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Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.

thermodynamic modeling --- molecular dynamics simulation --- poorly soluble drugs --- amorphous solid dispersions --- dissolution enhancement --- crystallization tendency --- continuous processing --- stability --- milling --- granulation --- thermal analysis --- amorphous --- ball milling --- pharmaceutical glass --- dissolution --- rebamipide --- poloxamer --- classification --- polyelectrolytes --- amorphisation --- self-assembly --- dissolution rate --- miscibility --- bioavailability --- solubility --- evaporation --- mesoporous --- polyelectrolyte excipient matrix --- polymer --- bicaludamide --- phase diagram --- Weibull dissolution model --- spectroscopic techniques --- anticancer drugs --- manufacturing methods --- nucleation --- molecular complex --- nanoaggregates --- enrofloxacin --- accelerated stability test --- solubility enhancement --- amorphous solid dispersion --- tadalafil --- process development --- amorphous polymeric salt --- Wood’s apparatus --- hot melt extrusion --- solid dispersions --- intrinsic dissolution rate --- solid dispersion --- interaction --- crystallization --- spray drying --- characterization --- ciprofloxacin

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This Book serves to highlight the mechanisms related to the low intestinal drug absorption, the strategies to overcome the obstacles or intestinal drug absorption, and in situ, in vitro, and in silico methodologies to predict to intestinal drug absorption. This Book presents a series of drug absorption studies and related technologies that predict intestinal permeation of drugs that govern the pharmacokinetic features of therapeutic drugs. It also contains the mechanistic understanding regarding the first-pass metabolism and intestinal efflux that modulate the pharmacokinetics of drug and suggest the formulation strategies to enhance the bioavailability of investigated drugs.

Medicine --- Pharmaceutical industries --- rebamipide --- nanocrystals --- oral mucositis --- hydrogel --- endocytosis --- enoxaparin --- lipid–polymer hybrid nanoparticles --- oral --- intestinal absorption --- naftidrofuryl oxalate --- solubility --- permeability --- dissolution profiles --- pharmaceutical availability --- BCS drug classification --- non-sink condition --- solubility–permeability interplay --- unstirred water layer --- poorly soluble drugs --- solubilizer additive --- phenylketonuria --- l-phenylalanine ammonia-lyase --- enzyme --- kinetics --- catabolism disorder --- biomedical drug --- P-glycoprotein --- breast cancer resistance protein --- LY335979 --- WK-X-34 --- in vivo–in vitro correlation --- lipolysis-permeation --- lipid-based drug delivery system --- PermeaPad --- cinnarizine --- lipolysis --- amorphous solid dispersion --- candesartan Cilexetil --- PVPK30 --- pH-modulation --- spray drying --- bioavailability --- nasal administration --- spray-drying --- chitosan --- microsphere --- meloxicam --- silymarin --- D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) --- liver distribution --- acetaminophen-induced hepatotoxicity --- extra virgin olive oil --- secoiridoids --- metabolism --- phenolic compounds --- intestinal permeability --- drug-phytochemical interaction --- hepatic metabolism --- mixed inhibition --- quercetin --- repaglinide