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Quel risque de fracture avec les IPPS ? : Apports des données de pharmacovigilance
Authors: --- --- ---
Year: 2017 Publisher: Bruxelles: UCL. Faculté de pharmacie et des sciences biomédicales,

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Proton pump inhibitors are drugs widely prescribed in gastric acid disorders. These are currently subject to a polemic between experts in the matter. Indeed, over the last ten years, a number of suspicions have accumulated about a potential risk of fracture during the use of proton pump inhibitors. By bringing together the opinions expressed by various federal and European organizations, the results of several meta-analyzes and therapeutic guidance organizations , this thesis goes through the data available so far on this subject and the confrontations between them question asked: what risk of fracture with PPis ? This reflection arrives at a point appointed at a time when Belgium is reviewing the reimbursement criteria for this family of drugs as part of the government’s budgetary efforts. Les inhibiteurs de la pompe à proton sont des médicaments largement prescrits dans les troubles de l’acidité gastrique. Ceux-ci sont actuellement sujets à polémique entre experts en la matière. En effet, depuis une dizaine d’année, un certain nombre de soupçons s’accumulent concernant un risque potentiel de fracture lors de l’usage des inhibiteurs de la pompe à protons. En rassemblant les avis émis par différents organismes de guidance thérapeutique, ce mémoire parcourt les données disponibles à ce jour sur ce sujet et les confrontent entre elles afin de tenter de répondre à la question posée : quel risque de fracture avec les IPPs ? Cette réflexion arrive à point nommé à l’heure où la Belgique est en pleine révision des critères de remboursement de cette famille de médicaments dans le cadre des efforts budgétaires du gouvernement.


Book
The influence of the pharmaceutical industry on medicine, as exemplified by proton pump inhibitors
Author:
ISBN: 1527559955 Year: 2020 Publisher: Newcastle upon Tyne, UK : Cambridge Scholars Publishing,

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Book
Vers une prescription plus appropriée des IPP en médecine générale
Authors: --- ---
Year: 2016 Publisher: Bruxelles: UCL. Faculté de médecine,

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Introduction : L’efficacité des inhibiteurs de la pompe à protons (IPP) n’est plus à démontrer. Ils ont fait leurs preuves dans le traitement des pathologies peptiques gastro-intestinales. Ils font partie des médicaments les plus prescrits du monde et leur utilisation n’est pas toujours justifiée. C’est essentiellement la prescription au long cours qui pose problème. Cette prescription en excès implique un coût plus important pour la société et peut entrainer l’apparition d’effets secondaires. Que faire pour éviter cela ? Comment viser une prescription plus appropriée. Méthodologie : J’ai élaboré ce travail selon le modèle d’assurance qualité en partant d’une question de recherche clinique. J’ai analysé ma pratique actuelle concernant la prescription des inhibiteurs de la pompe à protons, je l’ai comparée aux recommandations de bonnes pratiques, à partir desquelles j’ai élaboré un protocole de qualité me permettant de planifier le changement de ma pratique. Enfin, je me suis fixé des objectifs et j’ai déterminé des indicateurs pour évaluer ce processus de qualité et objectiver une progression de ma pratique. Résultats : Les résultats obtenus après chaque échéance sont positifs. Les objectifs ont été atteints avec une progression continue de chaque indicateur. Cette démarche a nécessité une application stricte du protocole établi. Il a nécessité un investissement en temps et une approche systématique de chaque patient. Conclusions : Cette recherche de qualité dans ma pratique médicale revient à adopter une philosophie « evidence-based » de travail utile pour moi et mes patients. En réalisant ce projet, j’ai progressé en tant que praticien et j’entends poursuivre dans cette voie tout le long de ma carrière. L’intérêt supplémentaire est de continuer ce projet et garder dans ma pratique cette philosophie d’assurance qualité.


