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In the last decade, research on cold atmospheric plasma (CAP) has significantly advanced our understanding of the effect of CAP on cancer cells and their potential for cancer treatment. This effect is due to the reactive oxygen and nitrogen species (RONS) created by plasma. This has been demonstrated for different cancer cell lines and the first clinical trials showed promising results. In addition, plasma could be combined with other treatments—such as immunotherapy—to boost its anticancer activity. The addition of new research tools to study the response of cancer cells to CAP—such as 3D in vitro, in ovo, and in vivo models and in silico approaches—as well as the use of -OMICS technologies could aid in unravelling the underlying mechanisms of CAP in cancer treatment. In order to progress towards widespread clinical application of CAP, an integrated study of the multidimensional effect of CAP in cancer treatment is essential. In this book, reviews and original research papers are published that provide new insights into the mechanisms of cold atmospheric plasma in cancer treatment, based on in vitro and in vivo experiments, clinical studies, as well as computer modeling.

Medicine --- cell adhesion --- plasma medicine --- oncology --- cold atmospheric plasma --- selectivity --- plasma-treated liquid --- dielectric barrier discharge --- pancreatic cancer --- pancreatic stellate cells --- immunogenic cell death --- dendritic cells --- cell communication --- extracellular matrix (ECM) --- reactive oxygen and nitrogen species (ROS) --- tumour microenvironment (TME) --- extracellular vesicles --- communication junctions --- three-dimensional in vitro culture models --- apoptosis --- breast cancer --- genome-wide expression --- reactive oxygen species --- anticancer drugs --- screening --- tumor spheroids --- combination therapy --- kINPen --- reactive oxygen and nitrogen species --- ROS --- cancer --- non-thermal atmospheric pressure plasma (NTP) --- indirect treatment --- plasma-treated phosphate-buffered saline --- electroporation --- electric pulses --- pulsed electric field amplitude --- melanoma --- long-lived reactive species --- bone cancer --- osteosarcoma --- reactive species --- plasma-activated liquid --- Ringer's saline --- organotypic model --- nonthermal biocompatible plasma --- soft jet plasma --- human glioblastoma --- p38/MAPK pathway --- tissue penetration --- non-thermal plasma --- non-invasive plasma treatment (NIPP) --- cervical intraepithelial neoplasia (CIN) --- Raman imaging --- Raman microspectroscopy --- Plasma lipid interactions --- cold physical plasma --- radiation therapy --- radio-frequency discharge --- PARP-inhibitor --- olaparib --- DNA-damage --- gold quantum dots --- plasma --- nanomaterials --- cellular uptake --- invasiveness --- cold atmospheric pressure plasma --- plasma-activated Ringer's lactate solution --- ovarian cancer --- cytotoxicity --- plasma-activated liquids --- multicellular tumor spheroids --- long-lived reactive oxygen and nitrogen species --- high frequency electrosurgery --- plasma treatment --- cold atmospheric plasma (CAP) --- free radicals --- cancer selectivity --- cervical cancer treatment --- cervical intraepithelial neoplasia --- cholangiocarcinoma --- cold plasma --- innovative therapy --- tumor cells --- macrophages --- plasma selectivity --- plasma jet --- cell adhesion --- plasma medicine --- oncology --- cold atmospheric plasma --- selectivity --- plasma-treated liquid --- dielectric barrier discharge --- pancreatic cancer --- pancreatic stellate cells --- immunogenic cell death --- dendritic cells --- cell communication --- extracellular matrix (ECM) --- reactive oxygen and nitrogen species (ROS) --- tumour microenvironment (TME) --- extracellular vesicles --- communication junctions --- three-dimensional in vitro culture models --- apoptosis --- breast cancer --- genome-wide expression --- reactive oxygen species --- anticancer drugs --- screening --- tumor spheroids --- combination therapy --- kINPen --- reactive oxygen and nitrogen species --- ROS --- cancer --- non-thermal atmospheric pressure plasma (NTP) --- indirect treatment --- plasma-treated phosphate-buffered saline --- electroporation --- electric pulses --- pulsed electric field amplitude --- melanoma --- long-lived reactive species --- bone cancer --- osteosarcoma --- reactive species --- plasma-activated liquid --- Ringer's saline --- organotypic model --- nonthermal biocompatible plasma --- soft jet plasma --- human glioblastoma --- p38/MAPK pathway --- tissue penetration --- non-thermal plasma --- non-invasive plasma treatment (NIPP) --- cervical intraepithelial neoplasia (CIN) --- Raman imaging --- Raman microspectroscopy --- Plasma lipid interactions --- cold physical plasma --- radiation therapy --- radio-frequency discharge --- PARP-inhibitor --- olaparib --- DNA-damage --- gold quantum dots --- plasma --- nanomaterials --- cellular uptake --- invasiveness --- cold atmospheric pressure plasma --- plasma-activated Ringer's lactate solution --- ovarian cancer --- cytotoxicity --- plasma-activated liquids --- multicellular tumor spheroids --- long-lived reactive oxygen and nitrogen species --- high frequency electrosurgery --- plasma treatment --- cold atmospheric plasma (CAP) --- free radicals --- cancer selectivity --- cervical cancer treatment --- cervical intraepithelial neoplasia --- cholangiocarcinoma --- cold plasma --- innovative therapy --- tumor cells --- macrophages --- plasma selectivity --- plasma jet

