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Germline and somatic mutations in von Hippel-Lindau disease gene and its significance in the development of kidney cancer -- Hereditary papillary renal carcinoma : pathology and pathogenesis -- Renal cell carcinomas in patients on long-term hemodialysis -- TSC1 and TSC2 gene mutations in human kidney tumors -- Classification of renal cell cancer based on (cyto)genetic analysis -- Wilms' tumor and the WT1 gene -- Gene-modified immunotherapy for renal cell carcinoma -- Wilm's tumor (nephroblastoma) -- Pathogenesis of renal cell adenomas and carcinomas in animal models.

Kidneys --- Kidney Neoplasms --- Cancer of the Kidney --- Neoplasms, Kidney --- Renal Neoplasms --- Cancer of Kidney --- Kidney Cancer --- Renal Cancer --- Cancer, Kidney --- Cancer, Renal --- Cancers, Kidney --- Cancers, Renal --- Kidney Cancers --- Kidney Neoplasm --- Neoplasm, Kidney --- Neoplasm, Renal --- Neoplasms, Renal --- Renal Cancers --- Renal Neoplasm --- Cancer

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This book covers all aspects of Wilms’ tumor, the second most typical solid tumor in children. Its potential for complete cure underscores correct management of this tumor. To achieve this goal, the book aims to provide all necessary details for practicing Pediatric surgeons, Oncologists, Pediatricians, Urologists, and Medical students. Topics ranging from epidemiology, etiology, pathology, clinical features, diagnostic methods, surgery, chemotherapy, radiotherapy to cutting-edge inventions are described in great detail. Detailed descriptions of surgical techniques and their nuances will greatly benefit surgeons and surgical residents. Importantly, all the chapters are written by authors who have first-hand experience with clinical management. Thus the text ensures the practical application of theoretical details.

Physics. --- Nephroblastoma. --- Wilms' tumor --- Cancer in children --- Embryonal tumors --- Kidneys --- Natural philosophy --- Philosophy, Natural --- Physical sciences --- Dynamics --- Cancer --- Wilms Tumor. --- Kidney Neoplasms. --- Cancer of the Kidney --- Neoplasms, Kidney --- Renal Neoplasms --- Cancer of Kidney --- Kidney Cancer --- Renal Cancer --- Cancer, Kidney --- Cancer, Renal --- Cancers, Kidney --- Cancers, Renal --- Kidney Cancers --- Kidney Neoplasm --- Neoplasm, Kidney --- Neoplasm, Renal --- Neoplasms, Renal --- Renal Cancers --- Renal Neoplasm --- Wilms Tumor 1 --- Wilms' Tumor --- Bilateral Wilms Tumor --- Nephroblastoma --- Nephroblastomas --- Tumor, Bilateral Wilms --- Tumor, Wilms --- Tumor, Wilms' --- Wilm Tumor --- Wilm's Tumor --- Wilms Tumor, Bilateral --- Genes, Wilms Tumor --- WT1 Proteins --- Pediatrics. --- Genitourinary organs --- Medical radiology. --- Oncology. --- Children --- Urological Surgery. --- Radiation Oncology. --- Pediatric Surgery. --- Surgery. --- Pediatric surgery --- Surgery, Pediatric --- Operative urology --- Urological surgery --- Urology, Operative --- Tumors --- Clinical radiology --- Radiology, Medical --- Radiology (Medicine) --- Medical physics --- Paediatrics --- Pediatric medicine --- Medicine --- Diseases --- Treatment --- Health and hygiene --- Kidney --- Neoplasms.

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This ebook includes original research articles and reviews to update readers on the state of the art systems approach to not only discover novel diagnostic and prognostic biomarkers for several cancer types, but also evaluate methodologies to map out important genomic signatures. In addition, therapeutic targets and drug repurposing have been emphasized for a variety of cancer types. In particular, new and established researchers who desire to learn about cancer systems biology and why it is possibly the leading front to a personalized medicine approach will enjoy reading this book.