Dissertation
Proton pump inhibitors in childhood cystic fibrosis
Authors: ---
ISBN: 9052783411 Year: 2002 Publisher: Maastricht Universiteit Maastricht

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Dissertation
Atrophic gastritis during acid-suppressive therapy with focus on ECL cell hyperplasia and intragastric bacteria
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ISBN: 9052783179 Year: 2001 Publisher: Maastricht Universitaire pers

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Book
Placental Related Disorders of Pregnancy
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ISBN: 3036558993 3036559000 Year: 2022 Publisher: Basel MDPI - Multidisciplinary Digital Publishing Institute

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The Special Issue “Placental Related Disorders of Pregnancy” was edited by Dr Hiten D. Mistry, Department of Women and Children's Health, School of Life Course and Population Health Sciences, King's College London, London, UK and Dr Eun D. Lee, Department of Obstetrics and Gynecology, Virginia Commonwealth University Health System, Richmond, VA, USA.

Keywords

Medicine --- Physiology --- low-dose aspirin --- preeclampsia --- placenta --- eicosanoids --- sphingolipids --- thromboxane --- prostacyclin --- isoprostanes --- neutrophils --- protease-activated receptor 1 --- cold shock protein --- intrauterine growth restriction --- placentation --- apoptosis --- NF-κB --- hypertension in pregnancy --- angiogenesis --- endothelial function --- oxidative stress --- antioxidants --- post-maturity --- senescence --- pre-eclampsia --- renin–angiotensin system --- megalin --- proton pump inhibitors --- telomere shortening --- prenatal depression --- sex differences --- flow culture system --- explant culture under flow --- placental insufficiency --- SPINT2/HAI-2 --- foetal growth restriction --- small for gestational age --- placentome --- pregnancy --- nutrient restriction --- gene expression --- transcriptome --- spontaneous preterm birth --- bioenergetic metabolism --- interactome --- fetal sex disparity --- CD24 --- cytotrophoblast --- syncytiotrophoblast --- immunohistochemistry --- quantitative polymerase chain reaction (qPCR) --- immune tolerance --- inflammation --- cytokines --- adipokines --- antimicrobial peptides --- metabolic stress --- IGF-I --- insulin --- lactotroph hormones --- decidual reaction --- fetal membranes --- placental hormones --- primates --- uterine spiral artery --- uterine NK cell --- chorionic somatomammotropin --- blood flow --- nutrient uptake --- uterus --- ERAP2 --- trophoblast cells --- RNA sequencing --- differentially expressed genes --- congenital heart disease --- hand1 --- vascular development --- intrahepatic cholestasis of pregnancy --- human placenta --- bile acids --- transporters --- pregnancy complications --- metabolism --- glycolysis --- mitochondrial respiration --- placental metabolism --- trophoblast glycolysis --- trophoblast mitochondrial respiration --- sexual dimorphism --- Interleukin-15 --- CD122 --- natural killer cells --- macrophages --- trophoblast --- Irisin --- TRPV6 --- calcium transport --- skeletal dysplasia --- serine proteases --- subunit assembly --- transient receptor potential --- antioxidant capacity --- decidua --- fetal growth restriction --- KEAP1 --- NRF2 --- n/a --- renin-angiotensin system


Book
Recent Advances and Clinical Outcomes of Kidney Transplantation : Volume 2
Authors: --- ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Advances in immunosuppression and kidney transplant techniques have led to significant improvements in the short-term survival of the renal allograft. Long-term graft survival, however, has relatively lagged behind and has now become one of the main problems in kidney transplantation. In this Special Issue, we discuss the recent research developments in kidney transplants that may affect long-term allografts, as well as the survival of the patient. The latest developments in living kidney donation are also explored.