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Atmospheric pressure plasma discharges have grown rapidly in importance in recent decades, due to the ease in handling and operation, plus their eco-friendly applications, for agriculture, food, medicine, materials and even the automotive and aerospace industries. In this context, the need for a collection of results based on plasma technologies is justified. Moreover, at the international level, the increased number of projects that translated to publications and patents in the multidisciplinary field of plasma-based technology gives researchers the opportunity to challenge their knowledge and contribute to a new era of green services and products that society demands. Therefore, this book, based on the Special Issue of “Frontiers in Atmospheric Pressure Plasma Technology” in the “Applied Physics” section of the journal Applied Sciences, provides results on some plasma-based methods and technologies for novel and possible future applications of plasmas in life sciences, biomedicine, agriculture, and the automotive industry.This book, entitled “Frontiers in Atmospheric Pressure Plasma Technology”, consists of 8 research articles, 2 review articles and 1 editorial. We know that we are only managing to address a small part of what plasma discharge can be used for, but we hope that the readers will enjoy this book and, therefore, be inspired with new ideas for future research in the field of plasma.

Technology: general issues --- cold atmospheric pressure plasma --- antimicrobial agent --- plasma medicine --- dentistry --- atmospheric pressure plasma jet (APPJ) --- optical emission spectroscopy (OES) --- plasma-surface interactions --- local surface modification --- polymers --- functionalization --- atmospheric pressure plasma --- transdermal permeability --- transdermal delivery --- nitric oxide --- wounds --- biofilm --- plasma jet --- DBD plasma --- plasma jets --- plasma properties --- reactive species --- RONS --- non-thermal plasma --- transient spark --- electrospray --- plasma-activated water --- nitrous acid --- nitrites --- atmospheric pressure plasma jet --- plasma-wine making --- plasma treatment --- UV-Vis spectroscopy --- ATR-FTIR spectroscopy --- bio-medicine application --- cold gas-discharge plasma --- digital holography --- digital holographic interferometry --- plasma diagnostics --- CAP --- electric diagnosis --- E-field measurements --- vacuum-ultraviolet spectroscopy --- patient leakage current --- power measurement --- voltage-charge plot --- OES --- bio-medical plasma applications --- surface-wave-sustained discharge --- microwave discharge --- cold atmospheric plasma --- microwave plasma torch --- cold atmospheric pressure plasma --- antimicrobial agent --- plasma medicine --- dentistry --- atmospheric pressure plasma jet (APPJ) --- optical emission spectroscopy (OES) --- plasma-surface interactions --- local surface modification --- polymers --- functionalization --- atmospheric pressure plasma --- transdermal permeability --- transdermal delivery --- nitric oxide --- wounds --- biofilm --- plasma jet --- DBD plasma --- plasma jets --- plasma properties --- reactive species --- RONS --- non-thermal plasma --- transient spark --- electrospray --- plasma-activated water --- nitrous acid --- nitrites --- atmospheric pressure plasma jet --- plasma-wine making --- plasma treatment --- UV-Vis spectroscopy --- ATR-FTIR spectroscopy --- bio-medicine application --- cold gas-discharge plasma --- digital holography --- digital holographic interferometry --- plasma diagnostics --- CAP --- electric diagnosis --- E-field measurements --- vacuum-ultraviolet spectroscopy --- patient leakage current --- power measurement --- voltage-charge plot --- OES --- bio-medical plasma applications --- surface-wave-sustained discharge --- microwave discharge --- cold atmospheric plasma --- microwave plasma torch

