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Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled “Ubiquitination in Health and Disease” successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field.

Humanities --- Social interaction --- deubiquitinase --- degradation --- therapeutic target --- cancer --- hematopoiesis --- hematopoietic stem cells --- immune response --- regulation of gene expression --- ubiquitin system --- genetic diseases --- ubiquitin ligase --- deubiquitinases --- monoubiquitin signaling --- vesicular trafficking --- protein complex formation --- inflammation --- inhibitor --- innate immune --- interferon --- LUBAC --- NF-κB --- ubiquitin --- Parkinson’s disease --- dopa-responsive dystonia --- tyrosine hydroxylase --- α-synuclein --- fatty acid-binding protein 3 --- ubiquitination --- proteasomal degradation --- ubiquitin-proteasome system --- mitochondria --- E3 ubiquitin ligase --- MITOL/MARCH5 --- salt-sensitive hypertension --- Nedd4L/Nedd4-2 --- epithelial sodium channel --- aldosterone sensitive distal nephron --- excitation-transcription coupling --- RNF183 --- RNF186 --- RNF182 --- RNF152 --- RING finger --- mTOR --- endoplasmic reticulum stress --- osmotic stress --- ubiquitin code --- virus infection --- virus-host interaction --- tau protein --- semisynthesis --- disulfide-coupling --- polyubiquitin --- fibrils --- aggregation --- neurodegeneration --- deubiquitination --- inhibitors --- protein quality control --- proteolysis --- protein stabilization --- regulatory T cells --- mesenchymal stem cell --- cortical bone derived stem cell --- myocardial infarction --- blood pressure --- renal salt reabsorption --- vascular function --- ubiquitin proteasome system --- ubiquitin–proteasome pathway --- cilia --- ciliogenesis --- differentiation --- proliferation --- ciliopathy --- E3s --- DUBs --- UPS --- neurodegenerative disease --- immune-related diseases

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Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled “Ubiquitination in Health and Disease” successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field.

Humanities --- Social interaction --- deubiquitinase --- degradation --- therapeutic target --- cancer --- hematopoiesis --- hematopoietic stem cells --- immune response --- regulation of gene expression --- ubiquitin system --- genetic diseases --- ubiquitin ligase --- deubiquitinases --- monoubiquitin signaling --- vesicular trafficking --- protein complex formation --- inflammation --- inhibitor --- innate immune --- interferon --- LUBAC --- NF-κB --- ubiquitin --- Parkinson’s disease --- dopa-responsive dystonia --- tyrosine hydroxylase --- α-synuclein --- fatty acid-binding protein 3 --- ubiquitination --- proteasomal degradation --- ubiquitin-proteasome system --- mitochondria --- E3 ubiquitin ligase --- MITOL/MARCH5 --- salt-sensitive hypertension --- Nedd4L/Nedd4-2 --- epithelial sodium channel --- aldosterone sensitive distal nephron --- excitation-transcription coupling --- RNF183 --- RNF186 --- RNF182 --- RNF152 --- RING finger --- mTOR --- endoplasmic reticulum stress --- osmotic stress --- ubiquitin code --- virus infection --- virus-host interaction --- tau protein --- semisynthesis --- disulfide-coupling --- polyubiquitin --- fibrils --- aggregation --- neurodegeneration --- deubiquitination --- inhibitors --- protein quality control --- proteolysis --- protein stabilization --- regulatory T cells --- mesenchymal stem cell --- cortical bone derived stem cell --- myocardial infarction --- blood pressure --- renal salt reabsorption --- vascular function --- ubiquitin proteasome system --- ubiquitin–proteasome pathway --- cilia --- ciliogenesis --- differentiation --- proliferation --- ciliopathy --- E3s --- DUBs --- UPS --- neurodegenerative disease --- immune-related diseases

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For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.

