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Genetic disorders. --- Noonan Syndrome --- Ras oncogenes. --- Ras proteins. --- Signal Transduction. --- Ras Proteins --- Genetics. --- Physiopathology.

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The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continua

GTP Phosphohydrolases. --- GTP-Phosphohydrolases. --- Guanosine triphosphatase. --- Physiology. --- ras GTPase-Activating Proteins. --- ras Proteins. --- Ras proteins. --- GTP phosphohydrolase --- GTPase --- Guanosine triphosphate phosphohydrolase --- Guanosinetriphosphatase --- G proteins --- Guanosine triphosphatase --- Phosphatases

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Signal Transduction --- ras Proteins --- GTP-Binding Proteins --- Blood Platelets --- GTP Phosphohydrolases --- physiology --- metabolism --- enzymology

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This second of two volumes discusses subfamily proteins involved in nucleo-cytoplasmic and vesicular transport mechanisms inside the cell. In this volume, the focus lies on the Rab, Ran and Arf subfamily members. Like Volume 1, the book was written by internationally renowned scientists in the field of small G-proteins. The biochemistry, structure, function and G-protein/effector interactions are described in detailed reviews. Together with Volume 1, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It was written for graduates and professors in biochemistry and cell biology interested in the mechanism and function of small G-proteins, but also offers an extremely valuable resource for those readers who are new to the field.

G proteins. --- Ras proteins. --- G proteins --- Guanosine triphosphatase --- GTP-binding proteins --- GTP regulatory proteins --- Guanine nucleotide-binding proteins --- Guanine nucleotide regulatory proteins --- Membrane proteins --- Cytology. --- Biochemistry. --- Cell Biology. --- Protein Science. --- Protein Structure. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Composition --- Cell biology. --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

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Protein-tyrosine kinase. --- Lecithin. --- Photoaffinity labeling. --- Biological physics. --- Cellular signal transduction. --- Phospholipases. --- Ras proteins. --- Organic chemistry. --- Biochemistry. --- Biophysics. --- Organic Chemistry. --- Biochemistry, general. --- Biological and Medical Physics, Biophysics. --- Biological physics --- Biology --- Medical sciences --- Physics --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Organic chemistry --- Composition --- Signal transduction, biological