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This reprint discusses the various applications, new materials, and evolution in the field of nanogenerators. This lays the foundation for the popularization of their broad applications in energy science, environmental protection, wearable electronics, self-powered sensors, medical science, robotics, and artificial intelligence.

Energy --- triboelectric nanogenerator (TENG) --- sodium chloride powder --- self-powered sensor --- low-cost --- human–machine interaction --- triboelectric nanogenerator --- self-powered sensing --- self-charging power unit --- remote telemetry and control --- self-powered --- triboelectric --- magnetorheological elastomer --- magnetic --- mechanical energy --- dioxygen activation --- triboelectric corona plasma --- O2− reactive species --- spin conversion --- coniform Helmholtz resonator --- acoustic energy harvesting --- organogel --- stable --- pressure sensing --- nanogenerator --- technology evolution pathway --- knowledge graph --- representation learning --- multi-source data --- nanomaterials --- AR and VR --- metal halide perovskite --- rare-earth metal --- solar cell --- light-emitting diode --- photodetector --- luminescent solar concentrators --- technology evolutionary path --- text vectorization --- theme mining --- theme river map --- triboelectric nanogenerators --- fluid dynamics sensing --- energy harvesting --- triboelectricity --- TENG --- contact-separation mode --- corona charging --- IoT --- n/a --- human-machine interaction

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Atmospheric pressure plasma discharges have grown rapidly in importance in recent decades, due to the ease in handling and operation, plus their eco-friendly applications, for agriculture, food, medicine, materials and even the automotive and aerospace industries. In this context, the need for a collection of results based on plasma technologies is justified. Moreover, at the international level, the increased number of projects that translated to publications and patents in the multidisciplinary field of plasma-based technology gives researchers the opportunity to challenge their knowledge and contribute to a new era of green services and products that society demands. Therefore, this book, based on the Special Issue of “Frontiers in Atmospheric Pressure Plasma Technology” in the “Applied Physics” section of the journal Applied Sciences, provides results on some plasma-based methods and technologies for novel and possible future applications of plasmas in life sciences, biomedicine, agriculture, and the automotive industry.This book, entitled “Frontiers in Atmospheric Pressure Plasma Technology”, consists of 8 research articles, 2 review articles and 1 editorial. We know that we are only managing to address a small part of what plasma discharge can be used for, but we hope that the readers will enjoy this book and, therefore, be inspired with new ideas for future research in the field of plasma.

cold atmospheric pressure plasma --- antimicrobial agent --- plasma medicine --- dentistry --- atmospheric pressure plasma jet (APPJ) --- optical emission spectroscopy (OES) --- plasma-surface interactions --- local surface modification --- polymers --- functionalization --- atmospheric pressure plasma --- transdermal permeability --- transdermal delivery --- nitric oxide --- wounds --- biofilm --- plasma jet --- DBD plasma --- plasma jets --- plasma properties --- reactive species --- RONS --- non-thermal plasma --- transient spark --- electrospray --- plasma-activated water --- nitrous acid --- nitrites --- atmospheric pressure plasma jet --- plasma-wine making --- plasma treatment --- UV-Vis spectroscopy --- ATR-FTIR spectroscopy --- bio-medicine application --- cold gas-discharge plasma --- digital holography --- digital holographic interferometry --- plasma diagnostics --- CAP --- electric diagnosis --- E-field measurements --- vacuum-ultraviolet spectroscopy --- patient leakage current --- power measurement --- voltage-charge plot --- OES --- bio-medical plasma applications --- surface-wave-sustained discharge --- microwave discharge --- cold atmospheric plasma --- microwave plasma torch --- n/a