Medicine --- tissue barrier --- tight junction --- claudins --- tricellulin --- tight junctions --- organ preservation --- intestine --- transplantation --- ischemia --- intestinal mucosa --- lung --- epithelia --- interleukin 13 --- UBE2Z --- ubiquitin --- osmolality --- hydrostatic pressure --- cancer --- sensor --- tricellular tight junctions --- endometrial cancer --- epithelial barrier dysfunction --- Claudin-7 --- permeability --- WNK4 --- epithelial sodium channel (ENaC), collecting duct cells --- claudin-1 --- hydrogen peroxide --- phosphorylation --- claudin --- angulin --- drug development --- angubindin-1 --- Clostridium perfringens enterotoxin --- Clostridium perfringens iota-toxin --- antibody --- Mz-ChA-1 cells --- biliary epithelial cells --- phosphatidylcholine --- mucus --- paracellular transport --- atopic dermatitis --- cytokines --- STAT3 --- ZO-2 --- cholestasis --- gene transcription --- hypertrophy --- tumor suppressor --- NLS --- NES --- CaSR --- RhoA --- barrier function --- paracellular permeability --- antidiuretic hormone --- Claudin-14 --- CLDN14 --- hearing loss --- vestibular function --- cochlear implantation --- Hepatitis C Virus --- viral entry --- epidermal barrier --- reconstructed human epidermis --- claudin targeting --- Campylobacter jejuni --- curcumin --- apoptosis --- co-culture --- mouse colon --- TNF --- NFκB --- lipolysis-stimulated lipoprotein receptor (LSR) --- epithelial barrier --- cell–cell contact --- caspase --- kidney stones --- ion reabsorption --- quercetin --- brain barriers --- blood-brain barrier --- neurovascular unit --- blood-cerebrospinal fluid barrier --- arachnoid barrier --- glia limitans --- adherens junctions --- paracellular sodium transport --- thick ascending limb --- nephropathy --- HELIX syndrome --- hypokalemia --- hypermagnesemia --- anhidrosis --- gland dysfunction --- aging --- blood–brain barrier --- mutations --- kidney --- liver --- skin --- human --- mice --- disease --- in silico --- drug discovery --- membrane proteins --- protein interactions --- molecular dynamics --- antibiotic-associated hemorrhagic colitis --- Klebsiella oxytoca --- tight junction assembly --- monocytes --- celiac disease --- claudin-2 --- epithelium --- inflammation --- fibrosis --- proliferation --- migration --- tricellular tight junction --- paracellular water transport --- tight epithelium --- MDCK C7 cells --- cell growth --- endothelia --- adherens junction --- apical junctional complex --- AMP-activated protein kinase (AMPK) --- paracellular barrier --- protein structure --- protein domain --- occludin --- junctional adhesion molecule --- zonula occludens --- MAGUK proteins --- PDZ domain --- stem cell --- chemoresistance --- retinal pigment epithelium --- retinopathy --- barrier formation --- collecting duct --- claudin-5 --- neuropathic pain --- nerve injury --- dorsal root ganglion --- enteropathogenic E. coli (EPEC) --- tight junctions (TJ) --- polarity --- atypical aPKCζ --- transepithelial electrical resistance (TER) --- sorting nexin 9 (SNX9) --- EspF --- claudin 1 --- tumor --- metastasis --- epithelial to mesenchymal transition --- cerebral cavernous malformation --- endothelial barrier --- Rho --- ROCK --- MEKK3 --- ion transport --- ion channel --- super-resolution microscopy --- structured illumination microscopy --- stimulated emission depletion --- single molecule localization microscopy --- Claudin --- blood-biliary barrier --- chronic liver disease --- hepatocellular carcinoma --- cholangiocellular carcinoma --- NISCH syndrome --- repair --- NHE2 --- ClC-2 --- inflammatory bowel disease --- mucosal immunology --- ZO-1 --- actomyosin --- aquaporin --- drinking rate --- epithelial fluid transport --- enterocyte --- osmoregulation --- paracellular --- proximal tubule --- calcium permeability --- claudin-12 --- paracellular channels and barriers --- cell polarity --- pathogens --- immune cells --- environmental sensors

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For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.