Keywords

Medicine --- malondialdehyde --- oxidative stress --- new-onset diabetes --- renal transplantation --- BK virus --- BK virus nephropathy --- kidney allograft --- transplantation --- Alport syndrome --- children --- autosomal dominant polycystic kidney disease --- epidemiology --- hospitalization --- kidney transplantation --- subarachnoid hemorrhage --- malignancy --- post-transplant malignancy --- renal cell carcinoma --- meta-analysis --- systematic reviews --- tacrolimus --- C/D-ratio --- pharmacokinetics --- opportunistic infection --- allograft survival --- urological complications --- ureteric stent --- urinary tract infection --- timing of removal --- living donor --- ethnicity --- age --- obesity --- genetic relationship donor/recipient --- atypical hemolytic uremic syndrome --- eculizumab --- glucose intolerance --- insulin secretion --- insulin resistance --- oral glucose tolerance test --- healthy subject --- hyperchloremia --- kidney graft dysfunction --- living donor kidney transplantation --- Uropathogenic E. coli --- UPEC --- phylogeny --- genomics --- antibiotic resistance --- virulence traits --- night-time renal transplantation --- graft survival --- patient survival/outcome --- surgical complications --- acute rejection --- lymphocyte --- CD45RC --- Belatacept --- cardiovascular high risk --- outcome --- machine perfusion --- organ preservation --- temperature --- hypothermic --- normothermic --- transplant --- proton-pump inhibitors --- iron --- iron deficiency --- polyomavirus --- BKV --- kidney --- glomerulus --- BKVAN --- nephropathy --- fluid management --- delayed graft function --- goal-directed fluid therapy --- calcineurin inhibitor nephrotoxcity --- C/D ratio --- tacrolimus metabolism --- ADPKD --- native nephrectomy --- patient outcome --- perioperative complications --- epidermal growth factor --- creatinine --- graft failure --- renal transplantation. --- new onset diabetes after renal transplantation --- single nucleotide polymorphisms --- n/a --- urinary biomarkers --- α-GST --- π-GST --- nephrotoxicity --- urinary excretion of N1-methylnicotinamide --- mortality --- niacin status --- dietary intake --- tryptophan --- vitamin B3 --- Kidney transplant --- vitamin C --- cancer mortality --- oxidative stress. --- mycophenolic acid --- immunosuppression --- plasmapheresis --- oxalate --- hyperoxaluria --- kidney transplant recipients --- post-transplantation diabetes mellitus --- all-cause mortality --- cardiovascular mortality --- infectious mortality --- magnesium --- hypomagnesaemia --- cancer --- kidney transplant --- survival --- living kidney donation --- living-donor kidney transplantation --- beliefs --- inequity --- ischemia reperfusion injury --- innate immune system --- adaptive immune system --- apoptosis --- necrosis --- hypoxic inducible factor --- endothelial dysfunction --- proton pump inhibitor --- transplant rejection --- GFR --- insulin-like growth factor 1 --- growth hormone --- muscle mass --- patient survival --- physical activity --- renal transplant recipients --- kidney transplant (KT) --- donor-specific antibodies (DSA) --- C3d-binding assay --- antibody-mediated rejection (AMR) --- arsenic --- diet --- fish consumption --- post-transplant diabetes mellitus --- N1-methyl-2-pyridone-5-carboxamide --- N1-methylnicotinamide --- urinary excretion --- kidney function --- biomarker --- branched chain amino acids --- posttransplant diarrhea --- methanogenesis --- Methanosphaera stadtmanae --- mucins --- sulfate-reducing bacteria --- acute humoral rejection --- first-line therapy --- outcomes --- proteasome inhibitor --- renal transplant --- transplant recipients --- calcineurin inhibitors --- FK506 --- pharmacokinetic --- fast tacrolimus metabolizers


Book
Recent Advances and Clinical Outcomes of Kidney Transplantation
Authors: --- ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Advances in immunosuppression and kidney transplant techniques have led to significant improvements in the short-term survival of the renal allograft. Long-term graft survival, however, has relatively lagged behind and has now become one of the main problems in kidney transplantation. In this Special Issue, we discuss the recent research developments in kidney transplants that may affect long-term allografts, as well as the survival of the patient. The latest developments in living kidney donation are also explored.

