, Peptides, and Proteins --- Polymers --- Phenomena and Processes --- Organisms --- Chemicals and Drugs --- Macromolecular Substances --- Medicine --- Health & Biological Sciences --- Gynecology & Obstetrics --- Ovaries --- Immunity. --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Medicine. --- Human physiology. --- Immunology. --- Reproductive medicine. --- Medicine & Public Health. --- Reproductive Medicine. --- Human Physiology. --- Adnexa uteri --- Ovum --- Disease resistance --- Immunobiology --- Life sciences --- Serology --- Human biology --- Medical sciences --- Physiology --- Human body --- Human reproduction --- Human reproductive health --- Human reproductive medicine --- Reproductive medicine --- Health --- Health aspects
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The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors. The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types. The 5th international workshop on the CCN family of genes, that was held in Toronto in 2008 brought together scientists from around the world who have an interest in the biological roles of this emerging family of proteins. On an educational point of view, the workshop was a unique place for an efficient diffusion of scientific information. The present book comprises a series of selected manuscripts that are based on the original communications that were presented at the meeting by worldwide leaders in the field of CCN biology. All major aspects of CCN proteins biology in both normal and pathological conditions are covered in this volume, from structure-functions analysis up to the involvement of CCN proteins in complex physiological functions. In addition to reports that support the Yin-Yang concept of CCN proteins driving opposite effects on the same biological process, this book also comprises several contributions that point to CCN proteins as amenable targets for therapeutic manipulation of disease processes. Together with the special issue of Journal of Cell Communication and Signaling in which authors have extended on the original data presented at the meeting, the present Proceedings provide an instant picture and unique update of the state of the art in the CCN field.
Cell differentiation -- Molecular aspects -- Congresses. --- Growth factors -- Congresses. --- Protein-protein interactions -- Congresses. --- Protein-protein interactions --- Cell differentiation --- Growth factors --- Intercellular Signaling Peptides and Proteins --- Extracellular Matrix Proteins --- Publication Formats --- CCN Intercellular Signaling Proteins --- Congresses --- Biological Factors --- Peptides --- Proteins --- Scleroproteins --- Publication Characteristics --- Chemicals and Drugs --- Amino Acids, Peptides, and Proteins --- Human Anatomy & Physiology --- Animal Biochemistry --- Health & Biological Sciences --- Molecular aspects --- Interactions, Protein-protein --- Protein interactions --- Cell fate specification --- Cell specification --- Cells --- Differentiation of cells --- Fate specification of cells --- Specification of cells --- Differentiation --- Fate specification --- Specification --- Medicine. --- Medical genetics. --- Molecular biology. --- Proteins. --- Cell biology. --- Biomedicine. --- Biomedicine general. --- Gene Function. --- Molecular Medicine. --- Protein Science. --- Cell Biology. --- Morphogenesis --- Molecular association --- Biochemistry. --- Cytology. --- Cell biology --- Cellular biology --- Biology --- Cytologists --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Clinical genetics --- Diseases --- Heredity of disease --- Human genetics --- Pathology --- Genetic disorders --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Physicians --- Composition --- Genetic aspects --- Health Workforce --- Proteins . --- Biomedicine, general. --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Systems biology
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Proteomics --- Proteins --- Biochemistry --- Proteome. --- Protéines --- Biochimie --- Biochemistry. --- Proteomics. --- Research --- genetics. --- Recherche --- Research. --- Protein research --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Proteomes --- Proteids --- Composition --- Protéines --- Molecular biology --- Biology --- Chemistry --- Medical sciences --- Biomolecules --- Polypeptides --- Health Sciences --- Physiology --- Proteome --- proteome. --- proteins. --- genetics --- Biological Sciences --- animal genetics --- cytogenetics --- gender --- genetic equilibrium --- genetic factors --- genetic relationships --- genetic selection --- genetic stability --- genetic structure --- genetic traits --- genetic vectors --- genomics --- human genetics --- immunogenetics --- inheritance (genetics) --- landscape genetics --- maternal effect --- metabolomics --- microbial genetics --- molecular genetics --- nutrigenomics --- paternal effect --- phenomics --- phenotype --- plant genetics --- population genetics --- proteomics --- quantitative genetics --- reproductive fitness --- sex determination --- transcriptomics --- biotechnology --- breeding --- genetic models --- genetic resources --- geneticists --- amino acids, peptides and proteins --- advanced glycation end products --- advanced oxidation protein products --- agglutinins --- algal proteins --- angiogenic proteins --- animal proteins --- antifreeze proteins --- antimicrobial proteins --- apoproteins --- binding proteins --- BTB-Kelch proteins --- chloroplast proteins --- conjugated proteins --- contractile proteins --- CRISPR-associated proteins --- crystal proteins --- crystallins --- cytoskeletal proteins --- gelatin --- GTPase-activating proteins --- helminth proteins --- heme proteins --- insecticidal proteins --- kinesin --- lectins --- luminescent proteins --- membrane proteins --- microbial proteins --- mitochondrial proteins --- molecular chaperones --- molecular motor proteins --- multiprotein complexes --- neoplasm proteins --- nuclear-encoded proteins --- nuclear proteins --- nucleoproteins --- peptones --- phosphoproteins --- phytohemagglutinin --- plant proteins --- polyproteins --- prions --- protein aggregates --- protein corona --- protein products --- protozoan proteins --- pulmonary surfactant associated proteins --- receptors --- recombinant proteins --- regulatory proteins --- ribonucleoproteins --- ribosomal proteins --- scaffolding proteins --- scleroproteins --- selenoproteins --- seminal plasma proteins --- silver proteins --- simple proteins --- storage proteins --- structural proteins --- sulfur proteins --- surface proteins --- thermostable proteins --- transcobalamins --- transcription factors --- tubulin --- ubiquitins --- viral proteins --- protein sweeteners --- proteinuria --- proteolytic bacteria --- proteome --- phosphoproteome --- metabolome --- proteins --- sialome --- biochemistry --- molecular biology --- proteomics --- protein science --- systems biology --- bioinformatics --- Protéomique --- Protéomes.
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