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Ribosomes. --- Ribonucleoprotein particles --- Cell organelles --- Microsomes --- Nucleoproteins --- Protoplasm

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ADVANCES IN PROTEIN CHEMISTRY VOL 36

Proteins. --- Ribosomes. --- Ribonucleoprotein particles --- Cell organelles --- Microsomes --- Nucleoproteins --- Protoplasm --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

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Nucleolus --- 576.311.336 --- Ribosomes. Polyribosomes. Agranular endoplasmic reticulum. --- Nucleolus. --- Ribosomes. --- 576.311.336 Ribosomes. Polyribosomes. Agranular endoplasmic reticulum. --- Ribosomes --- Ribonucleoprotein particles --- Cell organelles --- Microsomes --- Nucleoproteins --- Protoplasm --- Cell nucleolus --- Micronucleus --- Plasmosome --- Cell nuclei --- Ribosomes. Polyribosomes. Agranular endoplasmic reticulum --- REGULATION --- NUCLEOLUS --- MATURATION --- PRERIBOSOMES --- TRANSCRIPTION --- REPLICATION --- GENES --- RIBOSOMAL RNA --- RIBOSOMES --- BIOGENESIS --- PROTEINS --- SENESCENCE --- CARCINOGENESIS --- CELL CYCLE --- STRUCTURES

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Sex steroids, including androgens, estrogens, and progestogens, are knownto have widespread physiological actions beyond the reproductive systemvia binding to the sex hormone receptors. Meanwhile, emerging evidence hasindicated that sex hormone receptor signals are involved in the outgrowth ofsome malignancies, such as prostate and breast carcinomas, as well as othersthat have not traditionally been considered as endocrine-related neoplasms. ThisSpecial Issue “Sex Hormone Receptor Signals in Human Malignancies” coversvarious aspects of the potential role of sex hormone receptors and related signalsin prostate cancer, breast cancer, and other neoplastic conditions by depictingpromising findings derived from in vitro and in vivo experiments as well as theanalyses of surgical specimens. The current observations described may thusprovide a unique insight into novel or known functions of sex hormone receptorsand related molecules.

FOXA1 --- COBRA1 --- n/a --- estrogen --- progesterone receptor negative --- mutational profiling --- heterogeneous nuclear ribonucleoprotein K --- estrogen receptor alpha --- salivary gland tumors --- castration-resistant prostate cancer --- ELK1 --- fibroblasts --- androgen receptor --- melanocytes --- drug screening and proteomics --- PI3K pathway --- NELFB --- therapeutic targets --- immunohistochemistry --- androgen deprivation therapy --- ovarian cancer --- estrogen receptor --- epidermal growth factor receptor --- ethinylestradiol --- melanoma --- breast cancer --- keratinocytes --- G-protein coupled estrogen receptor --- prognosis --- levonorgestrel --- ultraviolet radiation --- sex hormone receptors --- upper urinary tract urothelial carcinoma --- CRPC --- nuclear factor erythroid 2-related factor 2 --- TP53

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The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.

Ribosomes -- Congresses. --- Ribosomes -- Structure -- Congresses. --- Ribosomes. --- RNA, Ribosomal. --- Ribosomes --- Proteins --- RNA --- Metabolic Phenomena --- Organelles --- Phenomena and Processes --- Nucleic Acids --- Cytoplasmic Structures --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Cytoplasm --- Nucleic Acids, Nucleotides, and Nucleosides --- Intracellular Space --- Cellular Structures --- Cells --- Anatomy --- Metabolism --- RNA, Ribosomal --- Ribosomal Proteins --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Cytology --- Physiology --- Structure --- Ribonucleoprotein particles --- Medicine. --- Gene expression. --- Nucleic acids. --- Biophysics. --- Biological physics. --- Biomedicine. --- Gene Expression. --- Nucleic Acid Chemistry. --- Biophysics and Biological Physics. --- Cell organelles --- Microsomes --- Nucleoproteins --- Protoplasm --- Biological and Medical Physics, Biophysics. --- Polynucleotides --- Biomolecules --- Genes --- Genetic regulation --- Expression --- Biological physics --- Medical sciences --- Physics --- Molecular genetics. --- Biomaterials. --- Molecular Genetics. --- Nucleic Acid. --- Genetics --- Molecular biology