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Although a histologically benign and relatively uncommon tumor, otolaryngologists and neurosurgeons have maintained a lasting and deep-rooted fascination with vestibular schwannoma, also known as acoustic neuroma. Advancements in microsurgical technique, radiosurgery, and radiotherapy, coupled with an increased understanding of the natural history of the disease, have made modern management of this tumor considerably more complex. Concurrently, new controversies have added to the original debates among pioneering surgeons, with the pendulum swinging between conservatism and definitive cure. Comprehensive Management of Vestibular Schwannoma, by distinguished Mayo Clinic clinicians and renowned international contributors, is a comprehensive textbook covering all the clinical aspects of vestibular schwannoma management. Eighty-four chapters written by multidisciplinary experts including otolaryngologists, neurosurgeons, radiation oncologists, neurologists, neuroradiologists, and audiologists, ensure a balanced view of all treatment modalities for sporadic and neurofibromatosis type 2-associated vestibular schwannoma.

Acoustic neuroma. --- Acoustic neurilemmonma --- Acoustic neurilemoma --- Acoustic neurinoma --- Neurilemmoma, Acoustic --- Neurilemoma, Acoustic --- Neurinoma, Acoustic --- Schwannoma, Vestibular --- Vestibular schwannoma --- Acoustic nerve --- Neuromas --- Tumors

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This volume of the Keio University International Symposia for LifeSciences and Medicine contains the proceedings of the eleventh symposium held under the sponsorship of the Keio University Medical Science Fund. As explained in the Opening Remarks by the President of Keio University, the fund was established by the generous donation of Dr. Mitsunada Sakaguchi. The Keio University International Symposia for Life Sciences and Medicine constitute one of the core activities sponsored by the fund, the objective of which is to contribute to the international community by developing human resources, promoting scientific knowledge, and encouraging mutual exchange. Each year, the Committee of the International Symposia for Life Sciences and Medicine selects the most significant symposium topic from applications received from the Keio medical community. The publication of the proceedings is intended to publicize and disseminate the information arising from the lively discussions of the most exciting and current issues presented during the symposium. On behalf of the Committee, I am most grateful to Dr. Mitsunada Sakaguchi, who made the symposia series possible. Weare also grateful to the prominent speakers for their contribution to this volume. In addition,wewould liketo acknowledge the efficientorganizational work performed by the members of the program committee and the staff of the fund. Naoki Aikawa,M.D.,D.M.Sc., EA.C.S.

Neuroma, Acoustic --- Epidemiologic Methods. --- Treatment Outcome. --- Acoustic neuroma --- -Acoustic neurilemmonma --- Acoustic neurilemoma --- Acoustic neurinoma --- Neurilemmoma, Acoustic --- Neurilemoma, Acoustic --- Neurinoma, Acoustic --- Schwannoma, Vestibular --- Vestibular schwannoma --- Acoustic nerve --- Neuromas --- Clinical Effectiveness --- Clinical Efficacy --- Patient-Relevant Outcome --- Treatment Efficacy --- Rehabilitation Outcome --- Treatment Effectiveness --- Clinical Effectivenesses --- Effectiveness, Clinical --- Effectiveness, Treatment --- Effectivenesses, Clinical --- Efficacy, Clinical --- Efficacy, Treatment --- Outcome, Patient-Relevant --- Outcome, Rehabilitation --- Outcome, Treatment --- Outcomes, Patient-Relevant --- Patient Relevant Outcome --- Patient-Relevant Outcomes --- Lysholm Knee Score --- Epidemiologic Method --- Epidemiological Methods --- Methods, Epidemiologic --- Epidemiological Method --- Method, Epidemiologic --- Method, Epidemiological --- Methods, Epidemiological --- Epidemiology --- epidemiology. --- pathology. --- therapy. --- Reporting --- Tumors --- methods --- Epidemiologic Methods --- Treatment Outcome --- epidemiology --- pathology --- therapy --- -epidemiology. --- Pathology --- Therapy --- Acoustic neurilemmonma --- Otorhinolaryngology. --- Ear, nose, and throat diseases --- ENT diseases --- Otorhinolaryngology --- Medicine

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The Hippo pathway is a highly dynamic cellular signaling nexus that plays central roles in multiple cell types and regulates regeneration, metabolism, and development. The Hippo pathway integrates mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving. This Special Issue contains ten articles contributed by established and up-and-coming Hippo pathway experts that, as a whole, provides an up-to-date overview of how dysregulated Hippo pathway activity is a common driver of specific diseases. The articles have a particular focus on the underlying molecular and cellular mechanisms that cause the Hippo pathway to go awry, and especially how this drives disease. The articles analyze disease-specific as well as common themes, which provides valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.

STRIPAK --- skin cancer --- n/a --- Lats2 --- transcription --- myofibroblast --- epigenetic --- Hippo --- cancer immunity --- TAZ --- Taz --- TAZ (transcriptional co-activator with PDZ-binding motif) --- adaptive immunity --- fibroblasts --- innate immunity --- LATS --- MST (mammalian STE20-like protein kinase) --- phosphorylation --- stem cells --- wound healing --- signal transduction --- angiogenesis --- LATS1/2 --- EMT --- protein-protein interactions --- structure biology --- Hippo pathway --- hippo pathway --- autoimmunity --- Mps one binder --- YAP/TAZ --- GPCR --- fibrosis --- MST1/2 --- YAP (yes-associated protein) --- YAP --- Yap --- protein kinase --- LATS (large tumor suppressor kinase) --- peripheral nerve sheath tumor --- signal cross-talk --- stem cell --- skin development --- STK38 --- tumorigenesis --- NDR --- schwannoma --- G protein-coupled receptor --- anti-cancer therapy --- feedback loops --- vascular mimicry --- castration resistance --- chromatin --- Hippo signalling --- ECM --- MST --- prostate cancer --- TEAD --- cancer --- zebrafish