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Primary progressive aphasia is a clinical syndrome that includes a group of neurodegenerative disorders characterized by progressive language impairment. Our knowledge about this disorder has evolved significantly in recent years. Notably, correlations between clinical findings and pathology have improved, and main clinical, neuroimaging, and genetic features have been described. Furthermore, primary progressive aphasia is a good model for the study of brain–behavior relationships, and has contributed to the knowledge of the neural basis of language functioning. However, there are many open questions remaining. For instance, classification into three variants (non-fluent, semantic, and logopenic) is under debate; further data about epidemiology and natural history of the diseases are needed; and, as in other neurodegenerative disorders, successful therapies are lacking. The Guest Editors expect that this book can be very useful for scholars.

primary progressive aphasia --- informativeness --- speech production --- assessment --- diagnosis --- cognitive approach --- dementia --- frontotemporal dementia --- Alzheimer’s disease --- neuropsychology --- span --- sentence repetition --- working memory --- phonological --- visuospatial --- natural history --- mortality --- survival --- memory clinic --- graphical markers --- graphical parameters --- writing pressure --- differential diagnosis --- longitudinal assessment --- cognitive changes --- behavioural and psychological symptoms of dementia --- level of functioning --- electroencephalography --- resting-state --- biomarkers machine learning --- K-Nearest Neighbors --- graph theory --- treatment --- speech and language therapy --- intervention --- cognitive rehabilitation --- bilingualism --- semantic dementia --- semantic variant primary progressive aphasia --- word finding --- language therapy --- behavioural therapy --- electroencephalography (EEG) --- network analysis --- progressive apraxia of speech --- n/a --- Alzheimer's disease

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It is important to prevent and manage the frailty of the elderly because their muscle strength and physical activity decrease in old age, making them prone to falling, depression, and social isolation. In the end, they need to be admitted to a hospital or a nursing home. When successful aging fails and motor ability declines due to illness, malnutrition, or reduced activity, frailty eventually occurs. Once frailty occurs, people with frailty do not have the power to exercise or the power to move. The functions of the heart and muscles are deteriorated more rapidly when they are not used. Consequently, frailty goes through a vicious cycle. As one’s physical fitness is deteriorated, the person has less power to exercise, poorer cognitive functions, and inferior nutrition intake. Consequently, the whole body of the person deteriorates. Therefore, in addition to observational studies to identify risk factors for preventing aging, various intervention studies have been conducted to develop exercise programs and apply them to communities, hospitals, and nursing homes for helping the elderly maintain healthy lives. Until now, most aging studies have focused on physical frailty. However, social frailty and cognitive frailty affect senile health negatively just as much as physical frailty. Nevertheless, little is known about social frailty and cognitive frailty. This special issue includes original experimental studies, reviews, systematic reviews, and meta-analysis studies on the prevention of senescence (physical senescence, cognitive senescence, social senescence), high-risk group detection, differentiation, and intervention.

Public health & preventive medicine --- brain stimulation --- dementia --- meta-analysis --- naming --- primary progressive aphasia --- qualitative evaluation --- cognitive function --- data mining --- Parkinson’s disease with mild cognitive impairment --- random forest --- neuropsychological test --- motoric cognitive risk syndrome --- fall --- gait speed --- three-item recall --- older adults --- mixing ability --- color-changing chewing gum --- frailty --- cross-sectional study --- spousal concordance --- aging --- aged --- accidental falls --- pain --- mild cognitive impairment --- depressive symptoms --- frailty profiles --- latent class analysis --- quality of life --- perceived health --- frailty syndrome --- physiotherapy --- exercise --- mood --- BDI --- STAI --- SWLS --- muscle strength --- community-dwelling older adults --- physical frailty --- prevalence --- risk factors --- non-robust --- FRAIL scale --- Tilburg Frailty Indicator --- determinants --- community-based --- sleep quality --- middle-aged and older adults --- SUNFRAIL --- psychometric properties --- screening tool --- social isolation --- social networks --- social support --- social participation --- Parkinson’s disease dementia --- instrumental activities of daily living --- clinical dementia rating --- convergence rate --- neuropsychological tests --- neuropsychiatric symptoms --- explainable artificial intelligence --- machine learning --- stacking ensemble --- Self-Rating Anxiety Scale --- multiple risk factors --- fall assessment sheet --- elderly patients --- hospitalization --- risk management --- driving cessation --- meaningful activities --- psychosomatic functions --- physical functional performance --- nursing homes --- physical fitness --- gait analysis --- indicators --- screening --- artificial intelligence --- healthcare --- frail --- Baduanjin --- strength training --- endurance training --- Explainable Artificial Intelligence