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Pathogenic bacteria for human and animals have developed sophisticated weapons, termed virulence factors, to ensure their replication and persistence into their hosts. The first role of these virulence factors is to loosen the host defenses against microorganisms represented by innate and adaptive immunities. Small GTPases of the Rho subfamily have been shown top play important functions in theses systems. The authors of this volume present the synthesis on how the various host cellular Rho GTPases activities are manipulated by bacteria to fulfill their virulence.

Pathogenic bacteria. --- Virulence (Microbiology) --- Rho GTPases. --- Rho G proteins --- Rho GTP-binding proteins --- G proteins --- Guanosine triphosphatase --- Microbial virulence --- Pathogenic microorganisms --- Bacteria, Pathogenic --- Disease germs --- Bacteria --- Bacterial diseases --- Medical bacteriology --- Medical virology. --- Virology. --- Medical microbiology --- Virology --- Virus diseases --- Microbiology

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Humans contain more than 20 Rho type GTPases. This volume not only presents a detailed phylogenetic analysis of Rho proteins, but also discusses the possible origins of the human members. Such an analysis of human Rho GTPases has not previously been attempted. The book includes an overview of how Rho GTPases become activated which is complemented by an extensive Chapter by Darerca Owen and Helen Mott who unravel the beautiful molecular details given to us by the many structural studies of Rho GTPases. The key areas currently being investigated in relation to these ubiquitous proteins are described for both in vitro and in vivo systems. These are presented in a format that ensures the reader can approach the topic with minimal background knowledge, while ultimately bringing the subject to the level of an expert. Timely and highly authoritative, this volume illuminates newer findings, particularly as they relate to Rho proteins in vertebrate biology.

Rho GTPases. --- G proteins. --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Membrane proteins --- Rho G proteins --- Rho GTP-binding proteins --- G proteins --- Guanosine triphosphatase --- Cytology. --- Enzymes. --- Biochemistry. --- Proteomics. --- Oncology. --- Medicine. --- Cell Biology. --- Enzymology. --- Biochemistry, general. --- Cancer Research. --- Molecular Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors --- Molecular biology --- Proteins --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Enzymology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Health Workforce --- Cell biology. --- Cancer research. --- Molecular biology. --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Enzymes

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Small GTPases play a key role in many aspects of contemporary cell biology: control of cell growth and differentiation; regulation of cell adhesion and cell movement; the organization of the actin cytoskeleton; and the regulation of intracellular vesicular transport.This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in these aspects of cell biology at the molecular level.

Guanosine triphosphatase. --- ras Proteins. --- ras Proteins --- Monomeric GTP-Binding Proteins --- GTP-Binding Proteins --- Intracellular Signaling Peptides and Proteins --- Peptides --- Carrier Proteins --- GTP Phosphohydrolases --- Proteins --- Amino Acids, Peptides, and Proteins --- Acid Anhydride Hydrolases --- Chemicals and Drugs --- Hydrolases --- Enzymes --- Enzymes and Coenzymes --- Ras proteins. --- G proteins. --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Guanosine triphosphatase --- Guanosine-trifosfatase --- Guanosinetriphosphatase --- Trifosfatase [Guanosine-] --- Triphosphatase [Guanosine] --- rho GTP-Binding Proteins --- Binding Protein --- Binding Proteins --- Transport Proteins --- Protein, Binding --- Proteins, Binding --- Proteins, Carrier --- Proteins, Transport --- G-Protein --- GTP-Binding Protein --- GTP-Regulatory Protein --- Guanine Nucleotide Coupling Protein --- G-Proteins --- GTP-Regulatory Proteins --- Guanine Nucleotide Regulatory Proteins --- G Protein --- G Proteins --- GTP Binding Protein --- GTP Binding Proteins --- GTP Regulatory Protein --- GTP Regulatory Proteins --- Protein, GTP-Binding --- Protein, GTP-Regulatory --- Proteins, GTP-Binding --- Proteins, GTP-Regulatory --- Intracellular Signaling Peptides --- Intracellular Signaling Proteins --- Peptides, Intracellular Signaling --- Proteins, Intracellular Signaling --- Signaling Peptides, Intracellular --- Signaling Proteins, Intracellular --- P21 (rho)Protein --- rho GTP-Binding Protein --- rho Protein P21 --- rho G-Proteins --- rho GTPases --- rho Small GTP-Binding Proteins --- G-Proteins, rho --- GTP-Binding Protein, rho --- GTP-Binding Proteins, rho --- GTPases, rho --- P21, rho Protein --- rho G Proteins --- rho GTP Binding Protein --- rho GTP Binding Proteins --- rho Small GTP Binding Proteins --- GTP Phosphohydrolase --- GTPase --- GTPases --- Guanosine Triphosphate Phosphohydrolases --- Guanosinetriphosphatases --- Phosphohydrolase, GTP --- Phosphohydrolases, GTP --- Phosphohydrolases, Guanosine Triphosphate --- Triphosphate Phosphohydrolases, Guanosine --- ras-Related G-Proteins --- ras-Related GTP-Binding Proteins --- G-Proteins, Monomeric --- GTP-Binding Proteins, Monomeric --- Monomeric G-Proteins --- Small G-Proteins --- Small GTPases --- ras-Related GTPases --- G Proteins, Monomeric --- G-Proteins, Small --- G-Proteins, ras-Related --- GTP Binding Proteins, Monomeric --- GTP-Binding Proteins, ras-Related --- GTPases, Small --- GTPases, ras-Related --- Monomeric G Proteins --- Monomeric GTP Binding Proteins --- Proteins, ras-Related GTP-Binding --- Small G Proteins --- ras Related G Proteins --- ras Related GTP Binding Proteins --- ras Related GTPases --- Anhydride Hydrolases, Acid --- Hydrolases, Acid Anhydride --- Biochemistry -- Periodicals. --- Biochemistry -- Technique. --- Enzymes -- Collections. --- Enzymes -- Periodicals. --- Enzymologie -- Technique -- Collections. --- GTP Phosphohydrolases. --- GTP phosphohydrolase --- Guanosine triphosphate phosphohydrolase --- GTP phosphohydrolases. --- Cytoplasmic Vesicles --- Physiological effect --- G proteins --- Membrane proteins --- Phosphatases --- Coenzymes and Enzymes --- Biocatalysts --- Molecular Mechanisms of Pharmacological Action --- Protein Binding --- Receptors, Transferrin --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Polypeptides --- Biocatalyst --- Enzyme --- Carrier Protein --- Transport Protein --- Protein, Carrier --- Protein, Transport --- Protein --- Peptide --- Polypeptide --- Hydrolase --- Small GTPase --- GTPase, Small --- rho GTPase --- GTPase, rho --- Gene expression. --- Gtp phosphohydrolases --- Map kinase signaling system --- Adp-ribosylation factors --- Gtp-binding proteins --- Gtp phosphohydrolase activators --- Gtp-binding protein regulators