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In the past decade, we have witnessed innovation in surgical treatment for renal cell carcinoma (RCC), including robotic platforms with integration of imaging approaches, and advances in targeted therapy, immunotherapy, and combination therapy to treat patients with advanced RCC. This book presents updated information on the epidemiology, genetics, diagnosis, screening, and advances in the treatment and management of RCC. It is a useful resource for any clinician involved in the management of patients with RCC, as well as other physicians, researchers, and patients.

Renal cell carcinoma.

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Clear cell renal cell carcinoma is currently one of the most interesting areas of study in oncology. Despite the advances made in this field, this tumor continues to be a health problem of major concern in Western societies, seriously affecting public health services. Several characteristics of this tumor make it an exciting meeting point for translational collaboration between clinicians and basic researchers. Clear cell renal cell carcinoma is a paradigmatic example of inter- and intra-tumor heterogeneity from morphological, immunohistochemical, and molecular viewpoints. This tumor is also a good example to investigate the complexity of tumor/tumor and tumor/environment relationships from an ecological perspective. A deeper identification of the varied internal tumor self-organization through the specialization of cell clones and subclones as local invaders and metastasizers, on one hand, and the interactions of specific subsets of tumor cells with the local host microenvironment, on the other, will significantly enrich our knowledge of this neoplasm. Clear cell renal cell carcinoma is also a paradigmatic test bench for antiangiogenic and immune checkpoint blockage therapies. The refinement of these therapeutic tools administered alone or in combination is a hot issue in oncology, and several international trials are underway.

Biomedical materials. --- Carcinoma, Renal Cell.

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Clear cell renal cell carcinoma is currently one of the most interesting areas of study in oncology. Despite the advances made in this field, this tumor continues to be a health problem of major concern in Western societies, seriously affecting public health services. Several characteristics of this tumor make it an exciting meeting point for translational collaboration between clinicians and basic researchers. Clear cell renal cell carcinoma is a paradigmatic example of inter- and intra-tumor heterogeneity from morphological, immunohistochemical, and molecular viewpoints. This tumor is also a good example to investigate the complexity of tumor/tumor and tumor/environment relationships from an ecological perspective. A deeper identification of the varied internal tumor self-organization through the specialization of cell clones and subclones as local invaders and metastasizers, on one hand, and the interactions of specific subsets of tumor cells with the local host microenvironment, on the other, will significantly enrich our knowledge of this neoplasm. Clear cell renal cell carcinoma is also a paradigmatic test bench for antiangiogenic and immune checkpoint blockage therapies. The refinement of these therapeutic tools administered alone or in combination is a hot issue in oncology, and several international trials are underway.

Biomedical materials. --- Carcinoma, Renal Cell.

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Life (Biology) --- Life sciences. --- Carcinoma, Renal Cell. --- Cancer. --- Merkel cell carcinoma. --- Polyomaviruses. --- carcinoma, renal cell.

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Surgical and medical oncologists have been unable to decrease renal cell carcinoma mortality for uncertain reasons, although a lot of progress has been made in diagnosis and imaging, recognition of different genetic and pathological entities, management of localized disease and in the research on new drug treatments for advanced stages of the disease, potentially combined with surgery. The purpose of this book, which tackles a number of separate interesting topics, is to provide further insight into the disease and the management of early and advanced renal cell carcinoma. The volume is divided into different parts; the first part covers the characterization of renal masses and the second part covers rare distinct pathological entity. In the management section, active surveillance, partial nephrectomy and radiofrequency ablation are presented. A separate chapter reviews the management of Von Hippel Lindau disease, and finally, conventional and aberrant signaling pathways are explored.

Oncology. --- Carcinoma, Renal Cell. --- Tumors --- Adenocarcinoma Of Kidney --- Adenocarcinoma, Renal --- Chromophil Renal Cell Carcinoma --- Chromophobe Renal Cell Carcinoma --- Clear Cell Renal Carcinoma --- Clear Cell Renal Cell Carcinoma --- Collecting Duct Carcinoma --- Collecting Duct Carcinoma (Kidney) --- Collecting Duct Carcinoma of the Kidney --- Nephroid Carcinoma --- Papillary Renal Cell Carcinoma --- Renal Cell Cancer --- Renal Cell Carcinoma --- Renal Cell Carcinoma, Papillary --- Renal Collecting Duct Carcinoma --- Sarcomatoid Renal Cell Carcinoma --- Adenocarcinoma, Renal Cell --- Carcinoma, Hypernephroid --- Grawitz Tumor --- Hypernephroma --- Renal Carcinoma --- Adenocarcinoma Of Kidneys --- Adenocarcinomas, Renal Cell --- Cancer, Renal Cell --- Carcinoma, Collecting Duct --- Carcinoma, Collecting Duct (Kidney) --- Carcinoma, Nephroid --- Carcinoma, Renal --- Carcinomas, Collecting Duct --- Carcinomas, Collecting Duct (Kidney) --- Carcinomas, Renal Cell --- Collecting Duct Carcinomas --- Collecting Duct Carcinomas (Kidney) --- Hypernephroid Carcinoma --- Hypernephroid Carcinomas --- Hypernephromas --- Kidney, Adenocarcinoma Of --- Nephroid Carcinomas --- Renal Adenocarcinoma --- Renal Adenocarcinomas --- Renal Carcinomas --- Renal Cell Adenocarcinoma --- Renal Cell Adenocarcinomas --- Renal Cell Cancers --- Renal Cell Carcinomas --- Tumor, Grawitz --- Oncology