Keywords

Medicine --- malondialdehyde --- oxidative stress --- new-onset diabetes --- renal transplantation --- BK virus --- BK virus nephropathy --- kidney allograft --- transplantation --- Alport syndrome --- children --- autosomal dominant polycystic kidney disease --- epidemiology --- hospitalization --- kidney transplantation --- subarachnoid hemorrhage --- malignancy --- post-transplant malignancy --- renal cell carcinoma --- meta-analysis --- systematic reviews --- tacrolimus --- C/D-ratio --- pharmacokinetics --- opportunistic infection --- allograft survival --- urological complications --- ureteric stent --- urinary tract infection --- timing of removal --- living donor --- ethnicity --- age --- obesity --- genetic relationship donor/recipient --- atypical hemolytic uremic syndrome --- eculizumab --- glucose intolerance --- insulin secretion --- insulin resistance --- oral glucose tolerance test --- healthy subject --- hyperchloremia --- kidney graft dysfunction --- living donor kidney transplantation --- Uropathogenic E. coli --- UPEC --- phylogeny --- genomics --- antibiotic resistance --- virulence traits --- night-time renal transplantation --- graft survival --- patient survival/outcome --- surgical complications --- acute rejection --- lymphocyte --- CD45RC --- Belatacept --- cardiovascular high risk --- outcome --- machine perfusion --- organ preservation --- temperature --- hypothermic --- normothermic --- transplant --- proton-pump inhibitors --- iron --- iron deficiency --- polyomavirus --- BKV --- kidney --- glomerulus --- BKVAN --- nephropathy --- fluid management --- delayed graft function --- goal-directed fluid therapy --- calcineurin inhibitor nephrotoxcity --- C/D ratio --- tacrolimus metabolism --- ADPKD --- native nephrectomy --- patient outcome --- perioperative complications --- epidermal growth factor --- creatinine --- graft failure --- renal transplantation. --- new onset diabetes after renal transplantation --- single nucleotide polymorphisms --- n/a --- urinary biomarkers --- α-GST --- π-GST --- nephrotoxicity --- urinary excretion of N1-methylnicotinamide --- mortality --- niacin status --- dietary intake --- tryptophan --- vitamin B3 --- Kidney transplant --- vitamin C --- cancer mortality --- oxidative stress. --- mycophenolic acid --- immunosuppression --- plasmapheresis --- oxalate --- hyperoxaluria --- kidney transplant recipients --- post-transplantation diabetes mellitus --- all-cause mortality --- cardiovascular mortality --- infectious mortality --- magnesium --- hypomagnesaemia --- cancer --- kidney transplant --- survival --- living kidney donation --- living-donor kidney transplantation --- beliefs --- inequity --- ischemia reperfusion injury --- innate immune system --- adaptive immune system --- apoptosis --- necrosis --- hypoxic inducible factor --- endothelial dysfunction --- proton pump inhibitor --- transplant rejection --- GFR --- insulin-like growth factor 1 --- growth hormone --- muscle mass --- patient survival --- physical activity --- renal transplant recipients --- kidney transplant (KT) --- donor-specific antibodies (DSA) --- C3d-binding assay --- antibody-mediated rejection (AMR) --- arsenic --- diet --- fish consumption --- post-transplant diabetes mellitus --- N1-methyl-2-pyridone-5-carboxamide --- N1-methylnicotinamide --- urinary excretion --- kidney function --- biomarker --- branched chain amino acids --- posttransplant diarrhea --- methanogenesis --- Methanosphaera stadtmanae --- mucins --- sulfate-reducing bacteria --- acute humoral rejection --- first-line therapy --- outcomes --- proteasome inhibitor --- renal transplant --- transplant recipients --- calcineurin inhibitors --- FK506 --- pharmacokinetic --- fast tacrolimus metabolizers


Book
Recent Advances and Clinical Outcomes of Kidney Transplantation : Volume 2
Authors: --- ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Advances in immunosuppression and kidney transplant techniques have led to significant improvements in the short-term survival of the renal allograft. Long-term graft survival, however, has relatively lagged behind and has now become one of the main problems in kidney transplantation. In this Special Issue, we discuss the recent research developments in kidney transplants that may affect long-term allografts, as well as the survival of the patient. The latest developments in living kidney donation are also explored.