tissue barrier --- tight junction --- claudins --- tricellulin --- tight junctions --- organ preservation --- intestine --- transplantation --- ischemia --- intestinal mucosa --- lung --- epithelia --- interleukin 13 --- UBE2Z --- ubiquitin --- osmolality --- hydrostatic pressure --- cancer --- sensor --- tricellular tight junctions --- endometrial cancer --- epithelial barrier dysfunction --- Claudin-7 --- permeability --- WNK4 --- epithelial sodium channel (ENaC), collecting duct cells --- claudin-1 --- hydrogen peroxide --- phosphorylation --- claudin --- angulin --- drug development --- angubindin-1 --- Clostridium perfringens enterotoxin --- Clostridium perfringens iota-toxin --- antibody --- Mz-ChA-1 cells --- biliary epithelial cells --- phosphatidylcholine --- mucus --- paracellular transport --- atopic dermatitis --- cytokines --- STAT3 --- ZO-2 --- cholestasis --- gene transcription --- hypertrophy --- tumor suppressor --- NLS --- NES --- CaSR --- RhoA --- barrier function --- paracellular permeability --- antidiuretic hormone --- Claudin-14 --- CLDN14 --- hearing loss --- vestibular function --- cochlear implantation --- Hepatitis C Virus --- viral entry --- epidermal barrier --- reconstructed human epidermis --- claudin targeting --- Campylobacter jejuni --- curcumin --- apoptosis --- co-culture --- mouse colon --- TNF --- NFκB --- lipolysis-stimulated lipoprotein receptor (LSR) --- epithelial barrier --- cell–cell contact --- caspase --- kidney stones --- ion reabsorption --- quercetin --- brain barriers --- blood-brain barrier --- neurovascular unit --- blood-cerebrospinal fluid barrier --- arachnoid barrier --- glia limitans --- adherens junctions --- paracellular sodium transport --- thick ascending limb --- nephropathy --- HELIX syndrome --- hypokalemia --- hypermagnesemia --- anhidrosis --- gland dysfunction --- aging --- blood–brain barrier --- mutations --- kidney --- liver --- skin --- human --- mice --- disease --- in silico --- drug discovery --- membrane proteins --- protein interactions --- molecular dynamics --- antibiotic-associated hemorrhagic colitis --- Klebsiella oxytoca --- tight junction assembly --- monocytes --- celiac disease --- claudin-2 --- epithelium --- inflammation --- fibrosis --- proliferation --- migration --- tricellular tight junction --- paracellular water transport --- tight epithelium --- MDCK C7 cells --- cell growth --- endothelia --- adherens junction --- apical junctional complex --- AMP-activated protein kinase (AMPK) --- paracellular barrier --- protein structure --- protein domain --- occludin --- junctional adhesion molecule --- zonula occludens --- MAGUK proteins --- PDZ domain --- stem cell --- chemoresistance --- retinal pigment epithelium --- retinopathy --- barrier formation --- collecting duct --- claudin-5 --- neuropathic pain --- nerve injury --- dorsal root ganglion --- enteropathogenic E. coli (EPEC) --- tight junctions (TJ) --- polarity --- atypical aPKCζ --- transepithelial electrical resistance (TER) --- sorting nexin 9 (SNX9) --- EspF --- claudin 1 --- tumor --- metastasis --- epithelial to mesenchymal transition --- cerebral cavernous malformation --- endothelial barrier --- Rho --- ROCK --- MEKK3 --- ion transport --- ion channel --- super-resolution microscopy --- structured illumination microscopy --- stimulated emission depletion --- single molecule localization microscopy --- Claudin --- blood-biliary barrier --- chronic liver disease --- hepatocellular carcinoma --- cholangiocellular carcinoma --- NISCH syndrome --- repair --- NHE2 --- ClC-2 --- inflammatory bowel disease --- mucosal immunology --- ZO-1 --- actomyosin --- aquaporin --- drinking rate --- epithelial fluid transport --- enterocyte --- osmoregulation --- paracellular --- proximal tubule --- calcium permeability --- claudin-12 --- paracellular channels and barriers --- cell polarity --- pathogens --- immune cells --- environmental sensors

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.