Medicine --- Sestrin2 --- lung cancer --- knockdown --- cancer progression --- bioinformatics --- patient survival --- lung adenocarcinoma --- circulating miR-1246 --- glycosaminoglycan binding --- prognosis --- PI3K-Akt signaling pathways --- TargetScan --- UBE2C --- cancer systems biology --- experimental model systems --- next-generation sequencing --- single-cell sequencing --- patient-derived xenografts --- patient-derived organoids --- triple-negative breast cancer --- personalized medicine --- computational methods --- drug repurposing --- clinical trials --- cancer stem cells --- ETS --- Elk-1 --- stem cell --- microarray --- brain-tumor-initiating cell (BTIC) --- pancreatic cancer --- systems biology --- omics --- biomarker --- genomics --- transcriptomics --- proteomics --- metabolomics --- glycomics --- metagenomics --- Ets --- PEA3 --- Ets-1 --- glioma --- optical genome mapping --- solid tumors --- cancer genomics --- breast --- ovarian --- cancer --- TCGA --- non-small-cell lung cancer --- lung adenocarcinoma (LUAD) --- lung squamous cell carcinoma (LUSC) --- differential expression --- SNV --- CNV --- risk group --- signature --- survival --- renal cancers --- protein interactome --- diagnostic biomarker --- prognostic biomarker --- virtual screening --- docking --- acute myeloid leukemia --- Boolean model --- drug resistance --- network --- Sestrin2 --- lung cancer --- knockdown --- cancer progression --- bioinformatics --- patient survival --- lung adenocarcinoma --- circulating miR-1246 --- glycosaminoglycan binding --- prognosis --- PI3K-Akt signaling pathways --- TargetScan --- UBE2C --- cancer systems biology --- experimental model systems --- next-generation sequencing --- single-cell sequencing --- patient-derived xenografts --- patient-derived organoids --- triple-negative breast cancer --- personalized medicine --- computational methods --- drug repurposing --- clinical trials --- cancer stem cells --- ETS --- Elk-1 --- stem cell --- microarray --- brain-tumor-initiating cell (BTIC) --- pancreatic cancer --- systems biology --- omics --- biomarker --- genomics --- transcriptomics --- proteomics --- metabolomics --- glycomics --- metagenomics --- Ets --- PEA3 --- Ets-1 --- glioma --- optical genome mapping --- solid tumors --- cancer genomics --- breast --- ovarian --- cancer --- TCGA --- non-small-cell lung cancer --- lung adenocarcinoma (LUAD) --- lung squamous cell carcinoma (LUSC) --- differential expression --- SNV --- CNV --- risk group --- signature --- survival --- renal cancers --- protein interactome --- diagnostic biomarker --- prognostic biomarker --- virtual screening --- docking --- acute myeloid leukemia --- Boolean model --- drug resistance --- network

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Written by an international group of high-profile contributors, this text provides a single, comprehensive source of information on renal and adrenal tumors.