Keywords

malondialdehyde --- oxidative stress --- new-onset diabetes --- renal transplantation --- BK virus --- BK virus nephropathy --- kidney allograft --- transplantation --- Alport syndrome --- children --- autosomal dominant polycystic kidney disease --- epidemiology --- hospitalization --- kidney transplantation --- subarachnoid hemorrhage --- malignancy --- post-transplant malignancy --- renal cell carcinoma --- meta-analysis --- systematic reviews --- tacrolimus --- C/D-ratio --- pharmacokinetics --- opportunistic infection --- allograft survival --- urological complications --- ureteric stent --- urinary tract infection --- timing of removal --- living donor --- ethnicity --- age --- obesity --- genetic relationship donor/recipient --- atypical hemolytic uremic syndrome --- eculizumab --- glucose intolerance --- insulin secretion --- insulin resistance --- oral glucose tolerance test --- healthy subject --- hyperchloremia --- kidney graft dysfunction --- living donor kidney transplantation --- Uropathogenic E. coli --- UPEC --- phylogeny --- genomics --- antibiotic resistance --- virulence traits --- night-time renal transplantation --- graft survival --- patient survival/outcome --- surgical complications --- acute rejection --- lymphocyte --- CD45RC --- Belatacept --- cardiovascular high risk --- outcome --- machine perfusion --- organ preservation --- temperature --- hypothermic --- normothermic --- transplant --- proton-pump inhibitors --- iron --- iron deficiency --- polyomavirus --- BKV --- kidney --- glomerulus --- BKVAN --- nephropathy --- fluid management --- delayed graft function --- goal-directed fluid therapy --- calcineurin inhibitor nephrotoxcity --- C/D ratio --- tacrolimus metabolism --- ADPKD --- native nephrectomy --- patient outcome --- perioperative complications --- epidermal growth factor --- creatinine --- graft failure --- renal transplantation. --- new onset diabetes after renal transplantation --- single nucleotide polymorphisms --- n/a --- urinary biomarkers --- α-GST --- π-GST --- nephrotoxicity --- urinary excretion of N1-methylnicotinamide --- mortality --- niacin status --- dietary intake --- tryptophan --- vitamin B3 --- Kidney transplant --- vitamin C --- cancer mortality --- oxidative stress. --- mycophenolic acid --- immunosuppression --- plasmapheresis --- oxalate --- hyperoxaluria --- kidney transplant recipients --- post-transplantation diabetes mellitus --- all-cause mortality --- cardiovascular mortality --- infectious mortality --- magnesium --- hypomagnesaemia --- cancer --- kidney transplant --- survival --- living kidney donation --- living-donor kidney transplantation --- beliefs --- inequity --- ischemia reperfusion injury --- innate immune system --- adaptive immune system --- apoptosis --- necrosis --- hypoxic inducible factor --- endothelial dysfunction --- proton pump inhibitor --- transplant rejection --- GFR --- insulin-like growth factor 1 --- growth hormone --- muscle mass --- patient survival --- physical activity --- renal transplant recipients --- kidney transplant (KT) --- donor-specific antibodies (DSA) --- C3d-binding assay --- antibody-mediated rejection (AMR) --- arsenic --- diet --- fish consumption --- post-transplant diabetes mellitus --- N1-methyl-2-pyridone-5-carboxamide --- N1-methylnicotinamide --- urinary excretion --- kidney function --- biomarker --- branched chain amino acids --- posttransplant diarrhea --- methanogenesis --- Methanosphaera stadtmanae --- mucins --- sulfate-reducing bacteria --- acute humoral rejection --- first-line therapy --- outcomes --- proteasome inhibitor --- renal transplant --- transplant recipients --- calcineurin inhibitors --- FK506 --- pharmacokinetic --- fast tacrolimus metabolizers


Book
Recent Advances and Clinical Outcomes of Kidney Transplantation
Authors: --- ---
Year: 2020 Publisher: Basel, Switzerland MDPI - Multidisciplinary Digital Publishing Institute

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Abstract

Advances in immunosuppression and kidney transplant techniques have led to significant improvements in the short-term survival of the renal allograft. Long-term graft survival, however, has relatively lagged behind and has now become one of the main problems in kidney transplantation. In this Special Issue, we discuss the recent research developments in kidney transplants that may affect long-term allografts, as well as the survival of the patient. The latest developments in living kidney donation are also explored.