Medicine --- tissue barrier --- tight junction --- claudins --- tricellulin --- tight junctions --- organ preservation --- intestine --- transplantation --- ischemia --- intestinal mucosa --- lung --- epithelia --- interleukin 13 --- UBE2Z --- ubiquitin --- osmolality --- hydrostatic pressure --- cancer --- sensor --- tricellular tight junctions --- endometrial cancer --- epithelial barrier dysfunction --- Claudin-7 --- permeability --- WNK4 --- epithelial sodium channel (ENaC), collecting duct cells --- claudin-1 --- hydrogen peroxide --- phosphorylation --- claudin --- angulin --- drug development --- angubindin-1 --- Clostridium perfringens enterotoxin --- Clostridium perfringens iota-toxin --- antibody --- Mz-ChA-1 cells --- biliary epithelial cells --- phosphatidylcholine --- mucus --- paracellular transport --- atopic dermatitis --- cytokines --- STAT3 --- ZO-2 --- cholestasis --- gene transcription --- hypertrophy --- tumor suppressor --- NLS --- NES --- CaSR --- RhoA --- barrier function --- paracellular permeability --- antidiuretic hormone --- Claudin-14 --- CLDN14 --- hearing loss --- vestibular function --- cochlear implantation --- Hepatitis C Virus --- viral entry --- epidermal barrier --- reconstructed human epidermis --- claudin targeting --- Campylobacter jejuni --- curcumin --- apoptosis --- co-culture --- mouse colon --- TNF --- NFκB --- lipolysis-stimulated lipoprotein receptor (LSR) --- epithelial barrier --- cell–cell contact --- caspase --- kidney stones --- ion reabsorption --- quercetin --- brain barriers --- blood-brain barrier --- neurovascular unit --- blood-cerebrospinal fluid barrier --- arachnoid barrier --- glia limitans --- adherens junctions --- paracellular sodium transport --- thick ascending limb --- nephropathy --- HELIX syndrome --- hypokalemia --- hypermagnesemia --- anhidrosis --- gland dysfunction --- aging --- blood–brain barrier --- mutations --- kidney --- liver --- skin --- human --- mice --- disease --- in silico --- drug discovery --- membrane proteins --- protein interactions --- molecular dynamics --- antibiotic-associated hemorrhagic colitis --- Klebsiella oxytoca --- tight junction assembly --- monocytes --- celiac disease --- claudin-2 --- epithelium --- inflammation --- fibrosis --- proliferation --- migration --- tricellular tight junction --- paracellular water transport --- tight epithelium --- MDCK C7 cells --- cell growth --- endothelia --- adherens junction --- apical junctional complex --- AMP-activated protein kinase (AMPK) --- paracellular barrier --- protein structure --- protein domain --- occludin --- junctional adhesion molecule --- zonula occludens --- MAGUK proteins --- PDZ domain --- stem cell --- chemoresistance --- retinal pigment epithelium --- retinopathy --- barrier formation --- collecting duct --- claudin-5 --- neuropathic pain --- nerve injury --- dorsal root ganglion --- enteropathogenic E. coli (EPEC) --- tight junctions (TJ) --- polarity --- atypical aPKCζ --- transepithelial electrical resistance (TER) --- sorting nexin 9 (SNX9) --- EspF --- claudin 1 --- tumor --- metastasis --- epithelial to mesenchymal transition --- cerebral cavernous malformation --- endothelial barrier --- Rho --- ROCK --- MEKK3 --- ion transport --- ion channel --- super-resolution microscopy --- structured illumination microscopy --- stimulated emission depletion --- single molecule localization microscopy --- Claudin --- blood-biliary barrier --- chronic liver disease --- hepatocellular carcinoma --- cholangiocellular carcinoma --- NISCH syndrome --- repair --- NHE2 --- ClC-2 --- inflammatory bowel disease --- mucosal immunology --- ZO-1 --- actomyosin --- aquaporin --- drinking rate --- epithelial fluid transport --- enterocyte --- osmoregulation --- paracellular --- proximal tubule --- calcium permeability --- claudin-12 --- paracellular channels and barriers --- cell polarity --- pathogens --- immune cells --- environmental sensors