Kidney Diseases --- Urologic Neoplasms --- Endocrine Gland Neoplasms --- Adrenal Gland Diseases --- Urogenital Neoplasms --- Endocrine System Diseases --- Neoplasms by Site --- Urologic Diseases --- Female Urogenital Diseases --- Male Urogenital Diseases --- Diseases --- Neoplasms --- Female Urogenital Diseases and Pregnancy Complications --- Kidney Neoplasms --- Adrenal Gland Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Adrenal Gland Cancer --- Adrenal Neoplasm --- Cancer of the Adrenal Gland --- Neoplasms, Adrenal Gland --- Adrenal Cancer --- Adrenal Cancers --- Adrenal Gland Cancers --- Adrenal Gland Neoplasm --- Adrenal Neoplasms --- Cancer, Adrenal --- Cancer, Adrenal Gland --- Cancers, Adrenal --- Cancers, Adrenal Gland --- Neoplasm, Adrenal --- Neoplasm, Adrenal Gland --- Neoplasms, Adrenal --- Male Genitourinary Diseases --- Genitourinary Disease, Male --- Genitourinary Diseases, Male --- Male Genitourinary Disease --- Male Urogenital Disease --- Urogenital Disease, Male --- Urogenital Diseases, Male --- Female Genitourinary Diseases --- Female Genitourinary Disease --- Female Urogenital Disease --- Genitourinary Disease, Female --- Genitourinary Diseases, Female --- Urogenital Disease, Female --- Urogenital Diseases, Female --- Urological Diseases --- Urinary Tract Diseases --- Disease, Urinary Tract --- Disease, Urologic --- Disease, Urological --- Diseases, Urinary Tract --- Diseases, Urologic --- Diseases, Urological --- Urinary Tract Disease --- Urologic Disease --- Urological Disease --- Urology --- Neoplasms by Sites --- Site, Neoplasm --- Sites, Neoplasm --- Neoplasm Site --- Neoplasm Sites --- Diseases of Endocrine System --- Endocrine Diseases --- Disease, Endocrine --- Disease, Endocrine System --- Diseases, Endocrine --- Diseases, Endocrine System --- Endocrine Disease --- Endocrine System Disease --- System Disease, Endocrine --- System Diseases, Endocrine --- Endocrinology --- Genito-urinary Cancer --- Genito-urinary Neoplasm --- Neoplasms, Genitourinary --- Neoplasms, Urogenital --- Genitourinary Cancer --- Genitourinary Neoplasms --- Urogenital Cancer --- Cancer, Genito-urinary --- Cancer, Genitourinary --- Cancer, Urogenital --- Cancers, Genito-urinary --- Cancers, Genitourinary --- Cancers, Urogenital --- Genito urinary Cancer --- Genito-urinary Cancers --- Genito-urinary Neoplasms --- Genitourinary Cancers --- Genitourinary Neoplasm --- Neoplasm, Genito-urinary --- Neoplasm, Genitourinary --- Neoplasm, Urogenital --- Neoplasms, Genito-urinary --- Urogenital Cancers --- Urogenital Neoplasm --- Adrenal Gland Disease --- Disease, Adrenal Gland --- Diseases, Adrenal Gland --- Gland Disease, Adrenal --- Gland Diseases, Adrenal --- Cancer of the Endocrine Gland --- Carcinoma of Endocrine Gland --- Endocrine Gland Carcinoma --- Neoplasms, Endocrine Gland --- Cancer of Endocrine Gland --- Endocrine Cancer --- Endocrine Gland Cancer --- Cancer, Endocrine --- Cancer, Endocrine Gland --- Cancers, Endocrine --- Carcinoma, Endocrine Gland --- Endocrine Cancers --- Endocrine Gland Neoplasm --- Neoplasm, Endocrine Gland --- Cancer of the Kidney --- Neoplasms, Kidney --- Renal Neoplasms --- Cancer of Kidney --- Kidney Cancer --- Renal Cancer --- Cancer, Kidney --- Cancer, Renal --- Cancers, Kidney --- Cancers, Renal --- Kidney Cancers --- Kidney Neoplasm --- Neoplasm, Kidney --- Neoplasm, Renal --- Neoplasms, Renal --- Renal Cancers --- Renal Neoplasm --- Benign Neoplasms --- Malignancy --- Malignant Neoplasms --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Malignant Neoplasm --- Neoplasias --- Neoplasm, Benign --- Neoplasm, Malignant --- Neoplasms, Malignant --- Tumor --- Medical Oncology --- Cancer of the Urinary Tract --- Neoplasms, Urologic --- Urinary Tract Neoplasms --- Urological Cancer --- Urological Neoplasms --- Cancer of Urinary Tract --- Urinary Tract Cancer --- Urologic Cancer --- Cancer, Urinary Tract --- Cancer, Urologic --- Cancer, Urological --- Cancers, Urinary Tract --- Cancers, Urologic --- Cancers, Urological --- Neoplasm, Urinary Tract --- Neoplasm, Urologic --- Neoplasm, Urological --- Neoplasms, Urinary Tract --- Neoplasms, Urological --- Tract Neoplasm, Urinary --- Tract Neoplasms, Urinary --- Urinary Tract Cancers --- Urinary Tract Neoplasm --- Urologic Cancers --- Urologic Neoplasm --- Urological Cancers --- Urological Neoplasm --- Disease, Kidney --- Diseases, Kidney --- Kidney Disease --- Nephrology --- Renal Replacement Therapy --- Kidneys --- Adrenal glands --- Tumors.