Keywords

malondialdehyde --- oxidative stress --- new-onset diabetes --- renal transplantation --- BK virus --- BK virus nephropathy --- kidney allograft --- transplantation --- Alport syndrome --- children --- autosomal dominant polycystic kidney disease --- epidemiology --- hospitalization --- kidney transplantation --- subarachnoid hemorrhage --- malignancy --- post-transplant malignancy --- renal cell carcinoma --- meta-analysis --- systematic reviews --- tacrolimus --- C/D-ratio --- pharmacokinetics --- opportunistic infection --- allograft survival --- urological complications --- ureteric stent --- urinary tract infection --- timing of removal --- living donor --- ethnicity --- age --- obesity --- genetic relationship donor/recipient --- atypical hemolytic uremic syndrome --- eculizumab --- glucose intolerance --- insulin secretion --- insulin resistance --- oral glucose tolerance test --- healthy subject --- hyperchloremia --- kidney graft dysfunction --- living donor kidney transplantation --- Uropathogenic E. coli --- UPEC --- phylogeny --- genomics --- antibiotic resistance --- virulence traits --- night-time renal transplantation --- graft survival --- patient survival/outcome --- surgical complications --- acute rejection --- lymphocyte --- CD45RC --- Belatacept --- cardiovascular high risk --- outcome --- machine perfusion --- organ preservation --- temperature --- hypothermic --- normothermic --- transplant --- proton-pump inhibitors --- iron --- iron deficiency --- polyomavirus --- BKV --- kidney --- glomerulus --- BKVAN --- nephropathy --- fluid management --- delayed graft function --- goal-directed fluid therapy --- calcineurin inhibitor nephrotoxcity --- C/D ratio --- tacrolimus metabolism --- ADPKD --- native nephrectomy --- patient outcome --- perioperative complications --- epidermal growth factor --- creatinine --- graft failure --- renal transplantation. --- new onset diabetes after renal transplantation --- single nucleotide polymorphisms --- n/a --- urinary biomarkers --- α-GST --- π-GST --- nephrotoxicity --- urinary excretion of N1-methylnicotinamide --- mortality --- niacin status --- dietary intake --- tryptophan --- vitamin B3 --- Kidney transplant --- vitamin C --- cancer mortality --- oxidative stress. --- mycophenolic acid --- immunosuppression --- plasmapheresis --- oxalate --- hyperoxaluria --- kidney transplant recipients --- post-transplantation diabetes mellitus --- all-cause mortality --- cardiovascular mortality --- infectious mortality --- magnesium --- hypomagnesaemia --- cancer --- kidney transplant --- survival --- living kidney donation --- living-donor kidney transplantation --- beliefs --- inequity --- ischemia reperfusion injury --- innate immune system --- adaptive immune system --- apoptosis --- necrosis --- hypoxic inducible factor --- endothelial dysfunction --- proton pump inhibitor --- transplant rejection --- GFR --- insulin-like growth factor 1 --- growth hormone --- muscle mass --- patient survival --- physical activity --- renal transplant recipients --- kidney transplant (KT) --- donor-specific antibodies (DSA) --- C3d-binding assay --- antibody-mediated rejection (AMR) --- arsenic --- diet --- fish consumption --- post-transplant diabetes mellitus --- N1-methyl-2-pyridone-5-carboxamide --- N1-methylnicotinamide --- urinary excretion --- kidney function --- biomarker --- branched chain amino acids --- posttransplant diarrhea --- methanogenesis --- Methanosphaera stadtmanae --- mucins --- sulfate-reducing bacteria --- acute humoral rejection --- first-line therapy --- outcomes --- proteasome inhibitor --- renal transplant --- transplant recipients --- calcineurin inhibitors --- FK506 --- pharmacokinetic --- fast tacrolimus metabolizers

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